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Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration

Autor
Srinivasan, S.; Cordomí, A.; Ramon, E.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
Cellular and molecular life sciences
Data de publicació
2016-03
Volum
73
Número
6
Pàgina inicial
1253
Pàgina final
1263
DOI
https://doi.org/10.1007/s00018-015-2043-7 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/102660 Obrir en finestra nova
Resum
Human red and green visual pigments are seven transmembrane receptors of cone photoreceptor cells of the retina that mediate color vision. These pigments share a very high degree of homology and have been assumed to feature analogous structural and functional properties. We report on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV–Vis/fluorescence spectroscopic analyses, molecular modeling and site-directed mutagenesis. We find that photoactivat...
Citació
Srinivasan, S., Cordomí, A., Ramon, E., Garriga, P. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration. "Cellular and molecular life sciences", Març 2016, vol. 73, núm. 6, p. 1253-1263.
Paraules clau
Color vision, G-protein coupled, Ligand binding, Receptors, Retinal, Visual phototransduction
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

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