SISBIO - Biomedical Signals and Systems
Total activity: 1264
Type
Research group
Type of group
UPC research group
Acronym
SISBIO
URL
http://www.creb.upc.es/component/option,com_jresearch/Itemid,14/id,6/lang,ca/task,show/view,researcharea/ Open in new window
Objectives
To design and develop advanced biomedical signal processing techniques for the monitoring, diagnosis and therapy of pathologies. The specific objectives are as follows: a) the study of theoretical aspects of signal processing techniques and their applicability to the interpretation of biomedical signals to improve the processing of medical information; b) the development of technological applications to be used in clinical environments, including the use of medical instrumentation; and c) the modelling and simulation of biological systems to improve knowledge of physiological systems and to design new therapeutic procedures. The fields of application are electrocardiography, mobile monitoring equipment, respiratory muscle activity, respiratory sounds, snoring signals, respiratory pattern variability, cardiorespiratory coupling, electroencephalography, polysomnographic signals, etc.
Keywords
Diagnòstic,Interpretació de senyals,Modelització de biosistemes,Monitorització,Processament de senyals,Senyals biomèdics,Sistemes biomèdics,Teràpia

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  • Biomimetic set up for chemosensor-based machine olfaction

     Ziyatdinov, Andrey
    Department of Automatic Control, Universitat Politècnica de Catalunya
    Theses

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    Esta tesis se enmarca en el campo de bioingeneria, mas particularmente en la configuración de un sistema experimental de sensores de gases químicos. Quizás más que en cualquier otra modalidad de sensores, los sensores químicos representan un conjunto de retos técnicos y conceptuales ya que deben lidiar con problemas como su baja especificidad, su respuesta temporal lenta, su inestabilidad a largo plazo, su alto consumo enérgético, su portabilidad, así como la necesidad de un sistema de datos y código robusto.En la última década, se ha observado una clara tendencia por parte de los sistemas de machine olfaction hacia la imitación del sistema de olfato biológico de insectos y mamíferos. Los diseñadores de estos sistemas se inspiran del sistema olfativo biológico, ya que los animales cumplen, sin apenas esfuerzo, algunos de los escenarios no resueltos en machine olfaction. Por ejemplo, las polillas machos recorren largas distancias para localizar las polillas hembra, detectando sus feromonas de forma rápida y robusta.La detección biomimética de gases químicos tiene como objetivo identificar los elementos fundamentales de la vía olfativa a todos los niveles, desde los receptores olfativos hasta el sistema nervioso central, y simular, en cierta medida, el funcionamiento de estos bloques, lo que permitiría acercar el rendimiento de la detección al rendimiento de los sistemas olfativos conociodos de los animales. Esto conlleva nuevos requisitos técnicos a nivel de equipamiento tanto hardware como software utilizado en este tipo de experimentos de machine olfaction.Este trabajo propone un enfoque bioinspirado para la ¿machine olfaction¿, explorando a fondo la parte tecnológica. A nivel hardware, un ordenador embedido se ha ensamblado, siendo ésta la parte más importante de la configuración experimental. Este ordenador integrado está interconectado con dos módulos principales biomiméticos diseñados por los colaboradores: una matriz de sensores a gran escala y una plataforma móvil robotizada para experimentos autónomos. A nivel software, el kit de desarrollo software se ha diseñado para recoger los modelos neuromórficos de los colaboradores para el procesamiento de las entradas sensoriales como en la vía olfativa biológica.La virtualización del sistema fue una de las soluciones ingenieriles clave de su desarrollo. Al ser un dispositivo, el sistema se ha transformado en un sistema virtual para la realización de simulaciones de datos, donde el entorno de software es esencialmente el mismo, y donde los sensores reales se sustituyen por sensores virtuales procedentes de una herramienta de simulación de datos especialmente diseñada. La propuesta de abstracción del sistema resulta en un ecosistema que contiene tanto los modelos del sistema olfativo como la matriz virtual . Este ecosistema se puede cargar en cualquier ordenador personal como una imagen del sistema desarrollado.Además de los productos de ingeniería entregados en esta tesis, los resultados científicos se han publicado en tres artículos en revistas, dos capítulos de libros y los proceedings de dos conferencias internacionales. Los principales resultados en la validación del sistema en el escenario de la localización robótica de olores se presentan en los capítulos del libro. Los tres artículos de revistas abarcan el trabajo en la herramienta de simulación de datos para machine olfaction: el novedoso modelo de drift, los modelos para simular la matriz de sensores basado en el conjunto de datos de referencia, y la parametrización de los datos simulados y los benchmarks propuestos por primera vez en machine olfaction. Esta tesis ofrece una base sólida para la investigación en simulaciones biomiméticas y en algoritmos en machine olfaction. Los resultados obtenidos en la tesis pretenden dar lugar a nuevas aplicaciones bioinspiradas en machine olfaction, lo que podría tener un significativo impacto en el área de investigación en ingeniería biomédica.

  • Development of nonlinear techniques based on time-frequency representation and information theory for the analysis of EEG signals to assess different states of consciousness

     Melia, Umberto Sergio Pio
    Department of Automatic Control, Universitat Politècnica de Catalunya
    Theses

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    El registro de la señal Electroencefalografíca (EEG) proporciona información sobre los cambios en la actividad cerebral asociados con varios estados de la anestesia, la epilepsia, la atención cerebral, los trastornos del sueño, los trastornos cerebrales, etc. Los EEG son señales complejas cuyas propiedades estadísticas dependen del espacio y del tiempo. Sus características aleatorias y no estacionarias hacen imposible que el EEG se describa de forma precisa con una técnica sencilla requiriendo un análisis y una caracterización que implica técnicas que tengan en cuenta su no estacionariedad. Todo esto aumenta la necesidad de desarrollar nuevas técnicas avanzadas con el fin de mejorar la eficiencia de los métodos utilizados en la práctica clínica que son basados en el análisis de EEG. En esta tesis se han investigado y aplicado diferentes métodos utilizando técnicas no lineales con el fin de desarrollar índices capaces de caracterizar el espectro de frecuencias, la dinámica no lineal y la complejidad de las señales EEG registradas en diferentes estados de conciencia. En primer lugar, se ha desarrollado un nuevo algoritmo basado en la envolvente de la señal para la eliminación de ruido de picos en las señales biológicas. Este algoritmo ha sido aplicado a señales simuladas y reales obteniendo resultados significativamente mejores comparados con los filtros adaptativos tradicionales. Seguidamente, se han llevado a cabo varios estudios con el fin de extraer y evaluar las medidas de EEG basadas en técnicas no lineales en diferentes contextos.Se han definido nuevos índices mediante el cálculo de la entropía de la distribución de Choi-Williams (DCW) con respecto al tiempo o la frecuencia. Se ha observado que los valores de estos índices tienden a disminuir, en diferentes proporciones, cuando el comportamiento de las señales evoluciona de caótico o aleatorio a periódico. Además, se han encontrado valores diferentes de estos índices aplicados a la señal EEG registrada en diferentes estados.Diferentes medidas basadas en la representación tiempo-frecuencia, la función de información mutua y la correntropia se han aplicado al EEG para la detección automática de la somnolencia en pacientes que sufren trastornos del sueño. Se ha observado en la zona frontal que la potencia en la banda ¿ es mayor en los pacientes con somnolencia diurna excesiva, mientras que la entropía espectral y la entropía espectral cruzada en la banda d es mayor en los pacientes sin somnolencia. En el grupo sin somnolencia se ha encontrado más complejidad en la zona occipital, mientras que el acoplamiento no lineal entre las regiones occipital y frontal ha resultado más fuerte en pacientes con somnolencia diurna excesiva, en la banda ß.La representación tiempo-frecuencia y las medidas no lineales se han utilizado para estudiar cómo la adaptación y la fatiga afectan a los potenciales cerebrales relacionados con estímulos térmicos, eléctricos y auditivos. Analizando el promedio de varias épocas de EEG grabadas después de la estimulación, se han encontrado diferencias entre las respuestas a la estimulación frecuente e infrecuente en diferentes períodos de registro.Todas las técnicas que se han desarrollado, se han aplicado a señales EEG registradas en pacientes sedados, con el fin de predecir las respuestas a la estimulación del dolor. Un conjunto de medidas calculadas en señales EEG filtradas en diferentes bandas de frecuencia ha permitido mejorar la evaluación del nivel de sedación. Las medidas propuestas han presentado un mejor rendimiento comparado con el índice bispectral, un indicador de hipnosis tradicional. En conclusión, las medidas no lineales basadas en la representación tiempo-frecuencia, funciones de información mutua y correntropia han proporcionado informaciones adicionales que contribuyeron a mejorar la detección automática de la somnolencia, la caracterización y predicción de las respuestas nociceptivas y por lo tanto la evaluación del nivel de sedación.

  • Machine Learning Methods for the Analysis of Liquid Chromatography-Mass Spectometry datasets in Metabolomics  Open access

     Fernandez Albert, Francesc
    Department of Automatic Control, Universitat Politècnica de Catalunya
    Theses

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    Els instruments de Cromatografia Líquida-Espectrometria de Masses (LC/MS) són àmpliament utilitzats en Metabolòmica. Per tal d'analitzar la seva sortida, és necessari utilitzar eines computacionals així com algorismes per poder extreure informació biològica rellevant. L'objectiu principal d'aquesta tesi es proporcionar nous mètodes i eines computacionals per a processar i analitzar dades de LC/MS en Metabolòmica. En total, s'han desenvolupat 4 eines i mètodes en el marc d'aquesta tesi.Primer, s'ha desenvolupat un nou mètode per a corregir possibles efectes de deriva no lineal en el temps de retenció de dades de LC/MS en Metabolòmica i s'ha implementat com un paquet d'R anomenat HCor. Aquest mètode aprofita que existeix una correlació de la deriva temporal en dades de LC/MS, en particular, hi ha regions cromatogràfiques en les quals el valor de la deriva és consistentment diferent d'altres regions. El nostre mètode fa la hipòtesi que aquesta correlació és monòtona en el temps de retentió i ajusta un model no lineal per a corregir la deriva temporal de les dades. Quan es compara amb altres algoritmes actuals, aquest mètode funciona especialment bé en dades on hi ha una deriva important.Segon, s'ha desenvolupat i implementat un mètode per a resoldre el problema de la deriva de la intensitat en dades de metabolòmica. Aquest mètode es basa en dues etapes en les quals es modela i corregeix la deriva i després es normalitzen les dades utilitzant la mediana de les dades corregides. La deriva és model utilitzant un Anàlisi de Components Principals Comuns sobre les classes de control de qualitat i seleccionant una, dues o tres components per a modelar l'espai de deriva. Aquest mètode es va comparar amb 4 altres mètodes de correcció de deriva i normalització de dades. El mètode de dues etapes va obtenir millors resultats en la correcció de la deriva que els altres mètodes. Tots els mètodes aplicats es van implementar en un paquet d'R anomenat intCor que és públic. Tercer, s'ha proposat la incorporació d'una nova etapa en el l'anàlisi de dades en LC/MS en Metabolòmica. En general quan s'utilitza un instrument de tipus LC/MS en Metabolòmica, a partir d'un metabòlit s'obtenen un conjunt de pics com a sortida. En aplicar tècniques de Machine Learning i tests estadístics, es considera que cada pic és una variable independent tot i la estructura de correlació present en aquells pics que provenen del mateix metabòlit. En aquest context, s'ha desenvolupat una estratègia anomenada tècnica d'agregació de pics que permet extreure una mesura per a cada metabòlit tenint en compte els valors de les intensitats a través de les mostres per als pics que vénen del mateix metabòlit. Al aplicar aquestes tècniques sobre cada metabòlit, s'obté un conjunt de dades on les variables no són pics sinó metabòlits. Es van definir 4 tècniques d'agregació de pics diferents i es van aplicar en una etapa de validació creuada amb mostra aleatòria. Els resultats van mostrar que aplicar aquesta etapa d'agregació de pics millora la capacitat predictiva de les dades.Quart, es va desenvolupar i implementar una eina computacional en R anomenada MAIT per a realitzar anàlisis de dades de LC/MS en Metabolòmica. El paquet MAIT és altament modular i programable, cosa que facilita el reemplaçament dels seus mòduls per d'altres creats pels usuaris per tal de realitzar els seus propis anàlisis de dades personalitzats. Per defecte, el paquet MAIT agafa els arxius crus de sortida d'un LC/MS i, mitjançant l'aplicació d'una sèrie de funcions, obté una taula d'identificació de metabòlits com a resultat. També proporciona un conjunt de figures i taules per tal que poder realitzar un anàlisi exhaustiu de les dades metabolòmiques. El paquet fins i tot accepta taules de pics ja detectats mitjançant una eina diferent i permet llançar les funcions específiques del paquet com ara una classificació o un minat de dades de la Human Metabolome Database, que està incluïda en el paquet.

    Tesi per compendi de publicacions

    Liquid Chromatography-Mass Spectrometry (LC/MS) instruments are widely used in Metabolomics. To analyse their output, it is necessary to use computational tools and algorithms to extract meaningful biological information. The main goal of this thesis is to provide with new computational methods and tools to process and analyse LC/MS datasets in a metabolomic context. A total of 4 tools and methods were developed in the context of this thesis. First, it was developed a new method to correct possible non-linear drift effects in the retention time of the LC/MS data in Metabolomics, and it was coded as an R package called HCor. This method takes advantage of the retention time drift correlation found in typical LC/MS data, in which there are chromatographic regions in which their retention time drift is consistently different than other regions. Our method makes the hypothesis that this correlation structure is monotonous in the retention time and fits a non-linear model to remove the unwanted drift from the dataset. This method was found to perform especially well on datasets suffering from large drift effects when compared to other state-of-the art algorithms. Second, it was implemented and developed a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which are corrected possible intensity drift effects by modelling the drift and then the data is normalised using the median of the resulting dataset. The drift was modelled using a Common Principal Components Analysis decomposition on the Quality Control classes and taking one, two or three Common Principal Components to model the drift space. This method was compared to four other drift correction and normalisation methods. The two-step method was shown to perform a better intensity drift removal than all the other methods. All the tested methods including the two-step method were coded as an R package called intCor and it is publicly available. Third, a new processing step in the LC/MS data analysis workflow was proposed. In general, when LC/MS instruments are used in a metabolomic context, a metabolite may give a set of peaks as an output. However, the general approach is to consider each peak as a variable in the machine learning algorithms and statistical tests despite the important correlation structure found between those peaks coming from the same source metabolite. It was developed an strategy called peak aggregation techniques, that allow to extract a measure for each metabolite considering the intensity values of the peaks coming from this metabolite across the samples in study. If the peak aggregation techniques are applied on each metabolite, the result is a transformed dataset in which the variables are no longer the peaks but the metabolites. 4 different peak aggregation techniques were defined and, running a repeated random sub-sampling cross-validation stage, it was shown that the predictive power of the data was improved when the peak aggregation techniques were used regardless of the technique used. Fourth, a computational tool to perform end-to-end analysis called MAIT was developed and coded under the R environment. The MAIT package is highly modular and programmable which ease replacing existing modules for user-created modules and allow the users to perform their personalised LC/MS data analysis workflows. By default, MAIT takes the raw output files from an LC/MS instrument as an input and, by applying a set of functions, gives a metabolite identification table as a result. It also gives a set of figures and tables to allow for a detailed analysis of the metabolomic data. MAIT even accepts external peak data as an input. Therefore, the user can insert peak table obtained by any other available tool and MAIT can still perform all its other capabilities on this dataset like a classification or mining the Human Metabolome Dataset which is included in the package.

  • Clinical decision support system to enhance quality control of forced spirometry using information and communication technologies

     Burgos Rincón, Felip; Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Velickovski, Filip; Lluch-Ariet, Magí; Caminal Magrans, Pedro; Roca-Torrent, Josep
    Journal of Medical Internet Research
    Vol. 2, num. 2, p. e29-1-e29-8
    DOI: 10.2196/medinform.3179
    Date of publication: 2014-10-21
    Journal article

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    Background: We recently demonstrated that quality of spirometry in primary care could markedly improve with remote offline support from specialized professionals. It is hypothesized that implementation of automatic online assessment of quality of spirometry using information and communication technologies may significantly enhance the potential for extensive deployment of a high quality spirometry program in integrated care settings. Objective: The objective of the study was to elaborate and validate a Clinical Decision Support System (CDSS) for automatic online quality assessment of spirometry. Methods: The CDSS was done through a three step process including: (1) identification of optimal sampling frequency; (2) iterations to build-up an initial version using the 24 standard spirometry curves recommended by the American Thoracic Society; and (3) iterations to refine the CDSS using 270 curves from 90 patients. In each of these steps the results were checked against one expert. Finally, 778 spirometry curves from 291 patients were analyzed for validation purposes. Results: The CDSS generated appropriate online classification and certification in 685/778 (88.1%) of spirometry testing, with 96% sensitivity and 95% specificity. Conclusions: Consequently, only 93/778 (11.9%) of spirometry testing required offline remote classification by an expert, indicating a potential positive role of the CDSS in the deployment of a high quality spirometry program in an integrated care setting.

  • Evaluation of Laplacian diaphragm electromyographic recordings in a static inspiratory maneuver

     Estrada, Luis; Torres Cebrian, Abel; Garcia Casado, Javier; Ye-Lin, Y.; Jane Campos, Raimon
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 977-980
    DOI: 10.1007/978-3-319-00846-2_242
    Presentation's date: 2014-09-27
    Presentation of work at congresses

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    Diaphragm electromyography (EMGdi) provides important information on diaphragm activity, to detect neuromuscular disorders of the most important muscle in the breathing inspiratory phase. EMGdi is habitually recorded using needles or esophageal catheters, with the implication of being invasive for patients. Surface electrodes offer an alternative for the non-invasive assessment of diaphragm activity. Ag/AgCl surface disc electrodes are used in monopolar or bipolar configuration to record EMGdi signals. On the other hand, Laplacian surface potential can be estimated by signal recording through active concentric ring electrodes. This kind of recording could reduce physiological interferences, increase the spatial selectivity and reduce orientation problems in the electrode location. The aim of this work is to compare EMGdi signals recorded simultaneously with disc electrodes in bipolar configuration and a Laplacian ring electrode over chest wall. EMGdi signal was recorded in one healthy subject during a breath hold maneuver and a static inspiratory maneuver based on Mueller¿s technique. In order to estimate the covered frequency range and the degree of noise contamination in both bipolar and Laplacian EMGdi signals, the cumulative percentage of the power spectrum and the signal to noise ratio in sub-bands were determined. Furthermore, diaphragm fatigue was evaluated by means of amplitude and frequency parameters. Our findings suggest that Laplacian EMGdi recording covers a broader frequency range although with higher noise contamination compared to bipolar EMGdi recording. Finally, in Laplacian recording fatigue indexes showed a clearer trend for muscle fatigue detection and also a reduced cardiac interference, providing an alternative to bipolar recording for diaphragm fatigue studies.

  • Interaction between EEG and drug concentration to predict response to noxious stimulation during sedation-analgesia : effect of the A118G genetic polymorphism

     Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Jospin, Mathieu; Valencia, Jose F.; Jensen, Erik W.; Gambus, Pedro L.; Perera Lluna, Alexandre; Caminal Magrans, Pedro
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 4298-4301
    DOI: 10.1109/EMBC.2014.6944575
    Presentation's date: 2014-08-26
    Presentation of work at congresses

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    The level of sedation in patients undergoing medical procedures is affected by the interaction between the effect of the anesthetic and analgesic agents and the pain stimuli. The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene affects the requirements of opioids for patients undergoing sedation-analgesia. The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 on EEG measures for the prediction of the response to pain stimulation during endoscopy procedure. The proposed measures were based on power spectral density and auto-mutual information function. It was found that the statistical performances of the EEG measures improved when the presence of the SNP was taken into account (prediction probability Pk>0.9).

  • Evaluation of very low amplitude intra-QRS potentials during the initial minutes of acute transmural myocardial ischemia

     Gomis Román, Pedro; Caminal Magrans, Pedro
    Journal of electrocardiology
    Vol. 47, num. 4, p. 512-519
    DOI: 10.1016/j.jelectrocard.2014.04.014
    Date of publication: 2014-07-01
    Journal article

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    Introduction: Low-level electrocardiographic changes from depolarization wavefront may accompany acute myocardial ischemia. The purpose of this study was to assess the changes of microvolt amplitude intra-QRS potentials induced by elective percutaneous coronary interventions (PCI).; Methods: Fifty-seven patients with balloon inflation periods ranging from 3.1 to 7.3 minutes (4.9 +/- 0.7 min) were studied. Nine leads continuous high-resolution ECG before and during PCI were recorded and signal-averaged. Abnormal intra-QRS at microvolt level (mu AIQP) were obtained using a signal modeling approach. mu AIQP, R-wave amplitude and QRS duration were measured in the processed ECG during baseline and PCI episodes.; Results: The mean mu AIQP amplitude significantly decreased for each of the standard 12 leads at the PCI event respect to baseline. Left anterior descending artery (LAD) occlusion resulted in a decrease mu AIQP in both the precordial leads and the limb leads, while right coronary (RCA) and left circumflex (LCx) arteries occlusions mainly affected limb leads. R-wave amplitude increased during PCI in RCA and LCx groups in lead III but decreased in the precordial leads, while the amplitude decreased in the LAD group in lead III. The average duration of the QRS augmented in groups RCA and LCx but not in the LAD group.; Conclusions: Abnormal intra-QRS potentials at the level of mu V provide an excellent tool to characterize the very-low amplitude fragmentation of the QRS complex and its changes due to ischemic injuries. mu AIQP shows promise as a new ECG index to measure electrophysiologic changes associated with acute myocardial ischemia. (c) 2014 The Authors. Published by Elsevier Inc.

  • Automatic capacitor bank identification in power distribution systems

     Perera Lluna, Alexandre; Manivannan, Karthick; Xu, Peng; Gutierrez Osuna, Ricardo; Benner, Carl; Russell, B. Don
    Electric power systems research
    Vol. 111, p. 96-102
    DOI: 10.1016/j.epsr.2014.02.003
    Date of publication: 2014-06-01
    Journal article

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    Tracking the performance and health of capacitor banks in distribution systems is a challenging task due to their high number and the widespread geographical distribution of feeder circuits. In this work we propose a signal processing technique capable of identifying and characterizing the number of capacitor banks connected to a standard North-American feeder circuit. The way the technique is applied allows a real-time remote monitoring of their operation, automatically identifying the switching activity for each capacitor bank connected. The technique is based on an unsupervised clustering of the three phase reactance step magnitudes. We demonstrate that using only passive monitoring of conventional substation bus PTs and feeder CTs, without any communication, nor visual inspection, to individual banks, it is possible to predict the number of capacitor banks on the distribution feeder and track their performance and activity over time. (C) 2014 Elsevier B.V. All rights reserved.

  • Prediction of response to noxious stimulation during sedation-analgesia by refined multiscale entropy analysis of EEG

     Valencia, Jose F.; Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Jospin, Mathieu; Jensen, Erik W.; Porta, Alberto; Gambus, Pedro L.; Caminal Magrans, Pedro
    Conference of the European Study Group on Cardiovascular Oscillations
    p. 61-62
    DOI: 10.1109/ESGCO.2014.6847519
    Presentation's date: 2014-05-25
    Presentation of work at congresses

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    The level of sedation in patients undergoing medical procedures evolves contin uously since the effect of the anesthetic and analgesic agents is counteracted by noxious stimuli. The monitors of depth of anesthesia, based on the analysis of the electroencephalogram (EEG), have been progressively introduced into the daily practice to provide additional information about the state of the patient. However, the quantification of analgesia still remains an open problem. The purpose of this work was to analyze the capability of prediction of nociceptive responses based on refined multiscale entropy (RMSE). Functions based on RMSE and CeRemi permitted to predict different stimulation responses during sedation with better prediction probability than bispectral index.

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    Measuring instantaneous and spectral information entropies by shannon entropy of choi-williams distribution in the context of electroencephalography  Open access

     Melia, Umberto Sergio Pio; Clarià Sancho, Francesc; Vallverdú Ferrer, Montserrat; Caminal Magrans, Pedro
    Entropy: international and interdisciplinary journal of entropy and information studies
    Vol. 16, num. 5, p. 2530-2548
    DOI: 10.3390/e16052530
    Date of publication: 2014-05-01
    Journal article

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    The theory of Shannon entropy was applied to the Choi-Williams time-frequency distribution (CWD) of time series in order to extract entropy information in both time and frequency domains. In this way, four novel indexes were defined: (1) partial instantaneous entropy, calculated as the entropy of the CWD with respect to time by using the probability mass function at each time instant taken independently; (2) partial spectral information entropy, calculated as the entropy of the CWD with respect to frequency by using the probability mass function of each frequency value taken independently; (3) complete instantaneous entropy, calculated as the entropy of the CWD with respect to time by using the probability mass function of the entire CWD; (4) complete spectral information entropy, calculated as the entropy of the CWD with respect to frequency by using the probability mass function of the entire CWD. These indexes were tested on synthetic time series with different behavior (periodic, chaotic and random) and on a dataset of electroencephalographic (EEG) signals recorded in different states (eyes-open, eyes-closed, ictal and non-ictal activity). The results have shown that the values of these indexes tend to decrease, with different proportion, when the behavior of the synthetic signals evolved from chaos or randomness to periodicity. Statistical differences (p-value < 0.0005) were found between values of these measures comparing eyes-open and eyes-closed states and between ictal and non-ictal states in the traditional EEG frequency bands. Finally, this paper has demonstrated that the proposed measures can be useful tools to quantify the different periodic, chaotic and random components in EEG signals. © 2014 by the authors; licensee MDPI, Basel, Switzerland.

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    Detecting unilateral phrenic paralysis by acoustic respiratory analysis  Open access

     Fiz Fernández, José Antonio; Jane Campos, Raimon; Lozano, Manuel; Gomez, Rosa; Ruiz, Juan
    PLoS one
    Vol. 9, num. 4, p. e93595-1-e93595-9
    DOI: 10.1371/journal.pone.0093595
    Date of publication: 2014-04-09
    Journal article

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    The consequences of phrenic nerve paralysis vary from a considerable reduction in respiratory function to an apparently normal state. Acoustic analysis of lung sound intensity (LSI) could be an indirect non-invasive measurement of respiratory muscle function, comparing activity on the two sides of the thoracic cage. Lung sounds and airflow were recorded in ten males with unilateral phrenic paralysis and ten healthy subjects (5 men/5 women), during progressive increasing airflow maneuvers. Subjects were in sitting position and two acoustic sensors were placed on their back, on the left and right sides. LSI was determined from 1.2 to 2.4 L/s between 70 and 2000 Hz. LSI was significantly greater on the normal (19.3±4.0 dB) than the affected (5.7±3.5 dB) side in all patients (p = 0.0002), differences ranging from 9.9 to 21.3 dB (13.5±3.5 dB). In the healthy subjects, the LSI was similar on both left (15.1±6.3 dB) and right (17.4±5.7 dB) sides (p = 0.2730), differences ranging from 0.4 to 4.6 dB (2.3±1.6 dB). There was a positive linear relationship between the LSI and the airflow, with clear differences between the slope of patients (about 5 dB/L/s) and healthy subjects (about 10 dB/L/s). Furthermore, the LSI from the affected side of patients was close to the background noise level, at low airflows. As the airflow increases, the LSI from the affected side did also increase, but never reached the levels seen in healthy subjects. Moreover, the difference in LSI between healthy and paralyzed sides was higher in patients with lower FEV1 (%). The acoustic analysis of LSI is a relevant non-invasive technique to assess respiratory function. This method could reinforce the reliability of the diagnosis of unilateral phrenic paralysis, as well as the monitoring of these patients.

  • Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1

     Bari, Vlasta; Valencia, Jose Fernando; Vallverdú Ferrer, Montserrat; Girardengo, Giulia; Marchi, Andrea; Bassani, Tito; Caminal Magrans, Pedro; Cerutti, Sergio; George Jr, Alfred L.; Brink, Paul A.; Crotti, Lia; Schwartz, Peter J.; Porta, Alberto
    PLoS one
    Vol. 9, num. 4
    DOI: 10.1371/journal.pone.0093808
    Date of publication: 2014-04-04
    Journal article

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    The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy (RMSE) computed over the beat-to-beat variability series of heart period (HP) and QT interval. HP and QT interval were approximated respectively as the temporal distance between two consecutive R-wave peaks and between the R-wave apex and T-wave end. Both measures were automatically taken from 24-hour electrocardiographic Holter traces recorded during daily activities in non mutation carriers (NMCs, n = 14) and mutation carriers (MCs, n = 34) belonging to a South African LQT1 founder population. The MC group was divided into asymptomatic (ASYMP, n = 11) and symptomatic (SYMP, n = 23) patients according to the symptom severity. Analyses were carried out during daytime (DAY, from 2PM to 6PM) and nighttime (NIGHT, from 12PM to 4AM) off and on beta-adrenergic blockade (BBoff and BBon). We found that the complexity of the HP variability at short time scale was under vagal control, being significantly increased during NIGHT and BBon both in ASYMP and SYMP groups, while the complexity of both HP and QT variability at long time scales was under sympathetic control, being smaller during NIGHT and BBon in SYMP subjects. Complexity indexes at long time scales in ASYMP individuals were smaller than those in SYMP ones regardless of therapy (i.e. BBoff or BBon), thus suggesting that a reduced complexity of the sympathetic regulation is protective in ASYMP individuals. RMSE analysis of HP and QT interval variability derived from routine 24-hour electrocardiographic Holter recordings might provide additional insights into the physiology of the cardiac control and might be fruitfully exploited to improve risk stratification in LQT1 population.

  • Access to the full text
    Filtering and thresholding the analytic signal envelope in order to improve peak and spike noise reduction in EEG signals  Open access

     Melia, Umberto Sergio Pio; Clarià Sancho, Francesc; Vallverdú Ferrer, Montserrat; Caminal Magrans, Pedro
    Medical engineering and physics
    Vol. 36, num. 4, p. 547-553
    DOI: 10.1016/j.medengphy.2013.11.014
    Date of publication: 2014-04-01
    Journal article

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    To remove peak and spike artifacts in biological time series has represented a hard challenge in the last decades. Several methods have been implemented mainly based on adaptive filtering in order to solve this problem. This work presents an algorithm for removing peak and spike artifacts based on a threshold built on the analytic signal envelope. The algorithm was tested on simulated and real EEG signals that contain peak and spike artifacts with random amplitude and frequency occurrence. The performance of the filter was compared with commonly used adaptive filters. Three indexes were used for testing the performance of the filters: Correlation coefficient (p), mean of coherence function (C), and rate of absolute error (RAE). All these indexes were calculated between filtered signal and original signal without noise. It was found that the new proposed filter was able to reduce the amplitude of peak and spike artifacts with rho > 0.85, C > 0.8, and RAE < 0.5. These values were significantly better than the performance of LMS adaptive filter (rho < 0.85, C < 0.6, and RAE > 1). (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

    To remove peak and spike artifacts in biological time series has represented a hard challenge in the last decades. Several methods have been implemented mainly based on adaptive filtering in order to solve this problem. This work presents an algorithm for removing peak and spike artifacts based on a threshold built on the analytic signal envelope. The algorithm was tested on simulated and real EEG signals that contain peak and spike artifacts with random amplitude and frequency occurrence. The performance of the filter was compared with commonly used adaptive filters. Three indexes were used for testing the performance of the filters: Correlation coefficient (p), mean of coherence function (C), and rate of absolute error (RAE). All these indexes were calculated between filtered signal and original signal without noise. It was found that the new proposed filter was able to reduce the amplitude of peak and spike artifacts with rho > 0.85, C > 0.8, and RAE < 0.5. These values were significantly better than the performance of LMS adaptive filter (rho < 0.85, C < 0.6, and RAE > 1).

  • An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit).

     Fernandez Albert, Francesc; Llorach Asunción, Rafael; Andres Lacueva, Cristina; Perera Lluna, Alexandre
    Bioinformatics
    Vol. 30, num. 13, p. 1937-1939
    DOI: 10.1093/bioinformatics/btu136
    Date of publication: 2014-03-17
    Journal article

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  • Peak aggregation as an innovative strategy for improving the predictive power of LC-MS metabolomic profiles

     Fernandez Albert, Francesc; Llorach Asunción, Rafael; Andres Lacueva, Cristina; Perera Lluna, Alexandre
    Analytical chemistry
    Vol. 86, num. 5, p. 2320-2325
    DOI: 10.1021/ac403702p
    Date of publication: 2014-02-28
    Journal article

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  • Peak aggregation as an innovative strategy for improving the predictive power of LC-MS metabolomic profiles

     Fernandez Albert, Francesc; Llorach Asunción, Rafael; Andres Lacueva, Cristina; Perera Lluna, Alexandre
    Analytical chemistry
    Vol. 86, num. 5, p. 2320-2325
    DOI: 10.1021/ac403702p
    Date of publication: 2014-02-28
    Journal article

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    Evidence towards improved estimation of respiratory muscle effort from diaphragm mechanomyographic signals with cardiac vibration interference using sample entropy with fixed tolerance values  Open access

     Sarlabous, Leonardo; Torres Cebrian, Abel; Fiz Fernández, José Antonio; Jane Campos, Raimon
    PLoS one
    Vol. 9, num. 2, p. e88902-1-e88902-10
    DOI: 10.1371/journal.pone.0088902
    Date of publication: 2014-02-19
    Journal article

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    The analysis of amplitude parameters of the diaphragm mechanomyographic (MMGdi) signal is a non-invasive technique to assess respiratory muscle effort and to detect and quantify the severity of respiratory muscle weakness. The amplitude of the MMGdi signal is usually evaluated using the average rectified value or the root mean square of the signal. However, these estimations are greatly affected by the presence of cardiac vibration or mechanocardiographic (MCG) noise. In this study, we present a method for improving the estimation of the respiratory muscle effort from MMGdi signals that is robust to the presence of MCG. This method is based on the calculation of the sample entropy using fixed tolerance values (fSampEn), that is, with tolerance values that are not normalized by the local standard deviation of the window analyzed. The behavior of the fSampEn parameter was tested in synthesized mechanomyographic signals, with different ratios between the amplitude of the MCG and clean mechanomyographic components. As an example of application of this technique, the use of fSampEn was explored also in recorded MMGdi signals, with different inspiratory loads. The results with both synthetic and recorded signals indicate that the entropy parameter is less affected by the MCG noise, especially at low signal-to-noise ratios. Therefore, we believe that the proposed fSampEn parameter could improve estimates of respiratory muscle effort from MMGdi signals with the presence of MCG interference.

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    Data simulation in machine olfaction with the R package chemosensors  Open access

     Ziyatdinov, Andrey; Perera Lluna, Alexandre
    PLoS one
    Vol. 9, num. 2, p. e88839
    DOI: 10.1371/journal.pone.0088839
    Date of publication: 2014-02
    Journal article

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    In machine olfaction, the design of applications based on gas sensor arrays is highly dependent on the robustness of the signal and data processing algorithms. While the practice of testing the algorithms on public benchmarks is not common in the field, we propose software for performing data simulations in the machine olfaction field by generating parameterized sensor array data. The software is implemented as an R language package chemosensors which is open-access, platform-independent and self-contained. We introduce the concept of a virtual sensor array which can be used as a data generation tool. In this work, we describe the data simulation workflow which basically consists of scenario definition, virtual array parameterization and the generation of sensor array data. We also give examples of the processing of the simulated data as proof of concept for the parameterized sensor array data: the benchmarking of classification algorithms, the evaluation of linear- and non-linear regression algorithms, and the biologically inspired processing of sensor array data. All the results presented were obtained under version 0.7.6 of the chemosensors package whose home page is chemosensors.r-forge.r-project.org.

  • Apathy in parkinson's disease: Neurophysiological evidence of impaired incentive processing

     Martinez Horta, Saul; Riba Serrano, Jordi; Fernandez De Bobadilla, Ramon; Pagonabarraga, Javier; Pascual Sedano, Berta; Antonijoan, Rosa Maria; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Garcia Sanchez, Carmen; Kulisevsky, Jaime J.
    Journal of neuroscience
    Vol. 34, num. 17, p. 5918-5926
    DOI: 10.1523/JNEUROSCI.0251-14.2014
    Date of publication: 2014
    Journal article

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    Apathy is one of the most common and debilitating nonmotor manifestations of Parkinson's disease (PD) and is characterized by diminished motivation, decreased goal-directed behavior, and flattened affect. Despite its high prevalence, its underlying mechanisms are still poorly understood, having been associated with executive dysfunction, and impaired emotional processing and decision making. Apathy, as a syndrome, has recently been associated with reduced activation in the ventral striatum, suggesting that early- to middle-stage Parkinson's disease patients with this manifestation may have a compromised mesocorticolimbic dopaminergic pathway and impaired incentive processing. To test this hypothesis, we measured the amplitude of the feedback-related negativity, an event-related brain potential associated with performance outcome valence, following monetary gains and losses in human PD patients (12 women) and healthy controls (6 women) performing a gambling task. Early- to middle-stage PD patients presenting clinically meaningful symptoms of apathy were compared with nonapathetic PD patients and healthy controls. Patients with cognitive impairment, depression, and other psychiatric disturbances were excluded. Results showed that the amplitude of the feedback-related negativity, measured as the difference wave in the event-related brain potential between gains and losses, was significantly reduced in PD patients with apathy compared with nonapathetic patients and healthy controls. These findings indicate impaired incentive processing and suggest a compromised mesocorticolimbic pathway in cognitively intact PD patients with apathy

  • Blood pressure variability analysis in supine and sitting position of healthy subjects

     Giraldo Giraldo, Beatriz F.; Calvo, Alejandro; Martínez, Beatriz; Arcentales Viteri, Andrés Ricardo; Jane Campos, Raimon; Benito Vales, Salvador
    DOI: 10.1007/978-3-319-00846-2_253
    Date of publication: 2014
    Book chapter

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    Blood pressure carries a great deal of information about people¿s physical attributes. We analyzed the blood pressure signal in healthy subjects considering two positions, supine and sitting. 44 healthy subjects were studied. Parameters extracted from the blood pressure signal, related to time and frequency domain were used to compare the effect of postural position between supine and sitting. In time domain analysis, the time systolic interval and the time of blood pressure interval were higher in supine than in sitting position (p = 0.001 in both case). Parameters related to frequency peak, interquartile range, in frequency domain presented statistically significant difference (p¿< 0.0005 in both case). The blood pressure variability parameters presented smaller values in supine than in sitting position (p¿< 0.0005). In general, the position change of supine to sitting produces an increment in the pressure gradient inside heart, reflected in the blood pressure variability.

  • Serious Games on Heart Failure patients. Estimation of their benefits on the Spanish Health System

     Vallverdú Ferrer, Montserrat; Clarià Sancho, Francesc; Perera Lluna, Alexandre; Domingo Teixidor, Mar; de Antonio Ferrer, Marta; Gomis Román, Pedro; Caminal Magrans, Pedro
    Competitive project

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  • A biomimetic approach to machine olfaction, featuring a very large-scale chemical sensor array and embedded neuro-bio-inspired computation

     Marco Colas, Santiago; Gutierrez Galvez, Agustín; Lansner, Anders; Martinez, Dominique; Rospars, Jean Piere; Beccherelli, Romeo; Perera Lluna, Alexandre; Pearce, Timmothy Charles; Verschure, Paulus Franciscus Maria Joseph; Persaud, Krishna C.
    Microsystem technologies-Micro-and nanosystems-Information storage and processing
    p. 1-14
    DOI: 10.1007/s00542-013-2020-8
    Date of publication: 2013-12-21
    Journal article

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  • Short-term vs.long-term heart rate variability in ischemic cardiomyopathy risk stratification

     Voss, Andreas; Schroeder, Rico; Vallverdú Ferrer, Montserrat; Schulz, S; Cygankiewicz, Iwona; Vázquez, Rafael; Bayes de Luna, Antonio; Caminal Magrans, Pedro
    Frontiers in Physiology
    Vol. 4, num. 364, p. 1-15
    DOI: 10.3389/fphys.2013.00364
    Date of publication: 2013-12-13
    Journal article

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    In industrialized countries with aging populations, heart failure affects 0.3-2% of the general population. The investigation of 24 h-ECG recordings revealed the potential of nonlinear indices of heart rate variability (HRV) for enhanced risk stratification in patients with ischemic heart failure (IHF). However, long-term analyses are time-consuming, expensive, and delay the initial diagnosis. The objective of this study was to investigate whether 30 min short-term HRV analysis is sufficient for comparable risk stratification in IHF in comparison to 24 h-HRV analysis. From 256 IHF patients [221 at low risk (IHFLR) and 35 at high risk (IHFHR)] (a) 24 h beat-to-beat time series (b) the first 30 min segment (c) the 30 min most stationary day segment and (d) the 30 min most stationary night segment were investigated. We calculated linear (time and frequency domain) and nonlinear HRV analysis indices. Optimal parameter sets for risk stratification in IHF were determined for 24 h and for each 30 min segment by applying discriminant analysis on significant clinical and non-clinical indices. Long- and short-term HRV indices from frequency domain and particularly from nonlinear dynamics revealed high univariate significances (p < 0.01) discriminating between IHFLR and IHFHR. For multivariate risk stratification, optimal mixed parameter sets consisting of 5 indices (clinical and nonlinear) achieved 80.4% AUC (area under the curve of receiver operating characteristics) from 24 h HRV analysis, 84.3% AUC from first 30 min, 82.2 % AUC from daytime 30 min and 81.7% AUC from nighttime 30 min. The optimal parameter set obtained from the first 30 min showed nearly the same classification power when compared to the optimal 24 h-parameter set. As results from stationary daytime and nighttime, 30 min segments indicate that short-term analyses of 30 min may provide at least a comparable risk stratification power in IHF in comparison to a 24 h analysis period.

  • Jornades de Recerca EUETIB 2013

    Date of publication: 2013-12-04
    Book

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    Les Jornades de recerca 2013 es programen, dissenyen i realitzen amb l'objectiu d'afavorir l'assistència dels estudiants, així com la seva participació activa. Inicialment, les jornades eren reunions entre investigadors per ara esdevenir trobades obertes a tota la comunitat acadèmica. En aquestes es visibilitza l'activitat dels investigadors i la seva contextualització amb la docència reglada a l'EUETIB posant a la seva disposició dels dos col·lectius (PDI i estudiants) nous marcs de col·laboració

  • Genetic association analysis of complex diseases through information theoretic metrics and linear pleiotropy  Open access

     Brunel Montaner, Helena
    Universitat Politècnica de Catalunya
    Theses

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    Esta tesis combina métodos lineales y no lineales con el fin de identificar variantes genéticas responsables de rasgos complejos.En primer lugar, se han propuesto dos estrategias de asociación de one-locus. La primera consiste en definir y caracterizar unaprueba de asociación no lineal basada en la medida de información mutua, y teniendo en cuenta la estructura genética de lapoblación. Para ello, se han utilizado los datos del GAW17 y, dado que corresponden a datos simulados cuya solución esconocida, este estudio ha servido para caracterizar el rendimiento de la prueba de asociación no lineal en comparación con losmétodos lineales estándar. La metodología propuesta ha recuperado los resultados obtenidos usando métodos lineales yademás ha identificado un SNP relacionado con la enfermedad. En términos de rendimiento, ambos métodos han mostradocifras similares de precisión en clasificación (AUC).La segunda alternativa consiste en un estudio exploratorio sobre la relación entre la variabilidad de secuencias entre especies ila asociación con la enfermedad, para diferentes regiones genómicas. Se han comparado dos conjuntos de SNPs, uno formadopor SNPs previamente asociados con enfermedades y el otro formado por SNPs neutros. Ambos han sido estratificados segúnla región genómica de los SNPs, característica que pudo influenciar su conservación entre especies. Se ha observado que parala mayoría de regiones genómicas, los SNPs asociados a enfermedades tienden a estar significativamente menos variablesentre especies que los SNPs neutros.En segundo lugar, se ha propuesto una metodología no lineal novedosa para asociación genética multiloci, con el objetivo dedetectar la asociación entre combinaciones de varios SNPs y fenotipos complejos. EL método propuesto, denominado MISS, seha basado en la significación estadística de la información mutua. Esta aproximación se ha comparado con el MLR (MultipleLinear Regression), un método estándar para asociación genética multiloci. Ambos se han aplicado como criterio de relevanciaen un algoritmo flotante de selección de características multi- solución (MSSFFS), propuesto en el contexto de asociaciónmultiloci. También se han comparado con MECPM, un algoritmo para la búsqueda predictiva de interacciones multilocales conun criterio de máxima entropía. Los tres métodos se han aplicado a los SNPs del gen F7 y los niveles de FVII en sangre con losdatos del proyecto GAIT. El método propuesto (MISS) ha mejorado los resultados obtenidos con los otros métodos, detectandonuevas interacciones entre SNPs. Los resultados están en concordancia con resultados funcionales encontrados en la literaturadonde los SNPs candidatos fueron descritos como elementos funcionales relacionados con el fenotipo.En tercer lugar, se ha propuesto un entorno metodológico lineal para el análisis simultáneo de múltiples fenotipos. Lametodología consiste en construir nuevas variables fenotípicas, denominadas metafenotipos, que capturen la actividad conjuntade un grupo de fenotipos que actúen en cascada en una determinada ruta metabólica. Estas nuevas variables se han usado enlos posteriores análisis de asociación con el fin de identificar elementos genéticos relacionados con el proceso biológicosubyacente, en su conjunto. Como implementación práctica, la metodología se ha aplicado a los datos del proyecto GAIT, paraidentificar marcadores genéticos relacionados con el proceso de la coagulación en su totalidad. Tres modelos matemáticos sehan usado para la definición de los metafenotipos, un modelo PCA y dos modelos ICA. Usando esta aproximación novedosa, sehan identificado asociaciones previamente reportadas y se han propuesto nuevos candidatos con un posible efecto global sobrela cascada de la coagulación como conjunto.

    The main goal of this thesis was to help in the identification of genetic variants that are responsible for complex traits, combining both linear and nonlinear approaches. First, two one-locus approaches were proposed. The first one defined and characterized a novel nonlinear test of genetic association, based on the mutual information measure. This test takes into account the genetic structure of the population. It was applied to the GAW17 dataset and compared to the standard linear test of association. Since the solution of the GAW17 simulation model was known, this study served to characterize the performance of the proposed nonlinear methods in comparison to the linear one. The proposed nonlinear test was able to recover the results obtained with linear methods but also detected an additional SNP in a gene related with the phenotype. In addition, the performance of both tests in terms of their accuracy in classification (AUC) was similar. In contrast, the second approach was an exploratory study on the relationship between SNP variability among species and SNP association with disease, at different genetic regions. Two sets of SNPs were compared, one containing deleterious SNPs and the other defined by neutral SNPs. Both sets were stratified depending on the region where the polymorphisms were located, a feature that may have influenced their conservation across species. It was observed that, for most functional regions, SNPs associated to diseases tend to be significantly less variable across species than neutral SNPs. Second, a novel nonlinear methodology for multiloci genetic association was proposed with the goal of detecting association between combinations of SNPs and a phenotype. The proposed method was based on the mutual information of statistical significance, called MISS. This approach was compared with MLR, the standard linear method used for genetic association based on multiple linear regressions. Both were applied as a relevance criterion of a new multi-solution floating feature selection algorithm (MSSFFS), proposed in the context of multi-loci genetic association for complex diseases. Both were also compared with MECPM, an algorithm for searching predictive multi-loci interactions with a criterion of maximum entropy. The three methods were tested on the SNPs of the F7 gene, and the FVII levels in blood, with the data from the GAIT project. The proposed nonlinear method (MISS) improved the results of traditional genetic association methods, detecting new SNP-SNP interactions. Most of the obtained sets of SNPs were in concordance with the functional results found in the literature where the obtained SNPs have been described as functional elements correlated with the phenotype. Third, a linear methodological framework for the simultaneous study of several phenotypes was proposed. The methodology consisted in building new phenotypic variables, named metaphenotypes, that capture the joint activity of sets of phenotypes involved in a metabolic pathway. These new variables were used in further association tests with the aim of identifying genetic elements related with the underlying biological process as a whole. As a practical implementation, the methodology was applied to the GAIT project dataset with the aim of identifying genetic markers that could be related to the coagulation process as a whole and thus to thrombosis. Three mathematical models were used for the definition of metaphenotypes, corresponding to one PCA and two ICA models. Using this novel approach, already known associations were retrieved but also new candidates were proposed as regulatory genes with a global effect on the coagulation pathway as a whole.

  • Evaluación no invasiva de la función muscular respiratoria mediante el análisis de la señal mecanomiográfica en pacientes con enfermedad pulmonar obstructiva crónica  Open access

     Sarlabous Uranga, Leonardo
    Universitat Politècnica de Catalunya
    Theses

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    El estudio y evaluación de la función muscular respiratoria en enfermedades respiratorias a través de técnicas no invasivas representa un tema de gran interés, dado que hasta la fecha no existen métodos satisfactorios aplicables en situaciones clínicas. En la enfermedad pulmonar obstructiva crónica (EPOC), el trabajo mecánico de los músculos respiratorios aumenta dando lugar a la fatiga, disminución de los movimientos de la caja torácica, y por tanto una disminución de la eficiencia muscular respiratoria. Es conocido que el músculo diafragma, principal responsable de la actividad mecánica respiratoria, al igual que otros músculos esqueléticos vibra lateralmente durante su contracción. De ahí, que estas vibraciones puedan ser registradas mediante micrófonos, sensores piezoeléctricos o acelerómetros posicionados encima de la pared inferior del pecho en la zona de aposición del diafragma con la caja torácica. El registro de estas vibraciones da lugar a la señal mecanomiográfica del diafragma (MMGdi). El principal objetivo de esta tesis ha sido el estudio y caracterización no invasiva de la función muscular respiratoria en pacientes con EPOC a través de la señal MMGdi registrada mediante acelerómetros posicionados entre el séptimo y octavo espacios intercostales, en la línea axilar izquierda y derecha del cuerpo durante la realización de los protocolos respiratorios de carga incremental progresiva y de flujo incremental progresivo. Para mejorar la estimación de la amplitud de la señal MMGdi se han propuesto tres nuevos índices, que tienen en cuenta la naturaleza aleatoria y el ruido asociado en las señales MMGdi, y están basados en: el algoritmo de Lempel-Ziv (LZM), la entropía aproximada (fApEn), y la entropía muestral (fSampEn). Todos ellos son calculados con intervalos de cuantificación fijos y empleando ventanas móviles. Los resultados obtenidos con éstos índices han permitido estimar con mayor fiabilidad y robustez la amplitud de las señales MMGdi, en relación a los métodos clásicos utilizados en el estudio de señales miográficas.El estudio del valor medio de los parámetros analizados ha mostrado, que existe una tendencia incremental de éste en los parámetros de amplitud, y una tendencia decreciente en los parámetros frecuenciales (frecuencias media y máxima), con el incremento de la carga y/o flujo. En este sentido, se ha observado que el valor medio es mayor cuanto mayor es la severidad del paciente con EPOC. Por otra parte, se ha observado que existe una fuerte correlación entre los parámetros de amplitud y la presión inspiratoria máxima en el protocolo de flujo incremental progresivo, con una tendencia decreciente con la severidad. Del mismo modo la eficiencia muscular respiratoria, evaluada como la relación entre la fuerza que producen los músculos respiratorios (la presión inspiratoria en boca) y lo que gastan o necesitan para producir esta presión (la vibración de los músculos respiratorios evaluada mediante las señales MMGdi), ha mostrado en general una tendencia decreciente con el aumento de la severidad.Finalmente, los resultados que se desprenden de esta tesis indican que el estudio de la señal MMGdi representa una herramienta útil con un gran potencial para evaluar el grado de la severidad presente en sujetos con EPOC y su relación con la debilidad de la musculatura respiratoria, y por tanto su aplicación en estudios clínicos podría ser de gran ayuda para evaluar el desarrollo de la EPOC.

    El estudio y evaluación de la función muscular respiratoria en enfermedades respiratorias a través de técnicas no invasivas representa un tema de gran interés, dado que hasta la fecha no existen métodos satisfactorios aplicables en situaciones clínicas. En la enfermedad pulmonar obstructiva crónica (EPOC), el trabajo mecánico de los músculos respiratorios aumenta dando lugar a la fatiga, disminución de los movimientos de la caja torácica, y por tanto una disminución de la eficiencia muscular respiratoria. Es conocido que el músculo diafragma, principal responsable de la actividad mecánica respiratoria, al igual que otros músculos esqueléticos vibra lateralmente durante su contracción. De ahí, que estas vibraciones puedan ser registradas mediante micrófonos, sensores piezoeléctricos o acelerómetros posicionados encima de la pared inferior del pecho en la zona de aposición del diafragma con la caja torácica. El registro de estas vibraciones da lugar a la señal mecanomiográfica del diafragma (MMGdi). El principal objetivo de esta tesis ha sido el estudio y caracterización no invasiva de la función muscular respiratoria en pacientes con EPOC a través de la señal MMGdi registrada mediante acelerómetros posicionados entre el séptimo y octavo espacios intercostales, en la línea axilar izquierda y derecha del cuerpo durante la realización de los protocolos respiratorios de carga incremental progresiva y de flujo incremental progresivo. Para mejorar la estimación de la amplitud de la señal MMGdi se han propuesto tres nuevos índices, que tienen en cuenta la naturaleza aleatoria y el ruido asociado en las señales MMGdi, y están basados en: el algoritmo de Lempel-Ziv (LZM), la entropía aproximada (fApEn), y la entropía muestral (fSampEn). Todos ellos son calculados con intervalos de cuantificación fijos y empleando ventanas móviles. Los resultados obtenidos con éstos índices han permitido estimar con mayor fiabilidad y robustez la amplitud de las señales MMGdi, en relación a los métodos clásicos utilizados en el estudio de señales miográficas. El estudio del valor medio de los parámetros analizados ha mostrado, que existe una tendencia incremental de éste en los parámetros de amplitud, y una tendencia decreciente en los parámetros frecuenciales (frecuencias media y máxima), con el incremento de la carga y/o flujo. En este sentido, se ha observado que el valor medio es mayor cuanto mayor es la severidad del paciente con EPOC. Por otra parte, se ha observado que existe una fuerte correlación entre los parámetros de amplitud y la presión inspiratoria máxima en el protocolo de flujo incremental progresivo, con una tendencia decreciente con la severidad. Del mismo modo la eficiencia muscular respiratoria, evaluada como la relación entre la fuerza que producen los músculos respiratorios (la presión inspiratoria en boca) y lo que gastan o necesitan para producir esta presión (la vibración de los músculos respiratorios evaluada mediante las señales MMGdi), ha mostrado en general una tendencia decreciente con el aumento de la severidad. Finalmente, los resultados que se desprenden de esta tesis indican que el estudio de la señal MMGdi representa una herramienta útil con un gran potencial para evaluar el grado de la severidad presente en sujetos con EPOC y su relación con la debilidad de la musculatura respiratoria, y por tanto su aplicación en estudios clínicos podría ser de gran ayuda para evaluar el desarrollo de la EPOC.

    The study and evaluation of the respiratory muscles function in people who suffer from respiratory diseases can be evaluated through the use of noninvasive techniques. This is a topic of great interest considering there are currently no existing methods that can be successfully applied in clinical situations. In chronic obstructive pulmonary disease (COPD), the mechanical work of the respiratory muscles increases, which could lead to muscular fatigue, decreased movement of the ribcage, and, therefore, a decrease in the respiratory muscle efficiency. The diaphragm muscle is the principal muscle of inspiration and the main mechanical responsible for the ventilation. Similar to other skeletal muscles the diaphragm laterally vibrates during its contraction. These vibrations can be recorded by microphones, piezoelectric sensors or accelerometers, which are placed above the lower chest wall in the area of apposition of the diaphragm to the ribcage. The record of these vibrations is known as mechanomyographic signal of the diaphragm muscle (MMGdi). The main objective of this thesis has been the study and noninvasive characterization of the respiratory muscles function in patients with COPD. This characterization has been made possible through the use of MMGdi signals recorded by accelerometers placed between the seventh and eighth intercostals spaces on the left and right anterior axillary lines of the body during two respiratory protocols. The first protocol is called progressive incremental load protocol and the second one progressive incremental flow protocol. In this thesis three new indices have been proposed to improve the MMGdi amplitude estimation. These indices take into account the random nature and the associated noise in the MMGdi signals, and are based on the: Lempel-Ziv algorithm (MLZ), approximate entropy (fApEn), and sample entropy (fSampEn). All of them are calculated with fixed quantization intervals and using moving windows. The obtained results with these new indices have shown improved reliability and robustness in the MMGdi amplitude estimation in comparison with classic methods used to study myographic signals. The study of the mean value of the analyzed parameters has shown an increasing trend of the amplitude parameters and a decreasing trend of the frequency parameters (mean and maximum frequencies) with increasing load and/or flow. Furthermore, we found that there was a direct relationship between these mean values and the severity of COPD; hence, the greater the mean value, the greater the severity of COPD. Moreover, we have seen that there is a strong correlation between the amplitude parameters and the maximum inspiratory pressure in the progressive incremental flow protocol with a decreasing trend as the severity of the patients increases. Likewise, the respiratory muscle efficiency, evaluated as the ratio between the force produced by the respiratory muscles (mouth inspiratory pressure) and what they need to produce this pressure (the vibration of respiratory muscles assessed by MMGdi signals), has also shown a generally decreasing trend as the severity of patients increases. Finally, the results of this thesis suggest that the study of the MMGdi signal is a useful tool with great potential to assess the relationship between respiratory muscle weakness and the degree of severity in patients with COPD. Therefore, the application of this innovative tool in clinical studies may be helpful to assess the development of COPD.

  • Cancellation of cardiac interference in diaphragm EMG signals using an estimate of ECG reference signal

     Torres Cebrian, Abel; Fiz Fernández, José Antonio; Jane Campos, Raimon
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 1000-1004
    DOI: 10.1007/978-3-319-00846-2_248
    Presentation's date: 2013-09-27
    Presentation of work at congresses

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    The analysis of the electromyographic signal of the diaphragm muscle (EMGdi) can provide important information in order to evaluate the respiratory muscular function. However, EMGdi signals are usually contaminated by the electrocardiographic (ECG) signal. An adaptive noise cancellation (ANC) based on event-synchronous cancellation can be used to reduce the ECG interference in the recorded EMGdi activity. In this paper, it is proposed an ANC scheme for cancelling the ECG interference in EMGdi signals using only the EMGdi signal (without acquiring the ECG signal). In this case the detection of the QRS complex has been performed directly in the EMGdi signal, and the ANC algorithm must be robust to false or missing QRS detections. Furthermore, an automatic criterion to select the adaptive constant of the LMS algorithm has been proposed (µ). The µ constant is selected automatically so that the canceling signal energy equals the energy of the reference signal (which is an estimation of the ECG interference present in the EMGdi signal). This approach optimizes the tradeoff between cancellation of ECG interference and attenuation of EMG component. A number of weights equivalent of a time window that contains several QRS complexes is selected in order to make the algorithm robust to QRS detection errors.

  • Evaluating spatial characteristics of upper-limb movements from EMG signals

     Urra, Oiane; Casals Gelpi, Alicia; Jane Campos, Raimon
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 1795-1798
    DOI: 10.1007/978-3-319-00846-2_443
    Presentation's date: 2013-09-27
    Presentation of work at congresses

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    Stroke is a major cause of disability, usually causing hemiplegic damage on the motor abilities of the patient. Stroke rehabilitation seeks restoring normal motion on the affected limb. However, `normality¿ of movements is usually assessed by clinical and functional tests, without considering how the motor system responds to therapy. We hypothesized that electromyographic (EMG) recordings could provide useful information for evaluating the outcome of rehabilitation from a neuromuscular perspective. Four healthy subjects were asked to perform 14 different functional movements simulating the action of reaching over a table. Each movement was defined according to the starting and target positions that the subject had to connect using linear trajectories. Bipolar recordings of EMG signals were taken from biceps and triceps muscles, and spectral and temporal characteristics were extracted for each movement. Using pattern recognition techniques we found that only two EMG channels were sufficient to accurately determine the spatial characteristics of motor activity: movement direction, length and execution zone. Our results suggest that muscles may fire in a patterned way depending on the specific characteristics of the movement and that EMG signals may codify such detailed information. These findings may be of great value to quantitatively assess poststroke rehabilitation and to compare the neuromuscular activity of the affected and unaffected limbs, from a physiological perspective. Furthermore, disturbed movements could be characterized in terms of the muscle function to identify, which is the spatial characteristic that fails, e.g. movement direction, and guide personalized rehabilitation to enhance the training of such characteristic.

  • Auto-mutual information function for predicting pin responses in EEG signals during sedation

     Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Jospin, Matieu; Jensen, Erik W.; Valencia, J.F.; Clarià, Francesc; Gambus, Pedro L.; Caminal Magrans, Pedro
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 623-626
    DOI: 10.1007/978-3-319-00846-2_154
    Presentation's date: 2013-09-25
    Presentation of work at congresses

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    The level of sedation in patients undergoing medical procedures evolves continuously, such as the effect of the anesthetic and analgesic agents is counteracted by pain stimuli. The monitors of depth of anesthesia, based on the analysis of the electroencephalogram (EEG), have been progressively introduced into the daily practice to provide additional information about the state of the patient. However, the quantification of analgesia still remains an open problem. The purpose of this work was to analyze the capability of prediction of nociceptive responses based on the auto-mutual information function (AMIF). AMIF measures were calculated on EEG signal in order to predict the presence or absence of the nociceptive responses to endoscopy tube insertion during sedation in endoscopy procedure. Values of prediction probability of Pk above 0.80 and percentages of sensitivity and specificity above 70% and 70% respectively were achieved combining AMIF with power spectral density and concentrations of remifentanil.

  • Obstructive sleep apnea in a rat model: effects of anesthesia on autonomic evaluation from heart rate variability measures

     Jane Campos, Raimon; Lázaro, Jesús; Ruiz, Puy; Gil, Eduardo; Navajas, Daniel; Farré, Ramon; Laguna, Pablo
    Computing in Cardiology
    p. 1011-1014
    Presentation's date: 2013-09-25
    Presentation of work at congresses

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    Rat model of Obstructive Sleep Apnea (OSA) is a realistic approach for studying physiological mechanisms involved in sleep. Rats are usually anesthetized and autonomic nervous system (ANS) could be blocked. This study aimed to assess the effect of anesthesia on ANS activity during OSA episodes. Seven male SpragueDawley rats were anesthetized intraperitoneally with urethane (1 g/kg). The experiments were conducted applying airway obstructions, simulating 15s-apnea episodes for 15 minutes. Five signals were acquired: respiratory pressure and flow, Sa02, ECG and photoplethysmography (PPG). In total, 210 apnea episodes were studied. Normalized power spectrum of Pulse Rate Variability (PRV) was analyzed in the Low Frequency (LF) and High Frequency (HF) bands, for each episode in consecutive 15s intervals (before, during and after the apnea). All episodes showed changes in respiratory flow and Sa02 signal. Conversely, decreases in the amplitude fluctuations of PPG (DAP) were not observed. Normalized LF presented extremely low values during breathing (median=7,67%), suggesting inhibition of sympathetic system due to anesthetic effect. Subtle increases of LF were observed during apnea. HRV and PPG analysis during apnea could be an indirect tool to assess the effect and deep of anesthesia.

    Rat model of Obstructive Sleep Apnea (OSA) is a realistic approach for studying physiological mechanisms involved in sleep. Rats are usually anesthetized and autonomic nervous system (ANS) could be blocked. This study aimed to assess the effect of anesthesia on ANS activity during OSA episodes. Seven male SpragueDawley rats were anesthetized intraperitoneally with urethane (1 g/kg). The experiments were conducted applying airway obstructions, simulating 15s-apnea episodes for 15 minutes. Five signals were acquired: respiratory pressure and flow, Sa02, ECG and photoplethysmography (PPG). In total, 210 apnea episodes were studied. Normalized power spectrum of Pulse Rate Variability (PRV) was analyzed in the Low Frequency (LF) and High Frequency (HF) bands, for each episode in consecutive 15s intervals (before, during and after the apnea). All episodes showed changes in respiratory flow and Sa02 signal. Conversely, decreases in the amplitude fluctuations of PPG (DAP) were not observed. Normalized LF presented extremely low values during breathing (median=7,67%), suggesting inhibition of sympathetic system due to anesthetic effect. Subtle increases of LF were observed during apnea. HRV and PPG analysis during apnea could be an indirect tool to assess the effect and deep of anesthesia.

  • Higuchi¿s fractal complexity of RR and QT interval eeries during transient myocardial ischemia

     Magrans Nicieza, Rudys; Gomis Román, Pedro; Caminal Magrans, Pedro; Voss, Andreas
    Computing in Cardiology
    p. 421-424
    Presentation's date: 2013-09-24
    Presentation of work at congresses

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    Myocardial ischemia may lead to significant changes in autonomic control of heart rate (HR) affecting its variability and alter beat-to-beat ventricular repolarization periods. We hypothesized that transient myocardial ischemia affects the complex dynamics of the HR and QT. The aim of this study was to assess the RR and QT interval time series complexity using Higuchi¿s fractal dimension (HFD) during prolonged balloon occlusion of one of the major coronary arteries. Eighty-five patients who underwent elective percutaneous coronary intervention procedures were selected. Patients were classified into 2 groups according to the presence of prior healed myocardial infarction (INF) (n = 29) or not (No_INF) (n = 56). RR, QT and QTc (Bazzet¿s formula) time series were obtained from continuous ECG. Three 3-minute stages were chosen: (1) preinflation as baseline (pre), (2) from the start of occlusion (pci), and (3) immediately post deflation (post_pci). HFD was calculated on each 3-minute stage time series to quantify the changing complexity and self-similarity of RR, QT and QTc time series (HFD RR, HFD QT and HFD QTc, respectively). Cohen¿s d statistics were included to measure the effect size of the procedure. HFD values decreased significantly from baseline to pci and post_pci in the three time-series. HFD RR, 1.76 ± 0.13 vs. 1.69 ± 0.15 (p<0.001, Cohen¿s d = -0.64); HFD QT, 1.90 ± 0.11 vs 1.82 ± 0.13 (p<0.001, d = -0.67); HFD QTc, 1.88 ± 0.09 vs. 1.83 ± 0.11 (p<0.01, d= -0.46). The HFD reduction was greater from baseline to post_pci (p<0.001, d = -0.99 (RR), d = -1.02 (QT)). HFD of QT intervals decreases during the procedure predominantly in the No_INF group. The time series studied, related to autonomic control of HR and to the variability of ventricular repolarization, exhibit a reduced complexity provoked by transient myocardial ischemia.

  • Access to the full text
    Non-linear dynamic analysis of RR signals in patients with and without excessive daytime sleepiness  Open access

     Melia, Umberto Sergio Pio; Guaita, Marc; Vallverdú Ferrer, Montserrat; Clarià Sancho, Francesc; Caminal Magrans, Pedro; Embid, Cristina; Vilaseca, Isabel; Salamero, Manuel; Santamaria, J.
    Computing in Cardiology
    p. 449-452
    Presentation's date: 2013-09-22
    Presentation of work at congresses

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    Linear and non-linear measures applied to heart rate variability (HRV) can be used to quantify modulation of the sympathetic and parasympathetic branches of the autonomic nervous system. RR signals were obtained from the ECG recorded during five Maintenance of Wakefulness (MWT) and Multiple Sleep Latency (MSLT) tests alternated throughout the day from patients suffering sleep disturbance. Two different end-points were considered: Study A, excessive daytime sleepiness (EDS) versus without daytime sleepiness (WDS); Study B, Pre-CPAP versus Post-CP AP (continuous positive airway pressure therapy) in EDS. Measures obtained from spectral analysis (PSD), time-frequency representation (TFR), auto-correntropy (ACORR) and auto-mutual-information function (AMIF) were applied to describe autonomic nervous system activity and RR regularity. Statistical differences between EDS and WDS groups were found in MSLT events. During MSLT, the parasympathetic activity and RR regularity in EDS were affected by CPAP therapy. Non-linear measures obtained from EDS in Post-CPAP differed from Pre-CPAP (p-value<0.05) and tended to be similar to WDS.

    Linear and non-linear measures applied to heart rate variability (HRV) can be used to quantify modulation of the sympathetic and parasympathetic branches of the autonomic nervous system. RR signals were obtained from the ECG recorded during five Maintenance of Wakefulness (MWT) and Multiple Sleep Latency (MSLT) tests alternated throughout the day from patients suffering sleep disturbance. Two different end-points were considered: Study A, excessive daytime sleepiness (EDS) versus without daytime sleepiness (WDS); Study B, Pre-CPAP versus Post-CP AP (continuous positive airway pressure therapy) in EDS. Measures obtained from spectral analysis (PSD), time-frequency representation (TFR), auto-correntropy (ACORR) and auto-mutual-information function (AMIF) were applied to describe autonomic nervous system activity and RR regularity. Statistical differences between EDS and WDS groups were found in MSLT events. During MSLT, the parasympathetic activity and RR regularity in EDS were affected by CPAP therapy. Non-linear measures obtained from EDS in Post-CPAP differed from Pre-CPAP (p-value<0.05) and tended to be similar to WDS.

  • Automatic Quality Control of Forced Spirometry

     Burgos Rincón, Felip; Roca Torrent, Josep; Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Caminal Magrans, Pedro; LLuch Ariet, Magi; Velickosvski, Felip
    Date of request: 2013-09-10
    Invention patent

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  • Análisis espectral no lineal del EEG de niños con epilepsia intratable

     Portolés, oscar; Schroeder, Rico; Vallverdú Ferrer, Montserrat; Voss, Andreas; Caminal Magrans, Pedro
    Jornadas de Automàtica
    p. 123-130
    Presentation's date: 2013-09-04
    Presentation of work at congresses

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  • Higuchi's fractal complexity of RR and QT interval series during transient myocardial ischemia

     Magrans Nicieza, Rudys; Gomis Román, Pedro; Caminal Magrans, Pedro; Voss, Andreas
    Computing in Cardiology
    p. 421-424
    Presentation's date: 2013-09
    Presentation of work at congresses

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    Myocardial ischemia may lead to significant changes in autonomic control of heart rate (HR) affecting its variability and alter beat-to-beat ventricular repolarization periods. We hypothesized that transient myocardial ischemia affects the complex dynamics of the HR and QT. The aim of this study was to assess the RR and QT interval time series complexity using Higuchi's fractal dimension (HFD) during prolonged balloon occlusion of one of the major coronary arteries.

  • Characterization of patients with different ventricular ejection fractions using blood pressure signal analysis

     Arcentales Viteri, Andrés Ricardo; Voss, Andreas; Caminal Magrans, Pedro; Bayés Genis, Antoni; Domingo, Mar Teresa; Giraldo Giraldo, Beatriz F.
    Computing in Cardiology
    p. 795-798
    Presentation's date: 2013-09
    Presentation of work at congresses

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    Ischemic and dilated cardiomyopathy are associated with disorders of myocardium. Using the blood pressure (BP) signal and the values of the ventricular ejection fraction, we obtained parameters for stratifying cardiomyopathy patients as low- and high-risk. We studied 48 cardiomyopathy patients characterized by NYHA =2: 19 patients with dilated cardiomyopathy (DCM) and 29 patients with ischemic cardiomyopathy (ICM). The left ventricular ejection fraction (LVEF) percentage was used to classify patients in low risk (LR: LVEF > 35%, 17 patients) and high risk (HR: LVEF = 35%, 31 patients) groups. From the BP signal, we extracted the upward systolic slope (BP sl), the difference between systolic and diastolic BP (BPA), and systolic time intervals (STI). When we compared the LR and HR groups in the time domain analysis, the best parameters were standard deviation (SD) of 1=STI, kurtosis (K) of BPsl, and K of BPA. In the frequency domain analysis, very low frequency (VLF) and high frequency (HF) bands showed statistically significant differences in comaprisons of LR and HR groups. The area under the curve of power spectral density was the best parameter in all classifications, and particularly in the very-low-and high- frequency bands (p < 0.001). These parameters could help to improve the risk stratification of cardiomyopathy patients.

  • Analysis of heart rate variability in elderly patients with chronic heart failure and periodic breathing

     Giraldo Giraldo, Beatriz F.; Tellez Gabriel, Juan Pablo; Herrera Mateo, Sergio; Benito Vales, Salvador
    Computing in Cardiology
    p. 991-994
    Presentation's date: 2013-09
    Presentation of work at congresses

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    Assessment of the dynamic interactions between cardiovascular signals can provide valuable information that improves the understanding of cardiovascular control. Heart rate variability (HRV) analysis is known to provide information about the autonomic heart rate modulation mechanism. Using the HRV signal, we aimed to obtain parameters for classifying patients with and without chronic heart failure (CHF), and with periodic breathing (PB), non-periodic breathing (nPB), and Cheyne-Stokes respiration (CSR) patterns. An electrocardiogram (ECG) and a respiratory flow signal were recorded in 36 elderly patients: 18 patients with CHF and 18 patients without CHF. According to the clinical criteria, the patients were classified into the follow groups: 19 patients with nPB pattern, 7 with PB pattern, 4 with Cheyne-Stokes respiration (CSR), and 6 non-classified patients (problems with respiratory signal). From the HRV signal, parameters in the time and frequency domain were calculated. Frequency domain parameters were the most discriminant in comparisons of patients with and without CHF: P Tot (p = 0.02), PLF (p = 0.022) and fpHF (p = 0.021). For the comparison of the nPB vs. CSR patients groups, the best parameters were RMSSD (p = 0.028) and SDSD (p = 0.028). Therefore, the parameters appear to be suitable for enhanced diagnosis of decompensated CHF patients and the possibility of developed periodic breathing and a CSR pattern.

  • Characterization of blood pressure signal considering low and high risk stratification in cardiomyopathy patients

     Arcentales Viteri, Andrés Ricardo; Voss, Andreas; Caminal Magrans, Pedro; Bayés Genis, Antoni; Domingo, Maite; Giraldo Giraldo, Beatriz F.
    Computing in Cardiology
    p. 795-798
    Presentation's date: 2013-09
    Presentation of work at congresses

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    Ischemic and dilated cardiomyopathy are associated with disorders of myocardium. Using the blood pressure (BP) signal and the values of the ventricular ejection fraction, we obtained parameters for stratifying cardiomyopathy patients as low- and high-risk. We studied 48 cardiomyopathy patients characterized by NYHA '22: 19 patients with dilated cardiomyopathy (DCM) and 29 patients with ischemic cardiomyopathy (lCM). The left ventricular ejection fraction (LVEF) percentage was used to classify patients in low risk (LR: LVEF > 35%, 17 patients) and high risk (HR: LVEF::; 35%, 31 patients) groups. From the BP signal, we extracted the upward systolic slope (BPsl), the difference between systolic and diastolic BP (B P A), and systolic time intervals (ST I). When we compared the LR and HR groups in the time domain analysis, the best parameters were standard deviation (SD) of 1/ ST I, kurtosis (K) of B Psl, and K of B P A. In the frequency domain analysis, very low frequency (VLF) and high frequency (HF) bands showed statistically significant differences in comaprisons of LR and HR groups. The area under the curve of power spectral density was the best parameter in all classifications, and particularly in the very low- and high- frequency bands (p < 0.001). These parameters could help to improve the risk stratification of cardiomyopathy patients.

  • Influence of respiration in the very low frequency modulation of QRS slopes and heart rate variability in cardiomyopathy patients

     Hernando, David; Alcaine, A; Pueyo, Esther; Laguna, Pablo; Arcentales Viteri, Andrés Ricardo; Giraldo Giraldo, Beatriz F.; Voss, Andreas; Bayés Genis, Antoni; Bailón, Raquel
    Computing in Cardiology
    p. 117-120
    Presentation's date: 2013-09
    Presentation of work at congresses

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    This work investigates the very low frequency (VLF) modulation of QRS slopes and heart rate variability (HRV). Electrocardiogram (ECG) and respiratory flow signal were acquired from patients with dilated cardiomyopathy and ischemic cardiomyopathy. HRV as well as the upward QRS slope (IUS) and downward QRS slope (IDS) were extracted from the ECG. The relation between HRV and QRS slopes in the VLF band was measured using ordinary coherence in 5-minute segments. Partial coherence was then used to remove the influence that respiration simultaneously exerts on HRV and QRS slopes. A statistical threshold was determined, below which coherence values were considered not to represent a linear relation.

  • Complexity of the autonomic heart rate control in coronary artery occlusion in patients with and without prior myocardial infarction

     Magrans Nicieza, Rudys; Gomis Román, Pedro; Caminal Magrans, Pedro; Wagner, G.S.
    Medical engineering and physics
    Vol. 35, num. 8, p. 1070-1078
    DOI: 10.1016/j.medengphy.2012.11.004
    Date of publication: 2013-08-01
    Journal article

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    Autonomic nervous system (ANS) is governed by complex interactions arising from feedback loops of nonlinear systems that operate over a wide range of temporal and spatial scales, enabling the organism to adapt to stress, metabolic changes and diseases. This study is aimed to assess multifractal and nonlinear characteristics of the ANS during ischemic events provoked by a prolonged percutaneous coronary intervention (PCI) procedure. Eighty-seven patients from the STAFF III database were used. Patients were classified into 2 groups: (1) with prior myocardial infarction (MI) and (2) without MI (noMI). R¿R signals during three 3-min stages of the procedures were analyzed using multifractal and surrogate data techniques. Multifractal indices increased significantly from the pre-inflation stage to the post-deflation stage. These variations were more marked for the noMI group. Multifractal changes significantly correlated with both the decreased parasympathetic and the increased sympathetic modulations accounted by classical linear indices. Multifractal measures resulted to be a more powerful indicator than linear HRV indices in quantifying the ischemia-induced changes. Right coronary artery (RCA) occlusions provoke greater multifractal reactions throughout the PCI procedure. Our findings suggest reduced complex multifractal and nonlinear reactions of ANS activity in patients with prior MI in comparison to the noMI group, possibly due to degradation in the complexity of control mechanism of heart rate generation

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    A cross-sectional study comparing strength profile of dorsal and palmar flexor muscles of the wrist in epicondylitis and healthy men  Open access

     Carme, Unyó; Chaler Vilaseca, Joaquim Lluís; Rojas Martínez, Mónica; Pujol Medina, Eduard; Müller, Bertram; Garreta, Roser; Mañanas Villanueva, Miguel Angel
    European Journal of Physical and Rehabilitation Medicine
    Vol. 49, num. 4, p. 507-515
    Date of publication: 2013-08
    Journal article

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    Background: Strength training has been proposed by several authors to treat Lateral Epicondylitis. However, there is still a lack of information concerning muscle weakness and its relationship to imbalances and fatigability of forearm muscles during dynamic conditions in subjects after epicondylitis recovery. Aim: To analyze the relationship between lateral humeral epicondylitis, and forearm muscle strength and fatigue. Setting: Rehabilitation specialized center Population: Cross-sectional study in eight former epicondylitis men free of symptoms and actively working at the moment of the evaluation and eight healthy men volunteers. Methods: Isokinetic tests were performed at different velocities in order to assess strength in concentric and eccentric contractions. Additionally, a long-term concentric test was carried out in order to analyze strength during endurance. The following variables were analyzed: Average torque of dorsal and palmar flexors of the wrist and ratio of agonist/antagonist for non-endurance contractions; length of initial and final plateaus and the slope of average torque decay during the endurance test. Results: In both groups, average torque produced by palmar flexor muscles was higher than that produced by dorsal flexor muscles. Patients showed higher strength in palmar flexor muscles, whereas dorsal flexor strength was similar for both populations. Palmar flexor vs. dorsal flexor ratio was significantly higher in patients for eccentric contractions. Regarding fatigue, results showed that torque decreased earlier in patients. Conclusions and clinical rehabilitation impact: Both palmar flexor force and palmar/dorsal ratio in eccentric exercise were significantly higher in patients. This finding indicates a muscular imbalance in patients underlying the epicondylitis condition. Additionally, former patients fatigued earlier. Findings indicate that muscle imbalances and fatigability might be related to lateral epicondylitis. [¿]

    Background: Strength training has been proposed by several authors to treat Lateral Epicondylitis. However, there is still a lack of information concerning muscle weakness and its relationship to imbalances and fatigability of forearm muscles during dynamic conditions in subjects after epicondylitis recovery. Aim: To analyze the relationship between lateral humeral epicondylitis, and forearm muscle strength and fatigue. Setting: Rehabilitation specialized center Population: Cross-sectional study in eight former epicondylitis men free of symptoms and actively working at the moment of the evaluation and eight healthy men volunteers. Methods: Isokinetic tests were performed at different velocities in order to assess strength in concentric and eccentric contractions. Additionally, a long-term concentric test was carried out in order to analyze strength during endurance. The following variables were analyzed: Average torque of dorsal and palmar flexors of the wrist and ratio of agonist/antagonist for non-endurance contractions; length of initial and final plateaus and the slope of average torque decay during the endurance test. Results: In both groups, average torque produced by palmar flexor muscles was higher than that produced by dorsal flexor muscles. Patients showed higher strength in palmar flexor muscles, whereas dorsal flexor strength was similar for both populations. Palmar flexor vs. dorsal flexor ratio was significantly higher in patients for eccentric contractions. Regarding fatigue, results showed that torque decreased earlier in patients. Conclusions and clinical rehabilitation impact: Both palmar flexor force and palmar/dorsal ratio in eccentric exercise were significantly higher in patients. This finding indicates a muscular imbalance in patients underlying the epicondylitis condition. Additionally, former patients fatigued earlier. Findings indicate that muscle imbalances and fatigability might be related to lateral epicondylitis. […]

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    Methodology for determine the moment of disconnection of patients of the mechanical ventilation using neural network  Open access

     Arizmendi Pereira, Carlos Julio; Giraldo Giraldo, Beatriz F.; Gonzalez Acevedo, Hernando; Acevedo, Holmann Erick
    Latin American and Caribbean Conference for Engineering and Technology
    p. 1-6
    Presentation's date: 2013-08
    Presentation of work at congresses

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    The process of weaning from mechanical ventilation is one of the challenges in intensive care units. In this paper 66 patients under extubation process (T-tube test) were studied: 33 patients with successful trials and 33 patients who failed to maintain spontaneous breathing and were reconnected. Each patient was characterized using 7 time series from respiratory signals, and for each serie was extracted 4 statistics data. Two types of Neural Networks were applied for discriminate between patients from the two groups: radial basis function and multilayer perceptron, getting better results with the second type of network.

  • Prediction of nociceptive responses during sedation by time-frequency representation

     Melia, Umberto Sergio Pio; Vallverdú Ferrer, Montserrat; Jospin, Mathieu; Jensen, Erik W.; Valencia, Jose Fernando; Clarià, Francesc; Gambus, Pedro L.; Caminal Magrans, Pedro
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 2547-2550
    DOI: 10.1109/EMBC.2013.6610059
    Presentation's date: 2013-07-03
    Presentation of work at congresses

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    The level of sedation in patients undergoing medical procedures evolves continuously, such as the effect of the anesthetic and analgesic agents is counteracted by pain stimuli. The monitors of depth of anesthesia, based on the analysis of the electroencephalogram (EEG), have been progressively introduced into the daily practice to provide additional information about the state of the patient. However, the quantification of analgesia still remains an open problem. The purpose of this work is to analyze the capability of prediction of nociceptive responses based on the time-frequency representation (TFR) of EEG signal. Functions of spectral entropy, instantaneous power and instantaneous frequency were calculated in order to predict the presence or absence of the nociceptive responses to different stimuli during sedation in endoscopy procedure. Values of prediction probability of Pk above 0.75 and percentages of sensitivity and specificity above 70% and 65% respectively were achieved combining TFR functions with bispectral index (BIS) and with concentrations of propofol (CeProp) and remifentanil (CeRemi).

  • Analysis of epileptic EEG signals in children by symbolic dynamics

     Paternoster, Luca; Vallverdú Ferrer, Montserrat; Melia, Umberto Sergio Pio; Voss, Andreas; Caminal Magrans, Pedro; Clarià Sancho, Francesc
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 4362-4365
    DOI: 10.1109/EMBC.2013.6610512
    Presentation's date: 2013-07-03
    Presentation of work at congresses

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    Epilepsy is one of the most prevalent neurological disorders among children. The study of surface EEG signals in patients with epilepsy by techniques based on symbolic dynamics can provide new insights into the epileptogenic process and may have considerable utility in the diagnosis and treatment of epilepsy. The goal of this work was to find patterns from a methodology based on symbolic dynamics to characterize seizures on surface EEG in pediatric patients with intractable epilepsy. A total of 76 seizures were analyzed by their pre-ictal, ictal and post-ictal phases. An analytic signal envelope algorithm was applied to each EEG segment and its performance was evaluated. Several variables were defined from the distribution of words constructed on the EEG transformed into symbols. The results showed strong evidences of detectable non-linear changes in the EEG dynamics from pre-ictal to ictal phase and from ictal to post-ictal phase, with an accuracy higher than 70%.

  • Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients

     Bari, Vlasta; Vallverdú Ferrer, Montserrat; Valencia, Jose Fernando; Girardengo, Giulia; Bassani, Tito; Marchi, Andrea; Calvillo, L.; Caminal Magrans, Pedro; Cerutti, Sergio; Brink, Paul A.; Crotti, Lia; Schwartz, Peter J.; Porta, A.
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 5554-5557
    Presentation's date: 2013-07-03
    Presentation of work at congresses

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    This study assesses complexity of cardiovascular control in patients affected by type-1 variant of long QT (LQT1) syndrome. Complexity was assessed by refined multiscale entropy of heart period (HP) and QT interval variabilities. HP was taken as the time distance between two consecutive R peaks (RR) and QT interval was approximated as the time distance between the R-peak and T-wave apex (RTa) and between R-peak and T-wave end (RTe). RR, RTa and RTe intervals were automatically extracted from 24h Holter recordings and the daytime period was analyzed (from 02:00 to 06:00 PM). Non mutation carrier (NMC) individuals (n=11), utilized as a control group, were taken from the same family line of the mutation carrier (MC) subjects (n=26). We found that, while NMC and MC groups were indistinguishable based on time domain and complexity analyses of RR dynamics, complexity analysis of RTa and RTe variabilities clearly separates the two populations and suggests an impairment in the cardiac control mechanisms acting on the ventricles.

  • Characterization of the respiratory pattern variability of patients with different pressure support levels

     Giraldo Giraldo, Beatriz F.; Chaparro Preciado, Javier; Caminal Magrans, Pedro; Benito Vales, Salvador
    IEEE Engineering in Medicine and Biology Society
    p. 3849-3852
    DOI: 10.1109/EMBC.2013.6610384
    Presentation's date: 2013-07-03
    Presentation of work at congresses

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    One of the most challenging problems in intensive care is still the process of discontinuing mechanical ventilation, called weaning process. Both an unnecessary delay in the discontinuation process and a weaning trial that is undertaken too early are undesirable. In this study, we analyzed respiratory pattern variability using the respiratory volume signal of patients submitted to two different levels of pressure support ventilation (PSV), prior to withdrawal of the mechanical ventilation. In order to characterize the respiratory pattern, we analyzed the following time series: inspiratory time, expiratory time, breath duration, tidal volume, fractional inspiratory time, mean inspiratory flow and rapid shallow breathing. Several autoregressive modeling techniques were considered: autoregressive models (AR), autoregressive moving average models (ARMA), and autoregressive models with exogenous input (ARX). The following classification methods were used: logistic regression (LR), linear discriminant analysis (LDA) and support vector machines (SVM). 20 patients on weaning trials from mechanical ventilation were analyzed. The patients, submitted to two different levels of PSV, were classified as low PSV and high PSV. The variability of the respiratory patterns of these patients were analyzed. The most relevant parameters were extracted using the classifiers methods. The best results were obtained with the interquartile range and the final prediction errors of AR, ARMA and ARX models. An accuracy of 95% (93% sensitivity and 90% specificity) was obtained when the interquartile range of the expiratory time and the breath duration time series were used a LDA model. All classifiers showed a good compromise between sensitivity and specificity. © 2013 IEEE.

  • Features extraction method for brain-machine communication based on the empirical mode decomposition

     Diez, Pablo F.; Mut, Vicente A.; Laciar, Eric; Torres Cebrian, Abel; Avila Perona, Enrique M.
    Biomedical Engineering: Applications, Basis and Communications
    Vol. 25, num. 2, p. 1-13
    DOI: 10.4015/S1016237213500580
    Date of publication: 2013-07
    Journal article

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    A brain-machine interface (BMI) is a communication system that translates human brain activity into commands, and then these commands are conveyed to a machine or a computer. It is proposes a technique for features extraction from electroencephalographic (EEG) signals and afterward, their classification on different mental tasks. The empirical mode decomposition (EMD) is a method capable of processing non-stationary and nonlinear signals, as the EEG. The EMD was applied on EEG signals of seven subjects performing five mental tasks. Six features were computed, namely, root mean square (RMS), variance, Shannon entropy, Lempel-Ziv complexity value, and central and maximum frequencies. In order to reduce the dimensionality of the feature vector, the Wilks' lambda (WL) parameter was used for the selection of the most important variables. The classification of mental tasks was performed using linear discriminant analysis (LDA) and neural networks (NN). Using this method, the average classification over all subjects in database is 91 5% and 87 5% using LDA and NN, respectively. Bit rate was ranging from 0.24 bits/trial up to 0.84 bits/trial. The proposed method allows achieving higher performances in the classification of mental tasks than other traditional methods using the same database. This represents an improvement in the brain-machine communication system. 2013 National Taiwan University.

  • Cardiac interference reduction in diaphragmatic MMG signals during a maintained inspiratory pressure test

     Sarlabous, Leonardo; Torres Cebrian, Abel; Fiz Fernández, José Antonio; Jane Campos, Raimon
    IEEE Engineering in Medicine and Biology Society
    p. 3845-3848
    DOI: 10.1109/EMBC.2013.6610383
    Presentation's date: 2013-07
    Presentation of work at congresses

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    A recursive least square (RLS) adaptive filtering algorithm for reduction of cardiac interference in diaphragmatic mecanomyographic (MMGdi) signals is addressed in this paper. MMGdi signals were acquired with a capacitive accelerometer placed between 7th and 8th intercostal spaces, on the right anterior axillary line, during a maintained inspiratory pressure test. Subjects were asked to maintain a constant inspiratory pressure with a mouthpiece connected to a closed tube (without breathing). This maneuver was repeated at five different contraction efforts: apnea (no effort), 20 cmH2O, 40 cmH2O, 60 cmH2O and maximum voluntary contraction. An adaptive noise canceller (ANC) using the RLS algorithm was applied on the MMGdi signals. To evaluate the behavior of the ANC, the MMGdi signals were analyzed in two segments: with and without cardiac interference (WCI and NCI, respectively). In both segments it was analyzed the power spectral density (PSD), and the ARV and RMS amplitude parameters for each contraction effort. With the proposed ANC algorithm the amplitude parameters of the WCI segments were reduced to a level similar to the one of the NCI segments. The obtained results showed that ANC using the RLS algorithm allows to significantly reduce the cardiac interference in MMGdi signals.

  • Reduction of metallic interference in MEG signals using AMUSE

     Migliorelli Falcone, Carolina Mercedes; Romero Lafuente, Sergio; Alonso López, Joan Francesc; Nowak, Rafal; Russi Tintoré, Antonio; Mañanas Villanueva, Miguel Angel
    IEEE Engineering in Medicine and Biology Society
    p. 5970-5973
    DOI: 10.1109/EMBC.2013.6610912
    Presentation's date: 2013-07
    Presentation of work at congresses

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    Magnetoencephalography is a technique that can noninvasively measure the brain signal. There are many advantages of using this technique rather than similar procedures such as the EEG for the evaluation of medical diseases. However, one of its main problems is its high sensitivity to sources causing metallic distortion of the signal, and the removal of this type of artifacts remains unsolved. In this study a technique for reducing metallic interference was presented. This algorithm was based on AMUSE, a second order blind source separation method, and a procedure for choosing the artifactual independent components was also presented. The results showed that the elimination of these artifacts would be possible by means of the application of this AMUSE-based interference reduction procedure

  • Characterization of laplacian surface electromyographic signals during isometric contraction in biceps brachii

     Estrada, Luis; Torres Cebrian, Abel; Garcia Casado, Javier; Prats Boluda, Gema; Jane Campos, Raimon
    IEEE Engineering in Medicine and Biology Society
    p. 535-538
    DOI: 10.1109/EMBC.2013.6609555
    Presentation's date: 2013-07
    Presentation of work at congresses

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    Surface electromyography (sEMG) is a noninvasive technique for monitoring the electrical activity produced by the muscles. Usually, sEMG is performed by carrying out monopolar or bipolar recordings by means of conventional Ag/AgCl electrodes. In contrast, Laplacian recordings of sEMG could also be obtained by using coaxial ring electrodes. Laplacian recordings increase spatial resolution and attenuate other distant bioelectric interferences. Nevertheless, the spectral characteristics of this kind of recordings have been scarcely studied. The objective of this paper is to characterize the sEMG signals recorded with a Laplacian ring electrode and to compare them with traditional bipolar recordings with disc electrodes. Both kinds of signals were collected simultaneously in two healthy subjects during resting and sustained isometric voluntary contraction activities in biceps brachii. The conducted study computed the cumulative percentage of the power spectrum of sEMG so as to determine the energy bandwidth of the two kinds of recordings and the signal to noise ratio in different bands of the sEMG spectrum. Also, muscle fatigue, a condition when muscle force is reduced, was assessed using indexes from amplitude and frequency domain. The results of this study suggest that Laplacian sEMG has higher spectral bandwidth but a lower signal to noise ratio in comparison to bipolar sEMG. In addition, frequency fatigue indexes showed that Laplacian recording had better response than bipolar recording, which suggests that Laplacian electrode can be useful to study muscular fatigue due to better spatial resolution.

    Surface electromyography (sEMG) is a noninvasive technique for monitoring the electrical activity produced by the muscles. Usually, sEMG is performed by carrying out monopolar or bipolar recordings by means of conventional Ag/AgCl electrodes. In contrast, Laplacian recordings of sEMG could also be obtained by using coaxial ring electrodes. Laplacian recordings increase spatial resolution and attenuate other distant bioelectric interferences. Nevertheless, the spectral characteristics of this kind of recordings have been scarcely studied. The objective of this paper is to characterize the sEMG signals recorded with a Laplacian ring electrode and to compare them with traditional bipolar recordings with disc electrodes. Both kinds of signals were collected simultaneously in two healthy subjects during resting and sustained isometric voluntary contraction activities in biceps brachii. The conducted study computed the cumulative percentage of the power spectrum of sEMG so as to determine the energy bandwidth of the two kinds of recordings and the signal to noise ratio in different bands of the sEMG spectrum. Also, muscle fatigue, a condition when muscle force is reduced, was assessed using indexes from amplitude and frequency domain. The results of this study suggest that Laplacian sEMG has higher spectral bandwidth but a lower signal to noise ratio in comparison to bipolar sEMG. In addition, frequency fatigue indexes showed that Laplacian recording had better response than bipolar recording, which suggests that Laplacian electrode can be useful to study muscular fatigue due to better spatial resolution.