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An optimized TOPS+ comparison method for enhanced TOPS models

Autor
Veeramalai, M.; Gilbert, D.; Valiente, G.
Tipus d'activitat
Article en revista
Revista
BMC bioinformatics
Data de publicació
2010-03-17
Volum
11
Número
138
DOI
https://doi.org/10.1186/1471-2105-11-138 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/12865 Obrir en finestra nova
Resum
Background: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. Previously we have discussed the basic mechanisms of our novel method for structure comparison based on our TOPS+ model (Topological descriptions of Protein Structures Enhanced with Ligand Information). In this paper we show how these results can be significantly improved...
Citació
Veeramalai, M.; Gilbert, D.; Valiente, G. An optimized TOPS+ comparison method for enhanced TOPS models. "BMC bioinformatics", 17 Març 2010, vol. 11, núm. 138.
Paraules clau
Molecular biophysics, Molecular configurations, Optimisation, Parameter estimation, Proteins
Grup de recerca
ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals

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