Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Stability hierarchy between Piracetam forms I, II, and III from experimental pressure–temperature diagrams and topological inferences

Autor
Toscani, S.; Céolin, R.; Ter Minassian, L.; Del Barrio, M.; Veglio, N.; Tamarit, J. Ll.; Louër, D.; Rietveld, I.
Tipus d'activitat
Article en revista
Revista
International journal of pharmaceutics
Data de publicació
2016-01-30
Volum
497
Número
1-2
Pàgina inicial
96
Pàgina final
105
DOI
https://doi.org/10.1016/j.ijpharm.2015.11.036 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/103564 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0378517315303811 Obrir en finestra nova
Resum
The trimorphism of the active pharmaceutical ingredient piracetam is a famous case of polymorphism that has been frequently revisited by many researchers. The phase relationships between forms I, II, and III were ambiguous because they seemed to depend on the heating rate of the DSC and on the history of the samples or they have not been observed at all (equilibrium II–III). In the present paper, piezo-thermal analysis and high-pressure differential thermal analysis have been used to elucidate...
Citació
Toscani, S., Céolin, R., Ter Minassian, L., Del Barrio, M., Veglio, N., Tamarit, J. Ll., Louër, D., Rietveld, I. Stability hierarchy between Piracetam forms I, II, and III from experimental pressure–temperature diagrams and topological inferences. "International journal of pharmaceutics", 30 Gener 2016, vol. 497, núm. 1-2, p. 96-105.
Paraules clau
Crystal polymorphism, Phase diagram, Phase transition, Physical stability, Preformulation, Solid state
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants

  • Toscani, Siro  (autor)
  • Céolin, René  (autor)
  • Ter Minassian, Leon  (autor)
  • Del Barrio Casado, Maria  (autor)
  • Veglio, Nestor Raul  (autor)
  • Tamarit Mur, Jose Luis  (autor)
  • Louër, Daniel  (autor)
  • Rietveld, Ivo B.  (autor)

Arxius