Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death

Autor
Fernandez, A.; Hervas, R.; Dominguez , M.; Garrido, N.; Gomez, P.; Vega, M.; Vitorica, J.; Perez, J.; Torres, I.
Tipus d'activitat
Article en revista
Revista
Journal of alzheimers disease
Data de publicació
2016-01-01
Volum
52
Número
4
Pàgina inicial
1471
Pàgina final
1478
DOI
https://doi.org/10.3233/JAD-160149 Obrir en finestra nova
URL
http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160149 Obrir en finestra nova
Resum
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase calcineurin with the transcription factor FOXO3 is a major driver in AD-associated pathological inflammation, suggesting a potential new druggable target for this devastating disease. We have now developed decoy molecules to interfere with calci...
Paraules clau
ALPHA, ALZHEIMERS-DISEASE, Alzheimer's disease, FOXO, GROWTH-FACTOR, PRECURSOR PROTEIN, astrocytes, calcineurin, decoy compounds
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

  • Fernandez, Ana M.  (autor)
  • Hervas, Ruben  (autor)
  • Dominguez Fraile, Manuel  (autor)
  • Garrido Victoria, Navarro  (autor)
  • Gomez Gutierrez, Patricia  (autor)
  • Vega, Miguel  (autor)
  • Vitorica, Javier  (autor)
  • Perez Gonzalez, Juan Jesus  (autor)
  • Torres Aleman, Ignacio  (autor)