García Álvarez, Montserrat
Total activity: 123
Research group
POL - Polymers
Department
Department of Chemical Engineering
School
Barcelona School of Industrial Engineering (ETSEIB)
E-mail
montserrat.garciaupc.edu
Contact details
UPC directory Open in new window

Graphic summary
  • Show / hide key
  • Information


Scientific and technological production
  •  

1 to 50 of 123 results
  • Poly(beta,L-malic acid)Doxorubicin ionic complex: A pH-dependent delivery system.

     Lanz Landazuri, Alberto; Martinez de Ilarduya Saez de Asteasu, Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Reactive and functional polymers
    Date of publication: 2014-08-01
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Poly(ß,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength

  • Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system

     Lanz Landazuri, Alberto; Martinez de Ilarduya Saez de Asteasu, Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Reactive and functional polymers
    Date of publication: 2014-08-01
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Poly(beta,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/ DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength.

  • Modification of Microbial Polyacids for Drug Delivery Systems

     Lanz Landazuri, Alberto
    Defense's date: 2014-04-28
    Universitat Politècnica de Catalunya
    Theses

    Read the abstract Read the abstract  Share Reference managers Reference managers Open in new window

    Polymers are becoming preferred materials in biomedical applications because of their vast diversity of properties, functionalities and applications. Properties as mechanical strength, stability against degradation, biocompatibility and biodegradability, among others, have been attractive for different medical applications. One of the most interesting applications of these materials is drug delivery systems. Biodegradable polymers and copolymers are the preferred materials for the manufacture of a variety of devices for temporal applications in medicine and pharmacology; these biodegradable polymers can be chemically synthesized or biologically produced. Biotechnological polymers have attracted much attention because two main advantages; first, they are produced from renewable resources; and second, as they are biologically produced they are biocompatible, biodegradable and bioresorbable materials. Thus, modification of biotechnological polymers to obtain specific properties or functionalities is a good strategy for the development of promising biomedical materials. In this Thesis the water soluble biotechnological polymer poly(ß,L-malic acid) (PMLA) was modified to change its hydrophilic character to produce a non water-soluble polymer capable of forming particulate systems for drug encapsulation and controlled release. PMLA is a polyester-3 with a pendant carboxylic group; it is biocompatible, biodegradable and bioresorbable. The carboxylic side group can be substituted in order to modify the properties of the polymer. As a polycarboxylic acid, it is a polyelectrolyte, and water-soluble. Different strategies were used for polymer derivatization: direct esterification and amidation through the activation of the carboxylic side groups with carbodiimide; ionic complex formation with a cationic drug (Doxorubicin); and esterification with aliphatic long chains by a two step method employing thiol-ene click reactions. Obtained PMLA derivatives resulted in hydrophobic or amphiphilic polymers, which were appropriated for nanoparticle formation, either by emulsion solvent evaporation or by precipitation dialysis techniques. Derivatives physicochemical characterization was made by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC) and differential scanning calorimetry. Hydrolytic degradation was followed by GPC and 1H NMR, while particles were observed by scanning electron microscopy and their size and surface charge characterized by dynamic light scattering and ¿-potential measurement. Assays of drug encapsulation and release were also performed and cytotoxicity tests were done on cancer cell lines. Nanoparticles (100-300 nm aprox.) were obtained from all PMLA derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery systems since they were able to encapsulate the anticancer drugs Temozolomide and Doxorubicin, as well as the model drugs Theophylline and Carbamazepine. Drug release was assessed under physiological conditions; the release rate was found to depend on encapsulation method, drug and polymer derivative. Hydrolytic degradation assays showed that free malic acid and the organic compound derived from the reagent used for modification were the last products of aqueous degradation of PMLA derivatives. Cytotoxicity tests demonstrated the low toxicity of the synthesized derivatives. Results generated in this Thesis suggest that the biotechnological polymer PMLA is a material of interest as a platform for the design and development of biodegradable drug delivery systems with potential in the therapy of diseases considered today challenging for pharmacologic treatment.

  • Modification of Microbial Polyacids for Drug Delivery Systems  Open access

     Lanz Landazuri, Alberto
    Defense's date: 2014-04-28
    Universitat Politècnica de Catalunya
    Theses

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Los polímeros se han convertido en los materiales preferidos para usos biomédicos debido a la gran diversidad de propiedades, funcionalidades y aplicaciones que poseen. Propiedades como resistencia mecánica, estabilidad a la degradación, biocompatibilidad y biodegradabilidad, entre otras, son atractivas para aplicaciones médicas. Una de las aplicaciones más interesantes son los sistemas de liberación controlada de fármacos. Los polímeros biodegradables son materiales predilectos para la fabricación de dispositivos de uso temporal en medicina y farmacología; estos polímeros biodegradables pueden ser sintetizados químicamente o producidos biológicamente. Los polímeros biotecnológicos han captado atención por dos razones principales; primero, son obtenidos a partir de recursos renovables; y segundo, que al ser biológicamente producidos, estos son biodegradables, biocompatibles y bioasimilables. Por esto, la modificación de polímeros biotecnológicos para la obtención de propiedades o funcionalidades específicas es una buena estrategia para el desarrollo de un material biomédico prometedor.En la presente Tesis el polímero biotecnológico, soluble en agua, acido poli(ß,L-málico) (PMLA) se modificó para cambiar su carácter hidrofílico para producir polímeros insolubles en agua capaces de formar sistemas particulados para laencapsulación y liberación controlada de fármacos. El PMLA es un poliéster-3 con un grupo carboxílico lateral; es biocompatible, biodegradable y bioasimilable. El grupo carboxílico lateral puede ser substituido para modificar sus propiedades.Se utilizaron diferentes estrategias para la derivatización del polímero: la esterificación y amidación directas, mediante la activación de los grupos carboxílicos laterales con carbodiimidas; la formación de complejos iónicos con un fármacocatiónico (Doxorrubicina); y la esterificación con cadenas alifáticas largas, utilizando un método de dos pasos mediante reacciones click tiol-eno. Los derivados de PMLA resultaron ser polímeros hidrofóbicos o anfifílicos, apropiados para la formación de nanopartículas, ya sea por el método de emulsión evaporación de solvente o por precipitación diálisis.La caracterización fisicoquímica de los derivados se realizó mediante resonancia magnética nuclear (RMN) de 1H y 13C, cromatografía de permeación en gel (GPC) y por calorimetría diferencial de barrido. La degradación hidrolítica fue monitoreada mediante GPC y 1H RMN, mientras que las partículas fueron observadas con microscopía electrónica de barrido y su tamaño y carga superficial caracterizadas mediante dispersión de luz y medición del potencial-¿. Estudios sobre la encapsulación de fármacos y su liberación fueron realizados, así como ensayos de citotoxicidad sobre líneas de células cancerígenas.Se obtuvieron nanopartículas (100-300 nm aprox.) con todos los derivados, excepto para el complejo iónico que formaron micropartículas. Las nanopartículas mostraron potencial como sistemas de liberación controlada ya que fue posible laencapsulación de los fármacos anticanerígenos Temozolomida y Doxorrubicina, así como de los fármacos modelos Teofilina y Carbamazepina. La liberación de fármacos se evaluó en condiciones fisiológicas; la tasa de liberación se encontró dependiente del método de encapsulación, el fármaco y el derivado polimérico utilizado.Los ensayos de degradación hidrolítica muestran que el ácido málico y la molécula orgánica derivada del compuesto utilizado para la modificación son los últimos productos de la degradación hidrolítica de los derivados de PMLA. Las pruebas de citotoxicidad demostraron la baja toxicidad de los derivados sintetizados.Los resultados generados en esta Tesis sugieren que el polímero biotecnológico PMLA es un material de interés como plataforma para el diseño y desarrollo de sistemas biodegradables de liberación controlada de fármacos con potencial en el tratamiento de enfermedades consideradas hoy día un reto para el tratamiento farmacológico.

    Polymers are becoming preferred materials in biomedical applications because of their vast diversity of properties, functionalities and applications. Properties as mechanical strength, stability against degradation, biocompatibility and biodegradability, among others, have been attractive for different medical applications. One of the most interesting applications of these materials is drug delivery systems. Biodegradable polymers and copolymers are the preferred materials for the manufacture of a variety of devices for temporal applications in medicine and pharmacology; these biodegradable polymers can be chemically synthesized or biologically produced. Biotechnological polymers have attracted much attention because two main advantages; first, they are produced from renewable resources; and second, as they are biologically produced they are biocompatible, biodegradable and bioresorbable materials. Thus, modification of biotechnological polymers to obtain specific properties or functionalities is a good strategy for the development of promising biomedical materials. In this Thesis the water soluble biotechnological polymer poly(ß,L-malic acid) (PMLA) was modified to change its hydrophilic character to produce non water-soluble polymers capable of forming particulate systems for drug encapsulation and controlled release. PMLA is a polyester-3 with a pendant carboxylic group; it is biocompatible, biodegradable and bioresorbable. The carboxylic side group can be substituted in order to modify the properties of the polymer. The polymer as polyelectrolyte, is also water-soluble. Different strategies were used for polymer derivatization: direct esterification and amidation through the activation of the carboxylic side groups with carbodiimides; ionic complex formation with a cationic drug (Doxorubicin); and esterification with aliphatic long chains by a two step method employing thiol-ene click reactions. Obtained PMLA derivatives resulted in hydrophobic or amphiphilic polymers, which were appropriated for nanoparticle formation, either by emulsion solvent evaporation or by precipitation dialysis techniques. Derivatives physicochemical characterization was made by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC) and differential scanning calorimetry. Hydrolytic degradation was followed by GPC and 1H NMR, while particles were observed by scanning electron microscopy and their size and surface charge characterized by dynamic light scattering and ζ-potential measurement. Assays of drug encapsulation and release were also performed and cytotoxicity tests were done on cancer cell lines. Nanoparticles (100-300 nm aprox.) were obtained from all PMLA derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery systems since they were able to encapsulate the anticancer drugs Temozolomide and Doxorubicin, as well as the model drugs Theophylline and Carbamazepine. Drug release was assessed under physiological conditions; the release rate was found to depend on encapsulation method, drug and polymer derivative. Hydrolytic degradation assays showed that free malic acid and the organic compound derived from the reagent used for modification were the last products of aqueous degradation of PMLA derivatives. Cytotoxicity tests demonstrated the low toxicity of the synthesized derivatives. Results generated in this Thesis suggest that the biotechnological polymer PMLA is a material of interest as a platform for the design and development of biodegradable drug delivery systems with potential in the therapy of diseases considered today challenging for pharmacologic treatment.

  • Chemical modifications of microbial poly(gamma-glutamic acid): progress and perspectives

     García Álvarez, Montserrat; Muñoz Guerra, Sebastian; Portilla Arias, Jose Antonio
    Journal of renewable materials
    Date of publication: 2013-01-07
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • BIOPLASTICOS DERIVADOS DE CARBOHIDRATOS PARA ENVASADO Y FARMACIA. SUBPROYECTO II

     Bermúdez Hermida, Marta María; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Participation in a competitive project

     Share

  • Poly(beta-L-malic acid) esterification for nanoparticle formation and drug encapsulation

     Lanz Landazuri, Alberto; Martinez de Ilarduya Saez de Asteasu, Antxon; Portilla Arias, José Antonio; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Conferencia Internacional de Polímeros para Investigadores Noveles
    Presentation's date: 2013-11-07
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Synthesis of comb-like alkyl polymalates via thiol-ene click chemistry: Nanoparticles formation and drug encapsulation

     Lanz Landazuri, Alberto; Martinez de Ilarduya Saez de Asteasu, Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    International Symposium Frontiers in Polymer Science
    Presentation's date: 2013-05-22
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Poly(beta-malic acid)/doxorubicin ionic complex for controlled drug delivery

     Lanz Landazuri, Alberto; Martinez de Ilarduya Saez de Asteasu, Antxon; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    International Symposium Frontiers in Polymer Science
    Presentation's date: 2013-05-22
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles

     Lanz Landazuri, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martinez de Ilarduya Saez de Asteasu, Antxon; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastian
    Macromolecular chemistry and physics
    Date of publication: 2012-08-14
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Microbial poly( β , L -malic acid) was modifi ed with either L -leucine ethyl ester (L) or L -phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. No alteration of the cell viability was observed after incubation of these nanoparticles in different cell lines. Anticancer drugs temozolomide and doxorubicin were encapsulated in the nanoparticles. Temozolomide was released within several hours whereas doxorubicin took several weeks to be completely liberated.

  • Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs

     Lanz Landazuri, Alberto; García Álvarez, Montserrat; Portilla Arias, Jose Antonio; Martinez de Ilarduya Saez de Asteasu, Antxon; Patil, Rameshwar; Holler, Eggehard; Ljubimova, Julia Y.; Muñoz Guerra, Sebastian
    Macromolecular bioscience
    Date of publication: 2011-10-10
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    PMLA nanoparticles with diameters of 150–250nm are prepared, and their hydrolytic degradation is studied under physiological conditions. Degradation occurs by hydrolysis of the side chain methyl ester followed by cleavage of the main-chain ester group with methanol and L-malic acid as the final degradation products. No alteration of the cell viability is found after 1 h of incubation, but toxicity increases significantly after 3 d, probably due to the noxious effect of the released methanol. Anticancer drugs temozolomide and doxorubicin are encapsulated in the NPs with 20–40% efficiency, and their release is monitored using in vitro essays. Temozolomide is fully liberated within several hours, whereas doxorubicin is steadily released from the particles over a period of 1 month.

  • Amidation of poly(beta,L-malic acid) with hydrophobic aminoacids for nanoparticle formation and drug encapsulation

     García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    International Conference on Biodegradable and Biobased Polymers
    Presentation's date: 2011-08-29
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Engineering nanoplatforms based on hydrophobic derivatives of Poly(ß,L-malic acid) for tumor drug delivery

     Portilla Arias, Jose Antonio; Patil, Rameshwar; Ding, Hui; Black, Keith L.; García Álvarez, Montserrat; Muñoz-Guerra, Sebastián; Ljubimova, Julia Y.; Holler, Eggehard
    American Association for Cancer Research. Annual Meeting
    Presentation's date: 2011
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Amidación of Poly(beta,L-malic acid) with hydrofobic aminoacids for nanoparticle formation and drug encapsulation

     Lanz Landazuri, Alberto; Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Muñoz-Guerra, Sebastián
    International Conference on Biodegradable and Biobased Polymers
    Presentation's date: 2011
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Engineering nanoplatforms based on hydrophobic derivatives of Poly(beta,L-malic acid)for tumor drug delivery

     García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    American Association for Cancer Research
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Certificat en reconeixement als mèrits docents d'especial qualitat

     García Álvarez, Montserrat
    Award or recognition

     Share

  • Nanoconjugate Platforms Development Based in Poly(beta,L-Malic Acid) Methyl Esters for Tumor Drug Delivery

     Portilla Arias, Jose Antonio; Patil, Rameshwar; Hu, Jinwei; Ding, Hui; Black, Keith L.; García Álvarez, Montserrat; Muñoz Guerra, Sebastian; Ljubimova, Julia Y.; Holler, Eggehard
    Journal of nanomaterials
    Date of publication: 2010
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • POLÍMEROS Y NANOPOLÍMEROS DE FUENTES RENOVABLES PARA APLICACIONES BIOMÉDICAS

     Alla Bedahnane, Abdelilah; Bermúdez Hermida, Marta María; García Álvarez, Montserrat; Herranz Agustin, Concepcion; Majo Roca, Maria Antonia; Martinez de Ilarduya Saez de Asteasu, Antxon; Japu, Cristina; Tolentino Chivite, Ainhoa; Lavilla Aguilar, Cristina; Muñoz Guerra, Sebastian
    Participation in a competitive project

     Share

  • Modificación del ácido poli(beta,L-málico) con aminoácidos hidrofóbicos para la formación de nanopartículas

     García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Congreso de Jóvenes Investigadores en Polímeros
    Presentation's date: 2010-05-02
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Nanoparticles Made of Microbial Poly(gamma-glutamate)s for Encapsulation and Delivery of Drugs and Proteins

     Portilla Arias, Jose Antonio; Camargo, B; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Muñoz Guerra, Sebastian
    Journal of biomaterials science. Polymer edition
    Date of publication: 2009-07
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • POLÍMERS INDUSTRIALS AVANÇATS I BIOPOLÍMERS

     Alla Bedahnane, Abdelilah; Bermúdez Hermida, Marta María; García Álvarez, Montserrat; Majo Roca, Maria Antonia; Martinez de Ilarduya Saez de Asteasu, Antxon; Muñoz Guerra, Sebastian
    Participation in a competitive project

     Share

  • Nanostructurated complexes of poly(beta,L-maleate) and cationic surfactants: synthesis, characterization and structural aspects

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Holler, E; Muñoz Guerra, Sebastian
    European Polymer Congress
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Synthesis, characterization and biomedical applications of microbial polymalic and polyglutamic acids derivatives  Open access

     Portilla Arias, José Antonio
    Defense's date: 2008-04-24
    Department of Chemical Engineering, Universitat Politècnica de Catalunya
    Theses

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    In the rapidly changing scientific world, contributions of scientists and engineers are leading to major new solutions of significant medical problems. Biology and medicine are beginning to reduce the problems of disease to problems of molecular science, and are creating new opportunities for treating and curing disease. Such advances are coupled closely with advances in biomaterials and are leading to a variety of approaches for relieving suffering and prolonging life.Of particular interest is the central position that materials especially biopolymers, have taken in the development of novel treatments over the last 30 years. Biopolymers are used in many biomedical and pharmaceutical preparations, they play a central role in extracorporeal devices; from contact lenses to kidney dialyzers, are essential components of implants; from vascular grafts to cardiac pacemakers, and are the basis of controlled drug delivery technology; from hydrogels to micro and nanoparticles.In the last few years, novel synthetic techniques have been used to impart desirable chemical, physical, and biological properties to biomaterials. Materials have either been synthesized directly, so that desirable chain segments or functional groups are built into the material, or indirectly, by chemical modification of existing structures to add desirable segments or functional groups.Polymeric biomaterials can be produced by copolymerizations of conventional monomers to achieve nearly monodisperse polymers. It is possible to produce polymers containing specific hydrophilic or hydrophobic entities or biodegradable repeating units.One interesting strategy to develop multitalented biomaterials is the biosynthesis of polymers because these macromolecules have several advantages like: biological resorbability, hydrodegradability, absence of immunogenicity, and appropriately high molecular mass. The chemical derivatizability of these polymers allows the formation of several products with a wide range of properties.

  • complexes of biotechnological polyacids with cationic surfactants

     García Álvarez, Montserrat
    7th International Conference Polymer-Solvent Complexes and Intercalates
    Presentation's date: 2008-05-21
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Ionic complexes of biotechnological polyacids with cationic surfactants

     Muñoz Guerra, Sebastian; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Portilla, J A; Alla Bedahnane, Abdelilah
    7th International Conference Polymer-Solvent Complexes and Intercalates
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Synthesis, Degradability, and Drug Releasing Properties of Methyl Esters of Fungal Poly(beta,L-malic acid)

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Holler, E; Galbis, J A; Muñoz Guerra, Sebastian
    Macromolecular bioscience
    Date of publication: 2008-06
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Biodegradable nanoparticles of partially methylated fungal poly(beta-L-malic acid) as a novel protein delivery carrier

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Galbis, J A; Muñoz Guerra, Sebastian; Martinez de Ilarduya Saez de Asteasu, Antxon
    Macromolecular bioscience
    Date of publication: 2008-06
    Journal article

     Share Reference managers Reference managers Open in new window

  • Ionic Complexes of Biotechnological Polyacids with Cationic Surfactants

     García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Portilla, J A; Alla Bedahnane, Abdelilah; Muñoz Guerra, Sebastian
    Macromolecular symposia
    Date of publication: 2008-11
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Polímeros biotecnológicos funcionalizados para aplicaciones biomédicas: El àcido poli(beta,L-málico)

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Muñoz Guerra, Sebastian
    Revista latinoamericana de metalurgia y materiales
    Date of publication: 2008-06
    Journal article

     Share Reference managers Reference managers Open in new window

  • Thermal decomposition of microbial poly(gamma-glutamic acid) and poly(gamma-glutamate)s

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Muñoz Guerra, Sebastian
    Polymer degradation and stability
    Date of publication: 2007-10
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Nanostructurated Complexes of Poly(beta,L-malate) and Cationic Surfactants: Synthesis, Characterization and Structural Aspects

     García Álvarez, Montserrat
    EUROPEAN POLYMER CONGRES 2005
    Presentation's date: 2007-06-27
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Complejos iónicos de tensioactivos catiónicos y ácido poliglutámico biotecnológico parcialmente sulfonado con taurina

     Majo Roca, Maria Antonia; García Álvarez, Montserrat; Herranz Agustin, Concepcion; Muñoz Guerra, Sebastian
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Combined WAXS and SAXS real-time study of phase transitions in comb-like ionic complexes of biosynthetic polypeptides and polyesters

     Alla Bedahnane, Abdelilah; Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Muñoz-Mahamud, E; Muñoz Guerra, Sebastian
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Methyl esters of poly(beta-L-malic acid): síntesis, Characterization and biorrelated properties

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Galbis, J A; Muñoz Guerra, Sebastian
    European Polymer Congress 2007
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Complejos iónicos de tensioactivos catiónicos y ácido poliglutámico biotecnológico parcialmente sulfonado con taurina

     García Álvarez, Montserrat
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation's date: 2007-09-16
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Combined WAXS and SAXS-real time study of phase transitions in comb-like complexes of biosynthetic polypeptides and polyesters

     García Álvarez, Montserrat
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation's date: 2007-09-16
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • METHYL ESTERS OF POLY(·,L-MALIC ACID): SYNTHESIS, CHARACTERIZATION AND BIORRELATED PROPERTIES

     García Álvarez, Montserrat
    European Polymer Congress 2007
    Presentation's date: 2007-07-02
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Complejos iónicos de tensioactivos catiónicos y ácido poliglutámico biotecnológico parcialmente sulfonado con taurina

     García Álvarez, Montserrat
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation's date: 2007-09-16
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Combined WAXS and SAXS-real time study of phase transitions in comb-like complexes of biosynthetic polypeptides and polyesters

     García Álvarez, Montserrat
    II Workshop on applications of Synchrotron Light to non-crystalline diffraction in materials and life sciences
    Presentation's date: 2007-10-15
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Nanoesferas de Ácido Polimálico Parcialmente Metilado para Transporte y Dosificación de Proteínas

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Galbis, Juan A; Muñoz Guerra, Sebastian
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Combined WAXS and SAXS real-time study of phase transitions in comb-like ionic complexes of biosynthetic polypeptides and polyesters

     García Álvarez, Montserrat
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation's date: 2007-09-16
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Nanoesferas de Ácido Polimálico Parcialmente Metilado para Transporte y Dosificación de Proteínas

     García Álvarez, Montserrat
    Reunión del grupo especializado de polímeros (RSEQ y RSEF)
    Presentation's date: 2007-09-16
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Combined WAXS and SAXS Real-Time Study of Phase Transition in Comb-Like Ionic Complexes of Biosynthetic Polypeptides and Polyesters, HASYLAB Annual Report

     Alla Bedahnane, Abdelilah; Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Muñoz-Mahamud, E; Muñoz Guerra, Sebastian; Funari, S S
    Date: 2007-12
    Report

     Share Reference managers Reference managers Open in new window

  • Comblike Complexes of Poly(aspartic acid) and Alkyltrimethylamonium Cationic Surfactants

     López-Carrasquero, F; Báez, M E; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Alla Bedahnane, Abdelilah; Fernández, C E; Muñoz Guerra, Sebastian
    Macromolecular symposia
    Date of publication: 2007-02
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Comblike Complexes of Poly(itaconic acid) and Poly(mono methyl itaconate) and Alkyltrimethylamonium Cationic Surfactants

     Baez, M E; Jimenez, E; Laredo, E; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Lopez Carrasquero, Francisco
    Polymer bulletin
    Date of publication: 2007-03
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Ionic Complexes of Biosynthetic Poly(beta-malic acid) and Poly(gamma-glutamic acid) as Prospective Drug-Delivery Systems

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Muñoz Guerra, Sebastian
    Macromolecular bioscience
    Date of publication: 2007-07
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Micro y nanoesferas de ésteres métílicos del ácido poli(beta,L-málico)

     Muñoz Guerra, Sebastian; García Álvarez, Montserrat; Portilla Arias, Jose Antonio
    Date of request: 2007-03-14
    Invention patent

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Micro y nanoesferas de ésteres metílicos del ácido poli (beta, L-málico).

    Micro y nanoesferas constituidas por ácido poli(beta, L-málico) de biosíntesis metilado al 100% o al 75%, ambos polímeros insolubles en agua. Las partículas se obtienen, de forma controlable y reproducible, por los métodos de emulsión/evaporación o diálisis. Son hidrolizables en condiciones fisiológicas y permiten la encapsulación homogénea de principios activos, tales como fármacos o proteínas, produciéndose la liberación completa de los mismos en el rango de días.

  • Nanoesferas de ésteres alquílicos del ácido poli(gamma-glutámico)

     Muñoz Guerra, Sebastian; García Álvarez, Montserrat; Portilla Arias, Jose Antonio
    Date of request: 2007-11-05
    Invention patent

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Nanoesferas de ésteres alquílicos del ácido poli(y-glutámico).

    Nanoesferas constituidas por ácido poli(y-glutámico) de biosíntesis esterificado con grupos metilo al 100%, o con grupos etilo al 75% o con grupos hexilo, dodecilo u octadecilo al 50%, todos ellos insolubles en agua. Las partículas se obtienen, de forma controlable y reproducible, por el método de precipitación-diálisis. Son hidrolizables en condiciones fisiológicas y permiten la encapsulación homogénea de principios activos, tales como fármacos o proteínas, produciéndose la liberación completa de los mismos en el rango de días.

  • Thermal Decomposition of Fungal Poly(beta,L-malic acid) and Poly(beta,L-malate)s

     Portilla Arias, Jose Antonio; García Álvarez, Montserrat; Martinez de Ilarduya Saez de Asteasu, Antxon; Holler, E; Muñoz Guerra, Sebastian
    Biomacromolecules
    Date of publication: 2006-11
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Biopolímeros y polímeros de síntesis para aplicaciones en Biomedicina

     Muñoz Guerra, Sebastian; Alla Bedahnane, Abdelilah; Bermúdez Hermida, Marta María; García Álvarez, Montserrat; Herranz Agustin, Concepcion; Majo Roca, Maria Antonia; Martinez de Ilarduya Saez de Asteasu, Antxon
    Participation in a competitive project

     Share