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Selecting the primary endpoint in a randomized clinical trial: the ARE method

Autor
Plana-Ripoll, O.; Gomez, G.
Tipus d'activitat
Article en revista
Revista
Journal of biopharmaceutical statistics
Data de publicació
2016
Volum
26
Número
5
Pàgina inicial
880
Pàgina final
898
DOI
https://doi.org/10.1080/10543406.2015.1094808 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/102360 Obrir en finestra nova
URL
http://www-tandfonline-com.recursos.biblioteca.upc.edu/doi/full/10.1080/10543406.2015.1094808 Obrir en finestra nova
Resum
The decision on the primary endpoint in a randomized clinical trial is of paramount importance and the combination of several endpoints might be a reasonable choice. Gómez and Lagakos (2013) have developed a method that quantifies how much more efficient it could be to use a composite instead of an individual relevant endpoint. From the information provided by the frequencies of observing the component endpoints in the control group and by the relative treatment effects on each individual endpo...
Citació
Plana-Ripoll, O., Gomez, G. Selecting the primary endpoint in a randomized clinical trial: the ARE method. "Journal of biopharmaceutical statistics", 2016, vol. 26, núm. 5, p. 880-898.
Paraules clau
Asymptotic relative efficiency, composite endpoint, copulas, logrank, randomized clinical trial
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

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