Moreno Chicano, Tadeo
Total activity: 2
Research group
MACROM - Crystallography, Structure and Function of Biological Macromolecules
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  • Structural studies of AT-rich DNA and its complexes with drugs and AT-hook peptides

     Moreno Chicano, Tadeo; Sanchez Giraldo, Raquel; Fonfria Subiros, Elsa; Condom, Núria; Pous, Joan; Subirana Torrent, Juan Antonio; Saperas Plana, Nuria; Urpi Garriga, Lourdes; MALININA, LUCY; Campos Lopez, Josefa de Lourdes
    The EMBO meeting
    p. 123
    Presentation's date: 2010-09
    Presentation of work at congresses

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  • Coiled-coil conformation of a pentamidine-DNA complex

     Moreno Chicano, Tadeo; Pous, Joan; Subirana Torrent, Juan Antonio; Campos Lopez, Josefa de Lourdes
    Acta crystallographica. Section D, biological crystallography
    Vol. 66, p. 251-257
    DOI: 10.1107/S0907444909055693
    Date of publication: 2010-03
    Journal article

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    The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A·T base pairs.