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  • Apathy in parkinson's disease: Neurophysiological evidence of impaired incentive processing

     Martinez Horta, Saul; Riba Serrano, Jordi; Fernandez De Bobadilla, Ramon; Pagonabarraga, Javier; Pascual Sedano, Berta; Antonijoan, Rosa Maria; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Garcia Sanchez, Carmen; Kulisevsky, Jaime J.
    Journal of neuroscience
    Date of publication: 2014
    Journal article

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    Apathy is one of the most common and debilitating nonmotor manifestations of Parkinson's disease (PD) and is characterized by diminished motivation, decreased goal-directed behavior, and flattened affect. Despite its high prevalence, its underlying mechanisms are still poorly understood, having been associated with executive dysfunction, and impaired emotional processing and decision making. Apathy, as a syndrome, has recently been associated with reduced activation in the ventral striatum, suggesting that early- to middle-stage Parkinson's disease patients with this manifestation may have a compromised mesocorticolimbic dopaminergic pathway and impaired incentive processing. To test this hypothesis, we measured the amplitude of the feedback-related negativity, an event-related brain potential associated with performance outcome valence, following monetary gains and losses in human PD patients (12 women) and healthy controls (6 women) performing a gambling task. Early- to middle-stage PD patients presenting clinically meaningful symptoms of apathy were compared with nonapathetic PD patients and healthy controls. Patients with cognitive impairment, depression, and other psychiatric disturbances were excluded. Results showed that the amplitude of the feedback-related negativity, measured as the difference wave in the event-related brain potential between gains and losses, was significantly reduced in PD patients with apathy compared with nonapathetic patients and healthy controls. These findings indicate impaired incentive processing and suggest a compromised mesocorticolimbic pathway in cognitively intact PD patients with apathy

  • Reduction of metallic interference in MEG signals using AMUSE

     Migliorelli Falcone, Carolina Mercedes; Romero Lafuente, Sergio; Alonso López, Joan Francesc; Nowak, Rafal; Russi Tintoré, Antonio; Mañanas Villanueva, Miguel Angel
    IEEE Engineering in Medicine and Biology Society
    Presentation's date: 2013-07
    Presentation of work at congresses

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    Magnetoencephalography is a technique that can noninvasively measure the brain signal. There are many advantages of using this technique rather than similar procedures such as the EEG for the evaluation of medical diseases. However, one of its main problems is its high sensitivity to sources causing metallic distortion of the signal, and the removal of this type of artifacts remains unsolved. In this study a technique for reducing metallic interference was presented. This algorithm was based on AMUSE, a second order blind source separation method, and a procedure for choosing the artifactual independent components was also presented. The results showed that the elimination of these artifacts would be possible by means of the application of this AMUSE-based interference reduction procedure

    Magnetoencephalography is a technique that can noninvasively measure the brain signal. There are many advantages of using this technique rather than similar procedures such as the EEG for the evaluation of medical diseases. However, one of its main problems is its high sensitivity to sources causing metallic distortion of the signal, and the removal of this type of artifacts remains unsolved. In this study a technique for reducing metallic interference was presented. This algorithm was based on AMUSE, a second order blind source separation method, and a procedure for choosing the artifactual independent components was also presented. The results showed that the elimination of these artifacts would be possible by means of the application of this AMUSE-based interference reduction procedure

  • Cross-conditional entropy and coherence analysis of pharmaco-EEG changes induced by alprazolam

     Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Rojas Martínez, Mónica; Riba Serrano, Jordi
    Psychopharmacology
    Date of publication: 2012-03
    Journal article

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    Rationale Quantitative analysis of electroencephalographic signals (EEG) and their interpretation constitute a helpful tool in the assessment of the bioavailability of psychoactive drugs in the brain. Furthermore, psychotropic drug groups have typical signatures which relate biochemical mechanisms with specific EEG changes. Objectives To analyze the pharmacological effect of a dose of alprazolam on the connectivity of the brain during wakefulness by means of linear and nonlinear approaches. Methods EEG signals were recorded after alprazolam administration in a placebo-controlled crossover clinical trial. Nonlinear couplings assessed by means of corrected cross-conditional entropy were compared to linear couplings measured with the classical magnitude squared coherence. Results Linear variables evidenced a statistically significant drug-induced decrease, whereas nonlinear variables showed significant increases. All changes were highly correlated to drug plasma concentrations. The spatial distribution of the observed connectivity changes clearly differed from a previous study: changes before and after the maximum drug effect were mainly observed over the anterior half of the scalp. Additionally, a new variable with very low computational cost was defined to evaluate nonlinear coupling. This is particularly interesting when all pairs of EEG channels are assessed as in this study. Conclusions Results showed that alprazolam induced changes in terms of uncoupling between regions of the scalp, with opposite trends depending on the variables: decrease in linear ones and increase in nonlinear features. Maps provided consistent information about the way brain changed in terms of connectivity being definitely necessary to evaluate separately linear and nonlinear interactions.

  • Analysis of sleep disturbances related to falls in cirrhotic patients

     Giménez Badia, Sandra; Romero Lafuente, Sergio; Clos, S.; Roman, E.; Soriano Tarin, Guillermo; Antonijoan, R.
    Journal of sleep research
    Date of publication: 2012-09
    Journal article

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  • Waking and sleep electroencephalogram variables as human sleep homeostatic process biomarkers after drug administration

     Giménez Badia, Sandra; Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj Rodriguez, Manel J.
    Neuropsychobiology
    Date of publication: 2011-04-13
    Journal article

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  • Characterization of the cerebral activity by time¿frequency representation of evoked EEG potentials

     Clarià, Francesc; Vallverdú Ferrer, Montserrat; Riba, J; Romero Lafuente, Sergio; Caminal Magrans, Pedro
    Physiological measurement
    Date of publication: 2011-07-15
    Journal article

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  • Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers

     Giménez, S.; Romero Lafuente, Sergio; Gich, I.; Clos, S.; Grasa, E.; Barbanoj Rodriguez, Manel J.
    Human psychopharmacology-Clinical and experimental
    Date of publication: 2011-10
    Journal article

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  • MEG Connectivity Analysis in Patients with Alzheimer¿s Disease Using Cross Mutual Information and Spectral Coherence

     Alonso López, Joan Francesc; Poza Crespo, Jesús; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Fernández Lucas, Alberto; Hornero Sánchez, Roberto
    Annals of biomedical engineering
    Date of publication: 2011-01
    Journal article

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  • Drug effect on EEG connectivity assessed by linear and nonlinear couplings

     Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Hoyer, Dirk; Riba, Jordi; Barbanoj Rodriguez, Manel J.
    Human brain mapping
    Date of publication: 2010-03
    Journal article

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    Quantitative analysis of human electroencephalogram (EEG) is a valuable method for evaluating psychopharmacological agents. Although the effects of different drug classes on EEG spectra are already known, interactions between brain locations remain unclear. In this work, cross mutual information function and appropriate surrogate data were applied to assess linear and nonlinear couplings between EEG signals. The main goal was to evaluate the pharmacological effects of alprazolam on brain connectivity during wakefulness in healthy volunteers using a cross-over, placebo-controlled design. Eighty-five pairs of EEG leads were selected for the analysis, and connectivity was evaluated inside anterior, central, and posterior zones of the scalp. Connectivity between these zones and interhemispheric connectivity were also measured. Results showed that alprazolam induced significant changes in EEG connectivity in terms of information transfer in comparison with placebo. Trends were opposite depending on the statistical characteristics: decreases in linear connectivity and increases in nonlinear couplings. These effects were generally spread over the entire scalp. Linear changes were negatively correlated, and nonlinear changes were positively correlated with drug plasma concentrations; the latter showed higher correlation coefficients. The use of both linear and nonlinear approaches revealed the importance of assessing changes in EEG connectivity as this can provide interesting information about psychopharmacological effects.

  • Benzodiazepine effects on EEG connectivity: linear and nonlinear couplings

     Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Hoyer, Dirk; Riba, J; Barbanoj Rodriguez, Manel J.
    Biennal Congress of the International Pharmaco-EEG Society
    Presentation's date: 2010-10
    Presentation of work at congresses

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  • Reducción de artefactos en señales electroencefalográficas mediante nuevas técnicas de filtrado automático basadas en separación ciega de fuentes  Open access

     Romero Lafuente, Sergio
    Defense's date: 2010-06-21
    Department of Automatic Control, Universitat Politècnica de Catalunya
    Theses

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    El análisis cuantitativo y la interpretación de las señales electroencefalográficas (EEG) permiten la comprensión de la función cerebral, ayudando al diagnóstico de estados disfuncionales. Sin embargo, es conocido que cierta actividad de origen no cortical contribuye también en los registros de EEG, siendo el caso más crítico y relevante el producido por la contaminación debida a la actividad ocular. El método considerado gold standard en neuropsicofarmacología para la reducción de artefactos oculares en señales EEG está basado en la regresión lineal. Sin embargo, esta técnica no sólo reduce la contaminación ocular sino que también elimina cierta actividad cerebral. Por tanto, el desarrollo de nuevos métodos automáticos para la reducción de la actividad ocular presente en las señales EEG, que superen las limitaciones presentadas por los métodos actualmente más utilizados, constituye un paso definitivo en los ensayos clínicos dedicados a evaluar los efectos de un fármaco en el sistema nervioso central. El objetivo principal de la tesis es el diseño y evaluación objetiva de métodos automáticos de filtrado de artefactos oculares en señales EEG espontáneas para la mejora cuantitativa en los estudios de fármaco-EEG. Para ello, se estudian las diferentes situaciones de contaminación ocular en las señales EEG y su problemática bajo la situación de vigilia, mediante bases de datos de registros adquiridos en voluntarios sanos tras la administración de fármacos. Se describen los métodos clásicos de filtrado ocular y la implementación del nuevo método de filtrado automático basado en BSS. La situación más propicia para una evaluación objetiva de los diferentes métodos de filtrado ocular precisa la utilización de señales electrooculográficas (EOG) y EEG simuladas, donde las actividades ocular y cerebral puedan ser conocidas de antemano. Se generan señales simuladas a partir de la mezcla de las actividades ocular y cerebral (extraídas de señales EOG y EEG reales) mediante dos estrategias: mezclas instantáneas y mezclas convolutivas. Se realiza un análisis comparativo de la eficacia de los métodos de filtrado ocular en las señales simuladas. A continuación, se determina el impacto del filtrado ocular en la evaluación de los efectos inducidos por un fármaco en el cerebro, comparando el método propuesto basado en BSS con el procedimiento considerado gold standard.A partir de los resultados obtenidos se puede concluir que el método para la reducción de artefactos oculares basado en BSS propuesto en esta tesis doctoral muestra un mejor comportamiento que el método gold standard tanto en señales simuladas [Romero et al, 2008] [Romero et al, 2009a] como en señales reales [Romero et al, 2009b].Las aportaciones más relevantes de esta tesis son: 1) La implementación de un nuevo método completamente automático para el filtrado de la contaminación ocular en señales EEG. Este método está basado en los algoritmos de BSS AMUSE o SOBI indistintamente, se aplica a segmentos de corta duración, e incluye la detección automática de las componentes fuente asociadas a la actividad ocular. 2) La estimación de modelos MISO que reflejan la propagación de las actividades ocular y cerebral a lo largo del cuero cabelludo. Dichos modelos han permitido aportar información para aclarar la discusión acerca de la dependencia o independencia de la frecuencia en la propagación ocular. Estos resultados afirman que ambas propagaciones de la actividad ocular y cerebral pueden considerarse independientes de la frecuencia, y por tanto totalmente de acuerdo con lo esperado a partir del conocimiento biofísico existente. 3) La realización de una herramienta informática para el procesado de señales EEG en estudios de fármaco-EEG. Esta interfaz gráfica interactiva ya ha empezado a ser utilizada en diversos estudios de evaluación del efecto de un fármaco en el sistema nervioso central [Alonso et al., 2010], por el CIM del Hospital de la Santa Creu i Sant Pau de Barcelona.

    Quantitative analysis and interpretation of electroencefalographic (EEG) signals are useful methods to study functional states of the brain, to evaluate drug effects and to diagnose psychiatric and neurological disorders. However, it is known that non-cortical interferences contribute to EEG recordings. Ocular artifacts are the most relevant and critical interference. The gold standard method in neuropsychopharmacology for reducing ocular contamination is based on linear regression. Nevertheless, this technique not only reduces the ocular contamination, but also cancels relevant cerebral information contained in the electrooculographic (EOG) recordings. In this way, the development of new automatic methods for reducing ocular artifacts in EEG signals, that solve the drawbacks shown by most common used techniques, is a crucial step in the clinical trials that assess the effects of a drug in the central nervous system. The aim of this PhD thesis is the design and the objective evaluation of automatic ocular filtering methods in spontaneous EEG signals in order to quantitatively improve the results and conclusions obtained in pharmaco-EEG studies. Thus, different ocular contamination situations in EEG signals are evaluated in order to understand this problematic situation during wakefulness by means of databases acquired from healthy volunteers after drug administration. The classical ocular filtering methods and the implementation of a new automatic procedure based on blind source separation (BSS) are described. The best situation for an objective evaluation of the different ocular reduction methods needs the use of simulated EOG and EEG signals, where ocular and cerebral activities can be known a priori. Simulated signals are generated from a linear mixture between ocular and cerebral activities (extracted from real EOG and EEG signals) by means of two strategies: instantaneous and convolutive mixing models. A comparative analysis of the effectiveness of the filtering methods on the simulated signals is performed. Next, the influence of ocular filtering procedures in the conclusions drawn from a pharmaco-EEG trial is assessed, comparing the method proposed in this PhD thesis based on BSS with the gold standard procedure.From the results obtained in time and frequency domain, it can be concluded that the method for reducing ocular artifacts based on BSS, developed in this PhD thesis, shows a better performance than the gold standard procedure in simulated signals [Romero et al, 2008] [Romero et al, 2009a] as much as in real signals [Romero et al, 2009b].The most relevant contributions of this thesis are: 1) The implementation of a new completely automatic method for reducing ocular contamination in EEG signals. This procedure is based on the BSS algorithms, AMUSE or SOBI indistinctly, it is applied in short duration segments, and it includes the automatic detection of the source components related to ocular activity. 2) The estimation of MISO models corresponding to the propagation of ocular and cerebral activities across the scalp. These models have contributed with interesting information about the discussion if ocular propagation is frequency dependent or independent. These results conclude that ocular and cerebral propagation can be considered practically frequency independent which is consistent to what would be expected from the biophysics knowledge. 3) The development of a computer tool for EEG signals processing in pharmaco-EEG studies. The Drug Research Center (CIM) of the Hospital de la Santa Creu i Sant Pau of Barcelona has started to use this interactive graphical user interface for evaluating the effect of a drug on the brain in several pharmaco-EEG studies [Alonso et al, 2010].

  • Filtrado ocular de señales EEG en el análisis de fármacos mediante topografía y tomografía cerebral

     Romero Lafuente, Sergio; Alonso López, Joan Francesc; Rojas Martínez, Mónica; Barbanoj Rodriguez, Manel J.; Mañanas Villanueva, Miguel Angel
    Simposio de Bioingeniería (Redes REDINBIO y RETADIM)
    Presentation's date: 2010-06
    Presentation of work at congresses

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    Ocular Reduction in EEG Signals Based on Adaptive Filtering, Regression and Blind Source Separation  Open access

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj, Mj
    Annals of biomedical engineering
    Date of publication: 2009-01
    Journal article

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    Quantitative electroencephalographic (EEG) analysis is very useful for diagnosing dysfunctional neural states and for evaluating drug effects on the brain, among others. However, the bidirectional contamination between electrooculographic (EOG) and cerebral activities can mislead and induce wrong conclusions from EEG recordings. Different methods for ocular reduction have been developed but only few studies have shown an objective evaluation of their performance. For this purpose, the following approaches were evaluated with simulated data: regression analysis, adaptive filtering, and blind source separation (BSS). In the first two, filtered versions were also taken into account by filtering EOG references in order to reduce the cancellation of cerebral high frequency components in EEG data. Performance of these methods was quantitatively evaluated by level of similarity, agreement and errors in spectral variables both between sources and corrected EEG recordings. Topographic distributions showed that errors were located at anterior sites and especially in frontopolar and lateral–frontal regions. In addition, these errors were higher in theta and especially delta band. In general, filtered versions of time-domain regression and of adaptive filtering with RLS algorithm provided a very effective ocular reduction. However, BSS based on second order statistics showed the highest similarity indexes and the lowest errors in spectral variables.

  • Influence of ocular filtering in EEG data on the assessment of drug-induced effects on the brain

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj Rodriguez, Manel J.
    Human brain mapping
    Date of publication: 2009-06
    Journal article

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  • ANALISIS DE LAS INTERACCIONES DINAMICAS EN BIOSEÑALES NO INVASIVAS MULTICANAL

     Alonso López, Joan Francesc; Marín Sánchez, Jesús; Romero Lafuente, Sergio; Rojas Martínez, Mónica; Mañanas Villanueva, Miguel Angel
    Participation in a competitive project

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  • Biofeedback per entrenament del sòl pèlvic en malalts amb incontinència urinària

     Mañanas Villanueva, Miguel Angel; Alonso López, Joan Francesc; Caminal Magrans, Pedro; Fernandez Chimeno, Mireya; Garcia Gonzalez, Miquel Angel; Ramos Castro, Juan Jose; Rojas Martínez, Mónica; Romero Lafuente, Sergio
    Participation in a competitive project

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  • Aplicación de la entropía condicional para el análisis del EEG bajo terapia farmacológica

     Alonso López, Joan Francesc; Martínez Vera, Naira Pilar; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Barbanoj Rodriguez, Manel J.
    Jornadas de Automática
    Presentation's date: 2009-09
    Presentation of work at congresses

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    El análisis del electroencefalograma humano constituye una herramienta muy útil para la evaluación de la biodisponibilidad de un fármaco en el cerebro. Se ha aplicado el calculo de entropía condicional a señales electroencefalográficas para la evaluación del acoplamiento cerebral tras la administración de un fármaco. El principal objetivo fue analizar el efecto farmacológico de una dosis de alprazolam en el cerebro durante vigilia. Los resultados preliminares que se presentan en este trabajo muestran diferencias estadísticamente significativas entre los estados correspondientes a placebo y fármaco. Las variables no lineales mostraron una buena correlación con la evolución temporal de efectos esperados.

  • EEG-Loreta and Spect: Troubles on Cross-Modality Correspondence

     Barbanoj, Mj; Romero Lafuente, Sergio; Riba, J
    Neuropsychobiology
    Date of publication: 2008-01
    Journal article

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  • Mean Lobe Intracortical Distribution of Electrical Activity after Benzodiazepine Intake: A Dose-Range Study

     Barbanoj, Mj; Romero Lafuente, Sergio; Riba, J
    Neuropsychobiology
    Date of publication: 2008-01
    Journal article

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  • R+D d'un sistema de neurorehabilitació de l'extremitat superior

     Mañanas Villanueva, Miguel Angel; Alonso López, Joan Francesc; Caminal Magrans, Pedro; Rojas Martínez, Mónica; Romero Lafuente, Sergio
    Participation in a competitive project

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    A comparative study of automatic techniques for ocular artifact reduction in spontaneous EEG signals based on clinical target variables: a simulation case  Open access

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj, M J
    Computers in biology and medicine
    Date of publication: 2008-03
    Journal article

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    Eye movement artifacts represent a critical issue for quantitative electroencephalography (EEG) analysis and a number of mathematical approaches have been proposed to reduce their contribution in EEG recordings. The aim of this paper was to objectively and quantitatively evaluate the performance of ocular filtering methods with respect to spectral target variables widely used in clinical and functional EEG studies. In particular the following methods were applied: regression analysis and some blind source separation (BSS) techniques based on second-order statistics (PCA, AMUSE and SOBI) and on higher-order statistics (JADE, INFOMAX and FASTICA). Considering blind source decomposition methods, a completely automatic procedure of BSS based on logical rules related to spectral and topographical information was proposed in order to identify the components related to ocular interference. The automatic procedure was applied in different montages of simulated EEG and electrooculography (EOG) recordings: a full montage with 19 EEG and 2 EOG channels, a reduced one with only 6 EEG leads and a third one where EOG channels were not available. Time and frequency results in all of them indicated that AMUSE and SOBI algorithms preserved and recovered more brain activity than the other methods mainly at anterior regions. In the case of full montage: (i) errors were lower than 5% for all spectral variables at anterior sites; and (ii) the highest improvement in the signal-to-artifact (SAR) ratio was obtained up to 40 dB at these anterior sites. Finally, we concluded that second-order BSS-based algorithms (AMUSE and SOBI)

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    Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers  Open access

     Barbanoj, M J; Riba, J; Clos, S; Gimenez, S; Grasa, E; Romero Lafuente, Sergio
    Psychopharmacology
    Date of publication: 2008-02
    Journal article

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    Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilianbased religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N, N-dimethyltryptamine (DMT) and β-carboline alkaloids with monoamine oxidase-inhibiting properties that render DMT orally active. DMT interacts with serotonergic neurotransmission acting as a partial agonist at 5-HT1A and 5-HT2A/2C receptor sites. Given the role played by serotonin in the regulation of the sleep/wake cycle, we investigated the effects of daytime ayahuasca consumption in sleep parameters.

  • Análisis del efecto de la ingestión simultánea de alcohol y antihistamínicos en la activitat base EEG mediante transformada wavelet discreta

     Poza, J; Caminal Magrans, Pedro; Vallverdú Ferrer, Montserrat; Romero Lafuente, Sergio
    Date: 2007-12
    Report

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  • ESTUDIO COMPARATIVO DE TÉCNICAS AUTOMÁTICAS PARA

     Romero Lafuente, Sergio
    Jornadas de Automática
    Presentation's date: 2007-09-06
    Presentation of work at congresses

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  • Connectivity analysis of EEG under drug theraphy

     Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Riba, J; Barbanoj, M J; Hoyer, D
    IEEE Engineering in Medicine and Biology Society
    Presentation of work at congresses

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  • Estudio comparativo de técnicas automáticas para el filtrado ocular en señales EEG simuladas

     Romero Lafuente, Sergio
    Jornadas de Automática
    Presentation's date: 2007-09-06
    Presentation of work at congresses

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  • Análisis de la conectividad cerebral en sujetos análisis de la conectividad cerebral en sujetos sometidos a terapia farmacológica

     Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Jordi, Riba; Barbanoj, Manel; Hoyer, Dirk
    Congreso Anual de la Sociedad Española de Ingeniería Biomédica
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  • Study of the EEG Changes During the Combined Ingestion of Alcohol and H1-Antihistamines by

     Poza, J; Caminal Magrans, Pedro; Vallverdú Ferrer, Montserrat; Hornero, R; Romero Lafuente, Sergio; Barbanoj, M
    IEEE Engineering in Medicine and Biology Society
    Presentation of work at congresses

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  • Estudio comparativo de técnicas automáticas para el filtrado ocular en señales EEG simuladas

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj, M
    Jornadas de Automática
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    Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers  Open access

     Gimenez, S; Clos, S; Romero Lafuente, Sergio; Grasa, E; Morte, A; Barbanoj, M J
    Psychopharmacology
    Date of publication: 2007-03
    Journal article

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    To compare the effects of typical and atypical antipsychotic drugs on sleep activity and subjective sleep quality. Design Randomised, double-blind, placebo-controlled, four-period cross-over, clinical trial was used to evaluate the effects of active treatments on objective and subjective sleep variables. Setting Sleep laboratory evaluation. Participants Twenty healthy young volunteers, both sexes. Interventions Single oral morning administrations of olanzapine 5 mg, risperidone 1 mg, haloperidol 3 mg and placebo.

  • Quantitative evaluation of automatic ocular removal from simulated EEG signals: regression vs. second order statistics methods

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Barbanoj, Manuel José
    IEEE Engineering in Medicine and Biology Society
    Presentation of work at congresses

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  • Population pharmacokinetic-pharmacodynamic modelling of olanzapine effects on the electroencephalogram in healthy volunteers

     Valle, M; Grasa, E; Yritia, M; Romero Lafuente, Sergio; Barbanoj, Mj
    15th Annual Meeting of the Population Approach Group in Europe (PAGE)
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  • Antipsychotic single oral administration as predictor of response to pharmacotherapy: EEG changes in high schizotypal scored healthy volunteers

     Barbanoj, Mj; Grasa, E; Clos, S; Romero Lafuente, Sergio; Yritia, M; Pérez, V
    14th Bienal Congreso of the International Pharmaco-EEG Society
    Presentation of work at congresses

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  • Increased sleep pressure, as measured by EEG slow wave activity, following daytime administration of ayahuasca, the amazonian hallucinogen

     Barbanoj, Mj; Riba, J; Clos, S; Giménez, S; Grasa Gras, Eduard; Romero Lafuente, Sergio
    18th Congreso of the European Sleep Research Society (ESRS)
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    Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant  Open access

     Riba, J; Romero Lafuente, Sergio; Grasa, E; Mena, E; Carrio, I; Barbanoj, Mj
    Human psychopharmacology-Clinical and experimental
    Date of publication: 2006-03
    Journal article

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    Ayahuasca is a South American psychoactive plant tea which contains the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and monoamine- oxidase inhibitors that render DMT orally active. Previous investigations with ayahuasca have highlighted a psychotropic effect profile characterized by enhanced introspective attention, with individuals reporting altered somatic perceptions and intense emotional modifications, frequently accompanied by visual imagery. Despite recent advances in the study of ayahuasca pharmacology, the neural correlates of acute ayahuasca intoxication remain largely unknown.

  • Quantifying drug-drug interactions in pharmaco-EEG

     Barbanoj, Mj; Riba, J; Valle, M; Romero Lafuente, Sergio; Jane, F
    Clinical EEG and neuroscience
    Date of publication: 2006-04
    Journal article

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  • Cataplejía: mecanismos causales y tratamiento. Focus en GHB

     Barbanoj, Mj; Clos, S; Giménez, S; Romero Lafuente, Sergio
    Vigilia y sueño
    Date of publication: 2005-06
    Journal article

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  • Efecto sobre la macroestructura del sueño del consumo diurno de Ayahuasca: estudio doble-ciego, cruzado y controlado con placebo y d-anfetamina en sujetos sanos

     Barbanoj, Mj; Riba, J; Clos, S; Giménez, S; Romero Lafuente, Sergio
    Efecto sobre la macroestructura del sueño del consumo diurno de Ayahuasca: estudio doble-ciego, cruzado y controlado con placebo y d-anfetamina en sujetos sanos
    Presentation of work at congresses

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  • Concurrent validity of the Somnolizer 24x7 based on results from a neuropsychopharmacological sleep laboratory study

     Barbanoj, Mj; Romero Lafuente, Sergio; Gich, I; Clos, S; Giménez, S
    First Congreso of the World Association of Sleep Medicine (WASM)
    Presentation of work at congresses

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  • Sleep laboratory study on single and repeated dose effects of paroxetine, alprazolam and their combination in healthy young volunteers

     Barbanoj, Mj; Clos, S; Romero Lafuente, Sergio; Morte, A; Gimenez, S; Lorenzo, Jl; Luque, A; Dal-Re, R
    Neuropsychobiology
    Date of publication: 2005-04
    Journal article

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  • Análisis comparativo de métodos del filtrado automático de artefactos oculares en señales EEG espontáneas mediante ICA y regresión lineal

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Riba, J; Morte, A; Giménez, S; Clos, S; Barbanoj, M J
    Jornadas de Investigación en Ingeniería Biomédica
    Presentation of work at congresses

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  • Nuevo método automático de filtrado ocular en señales EEG espontáneas basado en Análisis de Componentes Independientes

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Jordi, Riba; Adelaida, Morte; Barbanoj, Manel
    Jornadas de Automática
    Presentation of work at congresses

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  • Fiabilidad entre expertos en la aplicación de los criterios de Rechtschaffen & Kales en registros de sujetos jóvenes sanos tras tratamiento farmacológico

     Clos, S; Giménez, S; Morte, A; Romero Lafuente, Sergio; Lorenzo, Jl; Barbanoj, Mj
    XIII Reunión Anual de la Asociación Ibérica de Patología del Sueño (AIPS)
    Presentation of work at congresses

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  • Changes on sleep architecture after antipsychotic morning intake single oral doses in healthy volunteers

     Giménez, S; Clos, S; Morte, A; Romero Lafuente, Sergio; Grasa, E; Barbanoj, Mj
    17th Congreso of the European Sleep Research Society (ESRS)
    Presentation of work at congresses

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  • Análisis comparativo de métodos del filtrado automático de artefactos oculares en señales EEG espontáneas mediante ICA y regresión lineal

     Romero Lafuente, Sergio
    Jornadas de Investigación en Ingeniería Biomédica
    Presentation's date: 2004-06-09
    Presentation of work at congresses

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  • Topographic EEG changes after single oral doses of atypical neuroleptics with different pharmacological profile in healthy volunteers

     Barbanoj, Mj; Grasa, E; Morte, A; Romero Lafuente, Sergio; Clos, S; Giménez, S; Benito, L; Yritia, M; Pérez, V; Anderer, P
    13th Bienal Meeting on Pharmaco-EEG (IPEG)
    Presentation of work at congresses

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  • PK-PD modeling of human pharmaco-EEG data reveals information otherwise unseen

     Barbanoj, Mj; Valle, M; Urbano, G; Morte, A; Yritia, M; Romero Lafuente, Sergio
    13th Bienal Meeting on Pharmaco-EEG (IPEG)
    Presentation of work at congresses

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  • Nuevo método automático de filtrado ocular en señales EEG espontáneas basado en Análisis de Componentes Independientes

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Riba, J; Morte, A; Barbanoj, Mj
    Jornadas de Automática
    Presentation of work at congresses

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  • Evaluation of an automatic ocular filtering method for awake spontaneous EEG signals based on Independent Component Analysis

     Romero Lafuente, Sergio; Mañanas Villanueva, Miguel Angel; Riba, J; Morte, A; Giménez, S; Clos, S; Barbanoj, M J
    IEEE Engineering in Medicine and Biology Society
    Presentation of work at congresses

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  • Tractament i interpretació de senyals biomèdiques per l'avaluació clínica i la rehabilitació

     Rojas Martínez, Mónica; Caminal Magrans, Pedro; Mañanas Villanueva, Miguel Angel; Romero Lafuente, Sergio; Giraldo Giraldo, Beatriz F.; Gomis Román, Pedro; Vallverdú Ferrer, Montserrat; Alonso López, Joan Francesc
    Participation in a competitive project

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