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Two high-mobility group box domains act together to underwind and kink DNA.

Autor
Sanchez, R.; Acosta, F.J.; Malarkey, C.S.; Saperas, N.; Churchill, M.E.A.; Campos, J.Lourdes
Tipus d'activitat
Article en revista
Revista
Acta crystallographica. Section D, biological crystallography
Data de publicació
2015-07-02
Volum
D71
Número
part 7
Pàgina inicial
1423
Pàgina final
1432
DOI
https://doi.org/10.1107/S1399004715007452 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/78117 Obrir en finestra nova
URL
http://journals.iucr.org/d/issues/2015/07/00/mh5175/mh5175.pdf Obrir en finestra nova
Resum
High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little sequence specificity but have remarkable abilities to underwind and bend DNA. Although HMGB1 box A is thought to be responsible for the majority of HMGB1-DNA interactions with pre-bent or kinked DNA, little is known about how it recognizes unmodified DNA. Here, the crystal structure...
Citació
Sanchez, R., Acosta, F.J., Malarkey, C.S., Saperas, N., Churchill, M.E.A., Campos, J.Lourdes. Two high-mobility group box domains act together to underwind and kink DNA.. "Acta crystallographica. Section D, biological crystallography", 02 Juliol 2015, vol. D71, núm. part 7, p. 1423-1432.
Paraules clau
4-way junction dna, DNA binding, High-mobility group protein, X-ray crystallography, a-domain, binding proteins, chromatin, cisplatin-modified dna, duplex dna, histone h1, hmgb1, intercalating residues, mitochondrial transcription factor, tandem hmg boxes
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques

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