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Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts

Autor
Zhong, X.; Sun, B.; Vallmitjana, A.; Mi, T.; Guo, W.; Ni, M.; Wang, R.; Guo, A.; Duff, H.J.; Gillis, A.; Song, L.; Hove-Madsen, L.; Benitez, R.; Wayne Chen, S.R.
Tipus d'activitat
Article en revista
Revista
Biochemical journal
Data de publicació
2016-11-01
Volum
473
Número
21
Pàgina inicial
3951
Pàgina final
3964
DOI
https://doi.org/10.1042/BCJ20160606 Obrir en finestra nova
URL
http://www.biochemj.org/content/473/21/3951 Obrir en finestra nova
Resum
Beat-to-beat alternations in the amplitude of the cytosolic Ca2+ transient (Ca2+ alternans) are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias and sudden death. Despite its important role in arrhythmogenesis, the mechanism underlying Ca2+ alternans remains poorly understood. Here, we investigated the role of cardiac ryanodine receptor (RyR2), the major Ca2+ release channel responsible for cytosolic Ca2+ transients, in cardiac alternans. Using a unique m...
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
SISBIO - Senyals i Sistemes Biomèdics

Participants

  • Zhong, Xiaowei  (autor)
  • Sun, Bo  (autor)
  • Vallmitjana Lees, Alexander  (autor)
  • Mi, Tao  (autor)
  • Guo, Wenting  (autor)
  • Ni, Mingke  (autor)
  • Wang, Ruiwu  (autor)
  • Guo, Ang  (autor)
  • Duff, Henry J.  (autor)
  • Gillis, Anne M.  (autor)
  • Song, Long-Sheng  (autor)
  • Hove-Madsen, Leif  (autor)
  • Benitez Iglesias, Raul  (autor)
  • Chen, S.R. Wayne  (autor)