Rosell Ferrer, Francisco Javier
Total activity: 347
Professional category
University professor
Doctoral courses
Doctor Ingeniero de Telecomunicación
Research group
CREB - Biomedical Engineering Research Centre
IEB - Electronic and Biomedical Instrumentation
Department
Department of Electronic Engineering
School
Barcelona School of Telecommunications Engineering (ETSETB)
E-mail
javier.rosellupc.edu
Contact details
UPC directory Open in new window
Orcid
0000-0002-9691-328X Open in new window
Scopus Author ID
15056494300 35576621100 Open in new window

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1 to 50 of 347 results
  • Localized BIA identifies structural and pathophysiological changes in soft tissue after post-traumatic injuries in soccer

     Nescolarde Selva, Lexa Digna; Yanguas Leyes, Javier; Lukaski, Henry; Rodas Font, Gil; Rosell Ferrer, Francisco Javier
    International Conference of the IEEE Engineering in Medicine and Biology Society
    p. 3743-3746
    Presentation's date: 2014-08-27
    Presentation of work at congresses

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    Localized bioimpedance (BIA) was measured with a single frequency phase-sensitive analyzer at 50 kHz in three post-traumatic types of injuries on four professional soccer players: (1) myositis ossificans, (2) intramuscular seroma and (3) trochanteric (hip) bursitis. Normal reference value (no injury) was obtained from the contra lateral not injured limb at a mirror-like location of the injury. The relative variations resistance (R) and reactance (Xc) at the time of injury was confronted with the not injured values. Relative variations between acute measurements and post medication ones on intramuscular seroma and bursitis have been computed. In intramuscular seroma and trochanteric bursitis we have obtained a percent of change between injury data and after medical intervention. On myositis ossificans, localized BIA showed a 7-8 % decrease in Xc whereas the percent of change of R was negligible (1 %). These percent of changes are in concordance with histological evidence. In the case of a presence of seroma or the lower thigh and trochanteric bursitis, the soft tissue cavity accumulates fluid. Post-injury localized BIA, relative with respect to non-injured side, confirmed sizeable soft tissue destruction evidenced by 50 % decrease of Xc and 24-31 % decrease of R due to interstitial fluid accumulation. Once the seroma and the blood in the bursitis was removed the localized the immediate post-injury BIA parameters increased as follows: a) intramuscular seroma + 10 % on R and + 74 % of Xc; b) trochanteric bursitis + 20 % of R and +24 % of Xc. Localized BIA other than classifying soft tissue injuries, can be useful to understand the pathophysiology and structural impairments of other kind of injuries and to understand their behavior.

  • Intrumentació electrònica i biomèdica

     Riu Costa, Pere Joan; Fernandez Chimeno, Mireya; Garcia Gonzalez, Miquel Angel; Nescolarde Selva, Lexa Digna; Ramos Castro, Juan Jose; Silva Martinez, Fernando; Torrents Dolz, Josep Maria; Rosell Ferrer, Francisco Javier
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  • GRUP D'INSTRUMENTACIÓ ELECTRÒNICA I BIOMÈDICA. Grup de Recerca Consolidat 2013-2016

     Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Riu Costa, Pere Joan; Ramos Castro, Juan Jose; Nescolarde Selva, Lexa Digna; Garcia Gonzalez, Miquel Angel; Fernandez Chimeno, Mireya; Silva Martinez, Fernando
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  • Gene transfer to adherent cells by in situ electroporation with a spiral microelectrode assembly

     Garcia Sanchez, Tomas; Guitart, Maria; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    Mediterranean Conference on Medical and Biological Engineering and Computing
    p. 900-903
    DOI: 10.1007/978-3-319-00846-2_223
    Presentation's date: 2013-09-26
    Presentation of work at congresses

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    In this study, in situ electroporation is applied to adherent cell monolayers growing on standard multiwell plates. A new microelectrode assembly based on spiral geometry and fabricated using standard PCB tecnology with slight modifications is used. The system was tested in the electroporation of two different cell lines (CHO and HEK 293). A fluorescent probe was initially used to test the extent of permeabilization and adjust experimental conditions. Subsequently, plasmid DNA encoding green fluorescent protein (GFP) was transfered by electroporation. Together with these experiments, cell viability was studied. We show for permeabilization experiments up to 70 % of fluorescent cells detected in both cells lines. Successful gene electrotransfer was obtained with more than 9 % and 15 % for CHO and HEK 293 respectively. In this work we prove how our device can be used for electroporation of adherent cells under the same standard laboratory conditions as regular biochemical treatments.

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    Monitoring cell monolayers during electroporation: Electrical impedance spectroscopy measurements  Open access

     Garcia Sanchez, Tomas; Guitart, Maria; Sánchez Terrones, Benjamín; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    Symposium on Measurements of Electrical Quantities
    p. 581-586
    Presentation's date: 2013-07
    Presentation of work at congresses

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    Electroporation or electropermeabilization is a phenomenon observed when lipid bilayers, generally cell membranes, are exposed to high electric field pulses becoming transiently permeable to molecules that under regular conditions are not able to penetrate through them. This change in molecular permeability is believed to be produced by transient aqueous pores created in the lipidic structure and can be monitored by changes in the electrical conductivity of these membranes. The aim of this study is to use fast electrical impedance spectroscopy to measure the process of electroporation applied on cell monolayers growing attached to standard multiwell plates. The frequency response of the impedance can provide useful information about the extent of permeabilization in the cell membranes exposed to high electric fields and also the time dynamics of creation and resealing of these pores. For this study we used a microelectrode assembly specifically designed for in situ performance of both electroporation and impedance measurements. The design of the microelectrodes is based on a spiral geometry conceived to improve the uniformity of the electric field applied and to perform impedance measurements in a four-electrode configuration.

  • Low cost EIT system for monitoring the sausage ripening process in food industry

     Bragos Bardia, Ramon; Guasch Petit, Antonio; Sánchez Terrones, Benjamín; Giovinazzo, Giuseppe; Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan
    International Conference on Electrical Bio-impedance
    p. 89
    Presentation's date: 2013-04-24
    Presentation of work at congresses

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    A magnetic induction measurement system for adult vital sign monitoring: evaluation of capacitive and inductive effects  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-impedance
    DOI: 10.1088/1742-6596/434/1/012085
    Presentation's date: 2013-04
    Presentation of work at congresses

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    Magnetic induction (MI) measurement technique could provide an unobtrusive contactless method for continuous monitoring of vital signs such as breathing and cardiac activity in bed. In this paper, we present a magnetic induction system to evaluate the feasibility of monitoring heart and lung activity and the preliminary measurement results. The excitation and detection coils are designed to be implemented in a single printed circuit board, allowing the use of the system in a bed with coils under the mattress. The electronic system is based on a 16 bit arbitrary waveform generator (PXI-5422, National instrument) operating at a sample rate of 200 MS/s for the excitation signal and the detected amplified signal is then, sampled at 100 MS/s by a 14 bit digitizer (PXI-5122, National Instruments). The preliminary results at 10 MHz show the ability of the system to detect solutions with different conductivities. However the capacitive effect is in the same order of magnitude as the inductive effect due to eddy currents. Safety of the system has been evaluated to be in accordance with the standards of human exposure to the magnetic fields

    Magnetic induction (MI) measurement technique could provide an unobtrusive contactless method for continuous monitoring of vital signs such as breathing and cardiac activity in bed. In this paper, we present a magnetic induction system to evaluate the feasibility of monitoring heart and lung activity and the preliminary measurement results. The excitation and detection coils are designed to be implemented in a single printed circuit board, allowing the use of the system in a bed with coils under the mattress. The electronic system is based on a 16 bit arbitrary waveform generator (PXI-5422, National instrument) operating at a sample rate of 200 MS/s for the excitation signal and the detected amplified signal is then, sampled at 100 MS/s by a 14 bit digitizer (PXI-5122, National Instruments). The preliminary results at 10 MHz show the ability of the system to detect solutions with different conductivities. However the capacitive effect is in the same order of magnitude as the inductive effect due to eddy currents. Safety of the system has been evaluated to be in accordance with the standards of human exposure to the magnetic fields.

  • Red de Investigación Cardiovascular

     Bragos Bardia, Ramon; Riu Costa, Pere Joan; Rosell Ferrer, Francisco Javier
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  • DESARROLLO DE TECNOLOGÍAS AVANZADAS DE PRODUCCIÓN Y VALIDACIÓN DE UN PRODUCTO CELULAR

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Garcia Sanchez, Tomas; Bragos Bardia, Ramon
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    Simulation of a magnetic induction method for determining passive electrical property changes of human trunk due to vital activities  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    COMSOL Conference
    p. 1-4
    Presentation's date: 2012-10-11
    Presentation of work at congresses

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    Determining the changes in passive electrical properties of human tissues and the geometry changes of the body parts due to breathing and cardiac activity could be a method for monitoring these vital signs. We have designed a model with COMSOL Multiphysics to simulate a magnetic induction method for determining changes of these characteristics. Given the large number of parameters and variables, difficulties of anatomical modeling and various tissue properties, we are facing some numerical challenges. In addition, using magnetic induction method, we have to consider safety issues, standards and limitations. We used COMSOL to simulate the induced currents in the human body and the resulting perturbation in the magnetic field for different tissue properties and geometries. As a result, we obtained the expected changes during breathing and we know the minimum distances and maximum excitation currents that could be used to meet the international safety standards.

  • Unobtrusive activity measurement in patients with depression: the H4M approach

     Ramos Castro, Juan Jose; Mahdavi, Hadiseh; Pérez Diaz de Cerio, David; Garcia Gonzalez, Miquel Angel; Estevez, Soraya; Rosell Ferrer, Francisco Javier
    Information and Communication Technologies applied to Mental Health
    p. 18-23
    Presentation's date: 2012-10-04
    Presentation of work at congresses

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    Simulation of a magnetic induction method for determining passive electrical property changes of human trunk due to vital activities  Open access

     Mahdavi, Hadiseh; Rosell Ferrer, Francisco Javier
    COMSOL Conference
    p. 1
    Presentation's date: 2012-10-11
    Presentation of work at congresses

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    Automatic system for electroporation of adherent cells growing in standard multi-well plates*  Open access

     Garcia Sanchez, Tomas; Guitart, Maria; Rosell Ferrer, Francisco Javier; Gomez Foix, Anna Maria; Bragos Bardia, Ramon
    IEEE Engineering in Medicine and Biology Society
    p. 2571-2574
    Presentation's date: 2012-08-28
    Presentation of work at congresses

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    In this study an automatic system is presented to perform electroporation, also known as electropermeabilization, on adherent cells. It is an intention of this system to apply electric field pulses directly to cells growing in standard multiwell plates as a step forward to include this technique in standard laboratory protocols. An interdigitated microelectrode assembly constructed with Printed Circuit Board (PCB) is placed closely above the cell monolayer, and in order to avoid direct contact with cells, small micro-separators were included in the structure. Additionally, distribution of current density was modified by filling the gap between adjacent electrodes with a non conductive material as predicted by electric field simulations. This modification helps to concentrate the electric field intensity in the region where cells are present. The device was tested using C2C12 cell line growing adhered in 24 multiwell plates and fluorescent labeled dextran FD20S as the molecule to be delivered. Successful transfection was observed with minimal invasiveness of the operation reducing the stress caused to cells.

  • Methods and devices for mechanical and electrical stimulation of stem cell monolayer and 3d cultures for tissue engineering applications

     Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamín; Bragos Bardia, Ramon; Bayés Genis, Antoni; Llucía Valldeperas, Aida
    Date of request: 2012-06-13
    Invention patent

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  • Electrode assembly for generating electric field pulses to perform electroporation to a biological sample

     Garcia Sanchez, Tomas; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Gomez Foix, Anna Maria; Guitart de la Rosa, Maria; Sanchez Ortiz, Beatriz
    Date of request: 2012-05-11
    Invention patent

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  • A wireless sensor network design for the Help4Mood european project

     Pérez Diaz de Cerio, David; Ruiz Boque, Silvia; Rosell Ferrer, Francisco Javier; Ramos Castro, Juan Jose; Castro Robles, Joan Carles
    European Wireless
    p. 1-6
    Presentation's date: 2012-04
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    Help4Mood is a closed loop approach supporting the control, communication and treatment management of patients with Major Depression. The first out of the three main components of the Help4Mood solution is the Personal Monitoring System (PMS), a set of different wireless sensors whose data sink is centralized on a laptop. The objective of this PMS is to monitor the activity of the patients, so several sensors have been chosen to cover the needs of different individuals. These include a wrist watch, a key ring, a waist/belt sensor, an under mattress sensor and a cellular phone. This paper describes the first prototype and the results obtained from this Wireless Sensor Network.

  • Improvement of the actimetry agreement among sites by proper choice of signal processing stages

     Garcia Gonzalez, Miquel Angel; Giovinazzo, Giuseppe; Gomez Bule, Rafael; Landi, Francesca; Ramos Castro, Juan Jose; Rosell Ferrer, Francisco Javier
    IASTED International Conference Biomedical Engineering
    p. 1-5
    Presentation's date: 2012-02-15
    Presentation of work at congresses

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    Physical activity (PA) has been identified as a key health indicator and has been assessed in multiple studies as the study of cardiovascular diseases, diabetes mellitus, obesity and psychological conditions. For this reason the use of accelerometers to quantify PA is widely accepted in either clinical/laboratory settings as well as in freeliving environments. The use of accelerometers in the measurement of PA is a relatively new technique and, therefore, has been not standardized. The aim of this work is to study the influence of signal processing stages in the estimation of PA while measuring simultaneously in three different sites to provide robust indicators of activity in front of changes in site measurement. With our measurement we show that a proper choice of signal processing steps can improve the agreement among activity indices measured from different sites on the same individual. The results also show that the most suited index is the time above threshold. In this case, the best combination of axes is by applying the quadratic mean, the best filtering of axes is using a cut-off frequency of around 1.5 Hz and a threshold to compute the index of 0.04 g.

  • Help4Mood: testing and achievements of the first wireless sensor network prototype

     Pérez Diaz de Cerio, David; Ruiz Boque, Silvia; Rosell Ferrer, Francisco Javier; Ramos Castro, Juan Jose; Colomé Castellví, Josep Maria
    European Cooperative in Science And Technology
    Presentation's date: 2012-02-10
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    Help4Mood is a closed loop approach supporting the control, communication and treatment management of patients with Major Depression. The first out of the three main components of the Help4Mood solution is the Personal Monitoring System (PMS), a set of different wireless sensors whose data sink is centralized on a laptop. The objective of this PMS is to monitor the activity of the patients, so several sensors have been chosen to cover the needs of different individuals. These include a wrist watch, a key ring, a waist/belt sensor, an under mattress sensor and a cellular phone. This paper describes the first prototype and the results obtained from this Wireless Sensor Network

  • A wireless under-mattress sensor system for sleep monitoring in people with major depression

     Mahdavi, Hadiseh; Ramos Castro, Juan Jose; Giovinazzo, Giuseppe; Garcia Gonzalez, Miquel Angel; Rosell Ferrer, Francisco Javier
    IASTED International Conference Biomedical Engineering
    p. 1-5
    Presentation's date: 2012-02-16
    Presentation of work at congresses

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    Monitoring people during sleep time is of particular interest to patients with sleep disorders and elderly people or infants. We have developed a battery powered electronic system to monitor people in the bed, store the data and send them through a wireless link to a PC. The resulting data will be subject to further analysis using pattern recognition to evaluate the feasibility of using the system as an indicator of sleep quality. The system is able to detect presence on the bed and movements and breathing of the patient. The changes in pressure distribution on the mattress cause changes in pressure in the layers of the sensor and a voltage will appear on the electrodes. The detection ability depends strongly on the shape of the mattress and the bedbase.

  • Coil arrangement for a magnetic induction impedance measurement apparatus comprising a partly compensated magnetic excitation field in the detection coil

     Igney, Claudia Hannelore; Rosell Ferrer, Francisco Javier; Hamsch, Mathias
    Date of request: 2012-02-09
    Invention patent

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  • Desarrollo de bioimplantes para la regeneración cardiaca con células progenitoras derivadas de la grasa cardiaca, biomateriales y..

     Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamin; Macías Macías, Raul; Bermejo Sanchez, Sergio; Balleza Ordaz, José Marco; Bragos Bardia, Ramon
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  • Cardiac tissue engineering by electrical stimulation with subcutaneous and cardiac adipose-tissue derived progenitor cells (ATDPCs)

     Llucià-Valldeperas, Aida; Sánchez Terrones, Benjamin; Soler-Botija, C.; Roura, S.; Prat-Vidal, C.; Gálvez-Montón, C.; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon; Bayés Genis, Antoni
    Evolving Challenges in Promoting Cardiovascular Health Congress
    p. 1
    Presentation's date: 2011-11-04
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    A major challenge of cardiac tissue engineering is directing cells to establish the physiological structure and function of the myocardium being replaced. In native heart, pacing cells generate electrical stimuli that spread throughout the heart causing cell membrane depolarization and activation of contractile apparatus. We ought to examine whether electrical stimulation of adipose tissue-derived progenitor cells (ATDPCs) exerts phenotypic and genetic changes that enhance their cardiomyogenic potential.

  • FP7-262029-DRYCHECK

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Guasch Martinez, Aleix; Bragos Bardia, Ramon
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  • Muscle fatigue monitoring using a multifrequency bioimpedance technique

     Vescio, Giovanni; Rosell Ferrer, Francisco Javier; Nescolarde Selva, Lexa Digna; Giovinazzo, Giuseppe
    European Conference of the International Federation for Medical and Biological Engineering
    p. 1257-1260
    DOI: 10.1007/978-3-642-23508-5_325
    Presentation's date: 2011-09
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    The objective of this work is to measure the changes of electrical bioimpedance module and phase related to muscular fatigue. The results could also be interesting for medical diagnosis of leg oedema, related to heart diseases, or muscular lesions. With this purpose in mind we have done multifrequency bioimpedance measurements on volunteers to evaluate the change of the impedance due to some physical exercises with the leg and with the arm. In the case of the measures performed on the arm we have obtained an initial increase of the impedance module after the first three exercises. The change of the impedance module taken after the 5th exercise respect to the first measurement was significantly lower (p<0.05) at all frequencies. In the case of the measures performed on the leg we have obtained an increase of the impedance module after the first four exercises if compared with the module at rest. The measured module after the first exercise was significantly different respect to the module at rest (p<0.05) for frequencies lower than 50 kHz. Subsequently, making the measurement after the fifth exercise we have obtained a decrease of the impedance module, if it is compared with the previous measurement. The change of the module measured after the 6th exercise is greater than the system noise if compared with the 1st impedance measurement but this change is not significant, if compared to the first measurement, at all frequencies.

  • Assessment and follow-up of muscle injuries in athletes by bioimpedance: Preliminary results

     Nescolarde Selva, Lexa Digna; Yanguas Leyes, Javier; Medina Leal, Daniel; Rodas Font, Gil; Rosell Ferrer, Francisco Javier
    IEEE Engineering in Medicine and Biology Society
    p. 1137-1140
    Presentation's date: 2011-09-02
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    Mono-frequency (50 kHz) whole-body and segmental bioimpedance is measured before sport training in 14 high performance athletes. The athletes are classified in two groups according to the team sport: football and basketball. Bioelectrical impedance vector analysis (BIVA) method is used to obtain the individual whole-body impedance and 6 segmental impedance vectors in the main muscular groups in the lower- limbs. The whole-body vector is analyzed in the tolerance ellipses of the reference population. Individual impedance vector components are standardized by the height H of the subject, (R/H and Xc/H) to obtain the impedance vector (Z/H) of each segment. The hypotheses of the study are: 1) Not all the sports have the same pattern of bioimpedance vector by muscle group. 2) In elite well trained athletes their muscle groups are symmetrical (right and left sides), thus each athlete is its own reference for future comparisons. 3) We expect a change in the two components of bioimpedance vector (R/H and Xc/H) in front of a muscle injury. In order to compare the differences between the complex Z/H vector (R/H, Xc/H) we use Hotelling s T2 test. Preliminary results show a significant difference (P < 0.05) in bioimpedance vectors between groups according to the team sport, and also between normal muscle condition and after muscle injury producing hyper-hydration.

  • DESARROLLO DE TECNOLOGÍAS AVANZADAS DE PRODUCCIÓN Y VALIDACIÓN DE UN PRODUCTO CELULAR

     Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Bragos Bardia, Ramon
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  • Planar coil arrangement for a magnetic induction impedance measurement apparatus

     Rosell Ferrer, Francisco Javier; Igney, Claudia Hannelore; Hamsch, Mathias
    Date of request: 2011-02-03
    Invention patent

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  • Transoesophageal bioimpedance analysis for the detection of graft rejection after cardiac transpantation

     Giovinazzo, Giuseppe
    Department of Electronic Engineering, Universitat Politècnica de Catalunya
    Theses

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  • Localized bioimpedance measurements to assess muscle Injuries in the four major groups of lower limb

     Rosell Ferrer, Francisco Javier; Nescolarde Selva, Lexa Digna; Rodas Font, Gil; Yanguas Leyes, Xavier
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  • A COMPUTATIONAL DISTRIBUTED SYSTEM TO SUPPORT THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSION

     Rosell Ferrer, Francisco Javier; Caminal Magrans, Pedro; Ramos Castro, Juan Jose; Garcia Gonzalez, Miquel Angel; Mahdavi, Hadiseh
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  • In-cycle myocardium tissue electrical impedance monitoring using broadband impedance spectroscopy

     Sánchez Terrones, Benjamín; Vandersteen, Gerd; Rosell Ferrer, Francisco Javier; Cinca Cosculluela, Juan; Bragos Bardia, Ramon
    IEEE Engineering in Medicine and Biology Society
    p. 2518-2521
    DOI: 10.1109/IEMBS.2011.6090697
    Presentation's date: 2011
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  • PEP's characterization (s, e & µ) from biological culture and materials with similar characteristics using MIS

     Rodarte Dávila, Jesús; Rosell Ferrer, Francisco Javier
    Barcelona Forum on Ph.D. Research in Communications, Electronics and Signal Processing
    p. 31-32
    Presentation's date: 2010-10-21
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    Transoesophageal detection of heart graft rejection by electrical impedance: using Finite Element Method simulations  Open access

     Giovinazzo, Giuseppe; Ribas, N.; Rosell Ferrer, Francisco Javier; Cinca Cosculluela, Juan
    International Conference on Electrical Bio-impedance
    p. 1-4
    Presentation's date: 2010-04-05
    Presentation of work at congresses

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    Previous studies have shown that it is possible to evaluate heart graft rejection level using a bioimpedance technique by means of an intracavitary catheter. However, this technique does not present relevant advantages compared to the gold standard for the detection of a heart rejection, which is the biopsy of the endomyocardial tissue. We propose to use a less invasive technique that consists in the use of a transoesophageal catheter and two standard ECG electrodes on the thorax. The aim of this work is to evaluate different parameters affecting the impedance measurement, including: sensitivity to electrical conductivity and permittivity of different organs in the thorax, lung edema and pleural water. From these results, we deduce the best estimator for cardiac rejection detection, and we obtain the tools to identify possible cases of false positive of heart rejection due to other factors. To achieve these objectives we have created a thoracic model and we have simulated, with a FEM program, different situations at the frequencies of 13, 30, 100, 300 and 1000 kHz. Our simulation demonstrates that the phase, at 100 and 300 kHz, has the higher sensitivity to changes in the electrical parameters of the heart muscle.

    Postprint (author’s final draft)

  • Performance of an implantable impedance spectroscopy monitor using ZigBee

     Bogonez Franco, Francisco; Bayés Genis, Antoni; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon
    International Conference on Electrical Bio-impedance
    p. 1-4
    DOI: 10.1088/1742-6596/224/1/012163
    Presentation's date: 2010-04-04
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    This paper presents the characterization measurements of an implantable bioimpedance monitor with ZigBee. Such measurements are done over RC networks,performing short and long-term measurements, with and without mismatch in electrodes and varying the temperature and the RF range. The bioimpedance monitor will be used in organ monitoring through electrical impedance spectroscopy in the 100 Hz - 200 kHz range. The specific application is the study of the viability and evolution of engineered tissue in cardiac regeneration in an experimental protocol with pig models. The bioimpedance monitor includes a ZigBee transceiver to transmit the measured data outside the animal chest. The bioimpedance monitor is based in the 12 Bit Impedance Converter and Network Analyzer AD5933, improved with an analog front-end that implements a 4-electrode measurement structure and allows to measure small impedances. In the debugging prototype, the system autonomy exceeds 1 month when a 14 frequencies impedance spectrum is acquired every 5 minutes. The receiver side consists of a ZigBee transceiver connected to a PC to process the received data. In the current implementation, the effective range of the RF link was of a few centimeters, then needing a range extender placed close to the animal. We have increased it by using an antenna with higher gain. Basic errors in the phantom circuit parameters estimation after model fitting are below 1%.

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    Longitudinal and transversal bioimpedance measurements in addition to diagnosis of heart failure  Open access

     Ribas, Núria; Nescolarde Selva, Lexa Digna; Domingo, Maite; Gastelurrutia, Paloma; Bayés Genis, Antoni; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-Impedance
    DOI: 10.1088/1742-6596/224/1/012099
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    Heart Failure (HF) is a clinical syndrome characterised by signs of systemic and pulmonary fluid retention, shortness of breath and/or fatigue. There is a lack of reliable indicators of disease state. Benefits and applicability of non-invasive bioimpedance measurement in the hydration state of soft tissues have been validated, fundamentally, in dialysis patients. Four impedance configurations (2 longitudinal and 2 transversal) were analyzed in 48 HF patients (M=28, F=20) classified according to a clinical disease severity score (CDSS) derived from the Framingham criteria: CDSS 2 (G1: M= 23, F= 14) and CDSS>2 (G2: M= 5, F= 6). The aim of this study is to analyze longitudinal and transversal bioimpedance measurement at 50 kHz, in addition to clinical diagnosis parameters of heart failure, including: clinical disease severity score (CDSS) and a biomarker concentrations (NTproBNP). The Kolmogorov-Smirnov test was used for the normality test of all variables. The CDSS, NTproBNP and impedance parameters between groups (G1 and G2) were compared by mean of Mann Withney U-test. The statistical significance was considered with P < 0.05. Whole-body impedance measured was analyzed using RXc graph.

  • Applications of longitudinal and transversal bioimpedance measurements in peritoneal dialysis at 50 kHz

     Nescolarde Selva, Lexa Digna; Doñate, T.; Casañas, R.; Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-impedance
    p. 1-4
    DOI: 10.1088/1742-6596/224/1/012138
    Presentation of work at congresses

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    More relevant information of the fluid changes in peritoneal dialysis (PD) might be obtained with segmental bioimpedance measurements rather than whole-body measurement, who hidden information of body composition. Whole-body and segmental bioimpedance measurements were obtained using 5 configurations (whole-body or right-side (RS), longitudinal-leg (L-LEG), longitudinal-abdomen (L-AB), transversal-abdomen (T-AB), and transversal-leg (T-LEG)) in 20 patients: 15 males (56.5 ± 9.4 yr, 24.2 ± 4.2 kg/m2) and 5 females (58.4 ± 7.1 yr, 28.2 ± 5.9 kg/m2) in peritoneal dialysis (PD). The aim of this study is to analyze the relationship between whole-body, longitudinal-segmental (L-LEG and L-AB) and transversal-segmental (TAB and TLEG) bioimpedance measurement at 50 kHz, with clinical parameters of cardiovascular risk, dyslipidemia, nutrition and hydration. The Kolmogorov- Smirnov test was used for the normality test of all variables. Longitudinal bioimpedance parameters were normalized by the height of the patients. The Spearman correlation was used to analyze the correlation between bioimpedance and clinical parameters. The statistical significance was considered with P < 0.05. Transversal bioimpedance measurements have higher correlation with clinical parameters than longitudinal measurements.

  • GRUP D'INSTRUMENTACIÓ ELECTRÒNICA I BIOMÈDICA: Grup de Recerca Consolidat.

     Bragos Bardia, Ramon; Rosell Ferrer, Francisco Javier; Fernandez Chimeno, Mireya; Garcia Gonzalez, Miquel Angel; Nescolarde Selva, Lexa Digna; Ramos Castro, Juan Jose; Riu Costa, Pere Joan; Robert i Sanxis, Francesc Josep; Silva Martinez, Fernando; Torrents Dolz, Josep Maria
    Competitive project

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    Total body water changes using segmental bioimpedance in healthy population with similar anthropometry  Open access

     Rosell Ferrer, Francisco Javier; Nescolarde Selva, Lexa Digna; Elvira, J.
    World Congress on Medical Physics and Biomedical Engineering
    p. 60-63
    Presentation's date: 2009-09
    Presentation of work at congresses

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    Electrical bioimpedance was measured in 7 body segments, and also with the standard right-side method, using 11 electrodes at 6 different frequencies in 8 healthy male subjects with similar anthropometry. Our objective was to determine the capability of segmental bioimpedance measurements to estimate small changes of water on each segment (TWsegi)and total body water (TBW) in comparison with the standard right-side method. Water was also estimated with 40K and DXA. Volunteers were measured before and after a 3.5% water load of their individual TBW. The expected TBW mean increment after water load was 1.45 l. The estimator with lower Standard Error SE was the weight of the subject (0.15 l). For impedance methods, the SE of the segmental method was 0.94 l vs. 1.41 l for right-side. Segmental volume changes obtained by DXA and Impedance compared with expected values showed maximum differences of almost 2 l for DXA and 0.5 l for Z in the abdomen. In conclusion, in a healthy sample with similar anthropometry, such as astronauts and athletes, the use of a segmental impedance method improves the accuracy of the right-side method to estimate TBW. Changes in water segments estimated by impedance where more close to expected values than using DXA.

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  • Transoesophageal electrical bioimpedance measurements of the heart in humans

     Giovinazzo, Giuseppe; Raga, S.; Ribas, N.; Bayés Genis, Antoni; Cinca Cosculluela, Juan; Rosell Ferrer, Francisco Javier
    World Congress on Medical Physics and Biomedical Engineering
    p. 141-144
    Presentation of work at congresses

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    Previous studies have proved that posttransplant cardiac rejection is associated with changes in endomyocardial electrical impedance in humans. The aim of this study is to develop a safe transoesophageal system able to measure cardiac electrical impedance in transplanted patients and to evaluate the capability of this technique to detect heart graft rejection in humans in order to reduce the number of repetitive biopsies. The impedance measurement is performed using a four wire configuration. We measured the impedance spectrum from 13 kHz to 1 MHz. The oesophageal ECG signal is used to evaluate the position of the catheter in the oesophagus with regard to the patient’s heart. So far measurements have been carried out on a group composed of 11 healthy volunteers (5 men) and 9 cardiac transplanted patients (7 men) with no histological signs of cardiac rejection. Impedance spectrum measurements at different locations in the oesophagus showed a decrease of the impedance magnitude with the increase of the depth of the catheter in the oesophagus (about 1 ohm/cm). The phase value does not show significant changes when changing the catheter’s position in the oesophagus. There are gender differences in the magnitude but not in the phase angle of the transoesophageal cardiac electrical impedance. Transplanted patients with no graft rejection show impedance values similar to that of healthy volunteers, suggesting that the surgical intervention does not affect the impedance measures. The oesophageal approach is safe and was considered for transplanted patients less annoying than the biopsy method. In consequence, if further results show a significant change of impedance in patients with cardiac rejection, a new lessinvasive clinical method to detect graft rejection can be envisaged.

  • DESARROLLO DE TECNICAS DE MONITORIZACIÓN NO DESTRUCTIVA Y MINIMAMENTE INVASIVA EN APLICACIONES DE INGENIERIA CELULAR....

     Nescolarde Selva, Lexa Digna; Rosell Ferrer, Francisco Javier; Sánchez Terrones, Benjamin; Bogonez Franco, Francisco; Bragos Bardia, Ramon
    Competitive project

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    Implantable bioimpedance monitor using ZigBee  Open access

     Bogonez Franco, Francisco; Bragos Bardia, Ramon; Bayés Genis, Antoni; Rosell Ferrer, Francisco Javier
    IEEE Engineering in Medicine and Biology Society
    p. 4868-4871
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    In this paper, a novel implantable bioimpedance monitor using a free ZigBee protocol for the transmission of the measured data is described. The application field is the tissue and organ monitoring through electrical impedance spectroscopy in the 100 Hz – 200 kHz range. The specific application is the study of the viability and evolution of engineered tissue in cardiac regeneration. Additionally to the telemetric feature, the measured data are stored in a memory for backup purposes and can be downloaded at any time after an RF link break. In the debugging prototype, the system autonomy exceeds 1 month when a 14 frequencies impedance spectrum is acquired every 5 minutes. In the current implementation, the effective range of the RF link is reduced and needs for a range extender placed near the animal. Current work deals with improving this range.

  • Instrumentation for bio-impedance measurements

     Riu Costa, Pere Joan; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon
    Date of publication: 2009
    Book chapter

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  • In-vivo measurements of heart ischemia using transoesophageal electrical impedance

     Rosell Ferrer, Francisco Javier; Giovinazzo, Giuseppe; Galvez, C; Ramos Castro, Juan Jose; Raga, S; Sabate, M; Cinca Cosculluela, Juan
    European Conference of the International Federation for Medical and Biological Engineering
    p. 1163-1166
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  • Continuous oxygen consumption estimation method for animal cell bioreactors based on low-cost control of the medium dissolved oxygen concentration

     Fontova, A; Soley, A; Gálvez, J; Sarró, E; Lecina, M; Rosell Ferrer, Francisco Javier; Riu Costa, Pere Joan; Cairó, J; Gòdia, F; Bragos Bardia, Ramon
    European Conference of the International Federation for Medical and Biological Engineering
    p. 2190-2194
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  • Estudio de viabilidad de la medida de impedancia eléctrica para evaluar el rechazo cardíaco

     Rosell-Ferrer, J; Rosell Ferrer, Francisco Javier; Giovinazzo, Giuseppe; Galvez, C; Ramos Castro, Juan Jose; Garcia Gonzalez, Miquel Angel; Raga, S; Sabate, M; Cinca Cosculluela, Juan
    Congreso Anual de la Sociedad Española de Ingeniería Biomédica
    p. 209-212
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  • Transoesophageal electronic bioimpedance device for the study of post-transplant heart rejection

     Giovinazzo, Giuseppe; Ramos Castro, Juan Jose; Rosell Ferrer, Francisco Javier
    European Conference of the International Federation for Medical and Biological Engineering
    p. 1176-1179
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  • Espectroscopia de Impedancia Eléctrica para la caracterización de tejidos biológicos. Aplicación específica a medidas dinámicas

     Terrones, B Sánchez; Riu Costa, Pere Joan; Rosell Ferrer, Francisco Javier; Bragos Bardia, Ramon
    Congreso Anual de la Sociedad Española de Ingeniería Biomédica
    p. 217-220
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  • Effects of ventilation variations on attention system activation during a scrutiny perception task in social anxiety disorder

     Ortiz Valencia, Hector; Pujol, J; Harrison, BJ; Soriano-Mas, C; Lopez-Sola, M; Gimenez-Navarro, M; Deus, J; Cardoner, I. Narcís; Rosell Ferrer, Francisco Javier; Merlo-Pich, E
    Annual Meeting of the Organization for Human Brain Mapping
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  • Heart Graft Rejection Assessed by Multi-Frequency Electrical Impedance: Human Results

     Rosell Ferrer, Francisco Javier
    International Conference on Electrical Bio-impedance
    Presentation's date: 2007-08-29
    Presentation of work at congresses

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