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A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins

Autor
Kapp, T.; Rechenmacher, F.; Neubauer, S.; Maltsev, O.; Cavalcanti-Adam, E.; Zarka, R.; Reuning, U.; Notni, J.; Wester, H.J.; Mas-Moruno, C.; Spatz, J.; Geiger, B.; Kessler, H.
Tipus d'activitat
Article en revista
Revista
Scientific reports
Data de publicació
2017-01-11
Volum
7
DOI
https://doi.org/10.1038/srep39805 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/102476 Obrir en finestra nova
URL
http://www.nature.com/articles/srep39805 Obrir en finestra nova
Resum
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported ...
Citació
Kapp, T., Rechenmacher, F., Neubauer, S., Maltsev, O., Cavalcanti-Adam, E., Zarka, R., Reuning, U., Notni, J., Wester, H.J., Mas-Moruno, C., Spatz, J., Geiger, B., Kessler, H. A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. "Scientific reports", 11 Gener 2017, vol. 7.
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Kapp, Tobias G.  (autor)
  • Rechenmacher, Florian  (autor)
  • Neubauer, Stefanie  (autor)
  • Maltsev, Oleg V.  (autor)
  • Cavalcanti-Adam, Elisabetta Ada  (autor)
  • Zarka, Revital  (autor)
  • Reuning, Ute  (autor)
  • Notni, Johannes  (autor)
  • Wester, Hans-Jürgen  (autor)
  • Mas Moruno, Carlos  (autor)
  • Spatz, Joachim  (autor)
  • Geiger, Benjamin  (autor)
  • Kessler, Horst  (autor)