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Regenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials

Autor
Hoyos-Nogués, M.; Velasco, F.; Ginebra, M.P.; Manero, J.; Gil, F.J.; Mas-Moruno, C.
Tipus d'activitat
Article en revista
Revista
ACS applied materials and interfaces
Data de publicació
2017-07-05
Volum
9
Número
26
Pàgina inicial
21618
Pàgina final
21630
DOI
https://doi.org/10.1021/acsami.7b03127 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/106732 Obrir en finestra nova
URL
http://pubs.acs.org/doi/abs/10.1021/acsami.7b03127 Obrir en finestra nova
Resum
In dentistry and orthopedics, it is well accepted that implant fixation is a major goal. However, an emerging concern is bacterial infection. Infection of metallic implants can be catastrophic and significantly reduce patient quality of life. Accordingly, in this work, we focus on multifunctional coatings to simultaneously address and mitigate both these problems. We have developed a tailor-made peptide-based chemical platform that integrates the well-known RGD cell adhesive sequence and the lac...
Citació
Hoyos, M., Velasco, F., Ginebra, M.P., Manero, J., Gil, J., Mas-Moruno, C. Regenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials. "ACS applied materials and interfaces", 5 Juliol 2017, vol. 9, núm. 26, p. 21618-21630.
Paraules clau
antimicrobial peptides, cell adhesive peptides, multifunctionality, osseointegration, surface functionalization
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants