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Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic

Autor
Tripathi, P.; Romanini, M.; Tamarit, J. Ll.; Macovez, R.
Tipus d'activitat
Article en revista
Revista
International journal of pharmaceutics
Data de publicació
2015-11-10
Volum
495
Número
1
Pàgina inicial
420
Pàgina final
427
DOI
https://doi.org/10.1016/j.ijpharm.2015.09.012 Obrir en finestra nova
Projecte finançador
Vidrios Orgánicos y Metálicos: Estructura, Dinámica y Estabilidad
Vidrios orgánicos y metálicos: Estructura, dinámica y estabilidad
Repositori
http://hdl.handle.net/2117/81334 Obrir en finestra nova
Resum
We employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by dielectric spectroscopy is Tg=290±1K. The primary (a) relaxation dynamics is observed to follow a Vogel-Fulcher-Tammann temperature dependence, with a kinetic fragility index m=86±13, which classifies Biclotymol as a relatively fragile glass former. A secondary relaxation is also ...
Citació
Tripathi, P., Romanini, M., Tamarit, J. Ll., Macovez, R. Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic. "International journal of pharmaceutics", 10 Novembre 2015, vol. 495, núm. 1, p. 420-427.
Paraules clau
amorphous, avrami law, biclotymol, crystallization kinetics, dipolar relaxation, domain havriliak-negami, glass-transition, kohlrausch-williams-watts, molecular mobility, physical stability, secondary relaxations, stability, state, thermodynamic quantities, time, water
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

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