Rodriguez Cantalapiedra, Inmaculada
Total activity: 359
Professional category
University lecturer
Doctoral courses
Doctora en Ciències (Físiques)
Research group
GICITED - Interdisciplinary Group on Building Scienceand Technology
Department
Department of Applied Physics
School
Barcelona School of Civil Engineering (ETSECCPB)
E-mail
inmaculada.rodriguezupc.edu
Contact details
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Orcid
0000-0002-0070-8979 Open in new window
ResearcherID
L-6394-2014 Open in new window
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1 to 50 of 359 results
  • Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model

     Lugo Vélez, Carlos Antonio; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    American journal of physiology. Heart and circulatory physiology
    Vol. 306, num. 11, p. H1540-H1552
    DOI: 10.1152/ajpheart.00515.2013
    Date of publication: 2014-06-01
    Journal article

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    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of SR release refractoriness in the appearance of alternans, using a mathematical model of a single human atrial cell, based on the model by Nygren et al. (30), where we modified the dynamics of the RyR2 and of SR Ca release. The genesis of calcium alternans was studied stimulating the cell for different periods and values of the RyR2 recovery time from inactivation. At fast rates cytosolic calcium alternans were obtained without concurrent SR Ca content fluctuations. A transition from regular response to alternans was also observed, changing the recovery time from inactivation of the RyR2. This transition was found to be hysteretic, so for a given set of parameters different responses were observed. We then studied the relevance of RyR2 refractoriness for the generation of alternans, reproducing the same protocols as in recent experiments. In particular, restitution of Ca release during alternans was studied with a S1S2 protocol, obtaining a different response if the S2 stimulation was given after a long or a short release. We show that the experimental results can be explained by RyR2 refractoriness, arising from a slow RyR2 recovery from inactivation, stressing the role of the RyR2 in the genesis of alternans.

    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of SR release refractoriness in the appearance of alternans, using a mathematical model of a single human atrial cell, based on the model by Nygren et al. (30), where we modified the dynamics of the RyR2 and of SR Ca release. The genesis of calcium alternans was studied stimulating the cell for different periods and values of the RyR2 recovery time from inactivation. At fast rates cytosolic calcium alternans were obtained without concurrent SR Ca content fluctuations. A transition from regular response to alternans was also observed, changing the recovery time from inactivation of the RyR2. This transition was found to be hysteretic, so for a given set of parameters different responses were observed. We then studied the relevance of RyR2 refractoriness for the generation of alternans, reproducing the same protocols as in recent experiments. In particular, restitution of Ca release during alternans was studied with a S1S2 protocol, obtaining a different response if the S2 stimulation was given after a long or a short release. We show that the experimental results can be explained by RyR2 refractoriness, arising from a slow RyR2 recovery from inactivation, stressing the role of the RyR2 in the genesis of alternans.

    Postprint (author’s final draft)

  • Influence of the traditional slaking process on the lime putty characteristics

     Rosell Amigo, Juan Ramon; Haurie Ibarra, Laia; Navarro Ezquerra, Maria Antonia; Rodriguez Cantalapiedra, Inmaculada
    Construction & building materials
    Vol. 55, num. March, p. 423-430
    DOI: 10.1016/j.conbuildmat.2014.01.007
    Date of publication: 2014
    Journal article

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    The influence of the slaking method on the characteristics of lime putties has been investigated. There has been used the same raw lime, calcined in a traditional kiln, to perform in situ traditional slaking processes as well as laboratory controlled slaking processes. The obtained lime putties were characterized using different instrumental techniques such as X-ray diffraction (XRD), X-ray fluorescence (XRF), thermogravimetric analysis (TGA), specific surface area (BET), particle size using laser dispersion and viscosity. Particle morphology using scanning electron microscope (SEM) was also studied. The amount of water used during slaking as well as the temperatures distribution give raise to differences in the particle size distribution and in the resulting hydration products.

    The influence of the slaking method on the characteristics of lime putties has been investigated. There has been used the same raw lime, calcined in a traditional kiln, to perform in situ traditional slaking processes as well as laboratory controlled slaking processes. The obtained lime putties were characterized using different instrumental techniques such as X-ray diffraction (XRD), X-ray fluorescence (XRF), thermogravimetric analysis (TGA), specific surface area (BET), particle size using laser dispersion and viscosity. Particle morphology using scanning electron microscope (SEM) was also studied. The amount of water used during slaking as well as the temperatures distribution give raise to differences in the particle size distribution and in the resulting hydration products.

    Postprint (author’s final draft)

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    Dependency of calcium alternans on Ryanodine Receptor Refractoriness  Open access

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Cinca Cosculluela, Juan; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    PLoS one
    Vol. 8, num. 2
    DOI: 10.1371/journal.pone.0055042
    Date of publication: 2013-02-04
    Journal article

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    Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR were constructed depicting the beat-to-beat response. When alternans was observed, a novel numerical clamping was caused by oscillations in SR calcium loading or by RyR2 refractoriness. Using this protocol, we identified regio loading or RyR2 refractoriness underlie the induction of calcium alternans, and we found that at the onset of altern inactivation rates of the RyR2, calcium alternans was caused by alternation in SR calcium loading, while at low act level of available RyR2s. Conclusions/Significance We have mapped cardiomyocyte beat-to-beat responses as a function of RyR2 activation and inactivation, identify refractoriness underlie the induction of calcium alternans. A corollary of this work is that RyR2 refractoriness due t of calcium alternans even when alternation in SR calcium load is present.

  • Nonlinearities due to Refractoriness in SR Ca Release

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    Vol. 39, p. 297-300
    Date of publication: 2013-01-01
    Journal article

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  • Medición in situ del aislamiento al ruido aéreo de la cubierta y de una fachada en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-10-03
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  • Medición "in situ" de valores de inmisión sonora en el exterior y en el interior en horario diurno en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Lacasta Palacio, Ana Maria; Rodriguez Cantalapiedra, Inmaculada
    Date: 2013-10-03
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  • Medición "in situ" del aislamiento a ruido aéreo de la cubierta y de una fachada en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Lacasta Palacio, Ana Maria; Rodriguez Cantalapiedra, Inmaculada
    Date: 2013-10-03
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  • Vibraciones producidas por un aparato de climatización

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-03-15
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  • Determinación de vibraciones en una planta de la Facultad de Medicina de la Universidad de Barcelona

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-01-29
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  • Informe sobre medidas de ruido de actividades vecinales

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria; Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2013-07-15
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  • Realització de mesures acústiques i de vibracions en immoble al carrer Septimania de Barcelona

     Rodriguez Cantalapiedra, Inmaculada; Auguet Sangra, Carlota Eugenia
    Date: 2013-01-25
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  • Determinación del aislamiento a ruido aéreo del bar "Congost" en l'Hospitalet de Llobregat

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-03-06
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  • Aportaciones al conocimiento del comportamiento deformacional de pastas de cal. Tamaño y formas de las partículas y su viscosidad.  Open access

     Rosell Amigo, Juan Ramon
    Universitat Politècnica de Catalunya
    Theses

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    La cal, que había sido el material conglomerante por excelencia en el sector de la construcción se ha visto relegada casi exclusivamente, a partir de la irrupción generalizada del cemento, al mundo de la restauración, donde todavía perduranprofesionales y artesanos con oficio. Estos profesionales de la restauración valoran especialmente la trabajabilidad de la cal en estado fresco, y consideran que una cal en pasta envejecida tradicionalmente ofrece mejores prestaciones que unacal en pasta coetánea o que una cal en polvo. Esta mejor trabajabilidad se traduce en mayor viscosidad .El motivo de esta tesis es investigar en la caracterización a nivel microscópico de las cales y en el comportamiento deformacional en estado fresco, para así poder confrontar el conocimiento tradicional desde la investigación cientifica . Almismo tiempo, una segunda línea de investigación se ha centrado en verificar la aplicabilidad de distintas herramientas de medida para caracterizar las pastas de cal y las cales en pasta.Para la realización de esta tesis se han escogido algunas de las diferentes cales disponibles en el mercado y que pueden servir de ejemplo de las distintas maneras de fabricar y de producir este material y se han estudiado: la caracterización de las partículas que componen las pastas de cal mediante la granulometria laser, la Difracción de Rayos X (DRX) Y la microscopia electrónica; y también se ha estudiado el comportamiento deformacional de las cales a partir de la medida de la viscosidad.Otra parte importante de la investigación realizada se ha centrado en discernir cómo evolucionan las pastas de cal en el tiempo y tras procesos de agitación.Los resultados obtenidos de estos trabajos demuestran la aplicabilidad de la técnica de la granulometría laser y la medida de la viscosidad como herramientas válidas para caracterizar las cales , mientras que se demuestra que el parámetro A[0001] obtenido a partir de la DRX no es válido para datar la antígüedad de la cal en pasta.También ha quedado demostrada la capacidad que tienen las cales en polvo de evolucionar incrementando su viscosidad y su carácter tixotrópico tras breves periodos de estacionamiento en forma de pasta de cal.En cuanto a las cualidades de las cales en pasta envejecidas tradicionalmente, se ha constatado que éstas presentan, en general, mayores viscosidades y distribuciones de tamaños de partículas menores que las de las pastas de cal.La evolución del proceso de envejecimiento de una cal en pasta no conduce siempre e indefinidamente a resultados mejores . Por tanto, no siempre una cal en pasta envejecida y de más edad es mejor que una cal más joven.

    La cal, que había sido el material conglomerante por excelencia en el sector de la construcción se ha visto relegada casi exclusivamente, a partir de la irrupción generalizada del cemento, al mundo de la restauración, donde todavía perduran profesionales y artesanos con oficio. Estos profesionales de la restauración valoran especialmente la trabajabilidad de la cal en estado fresco, y consideran que una cal en pasta envejecida tradicionalmente ofrece mejores prestaciones que una cal en pasta coetánea o que una cal en polvo. Esta mejor trabajabilidad se traduce en mayor viscosidad. El motivo de esta tesis es investigar en la caracterización a nivel microscópico de las cales y en el comportamiento deformacional en estado fresco, para así poder confrontar el conocimiento tradicional desde la investigación científica. Al mismo tiempo, una segunda línea de investigación se ha centrado en verificar la aplicabilidad de distintas herramientas de medida para caracterizar las pastas de cal y las cales en pasta. Para la realización de esta tesis se han escogido algunas de las diferentes cales disponibles en el mercado y que pueden servir de ejemplo de las distintas maneras de fabricar y de producir este material y se han estudiado: la caracterización de las partículas que componen las pastas de cal mediante la granulometría láser, la Difracción de Rayos X (DRX) y la microscopia electrónica; y también se ha estudiado el comportamiento deformacional de las cales a partir de la medida de la viscosidad. Otra parte importante de la investigación realizada se ha centrado en discernir cómo evolucionan las pastas de cal en el tiempo y tras procesos de agitación. Los resultados obtenidos de estos trabajos demuestran la aplicabilidad de la técnica de la granulometría láser y la medida de la viscosidad como herramientas válidas para caracterizar las cales, mientras que se demuestra que el parámetro A[0001] obtenido a partir de la DRX no es válido para datar la antigüedad de la cal en pasta. También ha quedado demostrada la capacidad que tienen las cales en polvo de evolucionar incrementando su viscosidad y su carácter tixotrópico tras breves períodos de estacionamiento en forma de pasta de cal. En cuanto a las cualidades de las cales en pasta envejecidas tradicionalmente, se ha constatado que éstas presentan, en general, mayores viscosidades y distribuciones de tamaños de partículas menores que las de las pastas de cal. La evolución del proceso de envejecimiento de una cal en pasta no conduce siempre e indefinidamente a resultados mejores. Por tanto, no siempre una cal en pasta envejecida y de más edad es mejor que una cal más joven.

    Since the widespread irruption of the cement, the lime, which once had been the binding material par excellence in the construction sector, has been relegated almost exclusively to the world of restoration works, where skilled professionals and craftsmen still endure. These professionals especially appreciate the workability of fresh lime, and consider that a traditionally aged lime putty provides better performance either than a coetaneus lime putty or a powder lime. This better workability results into higher viscosity. The purpose of this thesis is to investigate the characterization of the limes at a microscopic level and the deformational behavior in fresh state, in order to be able to confront traditional knowledge with scientific research. At once, a second line of research has focused on verifying the applicability of various measurement tools to characterize lime putties and hydrated lime putties. In order to achieve the fulfillment of this thesis, some different limes available in the market, that could serve as an example of the various ways of manufacturing and producing this material, have been choosen. Right after, the following items have been studied: characterization using laser granulometry of the particles that make up lime, X-Ray Diffraction (XRD) and scanning electron microscopy; deformational behavior of limes after the measurement of viscosity has also been studied. Another important part of the research performed has focused on to discern how hydrated lime putties evolve in time and after stirring processes. The results of these works demonstrate that laser granulometry techniques and viscosity measurements can be applied as valid tools to characterize limes, whereas it is concluded that A[0001] parameter obtained from XRD is not valid to reckon the age of lime putty. The ability of powder lime to evolve increasing its viscosity and its thixotropic character after short periods of ageing in lime putty format has also been demonstrated. Regarding the qualities of traditionally aged limes putties, it has been stablished that they exhibit generally higher viscosities and smaller size particle distributions than hydrated lime putties. The evolution of lime putty aging process does not lead to better results, neither always nor indefinitely. Therefore, an aged lime putty is not necessarily better than a less aged lime .

  • Access to the full text
    Energy use and energy efficiency, the way to reduce energy consumption in university buildings  Open access

     Bosch González, Montserrat; Rodriguez Cantalapiedra, Inmaculada; Sabaté Ibáñez, Josep Manel
    Conference of the Environmental Management for Sustainable Universities
    p. 1-14
    Presentation's date: 2013-06-06
    Presentation of work at congresses

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    The Technical University of Catalonia (UPC) has been developing since 1996 a number of actions and strategies to reduce the energy consumption of its 96 buildings. From the collaboration agreement signed in 2006 with the Catalan Institute of Energy (ICAEN), UPC has agreed to develop measures to encourage energy savings and enhance energy efficiency on its own buildings, distributed over ten campuses. One of the first actions carried out was the implementation of the Resource Consumption Efficiency Plan (PECR), which culminated in 29 energy audits carried out on different types of buildings: schools, sports facilities, libraries and administration buildings and services. These were performed by Technical Architecture and Building Engineering students as a Final Degree Project.

  • Alternans due to refractoriness in SR Ca release dynamics

     Rodriguez Cantalapiedra, Inmaculada; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Dynamics Days Europe
    p. 91
    Presentation's date: 2013-06-04
    Presentation of work at congresses

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    Alternans is a well-known cardiac pathology, in which the duration of the action potential (AP) alternates at consecutive beats. Due to its proarrhythmic effects it is important to understand the mechanisms un- derlying its genesis. Inside the cell, the sarcoplasmic reticulum (SR) keeps a high calcium concentration, that is liberated when calcium is introduced into the cell, in a process known as calcium induced calcium release (CICR). It has been amply studied the case where alternans appears due to a steep relation- ship between the duration of an action potential and the time elapsed since the end of the previous AP. However, now it is widely accepted that alternans often appears due to instabilities in the dynamics of intracellular calcium cycling (itself an important messenger for the contraction of the cell). This instabil- ity can be due to a steep relationship between the amount of calcium released to the cytosol, and the calcium loading of the sarcoplasmic reticulum (SR), but in some occasions cytosolic calcium alternans is observed without concurrent oscillations in the SR Ca content. This situation suggests an alternative mechanism related with a dysfunction in the dynamics of the ryanodine receptor (RyR2).

  • Effect of RyR2 Refractoriness and Hypercalcemia on Calcium Overload, Spontaneous Release, and Calcium Alternans

     Alvarez Lacalle, Enrique; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 683-686
    Presentation's date: 2013-09-24
    Presentation of work at congresses

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    In this work we use a computer model of a ventricu- lar rabbit myocyte to study several factors that affect sar- coplasmic reticulum (SR) calcium load, such as hypercal- cemia, SR calcium buffering, or ryanodine receptor (RyR2) dynamics. General conditions for the appearance of cal- cium spontaneous release in situations with calcium over- load are obtained. Furthermore, we study the appearance of alternans under these conditions. The presence of cal- cium alternans may be due to either a steep calcium load release relation, resulting in oscillations in SR Ca content, or to a slow recovery from refractoriness of the RyR2. We find that a change in calsequestrin buffering dynamics or extracellular calcium concentration greatly affects the ap- pearance of the former type of alternans, but not of the latter.

  • Modeling Calcium Dynamics in Human Atria

     Rodriguez Cantalapiedra, Inmaculada; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 237-296
    Presentation's date: 2013-09-25
    Presentation of work at congresses

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    Mathematical models of cardiac electrophysiology are an important tool to investigate the underlying mechanisms responsible of arrhythmias. In particular, an important question is the origin of atrial fibrillation (AF). Often, AF initiation is preceded by action potential duration (APD) alternans, i.e., beat to beat oscillations in the APD, that arise at slower rates in patients with persistent AF than in those without AF or with paroxymal AF.

  • Cardiac wave instabilities in tissue with inhomogeneous distribution of calcium alternans

     Lugo Vélez, Carlos Antonio; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    SIAM Conference on Applications of Dynamical Systems
    p. 143-144
    Presentation's date: 2013-05-19
    Presentation of work at congresses

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    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this talk we consider alternans associated to instabilities in the cytosolic calcium transient. Particularly, we study how a malfunction of the ryanodine receptor (RyR) recovery time from inactivation may induce beat-to-beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inhomogeneous tissue, whose cells exhibit different calcium dynamics.

  • Effect of Ryanodine Receptor Refractoriness on the Induction of Calcium Alternans

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Biophysical journal
    Vol. 102(3), p. 308a
    Date of publication: 2012-01-31
    Journal article

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  • Cardiac dynamics: a simplified model for action potential propagation

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Bragard, Jean; Echebarria Dominguez, Blas
    Theoretical biology and medical modeling
    Vol. 9, p. 50-68
    DOI: 10.1186/1742-4682-9-50
    Date of publication: 2012-11-29
    Journal article

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    This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental data, or from more complex electrophysiological models. The model divides all ion currents into four groups according to their function, thus resulting into fast-slow and inward-outward currents. We show that this simplified model is flexible enough as to accurately capture the electrical properties of cardiac myocytes, having the advantage of being less computational demanding than detailed electrophysiological models. Under some conditions, it has been shown to be amenable to mathematical analysis. The model reproduces the action potential (AP) change with stimulation rate observed both experimentally and in realistic models of healthy human and guinea pig myocytes (TNNP and LRd models, respectively). When simulated in a cable it also gives the right dependence of the conduction velocity (CV) with stimulation rate. Besides reproducing correctly these restitution properties, it also gives a good fit for the morphology of the AP, including the notch typical of phase 1. Finally, we perform simulations in a realistic geometric model of the rabbit¿s ventricles, finding a good qualitative agreement in AP propagation and the ECG. Thus, this simplified model represents an alternative to more complex models when studying instabilities in wave propagation.

  • BAM Bioarquitectura Mediterránea

     Bosch González, Montserrat; Lacasta Palacio, Ana Maria; Rosell Amigo, Juan Ramon; Ciudad Alvarez, Aleix; Formosa Mitjans, Joan; Gómez Soberón, José Manuel Vicente; Haurie Ibarra, Laia; Hormias Laperal, Emilio; Monton Lecumberri, Joaquin; Navarro Ezquerra, Maria Antonia; Ramirez Casas, Judith; Rodriguez Cantalapiedra, Inmaculada; Ruiz Merida, Francsico; Segues Aguasca, Edgar
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  • Modelización de dinámica cardiaca a distintas escalas

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Participation in a competitive project

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  • Eficiencia enrgética en edificios patrimoniales: análisis y monitorización de tres casos

     Gonzalez Moreno-navarro, Jose Luis; Rodriguez Cantalapiedra, Inmaculada; Bosch González, Montserrat; Genis Viñals, Mariona; Olona Casas, Joan
    European Conference on Energy Efficiency and Sustainability in Architecture and Planning
    p. 89-96
    Presentation's date: 2012-07-03
    Presentation of work at congresses

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  • Mechanisms of intracellular calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina
    Congreso No Lineal
    p. 1
    Presentation's date: 2012-06-05
    Presentation of work at congresses

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  • RyR refractoriness effect on calcium alternans mecanics

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Hove Madsen, Leif
    Sitges Conference on Statistical Mechanics
    p. 85
    Presentation's date: 2012-06-05
    Presentation of work at congresses

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  • Eficiencia energética y reducción de consumos en edificios universitarios. El caso de la Universidad Politécnica de Catalunya (UPC)

     Bosch González, Montserrat; Rodriguez Cantalapiedra, Inmaculada
    European Conference on Energy Efficiency and Sustainability in Architecture and Planning
    p. 41-48
    Presentation's date: 2012-07-02
    Presentation of work at congresses

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    Nonlinearities due to refractoriness in SR Ca release  Open access

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    p. 297-300
    Presentation's date: 2012-09-11
    Presentation of work at congresses

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    Calcium alternans is a pro-arrhytmic cardiac dysfunction related to beat-to-beat changes in the amplitude of intracellular calcium transient, that typically occurs at rapid pacing rates. Although oscillations in sarcoplasmic reticulum (SR) content have been related with calcium alternans, the experimental appearance of alternans without these oscillations suggests that another mechanism related with refractoriness of SR calcium release might be key, at least, under certain conditions. We investigate how RyR2 refractoriness modulates calcium handling on a beat-to-beat basis using a numerical rabbit cardiomyocyte model. We find that a slow recovery from inactivation of the RyR2 might be crucial. On one hand, a steep relation between sarcoplasmic reticulum (SR) load and calcium release makes regular calcium cycling unstable at high SR calcium load and/or fast pacing rates, in agreement with previous explanation when RyR2 inactivation is not important. On the other hand, we show that calcium release can also depend strongly on the number of RyR2 ready to open if an important number of RyR2s inactivate after the release. This gives rise to a steep nonlinear relation between the calcium release and the level of recovered RyR2, so that a small change in the later produces big changes in calcium release. A conclusion of this result is that RyR2 refractoriness can be the main nonlinearity behind alternans even when alternation in SR-Ca load is present

  • Rehabilitación energética de edificios escolares en clima mediterráneo: caso de estudio, Barcelona

     Bosch González, Montserrat; Rodriguez Cantalapiedra, Inmaculada; Alvarez Del Castillo, Javier
    Congreso de Patología y Rehabilitación de Edificios
    p. 1-6
    Presentation's date: 2012-04-14
    Presentation of work at congresses

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  • Mechanisms for calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada
    Annual Meeting of the DPG and DPG Spring Meeting
    p. 1
    Presentation's date: 2012-03-27
    Presentation of work at congresses

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  • Método simple para determinar el módulo de Young dinámico a partir de una excitación por impacto, aplicado a morteros de cal y cemento

     Rosell Amigo, Juan Ramon; Rodriguez Cantalapiedra, Inmaculada
    Materiales de construcción (Madrid)
    Vol. 61, num. 301, p. 39-48
    DOI: 10.3989/mc.2010.53509
    Date of publication: 2011-01
    Journal article

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  • Determinació d'aïllament acústic de les façades corresponents als cubículs de Puigverd LLeida

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2011-07-05
    Report

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  • Determinació d'aïllament acústic de les taulades corresponents als cubículs de Puigverd LLeida

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2011-09-13
    Report

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  • Determinació d'aïllament acústic de les divisòries verticals dels cubículs experimentals de Puigverd LLeida

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2011-12-05
    Report

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  • Determinació del nivell d'immissió sonora ocasionat pel soroll d'aparells instalats en un restaurant

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2011-07-13
    Report

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  • Determinació de l'aïllament acústic a soroll aeri d'un local d'oci

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2011-07-28
    Report

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  • Informe de evaluación de experto

     Rodriguez Cantalapiedra, Inmaculada
    Date: 2011-02-10
    Report

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  • Caos y arritmogénesis en la dinámica del calcio intracelular

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 64-
    Presentation's date: 2011
    Presentation of work at congresses

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  • La experiencia del apagado tradicional en Zone (Italia)  Open access

     Haurie Ibarra, Laia; Rosell Amigo, Juan Ramon; Bosch González, Montserrat; Rattazzi, Andrea; Rodriguez Cantalapiedra, Inmaculada
    Jornadas del Fórum Ibérico de la Cal
    p. 41-54
    Presentation's date: 2011-04
    Presentation of work at congresses

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    Libro de ponencias de las II Jornadas FICAL, celebradas en Barcelona en Abril de 2011.

  • Metodologia d'avaluació energètica d'edificis

     Rodriguez Cantalapiedra, Inmaculada; Bosch González, Montserrat
    Jornada de Recerca i innovació a l'Escola de Camins
    p. 106-109
    Presentation's date: 2011-11-16
    Presentation of work at congresses

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  • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness

     Rodriguez Cantalapiedra, Inmaculada; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 645-648
    Presentation's date: 2011-09-12
    Presentation of work at congresses

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    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the cytosolic calcium transient. To this end we study particularly, how a malfunction of Ryanodine Receptor (RyR) recovery time from inactivation may induce beatto- beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inhomogeneous tissue, whose cells exhibit different calcium dynamics.

  • Arritmias cardiacas producidas por heterogeneidad en la dinámica del calcio

     Lugo Vélez, Carlos Antonio; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 143
    Presentation's date: 2011
    Presentation of work at congresses

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  • Existen diferencias en las cales apagadas por distintos métodos tradicionales?: la experiencia de Zone (BS)

     Rosell Amigo, Juan Ramon; Haurie Ibarra, Laia; Bosch González, Montserrat; Rattazzi, Andrea; Rodriguez Cantalapiedra, Inmaculada
    Arkos (Torino - Milano)
    num. 22, p. 34-39
    Date of publication: 2010
    Journal article

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    Phase-2 reentry in cardiac tissue: role of the slow calcium pulse  Open access

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas; Bragard, Jean
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 82, num. 1, p. 011907-1-011907-13
    DOI: 10.1103/PhysRevE.82.011907
    Date of publication: 2010-07-13
    Journal article

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    Phase-2 re-entry is thought to underlie many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. In this paper, we study under which circumstances a region of depolarized tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action potential. With the help of this model, we analyze the conditions that lead to very short action potentials (APs), as well as possible mechanisms for re-excitation in a cable. We then study the induction of re-entrant waves (spiral waves) in simulations of AP propagation in the heart ventricles. We show that re-excitation takes place via a slow pulse produced by calcium current that propagates into the region of short APs until it encounters excitable tissue. We calculate analytically the speed of the slow pulse, and also give an estimate of the minimal tissue size necessary for allowing reexcitation to take place.

  • Determinació de la rigidesa dinàmica segons norma UNE 29052-1

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2010-12-22
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  • Revisión de artículo en revista Informes de la Construcción

     Rodriguez Cantalapiedra, Inmaculada
    Date: 2010-03-01
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  • Informe de evaluación para la ANEP

     Rodriguez Cantalapiedra, Inmaculada
    Date: 2010-05-16
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