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  • Exercise capacity and N-terminal pro-brain natriuretic peptide levels with biventricular vs. right ventricular pacing for atrioventricular block: results from the PREVENT-HF German Substudy

     Stockburger, Martin; de Teresa Galván, Eduardo; Lamas, Gervasio; desaga, Martin; Koening, Carsten; Habedank, Dirk; Cobo Valeri, Erik; Navarro, Xavier; Wiegand, Uwe
    Europace-European Society of Cardiology
    Date of publication: 2014-01-01
    Journal article

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    Aims Previous studies showed unfavourable effects of right ventricular (RV) pacing. Ventricular pacing (VP), however, is required in many patients with atrioventricular (AV) block. The PREVENT-HF study explored left ventricular (LV) remodelling during RV vs. biventricular (BIV) pacing in AV block without advanced heart failure. The pre-specified PREVENT-HF German Substudy examined exercise capacity and N-terminal pro-brain natriuretic peptide (NT-proBNP).; Methods and results Patients with expected VP >= 80% were randomized to RV or BIV pacing. Endpoints were peak oxygen uptake (pVO(2)), oxygen uptake at the anaerobic threshold (VO(2)AT), ventilatory efficiency (VE/VCO2), and logNT-proBNP. Considering crossover, intention to treat (ITT), and on-treatment (OT) analyses of covariance (ANCOVA) were performed. For exercise testing 44 (RV: 25, BIV: 19), and for NT-proBNP 53 patients (RV: 29, BIV: 24) were included. The ITT analysis revealed significant differences in pVO(2) [ANCOVA effect 2.83 mL/kg/min, confidence interval (CI) 0.83-4.91, P = 0.007], VO(2)AT (ANCOVA effect 2.14 mL/min/k, CI 0.14-4.15, P = 0.03), and VE/VCO2 (ANCOVA effect -5.46, CI -10.79 to -0.13, P = 0.04) favouring BIV randomization. The significant advantage in pVO(2) persisted in OT analysis, while VO(2)AT and VE/VCO2 showed trends favouring BIV pacing. LogNT-proBNP did not differ between groups. (ITT:ANCOVA effect 0.008, CI -0.40 to +0.41, P = 0.97; OT: ANCOVA effect -0.03, CI -0.44 to 0.30, P = 0.90).; Conclusion Our study suggests that BIV pacing produces better exercise capacity over 1 year compared with RV pacing in patients without advanced heart failure and AV block. In contrast, we observed no significant changes of NT-proBNP. Larger trials will allow appraising the clinical usefulness of BIV pacing in AV block.

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    Desarrollo integral de las competencias genéricas mediante mapas competenciales  Open access

     Sanchez Carracedo, Fermin; Ageno Pulido, Alicia; Belanche Muñoz, Luis Antonio; Cabre Garcia, Jose Maria; Cobo Valeri, Erik; Farre Cirera, Rafael; Garcia Almiñana, Jordi; Lopez Alvarez, David; Mares Marti, Pere; Martin Escofet, Carme; Soler Cervera, Antonia
    Jornadas de Enseñanza Universitaria de la Informática
    Presentation's date: 2012-07
    Presentation of work at congresses

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    Los planes de estudio del EEES deben diseñarse a partir de las competencias de la titulación, tanto específicas como genéricas. La universidad española tiene una amplia experiencia en trabajar y evaluar las competencias específicas, pero las competencias genéricas suponen un nuevo reto que es preciso abordar. En este trabajo se hace una propuesta sobre cómo trabajar y evaluar, de forma global, las competencias genéricas en una titulación de Grado. La propuesta se está implantando en los estudios de Grado en Ingeniería Informática de la Facultat d’Informàtica de Barcelona. En lugar de establecer diversos niveles de competencia y asignar cada uno de estos niveles a distintas asignaturas, como suele hacerse con las competencias específicas usando la taxonomía de Bloom, se propone definir cada competencia genérica en términos de dimensiones. Cada una de las dimensiones (aspectos de la competencia) se define en términos de objetivos a tres niveles, y son los objetivos de un determinado nivel de cada dimensión lo que se encarga a las asignaturas. De esta forma, una misma asignatura puede trabajar distintas dimensiones de una competencia genérica, cada una de ellas a un nivel diferente. Diferentes competencias pueden compartir un subconjunto de dimensiones. Evitar repetir el trabajo de estas dimensiones en diferentes asignaturas cuando no es estrictamente necesario permite optimizar el trabajo realizado y favorece que los estudiantes adquieran las competencias genéricas definidas por la titulación.

  • Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

     Dávalos Errando, Antoni; Álvarez Sabin, José; Castillo Sánchez, José; Diez Tejedor, Exuperio; Ferro, José; Martínez Vila, Eduardo; Serena Leal, Joaquín; Segura Martin, Tomas; Tedim Cruz, Vítor; Masjuán Vallejo, Jaime; Cobo Valeri, Erik; Secades Ruiz, Julio José
    Lancet
    Date of publication: 2012-07-28
    Journal article

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    Background Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial. Methods We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals in Germany, Portugal, and Spain. Using a centralised minimisation process, patients were randomly assigned in a 1:1 ratio to receive citicoline or placebo within 24 h after the onset of symptoms (1000 mg every 12 h intravenously during the first 3 days and orally thereafter for a total of 6 weeks [2×500 mg oral tablets given every 12 h]). All study participants were masked. The primary outcome was recovery at 90 days measured by a global test combining three measures of success: National Institutes of Health Stroke Scale =1, modified Rankin score =1, and Barthel Index =95. Safety endpoints included symptomatic intracranial haemorrhage in patients treated with recombinant tissue plasminogen activator, neurological deterioration, and mortality. This trial is registered, NCT00331890. Results 2298 patients were enrolled into the study from Nov 26, 2006, to Oct 27, 2011. 37 centres in Spain, 11 in Portugal, and 11 in Germany recruited patients. Of the 2298 patients who gave informed consent and underwent randomisation, 1148 were assigned to citicoline and 1150 to placebo. The trial was stopped for futility at the third interim analysis on the basis of complete data from 2078 patients. The final randomised analysis was based on data for 2298 patients: 1148 in citicoline group and 1150 in placebo group. Global recovery was similar in both groups (odds ratio 1.03, 95% CI 0.86-1.25; p=0.364). No significant differences were reported in the safety variables nor in the rate of adverse events. Interpretation Under the circumstances of the ICTUS trial, citicoline is not efficacious in the treatment of moderateto-severe acute ischaemic stroke.

  • Incidence, determinants, and prognostic implications of true pleomorphism of ventricular tachycardia in patients with implantable cardioverter-defribillators: a substudy of the DATAS trial

     Hadid, Claudio; Almendral Garrote, Jésus; Ortiz, Mercedes; Schwab, Joerg Otto; Janko, Sabine; Mischke, Karl; Arribas Ynsaurriaga, Fernando; Wolpert, Christian; Ricci, Renato; Adragao, Pedro; Cobo Valeri, Erik; Navarro, Xavier; Quesada, Aurelio
    Circulation. Arrhythmia and electrophysiology
    Date of publication: 2011-02
    Journal article

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    Background-The occurrence of monomorphic ventricular tachycardia (M-VT) with >1 QRS morphology during the same episode (pleomorphism [PL]) or in different episodes (multiple morphologies [MM]) has been described through ECG. Implantable cardioverter-defribillator (ICD) electrograms (EGs) provide the opportunity to analyze virtually all spontaneous M-VT episodes. We sought to study the incidence, determinants, and prognostic significance of PL and MM as assessed by ICD-EG in a prospective series of patients with ICDs. Methods and Results-Spontaneous episodes of M-VT were analyzed before ICD intervention. PL was defined as >1 ICD-EG morphology, each having >6 consecutive identical beats during the same VT episode, and MM as >1 ICD-EG morphology in different M-VT episodes in the same patient. We analyzed 1881 M-VT episodes from 315 patients followed for 17 months. PL and MM occurred in 6% and 19%, respectively, of the total population (16% and 62% of patients with M-VT). Recurrent M-VT as diagnosis for ICD indication predicted PL and MM. Patients with PL more frequently developed MM (85% versus 15%; P=0.001) compared to patients without PL. Total mortality (5%) was significantly higher in patients with PL (20%), in patients with MM (11.5%), and in women (12%). In multivariate analysis, only PL (odds ratio, 5.33; P<0.009) and female sex (odds ratio, 3.1; P<0.038) predicted mortality. Conclusions-In a prospective series of patients with ICDs, mostly indicated for secondary prevention, both PL and MM of VT, as judged by ICD-EG, were not uncommon and were strongly associated. Female sex and the development of PL VT were the only independent predictors of mortality. © 2011 American Heart Association, Inc.

    Background— The occurrence of monomorphic ventricular tachycardia (M-VT) with >1 QRS morphology during the same episode (pleomorphism [PL]) or in different episodes (multiple morphologies [MM]) has been described through ECG. Implantable cardioverter-defribillator (ICD) electrograms (EGs) provide the opportunity to analyze virtually all spontaneous M-VT episodes. We sought to study the incidence, determinants, and prognostic significance of PL and MM as assessed by ICD-EG in a prospective series of patients with ICDs. Methods and Results— Spontaneous episodes of M-VT were analyzed before ICD intervention. PL was defined as >1 ICD-EG morphology, each having ≥6 consecutive identical beats during the same VT episode, and MM as >1 ICD-EG morphology in different M-VT episodes in the same patient. We analyzed 1881 M-VT episodes from 315 patients followed for 17 months. PL and MM occurred in 6% and 19%, respectively, of the total population (16% and 62% of patients with M-VT). Recurrent M-VT as diagnosis for ICD indication predicted PL and MM. Patients with PL more frequently developed MM (85% versus 15%; P<0.001) compared to patients without PL. Total mortality (5%) was significantly higher in patients with PL (20%), in patients with MM (11.5%), and in women (12%). In multivariate analysis, only PL (odds ratio, 5.33; P=0.009) and female sex (odds ratio, 3.1; P=0.038) predicted mortality. Conclusions— In a prospective series of patients with ICDs, mostly indicated for secondary prevention, both PL and MM of VT, as judged by ICD-EG, were not uncommon and were strongly associated. Female sex and the development of PL VT were the only independent predictors of mortality.

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    Preventing ventricular dysfunction in pacemaker patients without advanced heart failure: Results from a multicentre international randomized trial (PREVENT-HF)  Open access

     Stockburger, Martin; Gómez Doblas, Juan José; Lamas, Gervasio; Alzueta Rodriguez, Francisco Javier; Fernández Lozano, Ignacio; Cobo Valeri, Erik; Wiegand, Uwe; Fernández de la Concha, Joaquín; Navarro, Xavier; Navarro López, Francisco; de Teresa Galván, Eduardo
    European journal of heart failure
    Date of publication: 2011-06
    Journal article

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    AimsPrevious experimental and clinical studies have consistently suggested that right ventricular (RV) apical pacing has important adverse effects. Ventricular pacing (VP), however, is required, and cannot be reduced in many patients with atrioventricular (AV) block. The PREVENT-HF study was an international randomized trial that explored differences in left ventricular (LV) remodelling during RV apical vs. biventricular (BIV) pacing in patients with AV block.Methods and ResultsPatients with an expected VP prevalence <80 were assigned to RV apical or BIV pacing. The primary endpoint was the change in LV end-diastolic volume (EDV) >12 months. Secondary endpoints were LV end-systolic volume (ESV), LV ejection fraction (EF), mitral regurgitation (MR), and a combination of heart failure (HF) events and cardiovascular hospitalizations. Overall, 108 patients were randomized (RV: 58; BIV: 50). Intention to treat and on-treatment analyses revealed no significant differences in any of the outcomes. Analysis of covariance (ANCOVA) difference for treatment according to randomization (in mL): LVEDV -3.92 (-18.71 to 10.85), P 0.6; LVESV -1.38 (-12.07 to 9.31), P 0.80; LVEF 2.47 (-3.00 to 7.94), P 0.37. Analysis of covariance difference for the on-treatment analysis: LVEDV -4.90 (-20.02 to 10.22, PP 0.52; LVESV -6.45 (-17.28 to 4.38), P 0.24, LVEF 2.18 (-3.37 to 7.73), P 0.44. Furthermore, secondary endpoints did not differ significantly.ConclusionThis study did not demonstrate significant LV volume differences >12 months between RV apical and BIV pacing for AV block. Thus, BIV pacing cannot be recommended as a routine treatment for AV block in these patients. However, the results encourage and inform the design of subsequent larger trials with higher power for detecting small volume changes. © 2011 The Author.

    Aims Previous experimental and clinical studies have consistently suggested that right ventricular (RV) apical pacing has important adverse effects. Ventricular pacing (VP), however, is required, and cannot be reduced in many patients with atrioventricular (AV) block. The PREVENT-HF study was an international randomized trial that explored differences in left ventricular (LV) remodelling during RV apical vs. biventricular (BIV) pacing in patients with AV block. Methods and Results Patients with an expected VP prevalence ≥80% were assigned to RV apical or BIV pacing. The primary endpoint was the change in LV end-diastolic volume (EDV) >12 months. Secondary endpoints were LV end-systolic volume (ESV), LV ejection fraction (EF), mitral regurgitation (MR), and a combination of heart failure (HF) events and cardiovascular hospitalizations. Overall, 108 patients were randomized (RV: 58; BIV: 50). Intention to treat and on-treatment analyses revealed no significant differences in any of the outcomes. Analysis of covariance (ANCOVA) difference for treatment according to randomization (in mL): LVEDV −3.92 (−18.71 to 10.85), P= 0.6; LVESV −1.38 (−12.07 to 9.31), P= 0.80; LVEF 2.47 (−3.00 to 7.94), P= 0.37. Analysis of covariance difference for the on-treatment analysis: LVEDV −4.90 (−20.02 to 10.22, PP= 0.52; LVESV −6.45 (−17.28 to 4.38), P= 0.24, LVEF 2.18 (−3.37 to 7.73), P= 0.44. Furthermore, secondary endpoints did not differ significantly. Conclusion This study did not demonstrate significant LV volume differences >12 months between RV apical and BIV pacing for AV block. Thus, BIV pacing cannot be recommended as a routine treatment for AV block in these patients. However, the results encourage and inform the design of subsequent larger trials with higher power for detecting small volume changes. ClinicalTrials.gov Identifier: NCT00170326.

  • Effect of using reporting guidelines during peer review on quality of final manuscripts submitted to a biomedical journal: Masked randomised trial

     Cobo Valeri, Erik; Cortes Martinez, Jordi; Ribera, Josep Maria; Cardellach López, Francesc; Selva, Albert; Kostov, Belchin Adriyanov; Garcia, L.; Cirugeda, L.; Altman, D.G.; Gonzalez Alastrue, Jose Antonio; Sanchez Espigares, Jose Antonio; Miras, Francesc; Urrutia, Agustí; Fonollosa, Vicenç; Rey-Joly, Celestino; Vilardell, Miquel
    British medical journal
    Date of publication: 2011-11-26
    Journal article

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  • Effects of Prolonged-Release Torasemide Versus Furosemide on Myocardial Fibrosis in Hypertensive Patients with Chronic Heart Failure: A Randomized, Blinded End Point, Active-Controlled Study

     Anguita, M.; Castro-Beiras, Alfonso; Cobo Valeri, Erik; Coca, Antonio; de Teresa Galván, Eduardo; Díez, Javier; Lopez, B.; Cebollada, Jorge; Diaz, B.; Galve, E.; Gonzalez Juanatey, J.R.; [et, al]
    Clinical therapeutics
    Date of publication: 2011-09
    Journal article

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  • Tanteando a Bolonia: unas experiencias sobre cómo implicar al alumno

     Gonzalez Alastrue, Jose Antonio; Cobo Valeri, Erik; Rius Carrasco, Roser
    Congreso Nacional de Estadística e Investigación Operativa
    Presentation's date: 2010-09-15
    Presentation of work at congresses

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    A web-based learning tool improves student performance in statistics: a randomized masked trial  Open access

     Gonzalez Alastrue, Jose Antonio; Jover, Lluís; Cobo Valeri, Erik; Muñoz Gracia, Maria del Pilar
    Computers and education
    Date of publication: 2010-03
    Journal article

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    Background: e-status is a web-based tool able to generate different statistical exercises and to provide immediate feedback to students’ answers. Although the use of Information and Communication Technologies (ICTs) is becoming widespread in undergraduate education, there are few experimental studies evaluating its effects on learning. Method: All of the students (121) from an introductory course for statistics in dentistry were randomly assigned to use the tool with one of two 6-problem sets, known as types A and B. The primary endpoint was the grade difference obtained in the final exam, composed of two blocks of questions related to types A and B. The exam evaluator was masked to the intervention group. Results: We found that the effect of e-status on the student grade was an improvement of 0.48 points(95% CI:0.10-0.86) on a ten-point scale. Among the 94 students who actually employed e-status, the effect size was 0.63 (95% CI: 0.17-1.10). Conclusions: It is feasible to formally assess the learning effect of an innovative tool. Providing e-status exercises to students has a direct effect on learning numerical operations related to statistics. Further effects on higher cognitive levels still have to be explored.

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    Boosting the chances to improve stroke treatment  Open access

     Cobo Valeri, Erik; Secades Ruiz, Julio José; Miras, Francesc; Gonzalez Alastrue, Jose Antonio; Saver, Jeffrey L.; Corchero García, Cristina; Rius Carrasco, Roser; Dávalos Errando, Antoni
    Stroke
    Date of publication: 2010-03
    Journal article

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    Background and Purpose— There is a lack of agreement regarding measuring the effects of stroke treatment in clinical trials, which often relies on the dichotomized value of 1 outcome scale. Alternative analyses consist mainly of 2 strategies: use all the information from an ordinal scale and combine information from several outcome scales in a single estimate. Methods— We reanalyzed 3 outcome scales that assessed patient recovery (modified Rankin Scale, National Institutes of Health Stroke Scale, and Barthel Index). With data collected from the 1652 patients in the Citicoline pooling data analysis, we used 2 standard techniques of exploratory multivariate analysis to analyze the distances among ranks and to isolate the common and the unique information provided by each of the 3 scales. Results— The different scale values correspond to gradually different patient status, confirming that information is lost when a scale is collapsed to just 2 values, whether recovered or not. The scales shared 90.7% (95% CI, 84.5–96.9) of their information, with no individual scale contributing unique information. Conclusions— Salient stroke outcome information is lost when an ordinal scale is collapsed into fewer categories. In contrast, the full scales provide a comprehensive patient outcome estimate. Furthermore, in the context of stroke clinical trials, those scales are highly correlated, providing the rationale to pool them into a single estimate. These insights may be used to optimize the analysis of stroke trials to increase study power to detect efficacious interventions

  • Un paseo estadístico por las guías de publicación

     Cortes Martinez, Jordi; Cobo Valeri, Erik
    Date of publication: 2010
    Book chapter

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  • Multivariate variance components linkage analysis applications to the search of genes related to complex diseases

     Buil Demur, Alfonso Alberto
    Defense's date: 2010-10-21
    Department of Statistics and Operations Research, Universitat Politècnica de Catalunya
    Theses

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  • Is the Internet making markets more efficient? The evidence according to price indicators in Spain

     Sabate Garriga, Ferran; Cañabate Carmona, Antonio; Cobo Valeri, Erik; Garcia, D
    Intangible capital
    Date of publication: 2009-04
    Journal article

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  • The Glycemia in Acute Stroke Study Response

     Fuentes, B; Castillo Sánchez, José; Cobo Valeri, Erik; Diez Tejedor, Exuperio
    Stroke
    Date of publication: 2009-07
    Journal article

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  • Eficiencia en ensayos clínicos según método de análisis y fiabilidad de la medida.

     Medina Suarez, Maria Anunciación
    Defense's date: 2009-07-13
    Department of Statistics and Operations Research, Universitat Politècnica de Catalunya
    Theses

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  • Efficiency in the design of clinical trials with ordinal scales

     Torres, Juan Vicente; Cortés, Jordi; Gonzalez Alastrue, Jose Antonio; Muñoz Gracia, Maria del Pilar; Sánchez, Josep Anton; Secades Ruiz, Julio José; Cobo Valeri, Erik
    Conferencia Española de Biometría
    Presentation's date: 2009-09
    Presentation of work at congresses

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    The most popular statistical methods for analyzing ordinal data are reviewed in this work. Theoretical results are compared to empirical results by means of simulations. It is shown how the efficiency of the trial can be considerably improved if the statistical analysis controls the intrasubject variability

  • Investigar en atención primaria: La información adecuada como punto de partida

     Cobo Valeri, Erik
    Jornadas de Actualización semFYC-Novartis
    Presentation's date: 2009-02-26
    Presentation of work at congresses

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    Torafic study protocol: torasemide prolonged release versus furosemide heart failure  Open access

     Díez, Javier; Coca, Antonio; de Teresa Galván, Eduardo; Anguita, Manuel; Castro-Beiras, Alfonso; Conthe, Pedro; Cobo Valeri, Erik; Fernández, Ester
    Expert review of cardiovascular therapy
    Date of publication: 2009
    Journal article

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    Loop diuretics, such as torasemide and furosemide, are important agents in the treatment of chronic heart failure. Beneficial effects of torasemide immediate-release formulation beyond diuresis have been documented as the ability of this compound to inhibit myocardial synthesis and deposition of collagen type I in patients with chronic heart failure. In addition, torasemide-treated patients, but not furosemide-treated patients, showed decreased serum concentrations of the C-terminal propeptide of procollagen type I, a biochemical marker of myocardial fibrosis. The aim of the TORAFIC study is to test the efficacy of torasemide prolonged-release formulation (PR) in reducing myocardial fibrosis in chronic heart failure in a large, randomized clinical trial. METHODS: This prospective, Phase IV, randomized, blinded end point, active-controlled clinical trial will randomize 142 patients with chronic heart failure in New York Heart Association functional class II-IV to 8 months treatment with either torasemide-PR (10-40 mg daily) or furosemide (40-160 mg daily). The primary objective is to test the hypothesis that torasemide-PR is superior to furosemide in reducing myocardial fibrosis. The primary outcome measure is the difference in the change of serum propeptide of procollagen type I concentration from the initial to the final visit between both study groups. Secondary outcome measures include all efficacy variables related to heart failure (signs and symptoms, ECG, echocardiogram and serum levels of N-terminal brain natriuretic propeptide). Secondary safety variables are heart rate, blood pressure, laboratory data, adverse events, cardiovascular events (hospital admission, emergency department visits) and quality of life (Minnesota questionnaire). DISCUSSION: This trial will test whether torasemide-PR possesses antifibrotic properties, which may provide an additional benefit beyond diuresis in patients with chronic heart failure.

  • La declaración STROBE o cómo mejorar la presentación de los estudios observacionales

     Fernandez, E; Cobo Valeri, Erik; Guallar Castillon, Pilar
    Gaceta sanitaria
    Date of publication: 2008-04
    Journal article

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  • Impact of anti-tachycardia pacing on atrial fibrillation burden when added on top of preventive pacing algorithms: results of the prevention or termination (POT) trial

     Mont, Lluis; Ruiz Granell, Ricardo; Martínez, Juan Gabriel; Carmona, José Ramon; Fidalgo, Marisa; Cobo Valeri, Erik; Riera, Mireia; Navarro, Xavier
    Europace-European Society of Cardiology
    Date of publication: 2008-01
    Journal article

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  • Dual-chamber defibrillators reduce clinically significant adverse events compared with single-chamber devices: results from the DATAS (Dual chamber and Atrial Tachyarrhythmias Adverse events Study) trial

     Almendral Garrote, Jésus; Arribas Ynsaurriaga, Fernando; Wolpert, C; Ricci, R; Adragao, P; Cobo Valeri, Erik; Navarro, Xavier; Quesada, A
    Europace-European Society of Cardiology
    Date of publication: 2008-05
    Journal article

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  • Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline

     Bolland, Kim; Whitehead, John; Cobo Valeri, Erik; Secades Ruiz, Julio José
    Pharmaceutical statistics
    Date of publication: 2008-01
    Journal article

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  • De la Evidencia Científica a la Decisión Clínica

     Cobo Valeri, Erik
    Escuela de Verano: Evaluación Económica de las Intervenciones Sanitarias
    Presentation's date: 2008-06-17
    Presentation of work at congresses

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  • Stopping a trial early in oncology: for patients or for industry?

     Whitehead, John; Cobo Valeri, Erik
    Annals of oncology
    Date of publication: 2008-08
    Journal article

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    Data analysis and interpretation of results in DATAS trial: reply  Open access

     Cobo Valeri, Erik; Quesada, Aurelio; Arribas Ynsaurriaga, Fernando; Almendral Garrote, Jésus
    Europace-European Society of Cardiology
    Date of publication: 2008-09-16
    Journal article

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    We appreciate the letter from Vardanyan and Kanna, which provides us with the opportunity to clarify some issues about the DATAS trial.

  • La Declaración STROBE o cómo mejorar la presentación de los estudios observacionales

     Fernández, Esteve; Cobo Valeri, Erik; Guallar Castillon, Pilar
    Gaceta sanitaria
    Date of publication: 2008-02-01
    Journal article

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  • ESTADISTICA PER A ENGINYERS INFORMATICS

     Gonzalez Alastrue, Jose Antonio; Cobo Valeri, Erik; Muñoz Gracia, Maria del Pilar; Marti Recober, Manuel
    Date of publication: 2008-11
    Book

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  • Modelos de regresión

     Cobo Valeri, Erik; Corchero García, Cristina
    Date of publication: 2008-10
    Book chapter

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  • Estadística per a enginyers informàtics

     Cobo Valeri, Erik; Gonzalez Alastrue, Jose Antonio; Marti Recober, Manuel; Muñoz Gracia, Maria del Pilar
    Date of publication: 2008
    Book

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  • Métodos de difusión de resultados: ¿ Como conseguir una buena publicación ?

     Cobo Valeri, Erik
    2ª Reunión RETICS - RENEVAS
    Presentation's date: 2008-06-28
    Presentation of work at congresses

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  • Bioestadística per a no Estadístics

     Cobo Valeri, Erik
    2.a Jornada de Recerca de L'Institut Clínic D'Especialitats Médiques y Quirúrgiques
    Presentation's date: 2008-02-08
    Presentation of work at congresses

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  • Conceptos Metodológicos en el Análisis de la Literatura Científica

     Cobo Valeri, Erik
    Taller de Técnicas de Busqueda y Anállisis de la Bibliografía
    Presentation's date: 2008-11-07
    Presentation of work at congresses

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  • Análisis Crítico de un ensayo clínico

     Cobo Valeri, Erik
    Jornadas de Actualización semFYC-IFN
    Presentation's date: 2008-10-24
    Presentation of work at congresses

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  • Como ser más eficientes en el desarrollo de fármacos: aspectos estadísticos

     Cobo Valeri, Erik
    JORNADA AMIFE: EL FUTURO DE LA INVESTIGACIÓN CLÍNICA CON FÁRMACOS
    Presentation's date: 2008-05-27
    Presentation of work at congresses

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  • Preventing ventricular dysfunction in pacemaker patients without advanced Herat failure: Rationale and design of the prevent-HF study

     de Teresa Galván, Eduardo; Gómez Doblas, Juan José; Gervasio, Lamas; Alzuela, Javier; Fernández Lozano, Ignacio; Cobo Valeri, Erik; Navarro, Xavier; Navarro López, Francisco; Stockburger, Martin
    Europace-European Society of Cardiology
    Date of publication: 2007-01
    Journal article

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  • Discordance between reported intention-to-treat and per protocol analyses

     Porta Bleda, Nuria; Bonet Bonet, Catalina; Cobo Valeri, Erik
    Journal of clinical epidemiology
    Date of publication: 2007-07
    Journal article

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  • Statistical Reviewers Improve Reporting in Biomedical Articles: A Randomized Trial

     Cobo Valeri, Erik; Selva-O'Callagham, Albert; Ribera, Josep Maria; Cardellach López, Francesc; Domínguez Pareto, Ruth; Vilardell, Miquel
    PLoS One
    Date of publication: 2007-03-28
    Journal article

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  • Desarrollo Profesional "Metaanálisis"

     Cobo Valeri, Erik
    Jano. Medicina y Humanidades
    Date of publication: 2007-02
    Journal article

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  • Importancia del análisis estadístico en la preparación de un artículo

     Cobo Valeri, Erik; Domínguez Pareto, Ruth; Josep, Segú Lluís
    Date of publication: 2007-01
    Book chapter

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  • Disease and clinical trials modelling: a case study

     Abbas Abbas, Ismail; Rovira Forns, Joan; Cobo Valeri, Erik; Romeu Robert, Jordi; Casanovas Garcia, Jose
    Date of publication: 2007-11
    Book chapter

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  • Bioestadística para no estadísticos: bases para interpretar un estudio científico

     Cobo Valeri, Erik; Muñoz Gracia, Maria del Pilar; Gonzalez Alastrue, Jose Antonio; Corchero García, Cristina; Bigorra, Joan; Miras, Francesc; Selva, Albert; Videla, Sebastià
    Date of publication: 2007-09
    Book

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  • Investigación Clínica. Transparencia y divulgación. Conferencia Clausura

     Cobo Valeri, Erik
    Jornadas FACME. Las profesiones sanitarias y la prescripción colegio oficial de médicos de Madrid.
    Presentation's date: 2007-05-09
    Presentation of work at congresses

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  • E-status and the employment of reporting guidelines in teaching medicals postgraduates

     Cobo Valeri, Erik
    Burwalls Conference. Annual Meeting for teachers of medical statistics.
    Presentation's date: 2007-04-11
    Presentation of work at congresses

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  • Valor inicial en el análisis de ensayos clínicos en las sesiones científicas del congreso

     Cobo Valeri, Erik
    XI Conferencia española y 1er encuentro Iberoamericano de Biometría
    Presentation's date: 2007-06-20
    Presentation of work at congresses

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  • Incorporación de Actividades "Web-Based" en el aprendizaje de la bioestadística en Odontología: Evaluación experimental y valoración del alumnado

     Cobo Valeri, Erik
    IV Trobada de Professorat de Ciències de la Salut. XI Jornades de Docència de Medicina
    Presentation's date: 2007-06-01
    Presentation of work at congresses

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  • Preparación de un protocolo de Investigación Clínica

     Cobo Valeri, Erik
    Fundación ESAME
    Presentation's date: 2007-03-08
    Presentation of work at congresses

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  • Desarrollo y aplicación de nuevas tecnologías para la formación universitaria

     Gonzalez Alastrue, Jose Antonio; Cobo Valeri, Erik; Marti Recober, Manuel; Muñoz Gracia, Maria del Pilar
    Teoría de la educación. Educación y cultura en la sociedad de la información ¿ TESI
    Date of publication: 2006-03
    Journal article

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  • Implantación de semi-presencialidad en una asignatura optativa de la licenciatura en ciencias y técnicas estadísticas

     Cobo Valeri, Erik; Gonzalez Alastrue, Jose Antonio
    Teoría de la educación. Educación y cultura en la sociedad de la información ¿ TESI
    Date of publication: 2006-03
    Journal article

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  • Simulation models for optimizing the design of clinical trials

     Abbas Abbas, Ismail; Rovira, J; Cobo Valeri, Erik; Casanovas Garcia, Jose
    Quality and reliability engineering international
    Date of publication: 2006-06
    Journal article

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