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Role of ECM/peptide coatings on SDF-1a triggered mesenchymal stromal cell migration from microcarriers for cell therapy

Autor
Levato, R.; Planell, J. A.; Mateos, M.; Engel, E.
Tipus d'activitat
Article en revista
Revista
Acta biomaterialia
Data de publicació
2015-05-01
Volum
18
Pàgina inicial
59
Pàgina final
67
DOI
https://doi.org/10.1016/j.actbio.2015.02.008 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/28053 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1742706115000719 Obrir en finestra nova
Resum
Many cell therapies rely on the ability of mesenchymal stromal cells (MSCs) to diffuse and localize throughout the target tissue-such as tumoral and ischemic tissues-, in response to specific cytokine signals, rather than being concentrated at the site of implantation. Therefore, it is fundamental to engineer biomaterial carriers as reservoirs, from which cells can migrate, possibly in a controlled manner. In this work, microcarriers (µCs) made of polylactic acid are characterized as MSC delive...
Citació
Levato, R. [et al.]. Role of ECM/peptide coatings on SDF-1a triggered mesenchymal stromal cell migration from microcarriers for cell therapy. "Acta biomaterialia", 01 Maig 2015, vol. 18, p. 59-67.
Paraules clau
Cell therapy, Chemotaxis, ECM (extracellular matrix), Mesenchymal stromal cells, Surface modification
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants

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