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Simulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions

Autor
Gouvêa, B.; Weber, R.; Lobosco, M.; Alonso, S.
Tipus d'activitat
Article en revista
Revista
Biomed Research International
Data de publicació
2015-05-17
Volum
2015
Pàgina inicial
713058-1
Pàgina final
713058-19
DOI
https://doi.org/10.1155/2015/713058 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/78847 Obrir en finestra nova
Resum
The inclusion of nonconducting media, mimicking cardiac fibrosis, in two models of cardiac tissue produces the formation of ectopic beats. The fraction of nonconducting media in comparison with the fraction of healthy myocytes and the topological distribution of cells determines the probability of ectopic beat generation. First, a detailed subcellular microscopic model that accounts for the microstructure of the cardiac tissue is constructed and employed for the numerical simulation of action po...
Citació
Gouvêa, B., Weber, R., Lobosco, M., Alonso, S. Simulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions. "Biomed Research International", 17 Maig 2015, vol. 2015, p. 713058-1-713058-19.
Paraules clau
Cardiac arrhythmia, Ectopic beats, cardiac modeling, complex fractionated atrial electrograms
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos

Participants

  • Gouvêa de Barros, Bruno  (autor)
  • Weber dos Santos, Rodrigo  (autor)
  • Lobosco, Marcelo  (autor)
  • Alonso Muñoz, Sergio  (autor)