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DNA methylation profiling unveils TGF-ß hyperresponse in tumor associated fibroblasts from lung cancer patients

Autor
Vizioso, M.; Puig, M.; Carmona, F.; Maqueda, M.; Gomez, A.; Labernardie, N.; Gabasa, M.; Mendizuri, S.; Ikemori, R.; Trepat, X.; Moran, S.; Vidal, E.; Reguart, N.; Perera, A.; Esteller, M.; Alcaraz Casademunt, Jordi
Tipus d'activitat
Article en revista
Revista
Cancer research
Data de publicació
2016-07-22
Volum
76
Número
14 Supplement
Pàgina inicial
2764
Pàgina final
2764
DOI
https://doi.org/10.1158/1538-7445.AM2016-2763 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/102534 Obrir en finestra nova
Resum
There is growing interest in defining the aberrant molecular differences between normal and tumor-associated fibroblasts (TAFs) that support tumor progression. For this purpose, we recently conducted a genome-wide DNA methylation profiling of TAFs and paired control fibroblasts (CFs) from non-small cell lung cancer (NSCLC) patients, and reported a widespread hypomethylation concomitantly with focal gain of DNA methylation; in addition, we found evidence that a fraction of lung TAFs are fibrocyte...
Citació
Vizioso, M., Puig, M., Carmona, F., Maqueda, M., Gomez, A., Labernardie, N., Gabasa, M., Mendizuri, S., Ikemori, R., Trepat, X., Moran, S., Vidal, E., Reguart, N., Perera, A., Esteller, M., Alcaraz, J. DNA methylation profiling unveils TGF-ß hyperresponse in tumor associated fibroblasts from lung cancer patients. "Cancer research", 22 Juliol 2016, vol. 76, núm. 14 Supplement, p. 2764.
Grup de recerca
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Centre de Recerca en Enginyeria Biomedica

Participants

  • Vizioso, Miguel  (autor)
  • Puig, Marta  (autor)
  • Carmona, F. Javier  (autor)
  • Maqueda Gonzalez, Maria de Los Angeles  (autor)
  • Gomez, Antonio  (autor)
  • Labernardie, nna  (autor)
  • Gabasa, Marta  (autor)
  • Mendizuri, Saloa  (autor)
  • Ikemori, Rafael  (autor)
  • Trepat Guixer, Xavier  (autor)
  • Moran, Sebastian  (autor)
  • Vidal, Enrique  (autor)
  • Reguart, Noemí  (autor)
  • Perera Lluna, Alexandre  (autor)
  • Esteller Badosa, Manel  (autor)
  • Alcaraz Casademunt, Jordi  (autor)