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1 to 23 of 23 results
  • Neural response to the observable self in social anxiety disorder

     Pujol Nuez, Jesus; Giménez, Mònica; Ortiz Valencia, Hector; Soriano Mas, Carles; López Solà, Marina; Farré, Magí; Deus Yela, Joan; Merlo-Pich, Emilio; Harrison, B.J.; Cardoner, Narcís; Navinés, Ricard; Martin-Santos, Rocío
    Psychological medicine
    Date of publication: 2013-04
    Journal article

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    Influencia del estilo social en la evaluación de presentaciones académicas de proyectos de Ingeniería.  Open access

     Ortiz Valencia, Hector; García Carrillo, Agueda; Amante García, Beatriz; González Benítez, María Margarita
    Congreso Internacional de Ingeniería de Proyectos
    Presentation's date: 2012-07-11
    Presentation of work at congresses

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    El estudio de las impresiones subjetivas generadas por un producto debe incluir la consideración no sólo del usuario final del mismo, sino también de otros agentes o perfiles de cliente que seleccionan los diseños en su camino hacia el comprador, tales como los propios diseñadores, o los distribuidores. En este trabajo se presentan los resultados de un estudio de campo desarrollado con el objetivo, entre otros, de descubrir cuáles son las impresiones subjetivas que más influyen sobre las preferencias de pavimentos cerámicos, en función del perfil de cliente considerado. El estudio se realizó a través del desarrollo de un cuestionario web, en el que participaron más de 280 clientes, entre los que se consideran tanto usuarios finales como otros perfiles profesionales relacionados con el sector (arquitectos, distribuidores, diseñadores, etc.). Los resultados muestran que las impresiones que más influyen en las preferencias de producto son diferentes en función del perfil de cliente considerado. Por ejemplo, para la muestra utilizada en el estudio, los usuarios son los únicos que correlacionan el significado "fácil limpieza" con las preferencias

  • Altered brain functional connectivity in relation to perception of scrutiny in social anxiety disorder

     Gimenez, Monica; Pujol Nuez, Jesus; Ortiz Valencia, Hector; Soriano Mas, Carles; López Solà, Marina; Farré, Magí; Deus Yela, Joan; Merlo-Pich, Emilio; Martin-Santos, Rocío
    Psychiatry research. Neuroimaging
    Date of publication: 2012-06-30
    Journal article

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    Although the fear of being scrutinized by others in a social context is a key symptom in social anxiety disorder (SAD), the neural processes underlying the perception of scrutiny have not previously been studied by func- tional magnetic resonance imaging (fMRI). We used fMRI to map brain activation during a perception-of- scrutiny task in 20 SAD patients and 20 controls. A multi-dimensional analytic approach was used. Scrutiny perception was mediated by activation of the medial frontal cortex, insula – operculum region and cerebellum, and the additional recruitment of visual areas and the thalamus in patients. Between-group comparison demonstrated signi fi cantly enhanced brain activation in patients in the primary visual cortex and cerebellum. Functional connectivity mapping demonstrated an abnormal connectivity between regions underlying general arousal and attention. SAD patients showed signi fi cantly greater task-induced functional connectivity in the thalamo-cortical and the fronto-striatal circuits. A statistically signi ficant increase in task-induced functional connectivity between the anterior cingulate cortex and scrutiny-perception-related regions was observed in the SAD patients, suggesting the existence of enhanced behavior-inhibitory control. The presented data indicate that scrutiny perception in SAD enhances brain activity in arousal–attention systems,suggesting that fMRI may be a useful tool to explore such a behavioral dimension.

  • Structural covariance of the neostriatum with regional gray matter volumes

     Soriano Mas, Carles; Harrison, B.J.; Pujol Nuez, Jesus; López-Solà, M.; Hernández-Ribas, Rosa; Alonso, Pino; Contreras-Rodríguez, Oren; Giménez, Mònica; Blanco Hinojo, Laura; Ortiz Valencia, Hector; Deus, Joan; Menchón, JM; Cardoner, Narcís
    Brain structure and function
    Date of publication: 2012-05
    Journal article

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  • Neural correlates of moral sensitivity in obsessive-compulsive disorder moral sensitivity in obsessive-compulsive disorder

     Harrison, Ben; Pujol, Jesus; Soriano Mas, Carles; Hernández-Ribas, Rosa; López Solà, Marina; Ortiz Valencia, Hector; Alonso, Pino; Deus, Joan; Menchon, José Manuel; Real, Eva; Segalàs, Cinto; Contreras-Rodríguez, Oren; Blanco Hinojo, Laura; Cardoner, Narcís
    Archives of general psychiatry
    Date of publication: 2012-07
    Journal article

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  • The Influence of social style in evaluating academic presentations of engineering projects  Open access

     Ortiz Valencia, Hector; García Carrillo, Agueda; González Benítez, María Margarita
    Journal of technology and science education
    Date of publication: 2012
    Journal article

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    An individual’s social style is determined by behavioral patterns in the interactions with their peers. Some studies suggest that social style may influence the way in which an individual’s performance is evaluated. We studied the effects that speakers’ and evaluators’ social styles have on the marks given for end-of-term presentations in a project engineering master’s course. The participants completed a self-evaluation exercise that classified their social styles into one of four categories: Driver, expressive, analytical, or amiable. Students individually rated the content and appearance of their classmates’ presentations. A statistical analysis of these scores revealed that the speaker’s social style had a significant effect on the marks received for content and appearance. The evaluator’s social style also demonstrated a statistically significant effect on the marks given for appearance, though not for content. Students with expressive social style received the highest scores, while the analytical style received the lowest scores. These results reiterate the necessity to train students as evaluators in order to reduce bias when evaluating their classmates and co-workers during their academic and professional careers.

  • Optimizando la comunicación en la desagregación de proyectos de I+D+I

     Ortiz Valencia, Hector; Ferre, Daniel
    International Congress on Project Engineering
    Presentation's date: 2011-07
    Presentation of work at congresses

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  • Cross-sectional and longitudinal assessment of structural brain alterations in melancholic depression

     Soriano Mas, Carles; Hernández-Ribas, R.; Pujol Nuez, Jesus; Urretavizcaya, M; Deus Yela, Joan; Harrison, B.J.; Ortiz Valencia, Hector; López-Solà, M.; Menchón, JM; Cardoner, I. Narcís
    Biological psychiatry
    Date of publication: 2011-02-15
    Journal article

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  • Anatomical and functional overlap within the insula and anterior cingulate cortex during interoception and phobic symptom provocation

     Caseras, Xavier; Murphy, Kevin; López Solà, Marina; Mataix-Cols, David; Soriano Mas, Carles; Ortiz Valencia, Hector; Pujol, Jesus; Torrubia, Rafael
    Human brain mapping
    Date of publication: 2011-12-08
    Journal article

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    The anterior insula and the dorsal anterior cingulate cortex (ACC) are regarded as key brain structures associated with the integration of perceived phobic characteristics of external stimuli and the perception of ones own body responses that leads to emotional feelings. To test to what extent the activity in these two brain structures anatomically and functionally overlap during phobic reactions and interoception, we submitted the same group of phobic participants (n = 29; either spider or blood-injection-injury (BII) phobics) and controls (n = 17) to both type of experimental paradigms. Results showed that there was a clear anatomical overlap in the Blood Oxygen Level-Dependent (BOLD) responses within the anterior insula and ACC elicited during phobic symptom provocation and during interoceptive awareness. The activity within these two brain structures also showed to be correlated in the spider phobia group, but not in the BII phobic participants. Our results seem to support the idea that the activity within these two brain areas would be associated with the integration of perceived stimuli characteristics and bodily responses that lead to what we label as "fear." However, that seems not to be the case in BII phobia, where more research is needed in order to clarify to what extent that could be associated with the idiosyncratic physiological response that these patients present in front of phobic stimuli (i.e., drop in heart rate and blood pressure).

  • Variations in the shape of the frontobasal brain region in obsessive-compulsive disorder

     Pujol Nuez, Jesus; Soriano Mas, Carles; Gispert, Juan Domingo; Bossa, Matías; Reig, Santiago; Ortiz Valencia, Hector; Alonso, Pino; Cardoner, I. Narcís; López Solà, Marina; Harrison, B.J.; Deus Yela, Joan; Menchón, JM; Desco, Manuel; Olmos, Salvador
    Human brain mapping
    Date of publication: 2011-07
    Journal article

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  • Task-induced deactivation from rest extends beyond the default mode brain network

     Harrison, B.J.; Pujol Nuez, Jesus; Contreras Rodríguez, Oren; Soriano Mas, Carles; López-Solà, M.; Deus Yela, Joan; Ortiz Valencia, Hector; Blanco Hinojo, Laura; Alonso, Pino; Hernández Ribas, Rosa; Cardoner, I. Narcís; Menchón, JM
    PLoS One
    Date of publication: 2011-07-29
    Journal article

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  • Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder

     Cardoner, I. Narcís; Harrison, B.J.; Pujol, J.; Soriano Mas, C.; Hernndez Ribas, R.; López-Solà, M.; Real, E.; Deus, J.; Ortiz Valencia, Hector; Alonso, P.; Menchãn, J.M.
    World journal of biological psychiatry
    Date of publication: 2011-08
    Journal article

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  • Dynamic assessment of the right lateral frontal cortex response to painful stimulation

     López-Solà, M.; Pujol Nuez, Jesus; Hernández-Ribas, R.; Harrison, B.J.; Ortiz Valencia, Hector; Soriano Mas, Carles; Deus Yela, Joan; Menchón, JM; Vallejo, Julio; Cardoner, I. Narcís
    Neuroimage
    Date of publication: 2010-04-15
    Journal article

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    The lateral surface of the right frontal lobe has a relevant role in modulating behavioral responses to aversive stimuli and may significantly influence pain experience. Imaging studies suggest that this modulatory role is multifaceted, but no studies have assessed the regional specialization of this cortex on the basis of its response dynamics during pain processing. We aimed to investigate functional specialization within the right lateral frontal cortex using a dynamic fMRI approach. Brain responses to a mechanical painful stimulus and a preceding anticipatory cue (auditory tone) were assessed in 25 healthy subjects. Functional data were decomposed into 15 sequential activation maps covering the full anticipation-painful stimulation cycle using a finite impulse response (FIR) analysis approach. Movie sequences showing the temporal evolution of brain activation illustrate the findings. A region involving premotor–prefrontal cortices was activated soon after the anticipatory cue and showed a significant correlation with both anterior cingulate cortex activation and subjective pain ratings. The frontal operculum also showed a significant anticipatory response, but the most robust activation followed painful stimulation onset and was strongly correlated with insula activation. The anterior prefrontal cortex showed full activation during late painful stimulation and was negatively correlated with pain unpleasantness. In conclusion, different elements within the right lateral frontal cortex showed distinct activation dynamics in response to painful stimulation, which would suggest relevant regional specialization during pain processing. These findings are congruent with the broad functional role of the right frontal cortex and its influence on crucial aspects of human behavior.

  • Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes

     Caseras, Xavier; Mataix-Cols, David; Trasovares, MV; López-Solà, M.; Ortiz Valencia, Hector; Pujol Nuez, Jesus; Soriano Mas, Carles; Giampietro, V; Brammer, MJ; Torrubia, R
    European journal of neuroscience
    Date of publication: 2010-10
    Journal article

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  • Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder

     López Solà, Marina; Pujol, Jesus; Hernández-Ribas, Rosa; J Harrison, Ben; Contreras-Rodríguez, Oren; Soriano Mas, Carles; Deus, Joan; Ortiz Valencia, Hector; M Menchon, José; Vallejo, Julio; Cardoner, I. Narcís
    Neuropsychopharmacology
    Date of publication: 2010-07-28
    Journal article

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    Major depressive disorder (MDD) is characterized by a constellation of affective, cognitive, and somatic symptoms associated with functional abnormalities in relevant brain systems. Painful stimuli are primarily stressful and can trigger consistent responses in brain regions highly overlapping with the regions altered in MDD patients. Duloxetine has proven to be effective in treating both core emotional symptoms and somatic complaints in depression. This study aimed to assess the effects of duloxetine treatment on brain response to painful stimulation in MDD patients. A total of 13 patients and a reference group of 20 healthy subjects were assessed on three occasions (baseline, treatment week 1, and week 8) with functional magnetic resonance imaging (fMRI) during local application of painful heat stimulation. Treatment with duloxetine was associated with a significant reduction in brain responses to painful stimulation in MDD patients in regions generally showing abnormally enhanced activation at baseline. Clinical improvement was associated with pain-related activation reductions in the pregenual anterior cingulate cortex, right prefrontal cortex, and pons. Pontine changes were specifically related to clinical remission. Increased baseline activations in the right prefrontal cortex and reduced deactivations in the subgenual anterior cingulate cortex predicted treatment responders at week 8. This is the first fMRI study addressed to assess the effect of duloxetine in MDD. As a novel approach, the application of painful stimulation as a basic neural stressor proved to be effective in mapping brain response changes associated with antidepressant treatment and brain correlates of symptom improvement in regions of special relevance to MDD pathophysiology.

  • Age-related brain structural alterations in children with specific language impairment

     Soriano Mas, Carles; Pujol Nuez, Jesus; Ortiz Valencia, Hector; Deus Yela, Joan; López-Sala, A; Sans, Anna
    Human brain mapping
    Date of publication: 2009-05
    Journal article

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    Previous neuroimaging studies have suggested that children with specific language impairment (SLI) may show subtle anatomical alterations in specific brain regions. We aimed to characterize structural abnormalities in children with SLI using a voxel-wise analysis over the whole brain. Subjects covered a wide age range (5–17 years) in order to assess the dynamic nature of the disorder across childhood. Three-dimensional MRIs were collected from 36 children with SLI and from a comparable group of healthy controls. Global gray and white matter measurements were obtained for each subject, and voxel-based morphometry (VBM) was used to evaluate between-group differences in regional brain anatomy. Possible age-related changes were assessed in separate analyses of younger (below 11 years of age) and older children. SLI patients showed larger global gray and white matter volumes, particularly in the younger subgroup. Voxel-wise analyses of the whole sample showed two regions of increased gray matter volume in SLI: the right perisylvian region and the occipital petalia. Age-group analyses suggested a more extended pattern of volume increases in the younger subjects, which included entorhinal, temporopolar, caudate nucleus, motor-precentral and precuneus gray matter, and white matter of the frontal and temporal lobes. Our results suggest that in the SLI brain there are enduring anatomical alterations that exist across a wide age range, as well as a distributed pattern of abnormalities that appear to normalize with development. They also suggest that the neuroanatomical basis of SLI may be better characterized by considering the dynamic course of the disorder throughout childhood.

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    Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI  Open access

     Pujol Nuez, Jesus; López-Solà, M.; Ortiz Valencia, Hector; Vilanova, Joan Carles; Harrison, B.J.; Yücel, Murat; Cardoner, I. Narcís; Soriano Mas, Carles; Deus Yela, Joan
    PLoS One
    Date of publication: 2009-04-21
    Journal article

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    Background: Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressure in fibromyalgia patients by generating activation maps adjusted for the duration of brain responses. Methodology/Principal Findings: Twenty-seven women (mean age: 47.8 years) were assessed with fMRI. The sample included nine fibromyalgia patients and nine healthy subjects who received 4 kg/cm2 of pressure on the thumb. Nine additional control subjects received 6.8 kg/cm2 to match the patients for the severity of perceived pain. Independent Component Analysis characterized the temporal dynamics of the actual brain response to pressure. Statistical parametric maps were estimated using the obtained time courses. Brain response to pressure (18 seconds) consistently exceeded the stimulus application (9 seconds) in somatosensory regions in all groups. fMRI maps following such temporal dynamics showed a complete pain network response (sensory-motor cortices, operculo-insula, cingulate cortex, and basal ganglia) to 4 kg/cm2 of pressure in fibromyalgia patients. In healthy subjects, response to this low intensity pressure involved mainly somatosensory cortices. When matched for perceived pain (6.8 kg/cm2), control subjects showed also comprehensive activation of pain-related regions, but fibromyalgia patients showed significantly larger activation in the anterior insulabasal ganglia complex and the cingulate cortex. Conclusions/Significance: The results suggest that data-driven fMRI assessments may complement conventional neuroimaging for characterizing pain responses and that enhancement of brain activation in fibromyalgia patients may be particularly relevant in emotion-related regions.

  • Time course and functional neuroanatomy of speech segmentation in adults

     Cunillera, Toni; Càmara, Estela; Toro, JM; Marco-Pallares, J; Sebastian Gallés, Núria; Ortiz Valencia, Hector; Pujol Nuez, Jesus; Rodríguez Fornells, Antoni
    Neuroimage
    Date of publication: 2009-11-15
    Journal article

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  • Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety

     Cardoner, I. Narcís; Pujol Nuez, Jesus; Harrison, B.J.; Ortiz Valencia, Hector; Deus Yela, Joan; Soriano Mas, Carles; López-Solà, M.; Yücel, Murat; Perich, Xavier
    Psychological medicine
    Date of publication: 2009-07
    Journal article

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  • Altered corticostriatal functional connectivity in obsessive-compulsive disorder

     Cardoner, I. Narcís; Harrison, B.J.; Mas-Soriano, C.; Pujol, J.; Ortiz Valencia, Hector; López-Solà, M.; Hernández-Ribas, R.; Deus, J.; Alonso, P.; Yucel, M.; Pantelis, C.; Mechón, JM.
    Archives of general psychiatry
    Date of publication: 2009-11
    Journal article

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  • Modulation of Brain Resting-State Networks by Sad Mood Induction

     Harrison, Ben J; Jesus, Pujol; Ortiz Valencia, Hector; Fornito, Alex; Pantelis, C.; Yücel, Murat
    PLoS One
    Date of publication: 2008-03
    Journal article

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  • Consistency and Functional Specialization in the Default Mode Brain Network

     Harrison, Ben J; Jesus, Pujol; López Solà, Marina; Hernández-Ribas, Rosa; Joan, Deus; Ortiz Valencia, Hector; Soriano Mas, Carles; Murat, Yücel; Christos, Pantelis; Cardoner, I. Narcís
    Proceedings of the National Academy of Sciences of the United States of America
    Date of publication: 2008-07
    Journal article

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  • Identification of the sensorimotor cortex with functional MRI: Frequency and actual contribution in a neurosurgical context

     Pujol, J; Deus, J; Acebes, Jj; Villanueva, A; Soriano-Mas, C; Ortiz Valencia, Hector; Conesa, Gerardo
    Journal of neuroImaging
    Date of publication: 2008-01
    Journal article

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