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Testing for Hardy-Weinberg equilibrium at biallelic genetic markers on the X chromosome

Autor
Graffelman, J.; Weir, B.
Tipus d'activitat
Article en revista
Revista
Heredity
Data de publicació
2016-04-13
Volum
116
Número
6
Pàgina inicial
558
Pàgina final
568
DOI
https://doi.org/10.1038/hdy.2016.20 Obrir en finestra nova
Projecte finançador
Métodos Estadísticos en Espacios Restringidos (Metrics)
Statistical MEthods in resTRICted spaceS
Repositori
http://hdl.handle.net/2117/85774 Obrir en finestra nova
URL
http://www.nature.com/hdy/journal/vaop/ncurrent/full/hdy201620a.html Obrir en finestra nova
Resum
Testing genetic markers for Hardy-Weinberg equilibrium (HWE) is an important tool for detecting genotyping errors in large-scale genotyping studies. For markers at the X chromosome, typically the chi(2) or exact test is applied to the females only, and the hemizygous males are considered to be uninformative. In this paper we show that the males are relevant, because a difference in allele frequency between males and females may indicate HWE not to hold. The testing of markers on the X chromosome...
Citació
Graffelman, J., Weir, B. Testing for Hardy–Weinberg equilibrium at biallelic genetic markers on the X chromosome. "Journal of heredity", 13 Abril 2016.
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COSDA-UPC - COmpositional and Spatial Data Analysis

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