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Estimation of synaptic conductances in presence of nonlinear effects caused by subthreshold ionic currents

Autor
Vich, C.; Guillamon, A.; Ditlevsen, S.; Berg, R.
Tipus d'activitat
Article en revista
Revista
Frontiers in computational neuroscience
Data de publicació
2017-07
Volum
69
Pàgina inicial
1
Pàgina final
14
DOI
https://doi.org/10.3389/fncom.2017.00069 Obrir en finestra nova
Projecte finançador
Modelización y análisis multiescala en biología de sistemas y biomedicina
SISTEMES DINAMICS DE LA UPC
Repositori
http://hdl.handle.net/2117/107542 Obrir en finestra nova
URL
http://journal.frontiersin.org/article/10.3389/fncom.2017.00069/full Obrir en finestra nova
Resum
Subthreshold fluctuations in neuronal membrane potential traces contain nonlinear components, and employing nonlinear models might improve the statistical inference. We propose a new strategy to estimate synaptic conductances, which has been tested using in silico data and applied to in vivo recordings. The model is constructed to capture the nonlinearities caused by subthreshold activated currents, and the estimation procedure can discern between excitatory and inhibitory conductances using onl...
Citació
Vich, C., Guillamon, A., Ditlevsen, S., Berg, R. Estimation of synaptic conductances in presence of nonlinear effects caused by subthreshold ionic currents. "Frontiers in computational neuroscience", Juliol 2017, vol. 69, p. 1-14.
Paraules clau
Ornstein-Uhlenbeck process, intracellular recordings of membrane potentials, intrinsic currents, maximum likelihood estimation, oversampling method, quadratic integrate-and-fire model, spinal motoneurons, synaptic inhibition and excitation
Grup de recerca
SD - Sistemes Dinàmics de la UPC

Participants

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