Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Autor
De la Torre, R.; de Sola, S.; Hernández, G.; Farré, M.; Langohr, K.; Cuenca, A.; Xicota, L.; Janel, N.; Gonzalo Sanchez-Benavides; Blehaut, H.; del Hoyo, L.; Benejam, B.; Blanco,-Hinojo L.; Videla, S.; Dierssen, M.
Tipus d'activitat
Article en revista
Revista
Lancet neurology
Data de publicació
2016-07-01
Volum
15
Número
8
Pàgina inicial
801
Pàgina final
810
DOI
https://doi.org/10.1016/S1474-4422(16)30034-5 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/100655 Obrir en finestra nova
URL
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30034-5/abstract Obrir en finestra nova
Resum
Background Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that administration of a green tea extract containing epigallocatechin-3-gallate (EGCG) would improve the effects of non-pharmacological cognitive rehabilitation in young adults with Down's syndrome.; Methods We enrolled adults (aged 16-34 years) with Down's syndrome from outpatient settin...
Citació
De la Torre, R., de Sola, S., Hernández, G., Farré, M., Langohr, K., Cuenca, A., Xicota, L., Janel, N., Gonzalo Sanchez-Benavides, Blehaut, H., del Hoyo, L., Benejam, B., Blanco,-Hinojo L., Videla, S., Dierssen, M. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. "Lancet neurology", 1 Juliol 2016, vol. 15, núm. 8, p. 801-810.
Paraules clau
Brain, DYRK1A, Deficits, Expression, Green tea polyphenols, Kinase, Metabolism, Mouse models, Rescue
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

Participants

  • De la Torre Fornell, Rafael  (autor)
  • de Sola Llopis, Susana  (autor)
  • Hernández, Gimena  (autor)
  • Farré, Magí  (autor)
  • Langohr, Klaus  (autor)
  • Cuenca Royo, Aida  (autor)
  • Xicota, Laura  (autor)
  • Janel, Nathalie  (autor)
  • Sánchez Benavides, Gonzalo  (autor)
  • Blehaut, Henri  (autor)
  • del Hoyo, Laura  (autor)
  • Benejam, Bessy  (autor)
  • Blanco Hinojo, Laura  (autor)
  • Videla, Sebastià  (autor)
  • Dierssen, Mara  (autor)