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Exact inference for Hardy-Weinberg proportions with missing genotypes: single and multiple imputation

Autor
Graffelman, J.; Nelson, S.; Gogarten, S.; Weir, B.
Tipus d'activitat
Article en revista
Revista
G3-Genes Genomes Genetics
Data de publicació
2015-09-15
Volum
5
Número
11
Pàgina inicial
2365
Pàgina final
2373
DOI
https://doi.org/10.1534/g3.115.022111 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/82666 Obrir en finestra nova
Resum
This paper addresses the issue of exact-test based statistical inference for Hardy-Weinberg equilibrium in the presence of missing genotype data. Missing genotypes often are discarded when markers are tested for Hardy-Weinberg equilibrium, which can lead to bias in the statistical inference about equilibrium. Single and multiple imputation can improve inference on equilibrium. We develop tests for equilibrium in the presence of missingness by using both inbreeding coefficients (or, equivalently,...
Citació
Graffelman, J., Nelson, S., Gogarten, S., Weir, B. Exact inference for Hardy-Weinberg proportions with missing genotypes: single and multiple imputation. "G3-Genes Genomes Genetics", 15 Setembre 2015, vol. 5, núm. 11, p. 2365-2373.
Grup de recerca
COSDA-UPC - COmpositional and Spatial Data Analysis

Participants

  • Graffelman, Jan  (autor)
  • Nelson, S.  (autor)
  • Gogarten, S.M.  (autor)
  • Weir, B.S.  (autor)

Arxius