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Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Autor
Murase, S. K.; Aymat, M.; Calvet, A.; del Valle, LJ.; Puiggali, J.
Tipus d'activitat
Article en revista
Revista
European polymer journal
Data de publicació
2015-10-01
Volum
71
Pàgina inicial
196
Pàgina final
209
DOI
https://doi.org/10.1016/j.eurpolymj.2015.07.047 Obrir en finestra nova
Projecte finançador
Nuevos polímeros derivados de lactida: estructura, aplicaciones biomédicas y microprocesado.
Repositori
http://hdl.handle.net/2117/85128 Obrir en finestra nova
Resum
Electrospraying of poly(butylene succinate) and its mixture with different indole derivatives was successfully performed using chloroform as solvent and relatively low flow rates and concentrations. Morphology of particles (size, diameter distribution and surface texture) and encapsulation efficiency were dependent on the loaded drug and specifically on the type of substituent (methyl or phenyl) and its position in the indole core. In general, particles showed a raisin-like morphology caused by ...
Citació
Murase, S. K., Aymat, M., Calvet, A., del Valle, LJ., Puiggali, J. Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity. "European polymer journal", 01 Octubre 2015, vol. 71, p. 196-209.
Paraules clau
ANTITUMOR, Anticancer activity, DISCOVERY, DRUG-DELIVERY, Drug release, ELECTROHYDRODYNAMIC ATOMIZATION, Electrospraying, INDOLE-3-CARBINOL, Indole derivatives, MICROPARTICLES, NANOPARTICLES, NANOTECHNOLOGY, Poly(butylene succinate), RELEASE, SELECTIVE PDE5 INHIBITOR
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.

Participants

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