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  • Poly(butylene azelate-co-butylene succinate) copolymers: Crystalline morphologies and degradation

     Diaz Andrade, Angelica Maria; Franco Garcia, Maria Lourdes; Estrany Coda, Francisco; Del Valle Mendoza, Luis Javier; Puiggali Bellalta, Jorge
    Polymer degradation and stability
    Date of publication: 2014-01
    Journal article

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    Random copolymers derived from 1,4-butanediol and two dicarboxylic units differing in the parity of the number of methylene groups and length of the polymethylene sequence (i.e. succinic and azelaic acids) were studied in terms of thermal properties, crystalline structure and morphology, crystallization kinetics and biodegradability. All samples were semicrystalline and their thermal properties varied in a wide temperature range. Copolymers crystallized according to the monoclinic a-form of polybutylene succinate and the orthorhombic structure postulated for polybutylene azelate depending on the predominant dicarboxylate unit. The behavior of the copolymer with an intermediate composition was complex due to strong dependence of the predominant crystalline form on crystallization and processing conditions. Interestingly, crystallization into the azelate structure was favored when samples were rapidly cooled from the melt, resulting in an unexpected increase in the degree of crystallinity. Spherulitic morphologies were clearly different (i.e. ringed spherulites and axialites) depending on the preferential crystalline structure. Enzymatic degradability of the two homopolyesters was highly different and could be enhanced by incorporation of comonomer units. Preferential enzymatic attack on amorphous regions highlighted the spherulitic morphologies of copolymers having well developed, distinctive ringed structures. © 2013 Elsevier Ltd. All rights reserved.

  • Scaffolds with tuneable hydrophilicity from electrospun microfibers of polylactide and poly(ethylene glycol) mixtures: morphology, drug release behavior, and biocompatibility

     Llorens Domenjo, Elena; Del Valle Mendoza, Luis Javier; Ferran, Ricard; Rodriguez Galan, Rafael Alfonso; Puiggalí, Jordi
    Journal of polymer research
    Date of publication: 2014-01-29
    Journal article

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    Electrospun mats were obtained from different mixtures of polylactide (PLA) and poly(ethylene glycol) (PEG). Processing conditions were optimized for all compositions and the resulting micro/nanofiber morphologies (i.e., diameter size and surface texture) were characterized by scanning electron microscopy (SEM). NMR and FTIR spectroscopies were employed to verify the final compositions, and thermal properties were evaluated by DSC and TGA. XPS spectroscopy revealed that PEG was mainly deposited on the surfaces of the electrospun micro/nanofibers, leading to smooth textures. Interestingly, PLA/PEG scaffold solubility in ethanol was very different to that in water, since a significant amount of PEG was effectively retained in the PLA matrix after immersion in ethanol whereas only a low level of PEG was retained in the PLA matrix after immersion in water. The hydrophilicities of the scaffolds obtained from PLA/PEG mixtures were consequently higher than that of the PLA, even after exposure to water. As PEG can be used as a sacrificial polymer due to its high solubility in water, it was possible to increase the porosity of PLA/PEG scaffolds. PLA/PEG scaffolds loaded with triclosan (TCS) had very different release profiles in hydrophilic (e. g., PBS) and hydrophobic (e. g., Srensen/ethanol 30: 70v/v) media, while differences were small between scaffolds with different PLA/PEG ratios. TCS-loaded scaffolds exhibited good antibacterial properties for all compositions and allowed the adhesion of epithelial cells (i.e., MDCK and VERO). Significant differences in cell proliferation were found between unloaded and TCS-loaded scaffolds due to the clear improvement in cell colonization observed with increasing PEG content.

  • Analysis of quinolone-resistance in commensal and diarrheagenic escherichia coli isolates from infants in lima, Peru

     Pons, María Jesús; Mosquito, Susan; Gomes, Cláudia; Del Valle Mendoza, Luis Javier; Ochoa, Theresa J.; Ruiz Blazquez, Joaquim
    Transactions of the Royal Society of Tropical Medicine and Hygiene
    Date of publication: 2014-01
    Journal article

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    Background: Antibiotic resistance is an increasing problem, particularly in countries where antibiotic use is frequently not controlled. The aim of this study was to analyse the prevalence of the molecular mechanisms of quinolone-resistance in E. coli isolated from faeces of healthy Peruvian children or those presenting diarrhoea. Methods: The presence of target mutations, transferable quinolone-resistance mechanisms and the role of Phe-Arg-b-Naphtylamyde inhibitible efflux pumps were studied in 96 Escherichia coli (46 diarrheogenic and 50 non-diarrheogenic) isolates exhibiting resistance or diminished susceptibility to quinolones. Results: The most resistant phenotype, NalR and CipR, was most frequently present in isolates of healthy children. The distribution of quinolone resistance mechanisms between diarrheogenic (DEC) and commensal (non DEC) isolates was equitable, although the aac(6')Ib-cr gene was mainly detected in DEC isolates: 17 (34%) vs non DEC isolates nine (20%). QnrB was present in five (10%) DEC vs three (6%) non DEC isolates. Conclusions: Point mutations in gyrA and parC genes play a relevant role in quinolone resistance acquisition and highlight the role of efflux pumps also. This study provides knowledge about the molecular mechanisms involved in quinolone resistance in isolates in a non exposed population under high community antibiotic pressure. © The Author 2013. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.All rights reserved.

  • Mineralization of DNA into nanoparticles of hydroxyapatite

     Bertran Cànovas, Oscar; Del Valle Mendoza, Luis Javier; Revilla Lopez, Guillermo; Chaves Barboza, Gustavo Adolfo; Cardus Andreu, Lluis; Casas Becerra, M. Teresa; Casanovas Salas, Jordi; Turon, Pau; Puiggali Bellalta, Jorge; Aleman Llanso, Carlos Enrique
    Dalton transactions
    Date of publication: 2014-01-07
    Journal article

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    Encapsulation of DNA into hydroxyapatite (HAp) has been investigated using a rational approach that involves computer simulation and experimental techniques. The temporal evolution of the radial distribution functions derived from atomistic molecular dynamics simulations of Ca2+, PO 4 3- and OH--containing aqueous solutions in the presence and absence of B-DNA has been used to conclude that the backbone of the double helix acts as a template for HAp growth. More specifically, results reveal the formation of calcium phosphate clusters at the first stages of the simulations, which subsequently re-organize to nucleate HAp. This effect is produced in the absence and, especially, presence, of DNA indicating that the biomolecules do not inhibit but even promote mineral growth. Furthermore, computer simulations suggest that the diffusion of the OH- anions through the inorganic solution is the limiting step for the nucleation of the biomineral. Nanocapsules and crystalline nanorods of HAp containing DNA molecules inside have been prepared by mixing solutions containing Ca 2+ and PO4 3- ions with fish sperm DNA at high pH. The dimensions and morphology of such nanostructures have been examined by transmission electron microscopy, while the characterization of the biomineral has been focused on the identification of DNA inside HAp using infrared, X-ray photoelectron and UV-vis spectroscopies, as well as gel electrophoresis. The biominerals reported in this work are important for biomedical applications requiring the protection of DNA from aggressive environmental conditions. © 2014 The Royal Society of Chemistry.

  • Polythiophene-g-poly(ethylene glycol) graft copolymers for electroactive scaffolds

     Bendrea, Anca Dana; Fabregat Jove, Georgina; Torras Costa, Juan; Maione, Silvana; Cianga, Ioan; Del Valle Mendoza, Luis Javier; Cianga, Luminita; Aleman Llanso, Carlos Enrique
    Journal of materials chemistry B
    Date of publication: 2013
    Journal article

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    The properties, microscopic organization and behavior as the cellular matrix of an all-conjugated polythiophene backbone (PTh) and well-defined poly(ethylene glycol) (PEG) grafted chains have been investigated using different experimental techniques and molecular dynamic simulations. UV-vis spectroscopy has been used to determine the optical band gap, which has been found to vary between 2.25 and 2.9 eV depending on the length of the PEG chains and the chemical nature of the dopant anion, and to detect polaron ¿ bipolaron transitions between band gap states. The two graft copolymers have been found to be excellent cellular matrices, their behavior being remarkably better than that found for other biocompatible polythiophene derivatives [e.g. poly(3,4-ethylenedioxythiophene)]. This is fully consistent with the hydrophilicity of the copolymers, which increases with the molecular weight of the PEG chains, and the molecular organization predicted by atomistic molecular dynamics simulations. Graft copolymers tethered to the surface tend to form biphasic structures in solvated environments (i.e. extended PTh and PEG fragments are perpendicular and parallel to the surface, respectively) while they collapse onto the surface in desolvated environments. Furthermore, the electrochemical activity and the maximum of current density are remarkably higher for samples coated with cells than for uncoated samples, suggesting multiple biotechnological applications in which the transmission with cells is carried out at the electrochemical level.

  • Factors affecting caregivers' use of antibiotics available without a prescription in Peru

     Ecker, Lucie; Ochoa, Theresa J.; Vargas, Martha; Del Valle Mendoza, Luis Javier; Ruiz Blazquez, Joaquim
    Pediatrics
    Date of publication: 2013-06
    Journal article

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    OBJECTIVE: To determine factors that affect caregivers' decisions about antibiotic use in children in settings where antibiotics are available without prescription. METHODS: In a house-to-house survey, 1200 caregivers in 3 periurban districts of Lima, Peru, were asked about antibiotic use in young children. RESULTS: In this sample, 87.2% of children aged ,5 years had received an antibiotic drug in their lives; 70.3% had received antibiotics before 1 year of age, and 98.8% of those had been prescribed by a physician. Given hypothetical cases of common cold and nondysenteric diarrhea, caregivers would seek medical advice in 76.4% and 87.1%, respectively, and 84.6% of caregivers said they respected medical decisions even if an antibiotic was not prescribed. Caregivers with high school-level education accepted 80% more medical decisions of not using an antibiotic and used fewer pharmacist-recommended antibiotics. For each additional year of life, the risk of self-medicated antibiotic use and the use of pharmacistrecommended antibiotics increased in 30%. (OR: 1.3, 95% CI: 1.1-1.4, P = .001 and OR: 1.3, 95% CI: 1.2-1.5, P < .001, respectively). Caregivers respected a medical decision of not prescribing an antibiotic 5 times more when physicians had explained the reason for their advice (OR: 5.0, 95% CI: 3.2-7.8, P < .001). CONCLUSIONS: Prescribed antibiotic use in these young children is common. Even if they are available without prescription, caregivers usually comply with medical advice and follow physicians' recommendations when antibiotics are not prescribed. Improving physician prescribing habits could reduce irrational antibiotic use, decreasing future caregiver-driven misuse.

  • Hybrid materials consisting of an all-conjugated polythiophene backbone and grafted hydrophilic poly(ethylene glycol) chains

     Bendrea, Anca Dana; Fabregat Jove, Georgina; Cianga, Luminita; Estrany Coda, Francisco; Del Valle Mendoza, Luis Javier; Cianga, Ioan; Aleman Llanso, Carlos Enrique
    Polymer Chemistry
    Date of publication: 2013-03-01
    Journal article

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    Organic hybrid materials consisting of an all-conjugated polythiophene backbone and well-defined poly(ethylene glycol) (PEG) grafted chains have been prepared by anodic polymerization of chemically synthesized macromonomers. The latter consist of a pentathiophene sequence in which the central ring bears a PEG chain with Mw = 1000 or 2000 at the 3-position. The influence of the polymerization potential, the length of the PEG branches and the dopant agent on the structure and properties of the graft copolymers has been examined. The chemical structure of the grafted materials has been corroborated by FTIR and X-ray photoelectron spectroscopies. Scanning electron microscopy and atomic force microscopy studies reveal that the morphology and topography of these materials are influenced by the above mentioned factors, even though homogeneous films showing a compact distribution of nanoaggregates, very flat surfaces (i.e. roughness < 15 Å) and nanometric thickness (i.e. 100¿500 nm) were obtained in all cases. Cyclic voltammetry assays have been used to determine the presence of charged species, the electroactivity, the electrostability and the formation of cross-links. The electrochemical stability of the copolymer with grafted PEG chains of Mw = 1000 has been found to increase with the number of consecutive oxidation¿reduction cycles (self-electrostabilizing behavior). Finally, a preliminary investigation into the applicability of these hybrid materials as active surfaces for the selective adsorption of proteins is presented.

  • Amphiphilic polythiophenes- A multifunctional biomedical platform

     Bendrea, Anca-Dana; Cianga, Luminita; Fabregat Jove, Georgina; Del Valle Mendoza, Luis Javier; Aleman Llanso, Carlos Enrique; Timur, Suna; Cianga, Ioan
    Conference on Colloid and Surface Chemistry
    Presentation's date: 2013-05-09
    Presentation of work at congresses

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  • Nanospheres and nanocapsules of amphiphilic copolymers constituted by methoxypolyethylene glycol cyanoacrylate and hexadecyl cyanoacrylate units

     Valente, Ilaria; Del Valle Mendoza, Luis Javier; Casas Becerra, M. Teresa; Franco Garcia, Maria Lourdes; Rodriguez Galan, Rafael Alfonso; Puiggali Bellalta, Jorge; Marchisio, D.
    Express polymer letters
    Date of publication: 2013-01
    Journal article

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  • Bioactive nanomembranes of semiconductor polythiophene and thermoplastic polyurethane: Thermal, nanostructural and nanomechanical properties

     Perez Madrigal, Maria Del Mar; Giannotti, Marina I.; Oncins Marco, Gerard; Franco Garcia, Maria Lourdes; Armelin Diggroc, Elaine; Puiggali Bellalta, Jorge; Sanz Carrasco, Fausto; Del Valle Mendoza, Luis Javier; Aleman Llanso, Carlos Enrique
    Polymer Chemistry
    Date of publication: 2013-02-07
    Journal article

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  • Electrospun nanofibers of a degradable poly(ester amide). Scaffolds loaded with antimicrobial agents

     Del Valle Mendoza, Luis Javier; Roa Ardilla, Manuel; Diaz Andrade, Angelica Maria; Casas Becerra, M. Teresa; Puiggali Bellalta, Jorge; Rodriguez Galan, Rafael Alfonso
    Journal of polymer research
    Date of publication: 2012-01
    Journal article

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  • An electroactive and biologically responsive hybrid conjugate based on chemical similarity

     Fabregat Jove, Georgina; Ballano Ballano, María Gema; Armelin Diggroc, Elaine; Del Valle Mendoza, Luis Javier; Cativiela, Carlos; Aleman Llanso, Carlos Enrique
    Polymer Chemistry
    Date of publication: 2012-11-20
    Journal article

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    Synthetic amino acids have become very important tools for the design of new materials. In this work, an electroactive polymer¿amino acid hybrid material has been synthesized by conjugating poly(3,4-ethylenedioxythiophene) (PEDOT), a well known conducting polymer, with a synthetic amino acid bearing 3,4-ethylenedioxythiophene, which has been explicitly designed and prepared for such a purpose. Nanometric films have been electrochemically generated using a two-step procedure to evaluate the properties and potential applications of the resulting hybrid material. The successful incorporation of the amino acid as end-capping of the PEDOT chains has been proved by FTIR, energy dispersive X-ray and X-ray photoelectron spectroscopies. The fabrication of the hybrid material using an engineered tissue has allowed us to preserve not only morphological and structural characteristics of the conducting polymer but also, and most importantly, to preserve the electrical conductivity, electroactivity, electrochemical stability and specific capacitance. Finally, the behavior of the hybrid material as a cellular matrix has been compared with that of PEDOT using cellular adhesion and proliferation assays. Results obtained in this work represent the success of a new strategy for the preparation of peptide-conducting polymer hybrid materials, which is currently being improved upon by transforming the 3,4-ethylenedioxythiophene-containing amino acid into a cell adhesive peptide

  • Bioactive and electroactive response of flexible polythiophene:Polyester nanomembranes for tissue engineering

     Perez Madrigal, Maria Del Mar; Armelin Diggroc, Elaine; Del Valle Mendoza, Luis Javier; Estrany Coda, Francisco; Aleman Llanso, Carlos Enrique
    Polymer Chemistry
    Date of publication: 2012-04
    Journal article

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  • Examining the formation of specific interactions between poly(3,4-ethylenedioxythiophene) and nucleotide bases

     Zanuy Gomara, David; da Cruz Teixeira Dias, Bruno José; Del Valle Mendoza, Luis Javier; Poater, Jordi; Solà, Miquel; Aleman Llanso, Carlos Enrique
    RSC Advances
    Date of publication: 2012-12-17
    Journal article

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  • Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

     Del Valle Mendoza, Luis Javier; Diaz Andrade, Angelica Maria; Royo, M.; Rodriguez Galan, Rafael Alfonso; Puiggali Bellalta, Jorge
    Express polymer letters
    Date of publication: 2012
    Journal article

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  • A conducting polymer/protein composite with bactericidal and electroactive properties

     Teixeira Dias, Bruno; Del Valle Mendoza, Luis Javier; Aradilla Zapata, David; Estrany Coda, Francisco; Aleman Llanso, Carlos Enrique
    Macromolecular materials and engineering
    Date of publication: 2012-05
    Journal article

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  • Levels of quinolones resistance and other antimicrobial in non-pathogenic escherichia coli strains in children from the Periurban area of lima, Peru

     Ruiz Blazquez, Joaquim; Pons, María Jesús; Mosquito, Susan; Ochoa, Theresa J.; Vargas, Martha; Molina, Margarita; Lluque, A.; Gil, A.I.; Ecker, L.; Barletta, F.; Lanata, C.F.; Del Valle Mendoza, Luis Javier
    Revista Peruana de Medicina Experimental y Salud Publica
    Date of publication: 2012-03
    Journal article

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  • Dextrin- and conducting-polymer-containing biocomposites: Properties and behavior as cellular matrix

     Teixeira Dias, Bruno; Del Valle Mendoza, Luis Javier; Estrany Coda, Francisco; Mano, J.F.; Reis, Rui Luís; Aleman Llanso, Carlos Enrique
    Macromolecular materials and engineering
    Date of publication: 2012-04
    Journal article

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  • Influence Of Composition And Microstructure On Properties Of New Trimethylene Carbonate/Glycolide Copolymers With Biomedical Applications

     Díaz Celorio, Elena
    Defense's date: 2012-07-23
    Department of Chemical Engineering, Universitat Politècnica de Catalunya
    Theses

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    Long time survival of Bartonella bacilliformis in blood stored at 4 ºC. A risk for blood transfusions.  Open access

     Ruiz Blazquez, Joaquim; Silva, Wilmer; Pons, María Jesús; Del Valle Mendoza, Luis Javier; Tinco, Carmen R.; Casabona, Veronica D.; Gomes, Cláudia; Bazan, Jorge; Zabaleta, Víctor; Cornejo, Hernán; Champin, Denisse
    Blood transfusion
    Date of publication: 2012-03-29
    Journal article

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  • Biodegradable free-standing nanomembranes of conducting polymer:polyester blends as bioactive platforms for tissue engineering

     Armelin Diggroc, Elaine; Gomes, Alex Linardi; Perez Madrigal, Maria Del Mar; Puiggali Bellalta, Jorge; Franco Garcia, Maria Lourdes; Del Valle Mendoza, Luis Javier; Rodriguez Galan, Rafael Alfonso; Campos, J.S.D.C.; Ferrer Anglada, Nuria; Aleman Llanso, Carlos Enrique
    Journal of materials chemistry B
    Date of publication: 2012-01-14
    Journal article

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  • Binding of 6-mer single-stranded homo-nucleotides to poly(3,4-ethylenedioxythiophene): specific hydrogen bonds with guanine

     da Cruz Teixeira Dias, Bruno José; Zanuy Gomara, David; Poater, Jordi; Solà, Miquel; Estrany Coda, Francisco; Del Valle Mendoza, Luis Javier; Aleman Llanso, Carlos Enrique
    Soft matter
    Date of publication: 2011
    Journal article

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  • Principios y aplicaciones de los arrays de ADN

     Del Valle Mendoza, Luis Javier; Vargas, Martha
    Date of publication: 2011-03-22
    Book chapter

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  • Application of conducting polymers in nanobiotechnology

     Da Cruz teixeira dias, Bruno José
    Defense's date: 2011-10-28
    Department of Chemical Engineering, Universitat Politècnica de Catalunya
    Theses

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  • Electrospinning of polylactide and polycaprolactone mixtures for preparation of materials with tunable drug release properties

     Del Valle Mendoza, Luis Javier; Camps, Roger; Diaz Andrade, Angelica Maria; Franco Garcia, Maria Lourdes; Rodriguez Galan, Rafael Alfonso; Puiggali Bellalta, Jorge
    Journal of polymer research
    Date of publication: 2011-11
    Journal article

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    Nanocomposites of new biodegradable poliesters and polyesteramides  Open access

     Puiggali Bellalta, Jorge; Morales Gámez, Laura Teresa; Franco Garcia, Maria Lourdes; Casas Becerra, M. Teresa; Del Valle Mendoza, Luis Javier; Rodriguez Galan, Rafael Alfonso
    Plastics research online
    Date of publication: 2011-03-16
    Journal article

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    Polymers are easily prepared by bulk polycondensation based on metal-halide salt formation, while crystallization is strongly influenced by incorporation and distribution of silicate nanoparticles.

  • Preparation and release study of ibuprofen-loaded porous matrices of a biodegradable poly(ester amide) derived from L -alanine units

     Del Valle Mendoza, Luis Javier; Roca, Diana; Franco Garcia, Maria Lourdes; Puiggali Bellalta, Jorge; Rodriguez Galan, Rafael Alfonso
    Journal of applied polymer science
    Date of publication: 2011-11
    Journal article

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    Scaffolds of a biodegradable poly(ester amide)constituted of L-alanine, sebacic acid, and 1,12-dodecanediol units (abbreviated as PADAS) were prepared by the compression-molding/particulate-leaching method. The influence of the type, size, and percentage of salt on the scaffold porosity and morphology was evaluated. The thermal behavior and crystallinity were also studied for samples obtained under different processing conditions. PADAS scaffolds were not cytotoxic because they showed good cell viability and supported cell growth at a similar ratio to that observed for the biocompatible materials used as a reference. The use of PADAS scaffolds as a drug-delivery system was also evaluated by the employment of ibuprofen, a drug with well known anti-inflammatory effects. Different drug-loading methods were considered, and their influence on the release in a so¨rensen’s medium was evaluated as well as the influence of the scaffold morphology. A sustained release of ibuprofen could be attained without the production of a negative effect on the cell viability. The release kinetics of samples loaded before melt processing was well described by the combined Higuchi/first-order model. This allowed the estimation of the diffusion coefficients, which ranged between 3x10‾14 and 5x10‾13 m2/ s. Samples loaded by immersion in ibuprofen solutions showed a rapid release that could be delayed by the addition of polycaprolactone to the immersion medium (i.e., the release rate decreased from 0.027 to 0.015 h‾1).

  • Biphasic calcium sulfate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vitro study  awarded activity

     Vlad, Maria Daniela; Del Valle Mendoza, Luis Javier; Poeata, I.; Lopez Lopez, Jose; Torres Camara, Ricardo; Barraco Serra, Marc; Fernandez Aguado, Enrique
    Biomedical materials
    Date of publication: 2010-03
    Journal article

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    In this study, the cytocompatibility of new ‘iron-modified/alpha-tricalcium phosphate (IM/α-TCP) and calcium sulfate dihydrate (CSD)’ bone cement (IM/α-TCP/CSD-BC) intended for spinal applications has been approached. The objective was to investigate by direct-contact osteoblast-like cell cultures (from 1 to 14 days) the in vitro cell adhesion, proliferation, morphology and cytoskeleton organization of MG-63 cells seeded onto the new cements. The results were as follows: (a) quantitative MTT-assay and scanning electron microscopy (SEM) showed that cell adhesion, proliferation and viability were not affected with time by the presence of iron in the cements; (b) double immunofluorescent labeling of F-actin and α-tubulin showed a dynamic interaction between the cell and its porous substrates sustaining the locomotion phenomenon on the cements’ surface, which favored the colonization, and confirming the biocompatibility of the experimental cements; (c) SEM-cell morphology and cytoskeleton observations also evidenced that MG-63 cells were able to adhere, to spread and to attain normal morphology on the new IM/α-TCP/CSD-BC which offered favorable substratum properties for osteoblast-like cells proliferation and differentiation in vitro. The results showed that these new iron-modified cement-like biomaterials have cytocompatible features of interest not only as possible spinal cancellous bone replacement biomaterial but also as bone tissue engineering scaffolds.

    Premi del "National University Research Council" del Ministeri d'Educació i Recerca de Romania, a autors romanesos per l'impacte de la seva recerca.

  • Influence of the doping level on the interactions between poly(3,4-ethylenedioxythiophene) and plasmid DNA

     da Cruz Teixeira Dias, Bruno José; Zanuy Gomara, David; Del Valle Mendoza, Luis Javier; Estrany Coda, Francisco; Armelin Diggroc, Elaine; Aleman Llanso, Carlos Enrique
    Macromolecular chemistry and physics
    Date of publication: 2010-05-17
    Journal article

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    The influence of the doping level in the formation of specific interactions between plasmid DNA and PEDOT is investigated using experimental assays and theoretical calculations. Electrochemical methods are used to prepare polymer samples with oxidation degrees ranging from 0.14 to 1.05 positive charges per repeating unit. A combination of experimental and theoretical results are used to propose a mechanism for the formation of DNA/conducting polymer complexes, which consists of the initial stabilization of the adducts through non-specific interactions followed by small structural re-arrangements that allow to be established specific hydrogen bonds involving the polar groups of the conducting polymer and selected DNA bases.

  • MATERIALES BASADOS EN UNIDADES DE TRIMETILENCARBONATO. NANOCOMPUESTOS DE POLIESTERES Y POLIESTERAMIDAS CON APLICACIONES COMMODITIES

     Casas Becerra, M. Teresa; Franco Garcia, Maria Lourdes; Rodriguez Galan, Rafael Alfonso; Del Valle Mendoza, Luis Javier; Urpi Garriga, Lourdes; Puiggali Bellalta, Jorge
    Participation in a competitive project

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  • The role of viruses in the aetiology of IRA in Peruvian children

     del Valle, J.; Del Valle Mendoza, Luis Javier; Cornejo, A.; Pumarola, T.; Verne, E.; Helasvuo, V.; Nazario, R.; Champin, D.
    International journal of infectious diseases
    Date of publication: 2010-03
    Journal article

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  • Bartonella bacilliformis, endemic pathogen of the Andean region, is intrinsically resistant to quinolones

     Del Valle Mendoza, Luis Javier
    International journal of infectious diseases
    Date of publication: 2010-06
    Journal article

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  • Structural characterization of a zinc high-affinity binding site in rhodopsin

     Darwin, Toledo; Cordomí, Arnau; Proietti, Maria Grazia; Maurizio, Benfatto; Del Valle Mendoza, Luis Javier; Perez Gonzalez, Juan Jesus; Garriga Sole, Pere; Sepulcre Sanchez, Francesc
    Photochemistry and photobiology
    Date of publication: 2009-02
    Journal article

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  • A comprehensive study of the interactions between DNA and poly(3,4-ethylenedioxythiophene)

     Aleman Llanso, Carlos Enrique; da Cruz Teixeira Dias, Bruno José; Zanuy Gomara, David; Estrany Coda, Francisco; Armelin Diggroc, Elaine; Del Valle Mendoza, Luis Javier
    Polymer
    Date of publication: 2009-04
    Journal article

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  • GRUP DE QUÍMICA MACROMOLECULAR

     Casas Becerra, M. Teresa; Franco Garcia, Maria Lourdes; Rodriguez Galan, Rafael Alfonso; Del Valle Mendoza, Luis Javier; Urpi Garriga, Lourdes; Puiggali Bellalta, Jorge
    Participation in a competitive project

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  • High frequency of antimicrobial drug resistance of diarrheagenic Escherichia coli in infants in Peru

     Del Valle Mendoza, Luis Javier
    American journal of tropical medicine and hygiene
    Date of publication: 2009
    Journal article

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  • New poly(ester amide)s containing glycolic acid units: evaluation of biocompatibility

     Del Valle Mendoza, Luis Javier; Sepulcre Sanchez, Francesc; Gamez Lopez, Antonio; Rodriguez Galan, Rafael Alfonso; Puiggali Bellalta, Jorge
    Current trends in polymer science
    Date of publication: 2008-12
    Journal article

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  • New alternating polyesters containing glycolic acid units: Study of biocompatibility

     Del Valle Mendoza, Luis Javier; Martínez-Palau, Meritxell; Gamez Lopez, Antonio; Sepulcre Sanchez, Francesc; Puiggali Bellalta, Jorge
    Current trends in polymer science
    Date of publication: 2008-12
    Journal article

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  • Copolymers of pyrrole and N-(hydroxypropyl)pyrrole: properties and interactions with DNA

     Pfeiffer, P; Armelin Diggroc, Elaine; Estrany Coda, Francisco; Del Valle Mendoza, Luis Javier; Yao, C L; Aleman Llanso, Carlos Enrique
    Journal of polymer research
    Date of publication: 2008-06
    Journal article

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  • Cooperación en investigación biomédica: Bartonelosis, enfermedad endémica del Perú

     Del Valle Mendoza, Luis Javier
    Congreso Universidad y Cooperación al Desarrollo
    Presentation of work at congresses

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  • Cooperación en investigación biomédica: Bartonelosis, enfermedad endémica del Perú.

     Del Valle Mendoza, Luis Javier
    Congreso Universidad y Cooperación al Desarrollo
    Presentation's date: 2008-11-13
    Presentation of work at congresses

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  • Is Bartonella bacilliformis, endemic pathogen of the Andean areas, intrinsically resistant to quinolones?

     Del Valle Mendoza, Luis Javier
    European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Congress
    Presentation's date: 2008-04-19
    Presentation of work at congresses

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  • Structural characterization of zinc high-affinity binding site in rhodopsin

     Toledo, Darwin; Cordomi Montoya, Arnau; Proietti, Maria Grazia; Benfatto, Maurizio; Del Valle Mendoza, Luis Javier; Pérez, Juan J.; Garriga Sole, Pere; Sepulcre Sanchez, Francesc
    International Conference on Retinal Proteins
    Presentation's date: 2008-06-01
    Presentation of work at congresses

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  • High levels of antimicrobial resistance of diarrhoegenic Escherichia coli in peruvian infants.

     Del Valle Mendoza, Luis Javier
    European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Congress
    Presentation's date: 2008-04-19
    Presentation of work at congresses

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  • Injectable iron-modified apatitic bone cement intended for kyphoplasty: cytocompatibility study

     Vlad, M D; Del Valle Mendoza, Luis Javier; Poeata, I; Barraco Serra, Marc; Lopez, J; Torres Camara, Ricardo; Fernandez, E
    Journal of materials science. Materials in medicine
    Date of publication: 2008-10
    Journal article

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  • Iron oxide nanoparticles significantly enhances the injectability of apatitic bone cement for vertebroplasty

     Vlad, M D; Del Valle Mendoza, Luis Javier; Barraco Serra, Marc; Torres Camara, Ricardo; Lopez, J; Fernandez, E
    Spine
    Date of publication: 2008-10
    Journal article

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  • Embryotoxicity of serum from women smoking cocaine base paste (CBP)

     Del Valle Mendoza, Luis Javier; Pella, R; Mercedes, A; Velasquez, L A; Orihuela, P
    European journal of obstetrics gynecology and reproductive biology
    Date of publication: 2008-07
    Journal article

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  • Fenton and photo-Fenton degradation of 2-chlorophenol: Multivariate analysis and toxicity monitoring

     Pérez Moya, Montserrat; Graells Sobre, Moises; Del Valle Mendoza, Luis Javier; Centelles, E; Mansilla, Héctor D.
    Catalysis today
    Date of publication: 2007-06
    Journal article

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  • Symposium 5. Enfermedades ligadas a la pobreza. Un problema en el olvido

     Del Valle Mendoza, Luis Javier
    Congreso Nacional de Microbiología
    Presentation's date: 2007-09-18
    Presentation of work at congresses

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