Graphic summary
  • Show / hide key
  • Information


Scientific and technological production
  •  

1 to 50 of 197 results
  • Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model

     Lugo Vélez, Carlos Antonio; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    American journal of physiology. Heart and circulatory physiology
    Vol. 306, num. 11, p. H1540-H1552
    DOI: 10.1152/ajpheart.00515.2013
    Date of publication: 2014-06-01
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of SR release refractoriness in the appearance of alternans, using a mathematical model of a single human atrial cell, based on the model by Nygren et al. (30), where we modified the dynamics of the RyR2 and of SR Ca release. The genesis of calcium alternans was studied stimulating the cell for different periods and values of the RyR2 recovery time from inactivation. At fast rates cytosolic calcium alternans were obtained without concurrent SR Ca content fluctuations. A transition from regular response to alternans was also observed, changing the recovery time from inactivation of the RyR2. This transition was found to be hysteretic, so for a given set of parameters different responses were observed. We then studied the relevance of RyR2 refractoriness for the generation of alternans, reproducing the same protocols as in recent experiments. In particular, restitution of Ca release during alternans was studied with a S1S2 protocol, obtaining a different response if the S2 stimulation was given after a long or a short release. We show that the experimental results can be explained by RyR2 refractoriness, arising from a slow RyR2 recovery from inactivation, stressing the role of the RyR2 in the genesis of alternans.

    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of SR release refractoriness in the appearance of alternans, using a mathematical model of a single human atrial cell, based on the model by Nygren et al. (30), where we modified the dynamics of the RyR2 and of SR Ca release. The genesis of calcium alternans was studied stimulating the cell for different periods and values of the RyR2 recovery time from inactivation. At fast rates cytosolic calcium alternans were obtained without concurrent SR Ca content fluctuations. A transition from regular response to alternans was also observed, changing the recovery time from inactivation of the RyR2. This transition was found to be hysteretic, so for a given set of parameters different responses were observed. We then studied the relevance of RyR2 refractoriness for the generation of alternans, reproducing the same protocols as in recent experiments. In particular, restitution of Ca release during alternans was studied with a S1S2 protocol, obtaining a different response if the S2 stimulation was given after a long or a short release. We show that the experimental results can be explained by RyR2 refractoriness, arising from a slow RyR2 recovery from inactivation, stressing the role of the RyR2 in the genesis of alternans.

    Postprint (author’s final draft)

  • Access to the full text
    Dependency of calcium alternans on Ryanodine Receptor Refractoriness  Open access

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Cinca Cosculluela, Juan; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    PLoS one
    Vol. 8, num. 2
    DOI: 10.1371/journal.pone.0055042
    Date of publication: 2013-02-04
    Journal article

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR were constructed depicting the beat-to-beat response. When alternans was observed, a novel numerical clamping was caused by oscillations in SR calcium loading or by RyR2 refractoriness. Using this protocol, we identified regio loading or RyR2 refractoriness underlie the induction of calcium alternans, and we found that at the onset of altern inactivation rates of the RyR2, calcium alternans was caused by alternation in SR calcium loading, while at low act level of available RyR2s. Conclusions/Significance We have mapped cardiomyocyte beat-to-beat responses as a function of RyR2 activation and inactivation, identify refractoriness underlie the induction of calcium alternans. A corollary of this work is that RyR2 refractoriness due t of calcium alternans even when alternation in SR calcium load is present.

  • Medición "in situ" de valores de inmisión sonora en el exterior y en el interior en horario diurno en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Lacasta Palacio, Ana Maria; Rodriguez Cantalapiedra, Inmaculada
    Date: 2013-10-03
    Report

     Share Reference managers Reference managers Open in new window

  • Medición "in situ" del aislamiento a ruido aéreo de la cubierta y de una fachada en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Lacasta Palacio, Ana Maria; Rodriguez Cantalapiedra, Inmaculada
    Date: 2013-10-03
    Report

     Share Reference managers Reference managers Open in new window

  • Vibraciones producidas por un aparato de climatización

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-03-15
    Report

     Share Reference managers Reference managers Open in new window

  • Determinación de vibraciones en una planta de la Facultad de Medicina de la Universidad de Barcelona

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-01-29
    Report

     Share Reference managers Reference managers Open in new window

  • Informe sobre medidas de ruido de actividades vecinales

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria; Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2013-07-15
    Report

     Share Reference managers Reference managers Open in new window

  • Determinación del aislamiento a ruido aéreo del bar "Congost" en l'Hospitalet de Llobregat

     Peñaranda Ayllon, Angelina; Auguet Sangra, Carlota Eugenia; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-03-06
    Report

     Share Reference managers Reference managers Open in new window

  • Medición in situ del aislamiento al ruido aéreo de la cubierta y de una fachada en C/ Blanes nº 5, Gavà de Mar (Barcelona)

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria
    Date: 2013-10-03
    Report

     Share Reference managers Reference managers Open in new window

  • Realització de mesures in situ de vibracions a l'Hospital Clínic (Universitat de Barcelona)

     Lacasta Palacio, Ana Maria; Peñaranda Ayllon, Angelina
    Date: 2013-01-31
    Report

     Share Reference managers Reference managers Open in new window

  • ESTOCASTICIDAD EN SISTEMAS COMPLEJOS NOLINEALES

     Pons Rivero, Antonio Javier; Torrent Serra, Maria Del Carmen; Masoller Alonso, Cristina; Pigolotti, Simone; Ramirez de La Piscina Millan, Laureano; Peñaranda Ayllon, Angelina; Malagarriga Guasch, Daniel; Dies Miracle, Marta; Aragoneses Aguado, Andres; Deza, Juan Ignacio; Garcia Ojalvo, Jorge
    Competitive project

     Share

  • Nonlinearities due to Refractoriness in SR Ca Release

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    Vol. 39, p. 297-300
    Date of publication: 2013-01-01
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Effect of RyR2 Refractoriness and Hypercalcemia on Calcium Overload, Spontaneous Release, and Calcium Alternans

     Alvarez Lacalle, Enrique; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 683-686
    Presentation's date: 2013-09-24
    Presentation of work at congresses

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    In this work we use a computer model of a ventricu- lar rabbit myocyte to study several factors that affect sar- coplasmic reticulum (SR) calcium load, such as hypercal- cemia, SR calcium buffering, or ryanodine receptor (RyR2) dynamics. General conditions for the appearance of cal- cium spontaneous release in situations with calcium over- load are obtained. Furthermore, we study the appearance of alternans under these conditions. The presence of cal- cium alternans may be due to either a steep calcium load release relation, resulting in oscillations in SR Ca content, or to a slow recovery from refractoriness of the RyR2. We find that a change in calsequestrin buffering dynamics or extracellular calcium concentration greatly affects the ap- pearance of the former type of alternans, but not of the latter.

  • Alternans due to refractoriness in SR Ca release dynamics

     Rodriguez Cantalapiedra, Inmaculada; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Dynamics Days Europe
    p. 91
    Presentation's date: 2013-06-04
    Presentation of work at congresses

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Alternans is a well-known cardiac pathology, in which the duration of the action potential (AP) alternates at consecutive beats. Due to its proarrhythmic effects it is important to understand the mechanisms un- derlying its genesis. Inside the cell, the sarcoplasmic reticulum (SR) keeps a high calcium concentration, that is liberated when calcium is introduced into the cell, in a process known as calcium induced calcium release (CICR). It has been amply studied the case where alternans appears due to a steep relation- ship between the duration of an action potential and the time elapsed since the end of the previous AP. However, now it is widely accepted that alternans often appears due to instabilities in the dynamics of intracellular calcium cycling (itself an important messenger for the contraction of the cell). This instabil- ity can be due to a steep relationship between the amount of calcium released to the cytosol, and the calcium loading of the sarcoplasmic reticulum (SR), but in some occasions cytosolic calcium alternans is observed without concurrent oscillations in the SR Ca content. This situation suggests an alternative mechanism related with a dysfunction in the dynamics of the ryanodine receptor (RyR2).

  • Cardiac wave instabilities in tissue with inhomogeneous distribution of calcium alternans

     Lugo Vélez, Carlos Antonio; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    SIAM Conference on Applications of Dynamical Systems
    p. 143-144
    Presentation's date: 2013-05-19
    Presentation of work at congresses

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this talk we consider alternans associated to instabilities in the cytosolic calcium transient. Particularly, we study how a malfunction of the ryanodine receptor (RyR) recovery time from inactivation may induce beat-to-beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inhomogeneous tissue, whose cells exhibit different calcium dynamics.

  • Modeling Calcium Dynamics in Human Atria

     Rodriguez Cantalapiedra, Inmaculada; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 237-296
    Presentation's date: 2013-09-25
    Presentation of work at congresses

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Mathematical models of cardiac electrophysiology are an important tool to investigate the underlying mechanisms responsible of arrhythmias. In particular, an important question is the origin of atrial fibrillation (AF). Often, AF initiation is preceded by action potential duration (APD) alternans, i.e., beat to beat oscillations in the APD, that arise at slower rates in patients with persistent AF than in those without AF or with paroxymal AF.

  • Modelización de dinámica cardiaca a distintas escalas

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Competitive project

     Share

  • Effect of Ryanodine Receptor Refractoriness on the Induction of Calcium Alternans

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Biophysical journal
    Vol. 102(3), p. 308a
    Date of publication: 2012-01-31
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Cardiac dynamics: a simplified model for action potential propagation

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Bragard, Jean; Echebarria Dominguez, Blas
    Theoretical biology and medical modeling
    Vol. 9, p. 50-68
    DOI: 10.1186/1742-4682-9-50
    Date of publication: 2012-11-29
    Journal article

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental data, or from more complex electrophysiological models. The model divides all ion currents into four groups according to their function, thus resulting into fast-slow and inward-outward currents. We show that this simplified model is flexible enough as to accurately capture the electrical properties of cardiac myocytes, having the advantage of being less computational demanding than detailed electrophysiological models. Under some conditions, it has been shown to be amenable to mathematical analysis. The model reproduces the action potential (AP) change with stimulation rate observed both experimentally and in realistic models of healthy human and guinea pig myocytes (TNNP and LRd models, respectively). When simulated in a cable it also gives the right dependence of the conduction velocity (CV) with stimulation rate. Besides reproducing correctly these restitution properties, it also gives a good fit for the morphology of the AP, including the notch typical of phase 1. Finally, we perform simulations in a realistic geometric model of the rabbit¿s ventricles, finding a good qualitative agreement in AP propagation and the ECG. Thus, this simplified model represents an alternative to more complex models when studying instabilities in wave propagation.

  • Mechanisms of intracellular calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina
    Congreso No Lineal
    p. 1
    Presentation's date: 2012-06-05
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • RyR refractoriness effect on calcium alternans mecanics

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Hove Madsen, Leif
    Sitges Conference on Statistical Mechanics
    p. 85
    Presentation's date: 2012-06-05
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Access to the full text
    Nonlinearities due to refractoriness in SR Ca release  Open access

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    p. 297-300
    Presentation's date: 2012-09-11
    Presentation of work at congresses

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Calcium alternans is a pro-arrhytmic cardiac dysfunction related to beat-to-beat changes in the amplitude of intracellular calcium transient, that typically occurs at rapid pacing rates. Although oscillations in sarcoplasmic reticulum (SR) content have been related with calcium alternans, the experimental appearance of alternans without these oscillations suggests that another mechanism related with refractoriness of SR calcium release might be key, at least, under certain conditions. We investigate how RyR2 refractoriness modulates calcium handling on a beat-to-beat basis using a numerical rabbit cardiomyocyte model. We find that a slow recovery from inactivation of the RyR2 might be crucial. On one hand, a steep relation between sarcoplasmic reticulum (SR) load and calcium release makes regular calcium cycling unstable at high SR calcium load and/or fast pacing rates, in agreement with previous explanation when RyR2 inactivation is not important. On the other hand, we show that calcium release can also depend strongly on the number of RyR2 ready to open if an important number of RyR2s inactivate after the release. This gives rise to a steep nonlinear relation between the calcium release and the level of recovered RyR2, so that a small change in the later produces big changes in calcium release. A conclusion of this result is that RyR2 refractoriness can be the main nonlinearity behind alternans even when alternation in SR-Ca load is present

  • Mechanisms for calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada
    Annual Meeting of the DPG and DPG Spring Meeting
    p. 1
    Presentation's date: 2012-03-27
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Caos y arritmogénesis en la dinámica del calcio intracelular

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 64-
    Presentation's date: 2011
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Arritmias cardiacas producidas por heterogeneidad en la dinámica del calcio

     Lugo Vélez, Carlos Antonio; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 143
    Presentation's date: 2011
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness

     Rodriguez Cantalapiedra, Inmaculada; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 645-648
    Presentation's date: 2011-09-12
    Presentation of work at congresses

    Read the abstract Read the abstract View View Open in new window  Share Reference managers Reference managers Open in new window

    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the cytosolic calcium transient. To this end we study particularly, how a malfunction of Ryanodine Receptor (RyR) recovery time from inactivation may induce beatto- beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inhomogeneous tissue, whose cells exhibit different calcium dynamics.

  • DINÁMICA NO LINEAL Y ESTOCÁSTICA EN SISTEMAS FÍSICOS Y BIOFÍSICOS

     Formosa Mitjans, Joan; Haurie Ibarra, Laia; Peñaranda Ayllon, Angelina; Lacasta Palacio, Ana Maria; Meca Alvarez, Esteban; Ciudad Alvarez, Aleix; Ramirez de La Piscina Millan, Laureano
    Competitive project

     Share

  • Determinació dels nivells d'immissió sonora als voltants de la clínica Terres de l'Ebre SL

     Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2010-07-01
    Report

     Share Reference managers Reference managers Open in new window

  • Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 661-664
    Presentation's date: 2010-09-28
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Reexcitations in cardiac tissue with heterogeneity in repolarization induced by a calcium pulse

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas; Bragard, Jean
    Joint SIAM/RSME-SCM-SEMA Meeting Emerging Topics in Dynamical Systems and Partial Differential Equations
    Presentation's date: 2010-06-03
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Reexcitations in Cardiac tissue with heterogeneity in repolarization Induced by a Pulse due to Calcium Current

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas; Bragard, Jean
    Portuguese-Spanish Biophysics Congres
    Presentation's date: 2010-07-10
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Access to the full text
    Phase-2 reentry in cardiac tissue: role of the slow calcium pulse  Open access

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas; Bragard, Jean
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 82, num. 1, p. 011907-1-011907-13
    DOI: 10.1103/PhysRevE.82.011907
    Date of publication: 2010-07-13
    Journal article

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Phase-2 re-entry is thought to underlie many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. In this paper, we study under which circumstances a region of depolarized tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action potential. With the help of this model, we analyze the conditions that lead to very short action potentials (APs), as well as possible mechanisms for re-excitation in a cable. We then study the induction of re-entrant waves (spiral waves) in simulations of AP propagation in the heart ventricles. We show that re-excitation takes place via a slow pulse produced by calcium current that propagates into the region of short APs until it encounters excitable tissue. We calculate analytically the speed of the slow pulse, and also give an estimate of the minimal tissue size necessary for allowing reexcitation to take place.

  • Calcium alternans and ryanodine receptors in cardiomyocytes

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Emerging Topics in Dynamical Systems and Partial Differential Equations
    p. 1
    Presentation's date: 2010-06-01
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Avaluació del soroll produït pels ventiladors d'un equip de climatització ubicat al poliesportiu de la UPC

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria; Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2009-06-05
    Report

     Share Reference managers Reference managers Open in new window

  • Mesures d'aïllament acústic d'un recinte que ha d'allotjar una estació transformadora

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria; Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2009-07-17
    Report

     Share Reference managers Reference managers Open in new window

  • MODELOS Y CATACTERIZACIÓN DE DINÁMICA CARDIACA

     Echebarria Dominguez, Blas; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique
    Competitive project

     Share

  • REMODELLING OF ADENOSINE RECEPTORS IN HUMAN ATRIAL FIBRILLATION

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Competitive project

     Share

  • Determinació del nivell d'immissió sonora al carrer 6 del polígon industrial de la Zona Franca

     Rodriguez Cantalapiedra, Inmaculada; Lacasta Palacio, Ana Maria; Auguet Sangra, Carlota Eugenia; Peñaranda Ayllon, Angelina
    Date: 2009-07-29
    Report

     Share Reference managers Reference managers Open in new window

  • Cardiac dynamics: a simplified model for the action potential

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Bragard, Jean; Echebarria Dominguez, Blas
    Congreso de Física Estadística
    Presentation's date: 2009-09-10
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Reexcitation mechanisms in epicardial tissue: Role of Ito density heterogeneities and INa+ inactivation kinetics.

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Congreso de Física Estadística
    p. 135-
    Presentation's date: 2009-09-10
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Reexcitation mechanisms in epicardial tissue: Role of Ito density heterogeneities and INa+ inactivation kinetics.

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Cardiac Dynamics Workshop
    Presentation's date: 2009-12-24
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Dynamics and control of intracellular calcium dynamics in cell with RyRs

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    Presentation's date: 2009-09-10
    Presentation of work at congresses

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Reexcitation mechanisms in epicardial tissue: role of Ito density heterogeneities and INa inactivation kinetics

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Mont Girbau, Lluís; Brugada Terradellas, Josep; Echebarria Dominguez, Blas
    Journal of theoretical biology
    Vol. 259, num. 4, p. 850-859
    DOI: 10.1016/j.jtbi.2009.04.021
    Date of publication: 2009-08-18
    Journal article

    View View Open in new window  Share Reference managers Reference managers Open in new window

  • Red Temática de Dinámica Cardiaca y Simulación Multiescala Cardiovascular

     Peñaranda Ayllon, Angelina; Rodríguez, J.F.
    Competitive project

     Share

  • Mecanismos de reexicitación en tejido cardiaco

     Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada
    NoLineal 2008
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Mecanismos de reexcitación en tejido cardiaco.

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    NoLineal 2008
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Mecanismos de reexcitación en tejido cardiaco.

     Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas; Rodriguez Cantalapiedra, Inmaculada
    Congreso de Física Estadística
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window

  • Dinámica cardiaca

     Echebarria Dominguez, Blas; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina
    Nolineal 2007 : Nuevos retos y perspectivas de la dinámica no lineal y sus aplicaciones
    p. 52-53
    Presentation of work at congresses

     Share Reference managers Reference managers Open in new window