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Atomic scale insights into urea–peptide interactions in solution

Autor
Steinke, N.; Gillams, R.; Pardo, L.; Lorenz, C.; McLain, S.
Tipus d'activitat
Article en revista
Revista
Physical chemistry chemical physics
Data de publicació
2016-02-07
Volum
18
Número
5
Pàgina inicial
3862
Pàgina final
3870
DOI
https://doi.org/10.1039/c5cp06646h Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/103855 Obrir en finestra nova
URL
https://apps-webofknowledge-com.recursos.biblioteca.upc.edu/full_record.do?product=WOS&search_mode=GeneralSearch&qid=8&SID=3B82rjNOqGmtIAHfAnr&page=1&doc=1 Obrir en finestra nova
Resum
The mechanism by which proteins are denatured by urea is still not well understood, especially on the atomic scale where these interactions occur in vivo. In this study, the structure of the peptide GPG has been investigated in aqueous urea solutions in order to understand the combination of roles that both urea and water play in protein unfolding. Using a combination of neutron diffraction enhanced by isotopic substitution and computer simulations, it was found, in opposition with previous simu...
Citació
Steinke, N., Gillams, R., Pardo, L., Lorenz, C., McLain, S. Atomic scale insights into urea–peptide interactions in solution. "Physical chemistry chemical physics", 7 Febrer 2016, vol. 18, núm. 5, p. 3862-3870.
Paraules clau
AQUEOUS-SOLUTION, HYDRATION, INDUCED PROTEIN DENATURATION, LIQUID WATER, MOLECULAR-DYNAMICS, NEUTRON-DIFFRACTION EXPERIMENTS, PARTICLE MESH EWALD, POTENTIALS, SCATTERING, WATER-STRUCTURE
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants

  • Steinke, Nicola  (autor)
  • Gillams, Richard J.  (autor)
  • Pardo Soto, Luis Carlos  (autor)
  • Lorenz, Christian D.  (autor)
  • McLain, Sylvia E.  (autor)

Arxius