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Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes

Autor
Hiess, F.; Vallmitjana, A.; Wang, R.; Cheng, H.; ter Keurs, H.; Chen, J.; Hove-Madsen, L.; Benitez, R.; Chen, S.
Tipus d'activitat
Article en revista
Revista
Journal of biological chemistry
Data de publicació
2015-08-14
Volum
290
Número
33
Pàgina inicial
20477
Pàgina final
20487
DOI
https://doi.org/10.1074/jbc.M115.650531 Obrir en finestra nova
Projecte finançador
Análisis automático de datos experimentales en fisiología cardiaca
Repositori
http://hdl.handle.net/2117/79512 Obrir en finestra nova
Resum
The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not only on the expression of RyR2, but also on its distribution. Despite its importance, little is known about the distribution and organization of RyR2 in living cells. To study the distribution of RyR2 in living cardiomyocytes, we generated a knock-in mouse model expressing a GFP-...
Citació
Hiess, F., Vallmitjana, A., Wang, R., Cheng, H., ter Keurs, H., Chen, J., Hove-Madsen, L., Benitez, R., Chen, S. Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes. "Journal of biological chemistry", 14 Agost 2015, vol. 290, núm. 33, p. 20477-20487.
Paraules clau
Rat-heart Cells, Ca2+ Release Sites, Calcium Transients, 3-dimensional Distribution, Mitochondrial Calcium, Confocal Microscopy, Local-control, Muscle, Sparks, Channel
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
SISBIO - Senyals i Sistemes Biomèdics

Participants

  • Hiess, Florian  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Wang, Ruiwu  (autor)
  • Cheng, Hongqiang  (autor)
  • ter Keurs, Henk  (autor)
  • Chen, Ju  (autor)
  • Hove Madsen, Leif  (autor)
  • Benitez Iglesias, Raul  (autor)
  • Chen, S. R. Wayne  (autor)