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Structural and Functional Studies of AT-Rich DNA Ligands and Their Effect on Trypanosoma brucei

Autor
Millan, C.
Tipus d'activitat
Tesi doctoral
Altres unitats relacionades
Departament d'Enginyeria Química
Data de la defensa
2017-10-27
URL
http://hdl.handle.net/2117/114006 Obrir en finestra nova
Resum
AT-rich sequences confer unique properties to DNA, such as high polymorphism and flexibility. The abundance of AT-rich DNA in several pathogens' genomes and the ability of specific molecules to selectively target AT base pairs have prompted studies on ligands that interact with the minor groove of high AT content DNA. Of special interest are kinetoplastid parasites, such as Trypanosoma brucei, the causative agent of sleeping sickness, which are distinguished by the presence of a very AT-rich mit...
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques

Participants

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