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Molecular dynamics study on the Apo- and Holo-forms of 5-lipoxygenase

Autor
Torras, J.; Maccarrone, M.; Enrico, D.
Tipus d'activitat
Article en revista
Revista
Biotechnology and applied biochemistry
Data de publicació
2017-09-07
DOI
https://doi.org/10.1002/bab.1583 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/108425 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/bab.1583/abstract;jsessionid=6B55496FB4B2DAC10AE2AEBD7458B367.f03t03?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+7th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+08.00+EDT+%2F+13.00+BST+%2F+17%3A30+IST+%2F+20.00+SGT+and+Sunday+8th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+06.00+EDT+%2F+11.00+BST+%2F+15%3A30+IST+%2F+18.00+SGT+for+essential+maintenance.+Apologies+for+the+inconvenience+caused+. Obrir en finestra nova
Resum
Lipoxygenases (LOXs) are nonheme iron-containing enzymes catalyzing the dioxygenation of polyunsaturated fatty acids. LOX catalytic activity depends on the presence of iron in the active site and the iron removal is also able to affect the membrane binding properties of the enzyme. Leukotrienes biosynthesis is initiated by the action of 5-LOX at the level of nuclear membrane and the mechanism of enzyme-membrane interaction is thought to involve structural flexibility and conformational changes a...
Citació
Torras, J., Maccarrone, M., Enrico, D. Molecular dynamics study on the Apo- and Holo-forms of 5-lipoxygenase. "Biotechnology and applied biochemistry", 7 Setembre 2017.
Paraules clau
5-LOX, Enzyme flexibility, Molecular dynamics
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants