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  • The emergence of spontaneous activity in neuronal cultures

     Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Teller Amado, Sara; Soriano Fradera, Jordi; Casademunt Viader, Jaume
    AIP Conference proceedings
    Vol. 1510, p. 25-27
    DOI: 10.1063/1.4776497
    Date of publication: 2013-01
    Journal article

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    The timing statistics of spontaneous calcium release in cardiac myocytes  Open access

     Asfaw, Mesfin; Alvarez Lacalle, Enrique; Shiferaw, Yohannes
    PLoS one
    num. PLoS ONE 8(5): e62967.
    DOI: 10.1371/journal.pone.0062967
    Date of publication: 2013-05-17
    Journal article

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    A variety of cardiac arrhythmias are initiated by a focal excitation that disrupts the regular beating of the heart. In some cases it is known that these excitations are due to calcium (Ca) release from the sarcoplasmic reticulum (SR) via propagating subcellular Ca waves. However, it is not understood what are the physiological factors that determine the timing of these excitations at both the subcellular and tissue level. In this paper we apply analytic and numerical approaches to determine the timing statistics of spontaneous Ca release (SCR) in a simplified model of a cardiac myocyte. In particular, we compute the mean first passage time (MFPT) to SCR, in the case where SCR is initiated by spontaneous Ca sparks, and demonstrate that this quantity exhibits either an algebraic or exponential dependence on system parameters. Based on this analysis we identify the necessary requirements so that SCR occurs on a time scale comparable to the cardiac cycle. Finally, we study how SCR is synchronized across many cells in cardiac tissue, and identify a quantitative measure that determines the relative timing of SCR in an ensemble of cells. Using this approach we identify the physiological conditions so that cell-to-cell variations in the timing of SCR is small compared to the typical duration of an SCR event. We argue further that under these conditions inward currents due to SCR can summate and generate arrhythmogenic triggered excitations in cardiac tissue.

    A variety of cardiac arrhythmias are initiated by a focal excitation that disrupts the regular beating of the heart. In some cases it is known that these excitations are due to calcium (Ca) release from the sarcoplasmic reticulum (SR) via propagating subcellular Ca waves. However, it is not understood what are the physiological factors that determine the timing of these excitations at both the subcellular and tissue level. In this paper we apply analytic and numerical approaches to determine the timing statistics of spontaneous Ca release (SCR) in a simplified model of a cardiac myocyte. In particular, we compute the mean first passage time (MFPT) to SCR, in the case where SCR is initiated by spontaneous Ca sparks, and demonstrate that this quantity exhibits either an algebraic or exponential dependence on system parameters. Based on this analysis we identify the necessary requirements so that SCR occurs on a time scale comparable to the cardiac cycle. Finally, we study how SCR is synchronized across many cells in cardiac tissue, and identify a quantitative measure that determines the relative timing of SCR in an ensemble of cells. Using this approach we identify the physiological conditions so that cell-to-cell variations in the timing of SCR is small compared to the typical duration of an SCR event. We argue further that under these conditions inward currents due to SCR can summate and generate arrhythmogenic triggered excitations in cardiac tissue.

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    Dependency of calcium alternans on Ryanodine Receptor Refractoriness  Open access

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Cinca Cosculluela, Juan; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    PLoS one
    Vol. 8, num. 2
    DOI: 10.1371/journal.pone.0055042
    Date of publication: 2013-02-04
    Journal article

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    Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR were constructed depicting the beat-to-beat response. When alternans was observed, a novel numerical clamping was caused by oscillations in SR calcium loading or by RyR2 refractoriness. Using this protocol, we identified regio loading or RyR2 refractoriness underlie the induction of calcium alternans, and we found that at the onset of altern inactivation rates of the RyR2, calcium alternans was caused by alternation in SR calcium loading, while at low act level of available RyR2s. Conclusions/Significance We have mapped cardiomyocyte beat-to-beat responses as a function of RyR2 activation and inactivation, identify refractoriness underlie the induction of calcium alternans. A corollary of this work is that RyR2 refractoriness due t of calcium alternans even when alternation in SR calcium load is present.

  • Noise focusing and the emergence of coherent activity in neuronal cultures

     Gomez Orlandi, Javier; Soriano Fradera, Jordi; Alvarez Lacalle, Enrique; Teller Amado, Sara; Casademunt Viader, Jaume
    Nature physics
    Vol. 9, num. 9, p. 582-590
    DOI: 10.1038/nphys2686
    Date of publication: 2013-07-21
    Journal article

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    At early stages of development, neuronal cultures in vitro spontaneously reach a coherent state of collective firing in a pattern of nearly periodic global bursts. Although understanding the spontaneous activity of neuronal networks is of chief importance in neuroscience, the origin and nature of that pulsation has remained elusive. By combining high-resolution calcium imaging with modelling in silico, we show that this behaviour is controlled by the propagation of waves that nucleate randomly in a set of points that is specific to each culture and is selected by a non-trivial interplay between dynamics and topology. The phenomenon is explained by the noise focusing effect - a strong spatio-temporal localization of the noise dynamics that originates in the complex structure of avalanches of spontaneous activity. Results are relevant to neuronal tissues and to complex networks with integrate-and-fire dynamics and metric correlations, for instance, in rumour spreading on social networks. © 2013 Macmillan Publishers Limited.

  • Nonlinearities due to Refractoriness in SR Ca Release

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    Vol. 39, p. 297-300
    Date of publication: 2013-01-01
    Journal article

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  • Enfoca la física. Una revisió amb història

     Alvarez Lacalle, Enrique; Aznar Siguan, Gabriela
    Date of publication: 2013
    Book

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    Quan tot just ens acaben d'explicar una cosa, aquesta no acaba de tenir gaire sentit. No s'acaba d'enfocar. I, molt sovint, la falta d'enfocament dura anys. Aquest llibre voldria ajudar a tothom a recol·locar i entendre moltes coses. A fer que, com es diu popularment, tothom arribi a la universitat amb una bona base. I ho vol fer posant-nos en el mateix lloc d'aquells que van descobrir les coses per primera vegada. És una revisió -potser algú en diria repàs-, a partir de contes i d'històries de la història. Una revisió per tal que qualsevol persona pugui enfocar i donar sentit a tot el conei-xement que ha d'haver acumulat abans de començar la física de grau. Des de les regles de tres fins a les integrals i els vectors. L'esperança és que la història t'ajudi a recordar... i a enfocar. I és que, en el fons, tot aprenentatge té una història, i tota ciència és un gran aprenentatge.

  • Alternans due to refractoriness in SR Ca release dynamics

     Rodriguez Cantalapiedra, Inmaculada; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Dynamics Days Europe
    p. 91
    Presentation's date: 2013-06-04
    Presentation of work at congresses

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    Alternans is a well-known cardiac pathology, in which the duration of the action potential (AP) alternates at consecutive beats. Due to its proarrhythmic effects it is important to understand the mechanisms un- derlying its genesis. Inside the cell, the sarcoplasmic reticulum (SR) keeps a high calcium concentration, that is liberated when calcium is introduced into the cell, in a process known as calcium induced calcium release (CICR). It has been amply studied the case where alternans appears due to a steep relation- ship between the duration of an action potential and the time elapsed since the end of the previous AP. However, now it is widely accepted that alternans often appears due to instabilities in the dynamics of intracellular calcium cycling (itself an important messenger for the contraction of the cell). This instabil- ity can be due to a steep relationship between the amount of calcium released to the cytosol, and the calcium loading of the sarcoplasmic reticulum (SR), but in some occasions cytosolic calcium alternans is observed without concurrent oscillations in the SR Ca content. This situation suggests an alternative mechanism related with a dysfunction in the dynamics of the ryanodine receptor (RyR2).

  • Effect of RyR2 Refractoriness and Hypercalcemia on Calcium Overload, Spontaneous Release, and Calcium Alternans

     Alvarez Lacalle, Enrique; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Computing in Cardiology
    p. 683-686
    Presentation's date: 2013-09-24
    Presentation of work at congresses

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    In this work we use a computer model of a ventricu- lar rabbit myocyte to study several factors that affect sar- coplasmic reticulum (SR) calcium load, such as hypercal- cemia, SR calcium buffering, or ryanodine receptor (RyR2) dynamics. General conditions for the appearance of cal- cium spontaneous release in situations with calcium over- load are obtained. Furthermore, we study the appearance of alternans under these conditions. The presence of cal- cium alternans may be due to either a steep calcium load release relation, resulting in oscillations in SR Ca content, or to a slow recovery from refractoriness of the RyR2. We find that a change in calsequestrin buffering dynamics or extracellular calcium concentration greatly affects the ap- pearance of the former type of alternans, but not of the latter.

  • Cardiac wave instabilities in tissue with inhomogeneous distribution of calcium alternans

     Lugo Vélez, Carlos Antonio; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    SIAM Conference on Applications of Dynamical Systems
    p. 143-144
    Presentation's date: 2013-05-19
    Presentation of work at congresses

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    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this talk we consider alternans associated to instabilities in the cytosolic calcium transient. Particularly, we study how a malfunction of the ryanodine receptor (RyR) recovery time from inactivation may induce beat-to-beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inhomogeneous tissue, whose cells exhibit different calcium dynamics.

  • Minimization of Viscous Fluid Fingering: A Variational Scheme for Optimal Flow Rates

     O Dias, Eduardo; Alvarez Lacalle, Enrique; S Carvalho, Marcio; A Miranda, José
    Physical review letters
    Vol. 109, num. 14, p. 144502-1-144502-5
    DOI: 10.1103/PhysRevLett.109.144502
    Date of publication: 2012-10-05
    Journal article

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  • Effect of Ryanodine Receptor Refractoriness on the Induction of Calcium Alternans

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Hove-Madsen, Leif; Echebarria Dominguez, Blas
    Biophysical journal
    Vol. 102(3), p. 308a
    Date of publication: 2012-01-31
    Journal article

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  • sexenni de recerca

     Alvarez Lacalle, Enrique
    Award or recognition

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  • Modelización de dinámica cardiaca a distintas escalas

     Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Competitive project

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  • Automatic method for the detection and characterization of Calcium activity in cardiac cells

     Vallmitjana Lees, Alexander; Alvarez Lacalle, Enrique; Hove-Madsen, Leif; Benitez Iglesias, Raul
    IEEE International Symposium on Biomedical Imaging
    Presentation's date: 2012-05-05
    Presentation of work at congresses

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  • Mechanisms of intracellular calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina
    Congreso No Lineal
    p. 1
    Presentation's date: 2012-06-05
    Presentation of work at congresses

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  • RyR refractoriness effect on calcium alternans mecanics

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Hove Madsen, Leif
    Sitges Conference on Statistical Mechanics
    p. 85
    Presentation's date: 2012-06-05
    Presentation of work at congresses

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    Nonlinearities due to refractoriness in SR Ca release  Open access

     Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas
    Computers in Cardiology
    p. 297-300
    Presentation's date: 2012-09-11
    Presentation of work at congresses

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    Calcium alternans is a pro-arrhytmic cardiac dysfunction related to beat-to-beat changes in the amplitude of intracellular calcium transient, that typically occurs at rapid pacing rates. Although oscillations in sarcoplasmic reticulum (SR) content have been related with calcium alternans, the experimental appearance of alternans without these oscillations suggests that another mechanism related with refractoriness of SR calcium release might be key, at least, under certain conditions. We investigate how RyR2 refractoriness modulates calcium handling on a beat-to-beat basis using a numerical rabbit cardiomyocyte model. We find that a slow recovery from inactivation of the RyR2 might be crucial. On one hand, a steep relation between sarcoplasmic reticulum (SR) load and calcium release makes regular calcium cycling unstable at high SR calcium load and/or fast pacing rates, in agreement with previous explanation when RyR2 inactivation is not important. On the other hand, we show that calcium release can also depend strongly on the number of RyR2 ready to open if an important number of RyR2s inactivate after the release. This gives rise to a steep nonlinear relation between the calcium release and the level of recovered RyR2, so that a small change in the later produces big changes in calcium release. A conclusion of this result is that RyR2 refractoriness can be the main nonlinearity behind alternans even when alternation in SR-Ca load is present

  • Mechanisms for calcium alternans

     Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Lugo Vélez, Carlos Antonio; Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada
    Annual Meeting of the DPG and DPG Spring Meeting
    p. 1
    Presentation's date: 2012-03-27
    Presentation of work at congresses

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  • Cardiac contraction and mechano-electric feedback promotes discordant alternans

     Alvarez Lacalle, Enrique; Bär, Markus; Echebarria Dominguez, Blas; Radszuweit, Markus
    Annual Meeting of the DPG and DPG Spring Meeting
    p. 1
    Presentation's date: 2012-03-27
    Presentation of work at congresses

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  • Cardiac contraction and mechano-electric feedback promotes discordant alternans

     Radszuweit, Markus; Echebarria Dominguez, Blas; Alvarez Lacalle, Enrique; Bär, Markus
    Congreso No Lineal
    p. 1
    Presentation's date: 2012-06-05
    Presentation of work at congresses

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    Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes  Open access

     Llach, Anna; Molina, Cristina E.; Alvarez Lacalle, Enrique; Tort, Lluis; Hove-Madsen, Leif; Benitez Iglesias, Raul
    PLoS one
    Vol. 6, num. 8, p. e23708-
    DOI: 10.1371/journal.pone.0023708
    Date of publication: 2011-08-29
    Journal article

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    Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an emerging model for studies of cardiovascular function and regeneration we here sought to determine if basic features of SR calcium release are phylogenetically conserved. Confocal calcium imaging was used to detect spontaneous calcium release (calcium sparks and waves) from the SR. Calcium sparks were detected in 16 of 38 trout atrial myocytes and 6 of 15 ventricular cells. The spark amplitude was 1.4560.03 times the baseline fluorescence and the time to half maximal decay of sparks was 2763 ms. Spark frequency was 0.88 sparks mm21 min21 while calcium waves were 8.5 times less frequent. Inhibition of SR calcium uptake reduced the calcium transient (F/F0) from 1.7760.17 to 1.1260.18 (p=0.002) and abolished calcium sparks and waves. Moreover, elevation of extracellular calcium from 2 to 10 mM promoted early and delayed afterdepolarizations (from 0.660.3 min21 to 8.162.0 min21, p = 0.001), demonstrating the ability of SR calcium release to induce afterdepolarizations in the trout heart. Calcium sparks of similar width and duration were also observed in zebrafish ventricular myocytes. In conclusion, this is the first study to consistently report calcium sparks in teleosts and demonstrate that the basic features of calcium release through the ryanodine receptor are conserved, suggesting that teleost cardiac myocytes is a relevant model to study the functional impact of abnormal SR function.

  • Caos y arritmogénesis en la dinámica del calcio intracelular

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 64-
    Presentation's date: 2011
    Presentation of work at congresses

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  • Effects of atrial fibrillation on the distribution, dimensions, and frequency of calcium sparks in human atrial myocytes

     Barriga, Montserrat; Llach, Anna; Alvarez Lacalle, Enrique; Cabello, N.; Ballester, B.; Vallmitjana Lees, Alexander; Muñoz, C.; Benitez Iglesias, Raul; Cinca Cosculluela, Juan; Hove-Madsen, Leif
    European Society of Cardiology Congress
    p. 468
    Presentation's date: 2011-08-27
    Presentation of work at congresses

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  • Experiments on patterned neuronal cultures

     Teller Amado, Sara; Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Casademunt Viader, Jaume; Moses, Elisha; Soriano Fradera, Jordi
    Congreso de Física Estadística
    p. 211-
    Presentation's date: 2011-06
    Presentation of work at congresses

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  • Local noise amplification and synaptic de-pression control : the spontaneous activity in neuronal cultures

     Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Teller Amado, Sara; Soriano Fradera, Jordi; Casademunt Viader, Jaume
    Göttingen Meeting of the German Neuroscience Society
    p. 1346
    Presentation's date: 2011-03-26
    Presentation of work at congresses

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  • Arritmias cardiacas producidas por heterogeneidad en la dinámica del calcio

     Lugo Vélez, Carlos Antonio; Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    p. 143
    Presentation's date: 2011
    Presentation of work at congresses

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  • Unraveling spontaneous activity in neuronal cultures

     Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Teller Amado, Sara; Soriano Fradera, Jordi; Casademunt Viader, Jaume
    Congreso de Física Estadística
    p. 173-
    Presentation's date: 2011
    Presentation of work at congresses

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  • Effect of the resting membrane potential on the distribution, dimensions, and frequency of calcium sparks in human atrial myocytes

     Barriga, Montserrat; Alvarez Lacalle, Enrique; Llach, Anna; Vallmitjana Lees, Alexander; Muñoz, C.E.; Cinca Cosculluela, Juan; Benitez Iglesias, Raul; Hove-Madsen, Leif
    European heart journal
    Vol. 31, num. Supl.1 ESC 2010, p. 895
    Date of publication: 2010-09
    Journal article

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  • Effect of the resting membrane potential on the distribution, dimensions, and frequency of calcium sparks in human atrial myocytes

     Barriga, Montserrat; Alvarez Lacalle, Enrique; Llach, Anna; Vallmitjana Lees, Alexander; Muñoz, C.E.; Cinca Cosculluela, Juan; Benitez Iglesias, Raul; Hove-Madsen, Leif
    European Society of Cardiology Congress
    Presentation's date: 2010-09-01
    Presentation of work at congresses

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  • Nucleation and front propagation in patterned neural networks

     Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Amigó, Nuria; Soriano Fradera, Jordi; Casademunt Viader, Jaume
    Forum of European Neurosciences
    p. 192
    Presentation's date: 2010-07-07
    Presentation of work at congresses

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  • Calcium alternans and ryanodine receptors in cardiomyocytes

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Echebarria Dominguez, Blas
    Emerging Topics in Dynamical Systems and Partial Differential Equations
    p. 1
    Presentation's date: 2010-06-01
    Presentation of work at congresses

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  • Modelling spontaneous activity in neuronal cultures

     Gómez Orlandi, Javier; Alvarez Lacalle, Enrique; Amigó, Nuria; Soriano Fradera, Jordi; Casademunt Viader, Jaume
    Spanish Portuguese Biophysical Congress
    p. 109
    Presentation's date: 2010-07-08
    Presentation of work at congresses

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    Identification of intracellular calcium dynamics in stimulated cardiomyocytes  Open access

     Vallmitjana Lees, Alexander; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Alvarez Lacalle, Enrique; Hove-Madsen, Leif; Benitez Iglesias, Raul
    IEEE Engineering in Medicine and Biology Society
    p. 64
    DOI: 10.1109/IEMBS.2010.5626238
    Presentation's date: 2010-09-01
    Presentation of work at congresses

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    We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical patterns such as spatially concordant and discordant alternans, irregular behavior or phase-locking regimes such as period doubling or halving. The method can be applied to the analysis of different cardiac pathologies related to anomalies at the cellular level such as ventricular reentrant arrhythmias.

  • Pinch-off singularities in rotating Hele-Shaw flows at high viscosity contrast

     Alvarez Lacalle, Enrique; Casademunt Viader, Jaume; Eggers, J.
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 80, num. 5, p. 1-10
    DOI: 10.1103/PhysRevE.80.056306
    Date of publication: 2009-11-16
    Journal article

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  • Pattern formation and interface pinch-off in rotating Hele-Shaw flows: A phase-field approach

     Folch, R.; Alvarez Lacalle, Enrique; Ortin, J; Casademunt Viader, Jaume
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 80, num. 5, p. 1-10
    DOI: 10.1103/PhysRevE.80.056305
    Date of publication: 2009-11-19
    Journal article

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  • Slow and fast pulses in 1-D cultures of excitatory neurons

     Alvarez Lacalle, Enrique; Moses, E
    Journal of computational neuroscience
    Vol. 26, num. 3, p. 475-493
    Date of publication: 2009-06
    Journal article

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  • Global coupling in excitable media provides a simplified description of mechanoelectrical feedback in cardiac tissue

     Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 79, num. 3, p. 31921-31930
    DOI: 10.1103/PhysRevE.79.031921
    Date of publication: 2009-03
    Journal article

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  • MODELOS Y CATACTERIZACIÓN DE DINÁMICA CARDIACA

     Echebarria Dominguez, Blas; Rodriguez Cantalapiedra, Inmaculada; Peñaranda Ayllon, Angelina; Alvarez Lacalle, Enrique
    Competitive project

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  • REMODELLING OF ADENOSINE RECEPTORS IN HUMAN ATRIAL FIBRILLATION

     Peñaranda Ayllon, Angelina; Rodriguez Cantalapiedra, Inmaculada; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Competitive project

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  • Dynamics and control of intracellular calcium dynamics in cell with RyRs

     Alvarez Lacalle, Enrique; Rodriguez Cantalapiedra, Inmaculada; Echebarria Dominguez, Blas; Peñaranda Ayllon, Angelina
    Congreso de Física Estadística
    Presentation's date: 2009-09-10
    Presentation of work at congresses

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    Slow and fast pulses in 1D cultures of excitatory neurons  Open access

     Alvarez Lacalle, Enrique; Moses, Elisha
    European Science Foundation Conference on Functional Dynamics
    p. 6
    Presentation's date: 2009-03
    Presentation of work at congresses

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    We demonstrate that proper levels of additive white noisy currents generate such pulses spontaneously. In other words, we fully reproduce the experimental dynamics when we use the appropriate basic neuron model, the correct experimental connectivity and introduce the presence of white noise in the soma dynamics.

  • Cardiac tissue with mechano-electrical feedback as excitable media with global coupling

     Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Congreso de Fisica Estadistica
    Presentation's date: 2009-09-10
    Presentation of work at congresses

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  • Characterization of the nonlinear content of the heart rate dynamics during myocardial ischemia

     Benitez Iglesias, Raul; Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas; Gomis Román, Pedro; Vallverdú Ferrer, Montserrat; Caminal Magrans, Pedro
    Medical engineering and physics
    Vol. 31, num. 6, p. 660-667
    Date of publication: 2009-07
    Journal article

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  • Efecto del potencial de membrana sobre las dimensiones, la cinética y la frecuencia de la liberación local de calcio en miocitos auriculares humanos

     Barriga, Montserrat; Alvarez Lacalle, Enrique; Llach, Anna; Vallmitjana Lees, Alexander; Muñoz Guijosa, Cristian; Cinca Cosculluela, Juan; Benitez Iglesias, Raul; Hove-Madsen, Leif
    Congreso de la Sociedad Española de Cardiología
    p. 95
    Presentation's date: 2009-10-21
    Presentation of work at congresses

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  • Metodo de detección de eventos locales de Iiberación de calcio intracelular

     Benitez Iglesias, Raul; Alvarez Lacalle, Enrique; Alvarez-Lacalle, Enric; Hove-Madsen, Leif
    Date of request: 2009-03-13
    Invention patent

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    Método de detección de eventos locales de liberación de calcio intracelular.

    La presente invención trata de un método de detección de eventos locales de liberación de calcio intracelular comprendiendo las siguientes etapas:

    - adquirir una secuencia de imágenes bidimensionales de una sección determinada de una o más células, incluyendo información relativa a actividad de calcio intracelular;

    - normalizar dichas imágenes;

    - realizar un análisis estadístico de la distribución espacio-temporal de píxeles en dicha secuencia de imágenes normalizadas, para determinar unas regiones de interés, y determinar que dichas regiones de interés son candidatas a contener un evento local de liberación de calcio intracelular de interés; y.

    - realizar las siguientes etapas, automáticamente y de manera previa a dicho análisis estadístico:

    - detectar eventos globales de liberación de calcio en una o más de las imágenes de dicha sucesión de imágenes; y

    - realizar dicho análisis estadístico solamente sobre las imágenes en las cuales no se han detectado eventos globales de liberación de calcio.

  • MÉTODO DE DETECCIÓN DE EVENTOS LOCALES DE LIBERACIÓN DE CALCIO INTRACELULAR

     Benitez Iglesias, Raul; Alvarez Lacalle, Enrique; Hove-Madsen, Leif
    Date of request: 2009-03-13
    Invention patent

    Read the abstract Read the abstract Access to the full text Access to the full text Open in new window  Share Reference managers Reference managers Open in new window

    Método de detección de eventos locales de liberación de calcio intracelular.

    La presente invención trata de un método de detección de eventos locales de liberación de calcio intracelular comprendiendo las siguientes etapas:

    - adquirir una secuencia de imágenes bidimensionales de una sección determinada de una o más células, incluyendo información relativa a actividad de calcio intracelular;

    - normalizar dichas imágenes;

    - realizar un análisis estadístico de la distribución espacio-temporal de píxeles en dicha secuencia de imágenes normalizadas, para determinar unas regiones de interés, y determinar que dichas regiones de interés son candidatas a contener un evento local de liberación de calcio intracelular de interés; y.

    - realizar las siguientes etapas, automáticamente y de manera previa a dicho análisis estadístico:

    - detectar eventos globales de liberación de calcio en una o más de las imágenes de dicha sucesión de imágenes; y

    - realizar dicho análisis estadístico solamente sobre las imágenes en las cuales no se han detectado eventos globales de liberación de calcio.

  • Coriolis effects on fingering patterns under rotation

     Alvarez Lacalle, Enrique; Gadelha, H; Miranda, J A
    Physical review E: statistical, nonlinear, and soft matter physics
    Vol. 78, num. 2, p. 26305
    DOI: 10.1103/PhysRevE.78.026305
    Date of publication: 2008-09
    Journal article

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  • Oscillatory Regime in Excitatory Media with Global Coupling: Application to Cardiac Dynamics

     Alvarez Lacalle, Enrique; Rodriguez, Jf; Echebarria Dominguez, Blas
    Computers in cardiology
    Vol. 35, p. 189-192
    Date of publication: 2008-12
    Journal article

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  • Fundamental models of 1D cardiac tissue

     Alvarez Lacalle, Enrique
    SIAM Conference on Nonlinear waves and Coherent Structures
    Presentation's date: 2008-07-22
    Presentation of work at congresses

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  • Oscillatory regime in excitable media with global coupling. Application to cardiac dynamics

     Alvarez Lacalle, Enrique; Echebarria Dominguez, Blas
    Congreso de Física Estadística
    p. 54
    Presentation of work at congresses

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