Rosell Ferrer, Francisco Javier
Total activity: 346
Professional category
University professor
Doctoral courses
Doctor Ingeniero de Telecomunicación
Research group
CREB - Biomedical Engineering Research Centre
IEB - Electronic and Biomedical Instrumentation
Department
Department of Electronic Engineering
School
Barcelona School of Telecommunications Engineering (ETSETB)
E-mail
javier.rosellupc.edu
Contact details
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Orcid
0000-0002-9691-328X Open in new window
Scopus Author ID
15056494300 35576621100 Open in new window

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1 to 50 of 346 results
  • Intrumentació electrònica i biomèdica

     Riu Costa, Pere Joan; Fernandez Chimeno, Mireya; Garcia Gonzalez, Miquel Angel; Nescolarde Selva, Lexa Digna; Ramos Castro, Juan Jose; Silva Martinez, Fernando; Torrents Dolz, Josep Maria; Rosell Ferrer, Francisco Javier
    Competitive project

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  • Red de Investigación Cardiovascular

     Bragos Bardia, Ramon; Riu Costa, Pere Joan; Rosell Ferrer, Francisco Javier
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    Physiological conditioning by electric field stimulation promotes cardiomyogenic gene expression in human cardiomyocyte progenitor cells  Open access

     Llucía Valldeperas, Aida; Sánchez Terrones, Benjamin; Soler Botija, Carolina; Gálvez Montón, Carolina; Roura, Santiago; Prat Vidal, Cristina; Perea Gil, Isaac; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Bayés Genís, Antonio
    Stem Cell Research & Therapy
    Vol. 5, num. 4
    DOI: 10.1186/scrt482
    Date of publication: 2014-08-04
    Journal article

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    The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized that electrical conditioning of cardiomyocyte progenitor cells (CMPCs) might enrich their cardiovascular potential. CMPCs were isolated from human adult atrial appendages, characterized, and electrically stimulated for 7 and 14 days. Electrical stimulation modulated CMPCs gene and protein expression, increasing all cardiac markers. GATA-binding protein 4 (GATA4) early transcription factor was significantly overexpressed (P = 0.008), but also its coactivator myocyte enhancer factor 2A (MEF2A) was upregulated (P = 0.073) under electrical stimulation. Moreover, important structural proteins and calcium handling-related genes were enhanced. The cardioregeneration capability of CMPCs is improved by electrical field stimulation. Consequently, short-term electrical stimulation should be a valid biophysical approach to modify cardiac progenitor cells toward a cardiogenic phenotype, and can be incorporated into transdifferentiation protocols. Electrostimulated CMPCs may be best-equipped cells for myocardial integration after implantation.

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    Localized BIA identifies structural and pathophysiological changes in soft tissue after post-traumatic injuries in soccer  Open access

     Nescolarde Selva, Lexa Digna; Yanguas Leyes, Javier; Lukaski, Henry; Rodas Font, Gil; Rosell Ferrer, Francisco Javier
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 3743-3746
    Presentation's date: 2014-08-27
    Presentation of work at congresses

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    Localized bioimpedance (BIA) was measured with a single frequency phase-sensitive analyzer at 50 kHz in three post-traumatic types of injuries on four professional soccer players: (1) myositis ossificans, (2) intramuscular seroma and (3) trochanteric (hip) bursitis. Normal reference value (no injury) was obtained from the contra lateral not injured limb at a mirror-like location of the injury. The relative variations resistance (R) and reactance (Xc) at the time of injury was confronted with the not injured values. Relative variations between acute measurements and post medication ones on intramuscular seroma and bursitis have been computed. In intramuscular seroma and trochanteric bursitis we have obtained a percent of change between injury data and after medical intervention. On myositis ossificans, localized BIA showed a 7-8 % decrease in Xc whereas the percent of change of R was negligible (1 %). These percent of changes are in concordance with histological evidence. In the case of a presence of seroma or the lower thigh and trochanteric bursitis, the soft tissue cavity accumulates fluid. Post-injury localized BIA, relative with respect to non-injured side, confirmed sizeable soft tissue destruction evidenced by 50 % decrease of Xc and 24-31 % decrease of R due to interstitial fluid accumulation. Once the seroma and the blood in the bursitis was removed the localized the immediate post-injury BIA parameters increased as follows: a) intramuscular seroma + 10 % on R and + 74 % of Xc; b) trochanteric bursitis + 20 % of R and +24 % of Xc. Localized BIA other than classifying soft tissue injuries, can be useful to understand the pathophysiology and structural impairments of other kind of injuries and to understand their behavior.

  • DESARROLLO DE TECNOLOGÍAS AVANZADAS DE PRODUCCIÓN Y VALIDACIÓN DE UN PRODUCTO CELULAR

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Garcia Sanchez, Tomas; Bragos Bardia, Ramon
    Competitive project

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  • GRUP D'INSTRUMENTACIÓ ELECTRÒNICA I BIOMÈDICA. Grup de Recerca Consolidat 2013-2016

     Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Riu Costa, Pere Joan; Ramos Castro, Juan Jose; Nescolarde Selva, Lexa Digna; Garcia Gonzalez, Miquel Angel; Fernandez Chimeno, Mireya; Silva Martinez, Fernando
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  • The help4mood wearable sensor network for inconspicuous activity measurement

     Pérez Diaz de Cerio, David; Ruiz Boque, Silvia; Rosell Ferrer, Francisco Javier; Ramos Castro, Juan Jose; Valenzuela Gonzalez, Jose Luis; Colomé Castellví, Josep Maria
    IEEE Wireless communications
    Vol. 20, num. 4, p. 50-56
    DOI: 10.1109/MWC.2013.6590050
    Date of publication: 2013-08
    Journal article

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    The Help4Mood EU FP7 project (H4M) [1] proposes to significantly advance the state-ofthe-art in computerized support for people with Major Depression by monitoring mood, physical activity and voice characteristics while promoting activities in reaction to examined inputs. Employing actigraphy can provide supplementary data about patients with depression. Nonetheless, its use is not standardized and there is a lack of public analyses about treated patients with depression using this technique, which is the objective of the project. The purpose of the Personal Monitoring System (PMS) used in H4M is to compile objective data about the changes and trends of activity patterns during long periods of time. This would comprise daily activity, rest time and, if possible, sleep quality. The PMS uses inconspicuous methods but keeping the cost associated with sensor installation at the patient¿s home to a minimum. This work focuses on the Wireless Sensor Network (WSN) enhancements introduced after real testbeds and considering User Quality of Experience (QoE), mainly oriented to reduce energy consumption and required data transmission and consequently improving the autonomy and range of the sensors.

  • Localized bioimpedance to assess muscle injury

     Nescolarde Selva, Lexa Digna; Yanguas Leyes, Javier; Lukaski, Henry; Alomar, Xavier; Rosell Ferrer, Francisco Javier; Rodas Font, Gil
    Physiological measurement
    Vol. 34, num. 2, p. 237-245
    DOI: 10.1088/0967-3334/34/2/237
    Date of publication: 2013-01
    Journal article

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  • An implantable bioimpedance monitor using 2.45 GHz band for telemetry

     Bogonez Franco, Francisco; Nescolarde Selva, Lexa Digna; Gálvez Montón, Carolina; Bragos Bardia, Ramon; Rosell Ferrer, Francisco Javier
    Physiological measurement
    Vol. 34, num. 1, p. 1-16
    DOI: doi:10.1088/0967-3334/34/1/1
    Date of publication: 2013-01
    Journal article

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    Reference values of the bioimpedance vector components in a Caribbean population  Open access

     Nescolarde Selva, Lexa Digna; Núñez, Ana; Bogonez Franco, Francisco; Lara, Alcibiades; Vaillant, Guillermo; Morales, Ricardo; Rosell Ferrer, Francisco Javier
    e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism
    Vol. 8, num. 4, p. e141-e144
    DOI: 10.1016/j.clnme.2013.04.004
    Date of publication: 2013-07-23
    Journal article

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    Background & aims Application of bioelectrical impedance vector analysis (BIVA) requires comparison of an impedance vector to reference intervals derived from healthy subjects. The aim of this work is to obtain reference nomograms of bioimpedance vectors from healthy subjects living in Santiago de Cuba. Methods A sample of 4030 healthy people, ages 2¿80 y, was measured using a tetra-polar whole-body bioimpedance analyzer at 50 kHz. BIVA method uses the 50, 75 and 95% confidence ellipses of reference populations to classify individual and group vectors. Results The 95% confidence ellipses derived among boys and girls (2¿12 y) were similar (P > 0.05) with significant gender differences (P < 0.05) throughout adulthood. Furthermore, we can observe a progressive decrease in the modulus of the impedance with age with the same phase angle from 13 to 59 y. However, in both genders on subjects >60 y we also observed a phase downfall, possibly due to the reduction of mass and structure, by sarcopenia. Conclusions Reference ellipses are provided, distributed in six sets resulting in age separation intervals (not in gender) for children from 2 to 12 y; two gender specific reference ellipses for teenagers in the range of 13¿16 y, for adults from 17 to 59 y and for elderly people from 60 to 80 y.

    Background & aims Application of bioelectrical impedance vector analysis (BIVA) requires comparison of an impedance vector to reference intervals derived from healthy subjects. The aim of this work is to obtain reference nomograms of bioimpedance vectors from healthy subjects living in Santiago de Cuba. Methods A sample of 4030 healthy people, ages 2–80 y, was measured using a tetra-polar whole-body bioimpedance analyzer at 50 kHz. BIVA method uses the 50, 75 and 95% confidence ellipses of reference populations to classify individual and group vectors. Results The 95% confidence ellipses derived among boys and girls (2–12 y) were similar (P > 0.05) with significant gender differences (P < 0.05) throughout adulthood. Furthermore, we can observe a progressive decrease in the modulus of the impedance with age with the same phase angle from 13 to 59 y. However, in both genders on subjects >60 y we also observed a phase downfall, possibly due to the reduction of mass and structure, by sarcopenia. Conclusions Reference ellipses are provided, distributed in six sets resulting in age separation intervals (not in gender) for children from 2 to 12 y; two gender specific reference ellipses for teenagers in the range of 13–16 y, for adults from 17 to 59 y and for elderly people from 60 to 80 y.

  • Gene transfer to adherent cells by in situ electroporation with a spiral microelectrode assembly

     Garcia Sanchez, Tomas; Guitart, Maria; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 900-903
    DOI: 10.1007/978-3-319-00846-2_223
    Presentation's date: 2013-09-26
    Presentation of work at congresses

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    In this study, in situ electroporation is applied to adherent cell monolayers growing on standard multiwell plates. A new microelectrode assembly based on spiral geometry and fabricated using standard PCB tecnology with slight modifications is used. The system was tested in the electroporation of two different cell lines (CHO and HEK 293). A fluorescent probe was initially used to test the extent of permeabilization and adjust experimental conditions. Subsequently, plasmid DNA encoding green fluorescent protein (GFP) was transfered by electroporation. Together with these experiments, cell viability was studied. We show for permeabilization experiments up to 70 % of fluorescent cells detected in both cells lines. Successful gene electrotransfer was obtained with more than 9 % and 15 % for CHO and HEK 293 respectively. In this work we prove how our device can be used for electroporation of adherent cells under the same standard laboratory conditions as regular biochemical treatments.

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    Monitoring cell monolayers during electroporation: Electrical impedance spectroscopy measurements  Open access

     Garcia Sanchez, Tomas; Guitart, Maria; Sánchez Terrones, Benjamín; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    Symposium on Measurements of Electrical Quantities
    p. 581-586
    Presentation's date: 2013-07
    Presentation of work at congresses

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    Electroporation or electropermeabilization is a phenomenon observed when lipid bilayers, generally cell membranes, are exposed to high electric field pulses becoming transiently permeable to molecules that under regular conditions are not able to penetrate through them. This change in molecular permeability is believed to be produced by transient aqueous pores created in the lipidic structure and can be monitored by changes in the electrical conductivity of these membranes. The aim of this study is to use fast electrical impedance spectroscopy to measure the process of electroporation applied on cell monolayers growing attached to standard multiwell plates. The frequency response of the impedance can provide useful information about the extent of permeabilization in the cell membranes exposed to high electric fields and also the time dynamics of creation and resealing of these pores. For this study we used a microelectrode assembly specifically designed for in situ performance of both electroporation and impedance measurements. The design of the microelectrodes is based on a spiral geometry conceived to improve the uniformity of the electric field applied and to perform impedance measurements in a four-electrode configuration.

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    A magnetic induction measurement system for adult vital sign monitoring: evaluation of capacitive and inductive effects  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-impedance
    DOI: 10.1088/1742-6596/434/1/012085
    Presentation's date: 2013-04
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    Magnetic induction (MI) measurement technique could provide an unobtrusive contactless method for continuous monitoring of vital signs such as breathing and cardiac activity in bed. In this paper, we present a magnetic induction system to evaluate the feasibility of monitoring heart and lung activity and the preliminary measurement results. The excitation and detection coils are designed to be implemented in a single printed circuit board, allowing the use of the system in a bed with coils under the mattress. The electronic system is based on a 16 bit arbitrary waveform generator (PXI-5422, National instrument) operating at a sample rate of 200 MS/s for the excitation signal and the detected amplified signal is then, sampled at 100 MS/s by a 14 bit digitizer (PXI-5122, National Instruments). The preliminary results at 10 MHz show the ability of the system to detect solutions with different conductivities. However the capacitive effect is in the same order of magnitude as the inductive effect due to eddy currents. Safety of the system has been evaluated to be in accordance with the standards of human exposure to the magnetic fields

    Magnetic induction (MI) measurement technique could provide an unobtrusive contactless method for continuous monitoring of vital signs such as breathing and cardiac activity in bed. In this paper, we present a magnetic induction system to evaluate the feasibility of monitoring heart and lung activity and the preliminary measurement results. The excitation and detection coils are designed to be implemented in a single printed circuit board, allowing the use of the system in a bed with coils under the mattress. The electronic system is based on a 16 bit arbitrary waveform generator (PXI-5422, National instrument) operating at a sample rate of 200 MS/s for the excitation signal and the detected amplified signal is then, sampled at 100 MS/s by a 14 bit digitizer (PXI-5122, National Instruments). The preliminary results at 10 MHz show the ability of the system to detect solutions with different conductivities. However the capacitive effect is in the same order of magnitude as the inductive effect due to eddy currents. Safety of the system has been evaluated to be in accordance with the standards of human exposure to the magnetic fields.

  • Low cost EIT system for monitoring the sausage ripening process in food industry

     Bragos Bardia, Ramon; Guasch Petit, Antonio; Sánchez Terrones, Benjamín; Giovinazzo, Giuseppe; Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan
    International Conference on Electrical Bio-impedance
    p. 89
    Presentation's date: 2013-04-24
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  • Desarrollo de bioimplantes para la regeneración cardiaca con células progenitoras derivadas de la grasa cardiaca, biomateriales y..

     Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamin; Macías Macías, Raul; Bermejo Sanchez, Sergio; Bragos Bardia, Ramon
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  • Design and implementation of a microelectrode assembly for use on noncontact in situ electroporation of adherent cells

     Garcia Sanchez, Tomas; Sanchez Ortiz, Beatriz; Vila, Ingrid; Guitart, Maria; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    Journal of membrane biology
    Vol. 245, num. 10, p. 617-624
    DOI: 10.1007/s00232-012-9474-y
    Date of publication: 2012-10
    Journal article

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    In situ electroporation of adherent cells provides significant advantages with respect to electroporation systems for suspension cells, such as causing minimal stress to cultured cells and simplifying and saving several steps within the process. In this study, a new electrode assembly design is shown and applied to in situ electroporate adherent cell lines growing in standard multiwell plates. We designed an interdigitated array of electrodes patterned on copper with printed circuit board technology and covered with nickel/gold. Small interelectrode distances were used to achieve effective electroporation with low voltages. Epoxy-based microseparators were constructed to avoid direct contact with the cells and to create more uniform electric fields. The device was successful in the electropermeabilization of two different adherent cell lines, C2C12 and HEK 293, as assessed by the intracellular delivery of the fluorescent dextran FD20S. Additionally, as a collateral effect, we observed cell electrofusion in HEK 293 cells, thus making this device also useful for performing cell fusion. In summary, we show the effectiveness of this minimally invasive device for electroporation of adherent cells cultured in standard multiwell plates. The cheap technologies used in the fabrication process of the electrode assembly indicate potential use as a low-cost, disposable device.

  • Coil arrangement for a magnetic induction impedance measurement apparatus comprising a partly compensated magnetic excitation field in the detection coil

     Igney, Claudia Hannelore; Rosell Ferrer, Francisco Javier; Hamsch, Mathias
    Date of request: 2012-02-09
    Invention patent

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  • Electrode assembly for generating electric field pulses to perform electroporation to a biological sample

     Garcia Sanchez, Tomas; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Gomez Foix, Anna Maria; Guitart de la Rosa, Maria; Sanchez Ortiz, Beatriz
    Date of request: 2012-05-11
    Invention patent

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  • Methods and devices for mechanical and electrical stimulation of stem cell monolayer and 3d cultures for tissue engineering applications

     Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamín; Bragos Bardia, Ramon; Bayés Genís, Antonio; Llucía Valldeperas, Aida
    Date of request: 2012-06-13
    Invention patent

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  • Help4Mood: testing and achievements of the first wireless sensor network prototype

     Pérez Diaz de Cerio, David; Ruiz Boque, Silvia; Rosell Ferrer, Francisco Javier; Ramos Castro, Juan Jose; Colomé Castellví, Josep Maria
    European Cooperative in Science And Technology
    Presentation's date: 2012-02-10
    Presentation of work at congresses

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    Help4Mood is a closed loop approach supporting the control, communication and treatment management of patients with Major Depression. The first out of the three main components of the Help4Mood solution is the Personal Monitoring System (PMS), a set of different wireless sensors whose data sink is centralized on a laptop. The objective of this PMS is to monitor the activity of the patients, so several sensors have been chosen to cover the needs of different individuals. These include a wrist watch, a key ring, a waist/belt sensor, an under mattress sensor and a cellular phone. This paper describes the first prototype and the results obtained from this Wireless Sensor Network

  • Unobtrusive activity measurement in patients with depression: the H4M approach

     Ramos Castro, Juan Jose; Mahdavi, Hadiseh; Pérez Diaz de Cerio, David; Garcia Gonzalez, Miquel Angel; Estevez, Soraya; Rosell Ferrer, Francisco Javier
    Information and Communication Technologies applied to Mental Health
    p. 18-23
    Presentation's date: 2012-10-04
    Presentation of work at congresses

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    Simulation of a magnetic induction method for determining passive electrical property changes of human trunk due to vital activities  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    COMSOL Conference
    p. 1-4
    Presentation's date: 2012-10-11
    Presentation of work at congresses

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    Determining the changes in passive electrical properties of human tissues and the geometry changes of the body parts due to breathing and cardiac activity could be a method for monitoring these vital signs. We have designed a model with COMSOL Multiphysics to simulate a magnetic induction method for determining changes of these characteristics. Given the large number of parameters and variables, difficulties of anatomical modeling and various tissue properties, we are facing some numerical challenges. In addition, using magnetic induction method, we have to consider safety issues, standards and limitations. We used COMSOL to simulate the induced currents in the human body and the resulting perturbation in the magnetic field for different tissue properties and geometries. As a result, we obtained the expected changes during breathing and we know the minimum distances and maximum excitation currents that could be used to meet the international safety standards.

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    Automatic system for electroporation of adherent cells growing in standard multi-well plates*  Open access

     Garcia Sanchez, Tomas; Guitart, Maria; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    IEEE Engineering in Medicine and Biology Society
    p. 2571-2574
    Presentation's date: 2012-08-28
    Presentation of work at congresses

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    In this study an automatic system is presented to perform electroporation, also known as electropermeabilization, on adherent cells. It is an intention of this system to apply electric field pulses directly to cells growing in standard multiwell plates as a step forward to include this technique in standard laboratory protocols. An interdigitated microelectrode assembly constructed with Printed Circuit Board (PCB) is placed closely above the cell monolayer, and in order to avoid direct contact with cells, small micro-separators were included in the structure. Additionally, distribution of current density was modified by filling the gap between adjacent electrodes with a non conductive material as predicted by electric field simulations. This modification helps to concentrate the electric field intensity in the region where cells are present. The device was tested using C2C12 cell line growing adhered in 24 multiwell plates and fluorescent labeled dextran FD20S as the molecule to be delivered. Successful transfection was observed with minimal invasiveness of the operation reducing the stress caused to cells.

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    Simulation of a magnetic induction method for determining passive electrical property changes of human trunk due to vital activities  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    COMSOL Conference
    p. 1
    Presentation's date: 2012-10-11
    Presentation of work at congresses

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  • Improvement of the actimetry agreement among sites by proper choice of signal processing stages

     Garcia Gonzalez, Miquel Angel; Giovinazzo, Giuseppe; Gomez Bule, Rafael; Landi, Francesca; Ramos Castro, Juan Jose; Rosell Ferrer, Francisco Javier
    IASTED International Conference Biomedical Engineering
    p. 1-5
    Presentation's date: 2012-02-15
    Presentation of work at congresses

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    Physical activity (PA) has been identified as a key health indicator and has been assessed in multiple studies as the study of cardiovascular diseases, diabetes mellitus, obesity and psychological conditions. For this reason the use of accelerometers to quantify PA is widely accepted in either clinical/laboratory settings as well as in freeliving environments. The use of accelerometers in the measurement of PA is a relatively new technique and, therefore, has been not standardized. The aim of this work is to study the influence of signal processing stages in the estimation of PA while measuring simultaneously in three different sites to provide robust indicators of activity in front of changes in site measurement. With our measurement we show that a proper choice of signal processing steps can improve the agreement among activity indices measured from different sites on the same individual. The results also show that the most suited index is the time above threshold. In this case, the best combination of axes is by applying the quadratic mean, the best filtering of axes is using a cut-off frequency of around 1.5 Hz and a threshold to compute the index of 0.04 g.

  • A wireless sensor network design for the Help4Mood european project

     Pérez Diaz de Cerio, David; Ruiz Boque, Silvia; Rosell Ferrer, Francisco Javier; Ramos Castro, Juan Jose; Castro Robles, Joan Carles
    European Wireless
    p. 1-6
    Presentation's date: 2012-04
    Presentation of work at congresses

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    Help4Mood is a closed loop approach supporting the control, communication and treatment management of patients with Major Depression. The first out of the three main components of the Help4Mood solution is the Personal Monitoring System (PMS), a set of different wireless sensors whose data sink is centralized on a laptop. The objective of this PMS is to monitor the activity of the patients, so several sensors have been chosen to cover the needs of different individuals. These include a wrist watch, a key ring, a waist/belt sensor, an under mattress sensor and a cellular phone. This paper describes the first prototype and the results obtained from this Wireless Sensor Network.

  • A wireless under-mattress sensor system for sleep monitoring in people with major depression

     Mahdavi, Hadiseh; Ramos Castro, Juan Jose; Giovinazzo, Giuseppe; Garcia Gonzalez, Miquel Angel; Rosell Ferrer, Francisco Javier
    IASTED International Conference Biomedical Engineering
    p. 1-5
    Presentation's date: 2012-02-16
    Presentation of work at congresses

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    Monitoring people during sleep time is of particular interest to patients with sleep disorders and elderly people or infants. We have developed a battery powered electronic system to monitor people in the bed, store the data and send them through a wireless link to a PC. The resulting data will be subject to further analysis using pattern recognition to evaluate the feasibility of using the system as an indicator of sleep quality. The system is able to detect presence on the bed and movements and breathing of the patient. The changes in pressure distribution on the mattress cause changes in pressure in the layers of the sensor and a voltage will appear on the electrodes. The detection ability depends strongly on the shape of the mattress and the bedbase.

  • Transoesophageal bioimpedance analysis for the detection of graft rejection after cardiac transpantation

     Giovinazzo, Giuseppe
    Department of Electronic Engineering, Universitat Politècnica de Catalunya
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  • FP7-262029-DRYCHECK

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Guasch Martinez, Aleix; Bragos Bardia, Ramon
    Competitive project

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  • DESARROLLO DE TECNOLOGÍAS AVANZADAS DE PRODUCCIÓN Y VALIDACIÓN DE UN PRODUCTO CELULAR

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Bragos Bardia, Ramon
    Competitive project

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  • A COMPUTATIONAL DISTRIBUTED SYSTEM TO SUPPORT THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSION

     Rosell Ferrer, Francisco Javier; Caminal Magrans, Pedro; Ramos Castro, Juan Jose; Garcia Gonzalez, Miquel Angel; Mahdavi, Hadiseh
    Competitive project

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  • Localized bioimpedance measurements to assess muscle Injuries in the four major groups of lower limb

     Rosell Ferrer, Francisco Javier; Nescolarde Selva, Lexa Digna; Rodas Font, Gil; Yanguas Leyes, Xavier
    Competitive project

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  • The feasibility of transoesophageal bioimpedance measurements for the detection of heart graft rejection

     Giovinazzo, Giuseppe; Ribas, Núria; Cinca Cosculluela, Juan; Rosell Ferrer, Francisco Javier
    Physiological measurement
    Vol. 32, num. 7, p. 867-876
    DOI: 10.1088/0967-3334/32/7/S10
    Date of publication: 2011-07
    Journal article

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    Previous studies demonstrate that it is possible to evaluate a heart graft rejection condition using a bioimpedance technique by means of an intracavitary catheter. We propose to use a less invasive technique consisting in the use of a transoesophageal catheter and two standard ECG electrodes on the thorax. The aim of this work is to evaluate, using the finite element method, several parameters affecting the transoesophageal impedance measurement, including sensitivity to electrical conductivity and permittivity of different organs in the thorax, changes in magnitude and phase due to a lesion producing a scar, a global ischaemia of the heart, pleural effusion in the lungs, fat thickness increase, displacement of the catheter inside the oesophagus and movement of one electrode on the thorax surface. From these results, we deduce the best estimator for cardiac rejection detection and obtain the tools to identify eventual cases of false positives due to other factors. To achieve these objectives we have created a thoracic model and we have simulated different situations at the frequencies of 13, 30, 100, 300 and 1000 kHz. Our simulation demonstrates that the phase, at 100 and 300 kHz, would be a better estimator than the magnitude to evaluate a heart rejection condition.

  • Bioelectrical impedance vector analysis (BIVA) in stable and non-stable heart failure patients: A pilot study

     Gastelurrutia, Paloma; Nescolarde Selva, Lexa Digna; Rosell Ferrer, Francisco Javier; Domingo, Maite; Ribas, Núria; Bayés Genis, Antoni
    International journal of cardiology
    Vol. 146, num. 2, p. 262-264
    DOI: 10.1016/j.ijcard.2010.10.072
    Date of publication: 2011-01-21
    Journal article

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  • Planar coil arrangement for a magnetic induction impedance measurement apparatus

     Rosell Ferrer, Francisco Javier; Igney, Claudia Hannelore; Hamsch, Mathias
    Date of request: 2011-02-03
    Invention patent

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  • Muscle fatigue monitoring using a multifrequency bioimpedance technique

     Vescio, Giovanni; Rosell Ferrer, Francisco Javier; Nescolarde Selva, Lexa Digna; Giovinazzo, Giuseppe
    European Conference of the International Federation for Medical and Biological Engineering
    p. 1257-1260
    DOI: 10.1007/978-3-642-23508-5_325
    Presentation's date: 2011-09
    Presentation of work at congresses

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    The objective of this work is to measure the changes of electrical bioimpedance module and phase related to muscular fatigue. The results could also be interesting for medical diagnosis of leg oedema, related to heart diseases, or muscular lesions. With this purpose in mind we have done multifrequency bioimpedance measurements on volunteers to evaluate the change of the impedance due to some physical exercises with the leg and with the arm. In the case of the measures performed on the arm we have obtained an initial increase of the impedance module after the first three exercises. The change of the impedance module taken after the 5th exercise respect to the first measurement was significantly lower (p<0.05) at all frequencies. In the case of the measures performed on the leg we have obtained an increase of the impedance module after the first four exercises if compared with the module at rest. The measured module after the first exercise was significantly different respect to the module at rest (p<0.05) for frequencies lower than 50 kHz. Subsequently, making the measurement after the fifth exercise we have obtained a decrease of the impedance module, if it is compared with the previous measurement. The change of the module measured after the 6th exercise is greater than the system noise if compared with the 1st impedance measurement but this change is not significant, if compared to the first measurement, at all frequencies.

  • Cardiac tissue engineering by electrical stimulation with subcutaneous and cardiac adipose-tissue derived progenitor cells (ATDPCs)

     Llucià-Valldeperas, Aida; Sánchez Terrones, Benjamin; Soler-Botija, C.; Roura, S.; Prat-Vidal, C.; Gálvez-Montón, C.; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Bayés Genis, Antoni
    Evolving Challenges in Promoting Cardiovascular Health Congress
    p. 1
    Presentation's date: 2011-11-04
    Presentation of work at congresses

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    A major challenge of cardiac tissue engineering is directing cells to establish the physiological structure and function of the myocardium being replaced. In native heart, pacing cells generate electrical stimuli that spread throughout the heart causing cell membrane depolarization and activation of contractile apparatus. We ought to examine whether electrical stimulation of adipose tissue-derived progenitor cells (ATDPCs) exerts phenotypic and genetic changes that enhance their cardiomyogenic potential.

  • Assessment and follow-up of muscle injuries in athletes by bioimpedance: Preliminary results

     Nescolarde Selva, Lexa Digna; Yanguas Leyes, Javier; Medina Leal, Daniel; Rodas Font, Gil; Rosell Ferrer, Francisco Javier
    IEEE Engineering in Medicine and Biology Society
    p. 1137-1140
    Presentation's date: 2011-09-02
    Presentation of work at congresses

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    Mono-frequency (50 kHz) whole-body and segmental bioimpedance is measured before sport training in 14 high performance athletes. The athletes are classified in two groups according to the team sport: football and basketball. Bioelectrical impedance vector analysis (BIVA) method is used to obtain the individual whole-body impedance and 6 segmental impedance vectors in the main muscular groups in the lower- limbs. The whole-body vector is analyzed in the tolerance ellipses of the reference population. Individual impedance vector components are standardized by the height H of the subject, (R/H and Xc/H) to obtain the impedance vector (Z/H) of each segment. The hypotheses of the study are: 1) Not all the sports have the same pattern of bioimpedance vector by muscle group. 2) In elite well trained athletes their muscle groups are symmetrical (right and left sides), thus each athlete is its own reference for future comparisons. 3) We expect a change in the two components of bioimpedance vector (R/H and Xc/H) in front of a muscle injury. In order to compare the differences between the complex Z/H vector (R/H, Xc/H) we use Hotelling s T2 test. Preliminary results show a significant difference (P < 0.05) in bioimpedance vectors between groups according to the team sport, and also between normal muscle condition and after muscle injury producing hyper-hydration.

  • In-cycle myocardium tissue electrical impedance monitoring using broadband impedance spectroscopy

     Sánchez Terrones, Benjamín; Vandersteen, Gerd; Rosell Ferrer, Francisco Javier; Cinca Cosculluela, Juan; Bragos Bardia, Ramon
    IEEE Engineering in Medicine and Biology Society
    p. 2518-2521
    DOI: 10.1109/IEMBS.2011.6090697
    Presentation's date: 2011
    Presentation of work at congresses

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    Longitudinal and transversal bioimpedance measurements in addition to diagnosis of heart failure  Open access

     Ribas, Núria; Nescolarde Selva, Lexa Digna; Domingo, Maite; Gastelurrutia, Paloma; Bayés Genis, Antoni; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-Impedance
    DOI: 10.1088/1742-6596/224/1/012099
    Presentation of work at congresses

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    Heart Failure (HF) is a clinical syndrome characterised by signs of systemic and pulmonary fluid retention, shortness of breath and/or fatigue. There is a lack of reliable indicators of disease state. Benefits and applicability of non-invasive bioimpedance measurement in the hydration state of soft tissues have been validated, fundamentally, in dialysis patients. Four impedance configurations (2 longitudinal and 2 transversal) were analyzed in 48 HF patients (M=28, F=20) classified according to a clinical disease severity score (CDSS) derived from the Framingham criteria: CDSS 2 (G1: M= 23, F= 14) and CDSS>2 (G2: M= 5, F= 6). The aim of this study is to analyze longitudinal and transversal bioimpedance measurement at 50 kHz, in addition to clinical diagnosis parameters of heart failure, including: clinical disease severity score (CDSS) and a biomarker concentrations (NTproBNP). The Kolmogorov-Smirnov test was used for the normality test of all variables. The CDSS, NTproBNP and impedance parameters between groups (G1 and G2) were compared by mean of Mann Withney U-test. The statistical significance was considered with P < 0.05. Whole-body impedance measured was analyzed using RXc graph.

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    Transoesophageal detection of heart graft rejection by electrical impedance: using Finite Element Method simulations  Open access

     Giovinazzo, Giuseppe; Ribas, N.; Rosell Ferrer, Francisco Javier; Cinca Cosculluela, Juan
    International Conference on Electrical Bio-impedance
    p. 1-4
    Presentation's date: 2010-04-05
    Presentation of work at congresses

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    Previous studies have shown that it is possible to evaluate heart graft rejection level using a bioimpedance technique by means of an intracavitary catheter. However, this technique does not present relevant advantages compared to the gold standard for the detection of a heart rejection, which is the biopsy of the endomyocardial tissue. We propose to use a less invasive technique that consists in the use of a transoesophageal catheter and two standard ECG electrodes on the thorax. The aim of this work is to evaluate different parameters affecting the impedance measurement, including: sensitivity to electrical conductivity and permittivity of different organs in the thorax, lung edema and pleural water. From these results, we deduce the best estimator for cardiac rejection detection, and we obtain the tools to identify possible cases of false positive of heart rejection due to other factors. To achieve these objectives we have created a thoracic model and we have simulated, with a FEM program, different situations at the frequencies of 13, 30, 100, 300 and 1000 kHz. Our simulation demonstrates that the phase, at 100 and 300 kHz, has the higher sensitivity to changes in the electrical parameters of the heart muscle.

    Postprint (author’s final draft)

  • Applications of longitudinal and transversal bioimpedance measurements in peritoneal dialysis at 50 kHz

     Nescolarde Selva, Lexa Digna; Doñate, T.; Casañas, R.; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-impedance
    p. 1-4
    DOI: 10.1088/1742-6596/224/1/012138
    Presentation of work at congresses

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    More relevant information of the fluid changes in peritoneal dialysis (PD) might be obtained with segmental bioimpedance measurements rather than whole-body measurement, who hidden information of body composition. Whole-body and segmental bioimpedance measurements were obtained using 5 configurations (whole-body or right-side (RS), longitudinal-leg (L-LEG), longitudinal-abdomen (L-AB), transversal-abdomen (T-AB), and transversal-leg (T-LEG)) in 20 patients: 15 males (56.5 ± 9.4 yr, 24.2 ± 4.2 kg/m2) and 5 females (58.4 ± 7.1 yr, 28.2 ± 5.9 kg/m2) in peritoneal dialysis (PD). The aim of this study is to analyze the relationship between whole-body, longitudinal-segmental (L-LEG and L-AB) and transversal-segmental (TAB and TLEG) bioimpedance measurement at 50 kHz, with clinical parameters of cardiovascular risk, dyslipidemia, nutrition and hydration. The Kolmogorov- Smirnov test was used for the normality test of all variables. Longitudinal bioimpedance parameters were normalized by the height of the patients. The Spearman correlation was used to analyze the correlation between bioimpedance and clinical parameters. The statistical significance was considered with P < 0.05. Transversal bioimpedance measurements have higher correlation with clinical parameters than longitudinal measurements.

  • Performance of an implantable impedance spectroscopy monitor using ZigBee

     Bogonez Franco, Francisco; Bayés Genis, Antoni; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon
    International Conference on Electrical Bio-impedance
    p. 1-4
    DOI: 10.1088/1742-6596/224/1/012163
    Presentation's date: 2010-04-04
    Presentation of work at congresses

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    This paper presents the characterization measurements of an implantable bioimpedance monitor with ZigBee. Such measurements are done over RC networks,performing short and long-term measurements, with and without mismatch in electrodes and varying the temperature and the RF range. The bioimpedance monitor will be used in organ monitoring through electrical impedance spectroscopy in the 100 Hz - 200 kHz range. The specific application is the study of the viability and evolution of engineered tissue in cardiac regeneration in an experimental protocol with pig models. The bioimpedance monitor includes a ZigBee transceiver to transmit the measured data outside the animal chest. The bioimpedance monitor is based in the 12 Bit Impedance Converter and Network Analyzer AD5933, improved with an analog front-end that implements a 4-electrode measurement structure and allows to measure small impedances. In the debugging prototype, the system autonomy exceeds 1 month when a 14 frequencies impedance spectrum is acquired every 5 minutes. The receiver side consists of a ZigBee transceiver connected to a PC to process the received data. In the current implementation, the effective range of the RF link was of a few centimeters, then needing a range extender placed close to the animal. We have increased it by using an antenna with higher gain. Basic errors in the phantom circuit parameters estimation after model fitting are below 1%.

  • PEP's characterization (s, e & µ) from biological culture and materials with similar characteristics using MIS

     Rodarte Dávila, Jesús; Rosell Ferrer, Francisco Javier
    Barcelona Forum on Ph.D. Research in Communications, Electronics and Signal Processing
    p. 31-32
    Presentation's date: 2010-10-21
    Presentation of work at congresses

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  • Instrumentation for bio-impedance measurements

     Riu Costa, Pere Joan; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon
    Date of publication: 2009
    Book chapter

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  • DESARROLLO DE TECNICAS DE MONITORIZACIÓN NO DESTRUCTIVA Y MINIMAMENTE INVASIVA EN APLICACIONES DE INGENIERIA CELULAR....

     Nescolarde Selva, Lexa Digna; Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamin; Bogonez Franco, Francisco; Bragos Bardia, Ramon
    Competitive project

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  • GRUP D'INSTRUMENTACIÓ ELECTRÒNICA I BIOMÈDICA: Grup de Recerca Consolidat.

     Bragos Bardia, Ramon; Rosell Ferrer, Francisco Javier; Fernandez Chimeno, Mireya; Garcia Gonzalez, Miquel Angel; Nescolarde Selva, Lexa Digna; Ramos Castro, Juan Jose; Riu Costa, Pere Joan; Robert i Sanxis, Francesc Josep; Silva Martinez, Fernando; Torrents Dolz, Josep Maria
    Competitive project

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  • Access to the full text
    Measurement errors in multifrequency bioelectrical impedance analyzers with and without impedance electrode mismatch  Open access

     Bogonez Franco, Francisco; Nescolarde Selva, Lexa Digna; Bragos Bardia, Ramon; Rosell Ferrer, Francisco Javier; Yandiola, Iñigo
    Physiological measurement
    Vol. 30, num. 7, p. 573-587
    DOI: 10.1088/0967-3334/30/7/004
    Date of publication: 2009-06-03
    Journal article

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    The purpose of this study is to compare measurement errors in two commercially available multi-frequency bioimpedance analyzers, a Xitron 4000B and an ImpediMed SFB7, including electrode impedance mismatch. The comparison was made using resistive electrical models and in ten human volunteers. We used three different electrical models simulating three different body segments: the right-side, leg and thorax. In the electrical models, we tested the effect of the capacitive coupling of the patient to ground and the skin–electrode impedance mismatch. Results showed that both sets of equipment are optimized for right-side measurements and for moderate skin–electrode impedance mismatch. In right-side measurements with mismatch electrode, 4000B is more accurate than SFB7. When an electrode impedance mismatch was simulated, errors increased in both bioimpedance analyzers and the effect of the mismatch in the voltage detection leads was greater than that in current injection leads. For segments with lower impedance as the leg and thorax, SFB7 ismore accurate than 4000B and also shows less dependence on electrode mismatch. In both devices, impedance measurements were not significantly affected (p > 0.05) by the capacitive coupling to ground.

  • Transoesophageal electrical bioimpedance measurements of the heart in humans

     Giovinazzo, Giuseppe; Raga, S.; Ribas, N.; Bayés Genis, Antoni; Cinca Cosculluela, Juan; Rosell Ferrer, Francisco Javier
    World Congress on Medical Physics and Biomedical Engineering
    p. 141-144
    Presentation of work at congresses

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    Previous studies have proved that posttransplant cardiac rejection is associated with changes in endomyocardial electrical impedance in humans. The aim of this study is to develop a safe transoesophageal system able to measure cardiac electrical impedance in transplanted patients and to evaluate the capability of this technique to detect heart graft rejection in humans in order to reduce the number of repetitive biopsies. The impedance measurement is performed using a four wire configuration. We measured the impedance spectrum from 13 kHz to 1 MHz. The oesophageal ECG signal is used to evaluate the position of the catheter in the oesophagus with regard to the patient’s heart. So far measurements have been carried out on a group composed of 11 healthy volunteers (5 men) and 9 cardiac transplanted patients (7 men) with no histological signs of cardiac rejection. Impedance spectrum measurements at different locations in the oesophagus showed a decrease of the impedance magnitude with the increase of the depth of the catheter in the oesophagus (about 1 ohm/cm). The phase value does not show significant changes when changing the catheter’s position in the oesophagus. There are gender differences in the magnitude but not in the phase angle of the transoesophageal cardiac electrical impedance. Transplanted patients with no graft rejection show impedance values similar to that of healthy volunteers, suggesting that the surgical intervention does not affect the impedance measures. The oesophageal approach is safe and was considered for transplanted patients less annoying than the biopsy method. In consequence, if further results show a significant change of impedance in patients with cardiac rejection, a new lessinvasive clinical method to detect graft rejection can be envisaged.