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Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation

Autor
Granell, M.; Urbano-Ispiuza, Á.; Pons, A.; Aróstigui, J.; Gel, B.; Navarro, A.; Jansana, S.; Artells, R.; Gaya, A.; Talarn, C.; Fernández-Avilés, F.; Martinez, C.; Rovira, M.; Carreras, E.; Rozman, C.; Juan, M.; Yagüe, J.; Montserrat, E.; Monzó, M.
Tipus d'activitat
Article en revista
Revista
Blood
Data de publicació
2008-09-04
DOI
https://doi.org/10.1182/blood-2007-12-129247 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/6672 Obrir en finestra nova
Resum
The inflammasomes are macromolecular cytosolic complexes involved in the production of interleukin-1beta (IL-1beta) and IL-18 in response to several pathogen-derived stimuli. Such interleukins have been implicated in the origin of severe allogeneic stem cell transplant (allo-SCT) complications. We analyzed the relationship between the interindividual variability in inflammasome protein-encoding genes in donors and patients and clinical outcome after allo-SCT. Fourteen common genetic variants in ...
Citació
Granell, M. [et al.]. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. "Blood", 04 Setembre 2008.
Grup de recerca
ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals

Participants

  • Granell, Miquel  (autor)
  • Urbano-Ispiuza, Álvaro  (autor)
  • Pons, Aina  (autor)
  • Aróstigui, Juan Ignacio  (autor)
  • Gel Moreno, Bernat  (autor)
  • Navarro, Alfons  (autor)
  • Jansana, Sonia  (autor)
  • Artells, Rosa  (autor)
  • Gaya, Anna  (autor)
  • Talarn, Carme  (autor)
  • Fernández¡ Aviles, Francesc  (autor)
  • Martinez Chamorro, Carmen  (autor)
  • Rovira, Montserrat  (autor)
  • Carreras, Enric  (autor)
  • Rozman, Ciril  (autor)
  • Juan, Manel  (autor)
  • Yagüe, Jordi  (autor)
  • Montserrat, Emili  (autor)
  • Monzó, Mariano  (autor)