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Quorum-quenching and matrix-degrading enzymes in multilayer coatings synergistically prevent bacterial biofilm formation on urinary catheters

Autor
Ivanova, K.; Macedo, M.M.; Francesko, A.; Mendoza, E.; Tzanov, T.
Tipus d'activitat
Article en revista
Revista
ACS applied materials and interfaces
Data de publicació
2015-12-02
Volum
7
Número
49
Pàgina inicial
27066
Pàgina final
27077
DOI
https://doi.org/10.1021/acsami.5b09489 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/80862 Obrir en finestra nova
URL
http://pubs.acs.org/doi/10.1021/acsami.5b09489 Obrir en finestra nova
Resum
Bacteria often colonize in-dwelling medical devices and grow as complex biofilm communities of cells embedded in a self-produced extracellular polymeric matrix, which increases their resistance to antibiotics and the host immune system. During biofilm growth, bacterial cells cooperate through specific quorum-sensing (QS) signals. Taking advantage of this mechanism of biofilm formation, we hypothesized that interrupting the communication among bacteria and simultaneously degrading the extracellul...
Citació
Ivanova, K., Macedo, M.M., Francesko, A., Mendoza, E., Tzanov, T. Quorum-quenching and matrix-degrading enzymes in multilayer coatings synergistically prevent bacterial biofilm formation on urinary catheters. "ACS applied materials and interfaces", 02 Desembre 2015, vol. 7, núm. 49, p. 27066-27077.
Paraules clau
Acylase, Amylase, Multilayer Coatings, Quorum Quenching, Exopolysaccharides, Urinary Catheters, In Vitro And In Vivo Biofilm Prevention
Grup de recerca
GBMI - Grup de Biotecnologia Molecular i Industrial

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