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New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding

Autor
S. Lupala, C.; Gomez-Gutierrez, P.; Perez, J.
Tipus d'activitat
Article en revista
Revista
Journal of computer-aided molecular design
Data de publicació
2016-01-20
Volum
30
Número
1
Pàgina inicial
85
Pàgina final
101
DOI
https://doi.org/10.1007/s10822-015-9890-z Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/87094 Obrir en finestra nova
URL
http://link.springer.com/article/10.1007%2Fs10822-015-9890-z Obrir en finestra nova
Resum
Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases, provoking vasodilatation and increased vascular permeability among other effects. Their actions are mediated through at least two G-protein coupled receptors, B1 a receptor up-regulated during inflammation episodes or tissue trauma and B2 that is constitutively expressed in a variety of cell types. The goal of the present work is to carry out a st...
Citació
S. Lupala, C., Gomez-Gutierrez, P., Perez, J. New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding. "Journal of computer-aided molecular design", 20 Gener 2016, vol. 30, núm. 1, p. 85-101.
Paraules clau
Bradykinin B2 antagonism, Pharmacophore development, Virtual screening
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

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