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Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism

Autor
Roca, M.; Sanchis, P.; Vilanova, B.; Pauwels, K.; Martorell, G.; Perez, J.
Tipus d'activitat
Article en revista
Revista
RSC advances
Data de publicació
2015-01-01
Volum
5
Número
101
Pàgina inicial
83074
Pàgina final
83088
DOI
https://doi.org/10.1039/c5ra12753j Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/82621 Obrir en finestra nova
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA12753J#!divAbstract Obrir en finestra nova
Resum
Neuromedin C (NMC) is a peptide that regulates various processes in the central nervous system and gastrointestinal tract through its interaction with the bombesin receptor subtype-2 (BB2R). Hence, BB2R antagonists hold the potential to treat disorders that occur as a result of NMC dysfunction or misregulation. However, their efficient design requires a detailed understanding of the structural features of NMC, which hitherto are unknown. Herein, we describe the conformational ensembles of NMC in...
Citació
Roca, M., Sanchis, P., Vilanova, B., Pauwels, K., Martorell, G., Perez, J. Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism. "RSC advances", 01 Gener 2015, vol. 5, núm. 101, p. 83074-83088.
Paraules clau
Gastrin-releasing-peptide, antimicrobial peptide, backbone dynamics, biological macromolecules, bombesin-like peptides, intrinsically unstructured protein, membrane interactions, molecular-dynamics, n-15 nmr relaxation, rotational diffusion
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

  • Roca Adrover, Miquel  (autor)
  • Sanchis, Pilar  (autor)
  • Vilanova, Bartolome  (autor)
  • Pauwels, Kris  (autor)
  • Martorell, Gabriel  (autor)
  • Perez Gonzalez, Juan Jesus  (autor)

Arxius