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Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression

Autor
Udina, M.; Navines, R.; Egmond, E.; Oriolo, G.; Langohr, K.; Giménez, D.; Valdés, M.; Gomez, E.; Grande, I.; Gratacos, M.; Kapczinski, F.; Artigas, F.; Vieta, E.; Sola, R.; Martin, R.
Tipus d'activitat
Article en revista
Revista
International journal of neuropsychopharmacology
Data de publicació
2016-12-30
Volum
19
Número
4
Pàgina inicial
1
Pàgina final
12
DOI
https://doi.org/10.1093/ijnp/pyv135 Obrir en finestra nova
Projecte finançador
Métodos avanzados en estudios de seguimiento: diseño de ensayos clínicos, datos longitudinales y censura en un intervalo
Repositori
http://hdl.handle.net/2117/100658 Obrir en finestra nova
URL
http://ijnp.oxfordjournals.org/content/19/4/pyv135 Obrir en finestra nova
Resum
Background: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, proinflammatory cytokines change brain function in several ways, such as altering neurotransmitters, the glucocorticoid axis, and apoptotic mechanisms. This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with c...
Citació
Udina, M., Navines, R., Egmond, E., Oriolo, G., Langohr, K., Giménez, D., Valdés, M., Gomez, E., Grande, I., Gratacos, M., Kapczinski, F., Artigas, F., Vieta, E., Sola, R., Martin, R. Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression. "International journal of neuropsychopharmacology", 30 Desembre 2016, vol. 19, núm. 4, p. 1-12.
Paraules clau
5HT1A, COMT, GCR1, depression, genetic, hepatitis C, inflammation pathways, personality traits, risk factors
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

Participants

  • Udina, Marc  (autor)
  • Navinés, Ricard  (autor)
  • Egmond, E.  (autor)
  • Oriolo, G.  (autor)
  • Langohr, Klaus  (autor)
  • Giménez, Dolors  (autor)
  • Valdés, M.  (autor)
  • Gómez Gil, E.  (autor)
  • Grande, I.  (autor)
  • Gratacos, M.  (autor)
  • Kapczinski, F.  (autor)
  • Artigas, F.  (autor)
  • Vieta, E.  (autor)
  • Sola, R.  (autor)
  • Martin Santos, R.  (autor)

Arxius