Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells

Autor
Hernadez-Hernandez, G.; Alvarez-Lacalle, E.; Shiferaw, Y.
Tipus d'activitat
Article en revista
Revista
Physical review E: statistical, nonlinear, and soft matter physics
Data de publicació
2015-11-20
Volum
92
Número
052715
DOI
https://doi.org/10.1103/PhysRevE.92.052715 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/86187 Obrir en finestra nova
URL
http://journals.aps.org/pre/abstract/10.1103/PhysRevE.92.052715 Obrir en finestra nova
Resum
Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it is not understood what determines the timing and location of spontaneous calcium waves within cells. Here, we analyze a simplified model of SCR in which calcium release is modeled as a stochastic processes on a two-dimensional network of randomly di...
Citació
Hernadez-Hernandez, G., Alvarez-Lacalle, E., Shiferaw, Y. Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells. "Physical review E: statistical, nonlinear, and soft matter physics", 20 Novembre 2015, vol. 92, núm. 052715.
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos

Participants

Arxius