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Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes

Autor
Llacher Alsina, Anna Pilar; Vallmitjana, A.; Benitez, R.; Montiel, J.; Cinca, J.
Tipus d'activitat
Article en revista
Revista
Basic research in cardiology
Data de publicació
2016-01-01
Volum
111
Pàgina inicial
1
Pàgina final
1
DOI
https://doi.org/10.1007/s00395-015-0525-2 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/82603 Obrir en finestra nova
Resum
© 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) expression and activation. Here we tested whether this may favor atrial arrhythmogenesis by promoting beat-to-beat alternation and irregularity. Patch-clamp and confocal calcium imaging was used to measure the beat-to-beat response of the calcium current and transient in human atri...
Citació
Llacher Alsina, Anna Pilar, Vallmitjana, A., Benitez, R., Montiel, J., Cinca, J. Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes. "Basic research in cardiology", 01 Gener 2016, vol. 111, p. 1.
Paraules clau
Adenosine Receptor, Atrial Myocyte, Electrophysiology, L-type Calcium Current, Sarcoplasmic Reticulum
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
SISBIO - Senyals i Sistemes Biomèdics

Participants

  • Llacher Alsina, Anna Pilar  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Benitez Iglesias, Raul  (autor)
  • Montiel Dacosta, José Antonio  (autor)
  • Cinca Cuscullola, Juan Maria  (autor)

Arxius