Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium handling in the human heart is sparse. Therefore, this study aimed to analyse how ageing affects key mechanisms that regulate intracellular
calcium in human atrial myocytes.
Herrainz, A., Álvarez-García, Jesus, Llach, A., Molina, C., Fernandes, J., Ferrero-Gregori, A., Rodríguez, C., Vallmitjana, A., Benitez, R., Padró, J., Martínez-González, J., Cinca, J., Hove-Madsen, L. Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes. "Cardiovascular research", 24 Febrer 2015, p. 76-86.