Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Antimicrobial electrospun fibers of polyester loaded with engineered cyclic gramicidin analogues

Autor
Maione, S.; del Valle, LJ.; Pérez-Madrigal, Maria M.; Cativiela, C.; Puiggali, J.; Aleman, C.
Tipus d'activitat
Article en revista
Revista
Fibers
Data de publicació
2017
Volum
5
Número
34
Pàgina inicial
1
Pàgina final
20
DOI
https://doi.org/10.3390/fib5030034 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/112146 Obrir en finestra nova
Resum
Biodegradable polyester fibers have been loaded with two engineered analogues of gramicidin soviet. In these cyclic peptide derivatives, which were designed in a previous work to stabilize the bioactive conformation while enhancing the antimicrobial activity, the D-Phe was replaced by D-Pro, and the L-Pro was changed by 1-aminocyclopropanecarboxylic acid (Ac3c) or by an Ac3c derivative with two vicinal phenyl substituents in a trans relative disposition (S,S-c3diPhe). The diameter, topography, t...
Citació
Maione, S., del Valle, LJ., Pérez-Madrigal, Maria M., Cativiela, C., Puiggali, J., Aleman, C. Antimicrobial electrospun fibers of polyester loaded with engineered cyclic gramicidin analogues. "Fibers", 2017, vol. 5, núm. 34, p. 1-20.
Paraules clau
biocompatibility, conformational restrictions, electrospinning, encapsulation, engineered peptides, hydrophobic peptides
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.

Participants

Arxius