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New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding.

Autor
S. Lupala, C.; Gomez-Gutierrez, P.; Perez, J.
Tipus d'activitat
Article en revista
Revista
Journal of molecular graphics and modeling
Data de publicació
2016-07-26
Volum
68
Pàgina inicial
184
Pàgina final
196
DOI
https://doi.org/10.1016/j.jmgm.2016.06.010 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/90190 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1093326316301048 Obrir en finestra nova
Resum
Bradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, BK antagonists have long been sought after for therapeutic intervention. Action of BK is mediated through two different G-protein coupled receptors known as B1 and B2. Although there are several B1 antagonists reported in literature, their pharmacological profile is not yet opti...
Citació
S. Lupala, C., Gomez-Gutierrez, P., Perez, J. New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding.. "Journal of molecular graphics and modeling", 26 Juliol 2016, vol. 68, p. 184-196.
Paraules clau
B1 antagonist, Bradykinin B1 receptor, GPCR homology modeling, Pharmacophore development
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants