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Bone tissue properties measurement by reference point indentation in glucocorticoid-induced osteoporosis

Autor
Mellibovsky, L.; Prieto, D.; Mellibovsky, F.; Gueerri, R.; Nogues, X.; Randall, C.; Hansma, P.; Díez-Perez, A.
Tipus d'activitat
Article en revista
Revista
Journal of bone and mineral research
Data de publicació
2015-09-01
Volum
30
Número
9
Pàgina inicial
1651
Pàgina final
1656
DOI
https://doi.org/10.1002/jbmr.2497 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/86742 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2497/abstract Obrir en finestra nova
Resum
Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detect bone tissue property changes early after glucocorticoid treatment initiation. After initial laborator...
Citació
Mellibovsky, L., Prieto, D., Mellibovsky, F., Gueerri, R., Nogues, X., Randall, C., Hansma, P., Diez, A. Bone tissue properties measurement by reference point indentation in glucocorticoid-induced osteoporosis. "Journal of bone and mineral research", 01 Setembre 2015, vol. 30, núm. 9, p. 1651-1656.
Paraules clau
anabolics, antiresorptive drugs, antiresorptives, biomechanics, bone material strength, cortical bone, corticosteroids, finite-element-analysis, fracture risk, in-vivo measurement, mechanical-properties, mineral density, postmenopausal women, reference point indentation, strength, structural basis
Grup de recerca
DF - Dinàmica de Fluids: formació d'estructures i aplicacions geofísiques

Participants

  • Mellibovsky, Leonardo  (autor)
  • Prieto Alhambra, Daniel  (autor)
  • Mellibovsky Elstein, Fernando  (autor)
  • Gueerri Fernandez, Roberto  (autor)
  • Nogues, Xavier  (autor)
  • Randall, Connor  (autor)
  • Hansma, Paul K.  (autor)
  • Díez Pérez, Adolfo  (autor)

Arxius