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Neuroprotective Role of Gap Junctions in a Neuron Astrocyte Network Model

Autor
Huguet, G.; Joglekar, A.; Messi, L.; Buckalew, R.; Wong, S.; Terman, D.
Tipus d'activitat
Article en revista
Revista
Biophysical journal
Data de publicació
2016-07-26
Volum
111
Número
2
Pàgina inicial
452
Pàgina final
462
DOI
https://doi.org/10.1016/j.bpj.2016.05.051 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/90099 Obrir en finestra nova
URL
http://www.cell.com/biophysj/abstract/S0006-3495(16)30443-X Obrir en finestra nova
Resum
A detailed biophysical model for a neuron/astrocyte network is developed to explore mechanisms responsible for the initiation and propagation of cortical spreading depolarizations and the role of astrocytes in maintaining ion homeostasis, thereby preventing these pathological waves. Simulations of the model illustrate how properties of spreading depolarizations, such as wave speed and duration of depolarization, depend on several factors, including the neuron and astrocyte Na+-K+ ATPase pump str...
Citació
Huguet, G., Joglekar, A., Messi, L., Buckalew, R., Wong, S., Terman, D. Neuroprotective Role of Gap Junctions in a Neuron Astrocyte Network Model. "Biophysical journal", 26 Juliol 2016, vol. 111, núm. 2, p. 452-462.
Paraules clau
Cortical spreading depression, brain-injury, central-nervous-system, computer-simulations, depolarization, glial-cells, ischemic-stroke, metabolism, propagation, seizures
Grup de recerca
SD - Sistemes Dinàmics de la UPC

Participants

  • Huguet Casades, Gemma  (autor)
  • Joglekar, Anoushka  (autor)
  • Messi, Leopold Matamba  (autor)
  • Buckalew, Richard  (autor)
  • Wong, Sarah  (autor)
  • Terman, David  (autor)

Arxius