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Differential neuronal and glial behavior on flat and micro patterned chitosan films

Autor
Mattotti, M.; Álvarez, Z.; Delgado, L.; Mateos, M.; Aparicio, C.; Planell, J. A.; Alcántara, S.; Engel, E.
Tipus d'activitat
Article en revista
Revista
Colloids and Surfaces B: Biointerfaces
Data de publicació
2017-10-01
Volum
158
Pàgina inicial
569
Pàgina final
577
DOI
https://doi.org/10.1016/j.colsurfb.2017.07.045 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/107896 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0927776517304575?via%3Dihub Obrir en finestra nova
Resum
Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan either flat or patterned with grooves in the micrometric range. Chitosan demonstrated to be a good substrate for the attachment and growth of both neurons and glial cells. Chitosan micropatterns promoted glial cell maturation, suggesting astroglial activation. Nevertheless, tho...
Paraules clau
Brain, Chitosan, Glia, Micropattern, Neuron
Grup de recerca
BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
ICARUS - Intelligent Communications and Avionics for Robust Unmanned Aerial Systems

Participants