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  • Calcium phosphate cements as drug delivery materials

     Ginebra Molins, Maria Pau; Canal Barnils, Cristina; Español Pons, Montserrat; Pastorino, David; Montufar Jimenez, Edgar Benjamin
    Advanced drug delivery reviews
    Date of publication: 2012-01-25
    Journal article

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    Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions.

  • Ceramics

     Español Pons, Montserrat; Perez Antoñanzas, Roman; Montufar Jimenez, Edgar Benjamin; Ginebra Molins, Maria Pau
    Date of publication: 2012-04-10
    Book chapter

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  • Premio extraordinario de doctorado UPC

     Montufar Jimenez, Edgar Benjamin
    Award or recognition

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  • The relevance of the setting reaction on the injectability of tricalcium phosphate pastes

     Montufar Jimenez, Edgar Benjamin; Fernandez, Francesc; Maazouz, Yassine; Ginebra Molins, Maria Pau
    Symposium and Annual Meeting of International Society for Ceramics in Medicine
    Presentation's date: 2011-11-07
    Presentation of work at congresses

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  • Espumas inyectables de hidroxiapatita para regeneración ósea

     Montufar Jimenez, Edgar Benjamin; Ginebra Molins, Maria Pau
    Date of publication: 2011-10-08
    Book

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  • European Biomaterials and Tissue Engineering Doctoral Award (EDA)

     Montufar Jimenez, Edgar Benjamin
    Award or recognition

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  • Comparison of a low molecular weight and a macromolecular surfactant as foaming agents for injectable self setting hydroxyapatite foams: Polysorbate 80 versus gelatine

     Montufar Jimenez, Edgar Benjamin; Traykova, Tania; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    Materials science and engineering C. Biomimetic and supramolecular systems
    Date of publication: 2011-10-10
    Journal article

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    Hydroxyapatite foams are potential synthetic bone grafting materials or scaffolds for bone tissue engineering. A novel method to obtain injectable hydroxyapatite foams consists in foaming the liquid phase of a calcium phosphate cement. In this process, the cement powder is incorporated into a liquid foam, which acts as a template for macroporosity. After setting, the cement hardens maintaining the macroporous structure of the foam. In this study a low molecular weight surfactant, Polysorbate 80, and a protein, gelatine, were compared as foaming agents of a calcium phosphate cement. The foamability of Polysorbate 80 was greater than that of gelatine, resulting in higher macroporosity in the set hydroxyapatite foam and higher macropore interconnectivity. Gelatine produced less interconnected foams, especially at high concentrations, due to a higher liquid foam stability. However it increased the injectability and cohesion of the foamed paste, and enhanced osteoblastic-like cell adhesion, all of them important properties for bone grafting materials.

  • Injectable hydroxyapatite foams for bone regeneration

     Montufar Jimenez, Edgar Benjamin; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    TOPEA
    Presentation's date: 2010-07-01
    Presentation of work at congresses

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  • New processing approaches in calcium phosphate cements and their applications in regenerative medicine

     Ginebra Molins, Maria Pau; Español Pons, Montserrat; Montufar Jimenez, Edgar Benjamin; Mestres, Gemma; Perez Antoñanzas, Roman
    International Congress on Biomaterials
    Presentation's date: 2010-03-17
    Presentation of work at congresses

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  • Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration

     Montufar Jimenez, Edgar Benjamin; Traykova, Tania Valentinova; Gil, C.; Harr, I.; Almirall Gonzalo, Arturo; Aguirre Cano, Aitor; Engel Lopez, Elisabet; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    Acta biomaterialia
    Date of publication: 2010-03
    Journal article

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  • New processing approaches in calcium phosphate cements and their applications in regenerative medicine

     Ginebra Molins, Maria Pau; Español Pons, Montserrat; Montufar Jimenez, Edgar Benjamin; Pérez, Ricardo A.; Mestres Bea, Gemma
    Acta biomaterialia
    Date of publication: 2010-08
    Journal article

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    The key feature of calcium phosphate cements (CPCs) lies in the setting reaction triggered by mixing one or more solid calcium phosphate salts with an aqueous solution. Upon mixture, the reaction takes place through a dissolution–precipitation process which is macroscopically observed by a gradual hardening of the cement paste. The precipitation of hydroxyapatite nanocrystals at body or room temperature, and the fact that those materials can be used as self-setting pastes, have for many years been the most attractive features of CPCs. However, the need to develop materials able to sustain bone tissue ingrowth and be capable of delivering drugs and bioactive molecules, together with the continuous requirement from surgeons to develop more easily handling cements, has pushed the development of new processing routes that can accommodate all these requirements, taking advantage of the possibility of manipulating the self-setting CPC paste. It is the goal of this paper to provide a brief overview of the new processing developments in the area of CPCs and to identify the most significant achievements.

  • Espumas inyectables de hidroxiapatita obtenidas por el método de espumado de la fase líquida de un cemento de fostato tricálcico alfa  Open access  awarded activity

     Montufar Jimenez, Edgar Benjamin
    Defense's date: 2010-07-26
    Department of Automatic Control, Universitat Politècnica de Catalunya
    Theses

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    Actualmente existe un gran número de lesiones y enfermedades que afectan el tejido óseo. El origen de estos problemas es diverso y su tratamiento también es diferente en cada caso. Uno de los principales problemas es la pérdida de masa ósea, que puede ser causada por la reabsorción de hueso, fracturas o extirpación de tumores; en estos casos el tratamiento requiere de un material de relleno óseo. Se espera que este material de relleno sea capaz de promover la regeneración de hueso; los materiales que cumplen con este requisito se les denomina injertos óseos. Otras aplicaciones de los injertos óseos son el aumento de hueso para corregir deformaciones o para fijar implantes dentales u ortopédicos. Se estima que en Europa los sustitutos óseos se utilizan en un millón de cirugías anualmente. El mercado mundial de estos materiales se estima en cinco billones de Euros con una tasa de crecimiento anual de 8-15 %.La hidroxiapatita, que corresponde a la fase mineral de hueso y dientes, es uno de los mejores materiales utilizados en el desarrollo de injertos óseos sintéticos. Las bioactividad y osteoconductividad de la hidroxiapatita son la razón de su éxito. Sin embargo, la hidroxiapatita es relativamente estable, por ello, los bloques sólidos no son reabsorbidos a largo plazo. Para incrementar la reabsorción de la hidroxiapatita, y permitir la formación de nuevo hueso hacia su interior, se incorporan macroporos abiertos en el material, mejorando también la osteointegración del implante. Un método para conseguir lo anterior es el espumado de los cementos de fosfatos de calcio; este enfoque tiene la ventaja de que la hidroxiapatita obtenida después del fraguado del cemento es más similar a la hidroxiapatita biológica que las hidroxiapatitas sinterizadas. Además, debido a que los cementos son inyectables cuando son una pasta, es posible obtener injertos óseos inyectables, macroporosos y autoconsolidables. El objetivo de la presente tesis es desarrollar espumas sólidas de hidroxiapatita a través del método de espumado de la fase líquida de un cemento de fosfato de calcio. Se espera que las espumas obtenidas puedan ser utilizadas como injertos óseos inyectables y autoconsolidables bajo condiciones fisiológicas. A lo largo de la tesis se estudian dos tipos de agentes espumantes. En primer lugar, el surfactante no iónico Tween 80 se estudia como agente espumante sintético, en segundo lugar, la gelatina, el alginato de sodio y el extracto de soja se estudian como agentes espumantes naturales. Estos polímeros se proponen como agentes espumantes con la intención de obtener espumas compuestas que imiten la composición y la estructura del nanocompuesto natural que es el tejido óseo.Los resultados mostraron que es posible obtener espumas inyectables de hidroxiapatita empleando contenidos de Tween 80 por debajo de la dosis máxima recomendada en administración parenteral. También se comprobó que la gelatina y el extracto de soja permiten obtener espumas inyectables y autofraguables in situ. Por el contrario, el alginato de sodio no mostró ser un buen agente espumante. Al comparar los dos tipos de agentes espumantes estudiados (sintético y natural) se puede concluir que el espumante sintético Tween 80 es más eficiente que los espumantes naturales; no obstante, la gelatina y el extracto de soja mejoran la Inyectabilidad y/o la cohesión de las espumas, ambas propiedades indispensables para utilizar estos materiales como injertos óseos inyectables y autoconsolidables.Los estudios in vitro e in vivo mostraron que las espumas obtenidas de hidroxiapatita no son toxicas, que pueden ser preparadas bajo condiciones estériles dentro del quirófano sin equipos especiales, y que las espumas seleccionadas tienen cohesión para endurecer in situ bajo condiciones fisiológicas, adaptando la forma y rellenando perfectamente el defecto cuando son implantadas por inyección.

    Nowadays, there are great number of injuries and illnesses that affect bone tissue. The origin of these diseases is diverse and their treatment is also different in each case. A great problem is bone loss, which can be caused by bone resorption, fractures or bone tumor extirpation; in these cases, a bone filler material will be required. It is expected that the filling material should be able to promote bone healing; materials that meet this properties are known as bone grafts. Other applications of bone grafting materials are the bone mass augmentation to correct deformations or to fix dental and orthopedic implants. It is estimated that in Europe bone substitutes are used in one million surgical procedures annually. The worldwide market of these materials is an estimated of five billion Euros with annual growth rate of 8-15%.One of the most successful materials used in the development of synthetic bone grafting materials is hydroxyapatite, which correspond to the mineral phase of bone and teeth. The bioactivity and the osteoconductivity properties of hydroxyapatite are the reasons of its success. Nevertheless, hydroxyapatite is relatively stable; therefore, solid blocks are not resorbed in the long term. In order to increase the hydroxyapatite resorption, and allow new bone ingrowth, open macropores are incorporated to the material, improving also implant osteointegration. One method to do this is by foaming calcium phosphate cements; this approach has the advantage that the resulting hydroxyapatite after cement setting is more similar to the biological apatite than sintered hydroxyapatite. In addition, since bone cements are injectable when they are a paste, it is possible to develop an injectable, macroporous, and self-setting bone graft.The objective of this thesis was to develop solid hydroxyapatite foams through the liquid phase foaming of a calcium phosphate bone cement. It is expected that the developed foams can be applied as injectable, self-setting, synthetic bone grafts under physiological conditions. Along with this thesis, two types of foaming agent were studied. In first place, non ionic surfactant Tween 80 was tested as syntactic foaming agent; and second, gelatin, sodium alginate and soy extract were tested as natural foaming agents. These biopolymers are proposed as foaming agents with the objective of obtaining composite foams that mimic the composition and structure of the natural nanocomposite that is bone tissue.The results showed that is possible to obtain injectable hydroxyapatite foams using Tween 80 amounts below the maximum dosage recommended for parenteral administration. Also, it was validated that gelatin and soy extract allow obtaining injectable, in situ self-setting foams. In contrast, sodium alginate did not show a good foaming capacity. Comparing the two types of studied foaming agents (synthetic and natural) it can be concluded that the synthetic foaming agent Tween 80 is more efficient than the natural foaming agents; however, gelatin and soy extract improved the injectability and/or the cohesion of the foams, both essential properties to use these materials as injectable and self-setting grafts.The in vitro and in vivo studies showed that the hydroxyapatite foams obtained were not toxic, they could be prepared under sterile conditions in the operating room without special staff, and the selected foams maintained their cohesion to set in situ under physiological conditions, adapting and filling perfectly the shape of the defect when implanted through injection.

  • Máquina de preparación de muestras para Histologías de Tejidos con Biomateriales Implantados

     Pegueroles Neyra, Marta; Canal Barnils, Cristina; Rodriguez Rius, Daniel; Español Pons, Montserrat; Manero Planella, Jose M.; Gil Mur, Francisco Javier; Montufar Jimenez, Edgar Benjamin; Ginebra Molins, Maria Pau
    Participation in a competitive project

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  • Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration

     Montufar Jimenez, Edgar Benjamin; Traykova, Tania; Schacht, Etienne; Ambrosio, Luigi; Santin, Matteo Alfredo Giovanni; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    Journal of materials science. Materials in medicine
    Date of publication: 2010-03
    Journal article

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    In this work gelatine was used as multifunctional additive to obtain injectable self-setting hydroxyapatite/ gelatine composite foams for bone regeneration. The foaming and colloidal stabilization properties of gelatine are well known in food and pharmaceutical applications. Solid foams were obtained by foaming liquid gelatine solutions at 50 C, followed by mixing them with a cement powder consisting of alpha tricalcium phosphate. Gelatine addition improved the cohesion and injectability of the cement paste. After setting the foamed paste transformed into a calcium deficient hydroxyapatite. The final porosity, pore interconnectivity and pore size were modulated by modifying the gelatine content in the liquid phase.

  • Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response

     Perut, Francesca; Montufar Jimenez, Edgar Benjamin; Ciapetti, Gabriela; Santin, Matteo Alfredo Giovanni; Salvage, J; Traykova, Tania; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau; Baldini, Nicola
    Acta biomaterialia
    Date of publication: 2010-12-10
    Journal article

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    Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. However, injectable formulations have so far only been obtained through the addition of relatively toxic surfactants. The present work describes the response of osteoblasts to a novel injectable foamed bone cement based on a composite formulation including the bioactive foaming agents soybean and gelatine. The foaming properties of both defatted soybean and gelatine gels were exploited to develop a self-hardening soy/gelatine/hydroxyapatite composite foam able to retain porosity upon injection. After setting, the foamed paste produced a calcium-deficient hydroxyapatite scaffold, showing good injectability and cohesion as well as interconnected porosity after injection. The intrinsic bioactivity of soybean and gelatine was shown to favour osteoblast adhesion and growth. These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery.

  • Injectable hydroxapatite foams for bone regeneration applications: comparison of synthetic and natural foaming agents

     Montufar Jimenez, Edgar Benjamin; Traykova, Tania; Schacht, Etienne; Ambrosio, Luigi; Santin, Matteo; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    Biofoams
    Presentation's date: 2009-10-28
    Presentation of work at congresses

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  • PREMI ICREA ACADEMIA

     Montufar Jimenez, Edgar Benjamin; Ginebra Molins, Maria Pau
    Participation in a competitive project

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  • Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications

     Español Pons, Montserrat; Pérez, Ricardo A.; Montufar Jimenez, Edgar Benjamin; Marichal, C.; Sacco, A.; Ginebra Molins, Maria Pau
    Acta biomaterialia
    Date of publication: 2009-09
    Journal article

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  • Foamed beta-tricalcium phosphate scaffolds

     Montufar Jimenez, Edgar Benjamin; Gil, C; Traykova, T; Ginebra Molins, Maria Pau; Planell Estany, Josep Antón
    Key engineering materials
    Date of publication: 2008-02
    Journal article

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  • Foamed beta-tricalcium phosphate scaffolds

     Montufar Jimenez, Edgar Benjamin; Ginebra Molins, Maria Pau; Planell Estany, Josep Antón
    Symposium and Annual Meeting of International Society for Ceramics in Medicine
    Presentation's date: 2007-10-26
    Presentation of work at congresses

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  • Substratos macroporosos bioactivos para ingeniería de tejido óseo

     Montufar Jimenez, Edgar Benjamin; Gil, C; Traykova, T; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    Materia 2007
    Presentation of work at congresses

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  • Macroporous scaffolds for bone tissue engineering obtained via foaming of calcium phosphate cement

     Montufar Jimenez, Edgar Benjamin; Almirall, A; Palmqvist, A; Traykova, T; Planell Estany, Josep Antón; Ginebra Molins, Maria Pau
    4th Research Conference, European School of Materials Science and Engineering
    Presentation of work at congresses

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