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Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo

Autor
Fraioli, R.; Dashnyam, K.; Kim, J.; Perez, R.; Kim, H-W.; Gil, F.J.; Ginebra, M.P.; Manero, J.; Mas-Moruno, C.
Tipus d'activitat
Article en revista
Revista
Acta biomaterialia
Data de publicació
2016-10-01
Volum
43
Pàgina inicial
269
Pàgina final
281
DOI
https://doi.org/10.1016/j.actbio.2016.07.049 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/100440 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S1742706116303841 Obrir en finestra nova
Resum
Surface modification stands out as a versatile technique to create instructive biomaterials that are able to actively direct stem cell fate. Chemical functionalization of titanium has been used in this work to stimulate the differentiation of human mesenchymal stem cells (hMSCs) into the osteoblastic lineage, by covalently anchoring a synthetic double-branched molecule (PTF) to the metal that allows a finely controlled presentation of peptidic motifs. In detail, the effect of the RGD adhesive pe...
Citació
Fraioli, R., Dashnyam, K., Kim, J., Perez, R.A., Kim, H-W., Gil, J., Ginebra, M.P., Manero, J., Mas-Moruno, C. Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo. "Acta biomaterialia", 1 Octubre 2016, vol. 43, p. 269-281.
Paraules clau
Integrin-binding peptides, Osseointegration, RGD-PHSRN, Titanium, hMSCs
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants