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  • Development and characterization of biphasic hydroxyapatite/ß-TCP cements

     Gallinetti, Sara; Canal Barnils, Cristina; Ginebra Molins, Maria Pau
    Journal of the American Ceramic Society
    Date of publication: 2014-04
    Journal article

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    Biphasic calcium phosphate bioceramics composed of hydroxyapatite (HA) and ß-tricalcium phosphate (ß-TCP) have relevant properties as synthetic bone grafts, such as tunable resorption, bioactivity, and intrinsic osteoinduction. However, they have some limitations associated to their condition of high-temperature ceramics. In this work self-setting Biphasic Calcium Phosphate Cements (BCPCs) with different HA/ß-TCP ratios were obtained from self-setting a-TCP/ß-TCP pastes. The strategy used allowed synthesizing BCPCs with modulated composition, compressive strength, and specific surface area. Due to its higher solubility, a-TCP was fully hydrolyzed to a calcium-deficient HA (CDHA), whereas ß-TCP remained unreacted and completely embedded in the CDHA matrix. Increasing amounts of the non-reacting ß-TCP phase resulted in a linear decrease of the compressive strength, in association to the decreasing amount of precipitated HA crystals, which are responsible for the mechanical consolidation of apatitic cements. Ca2+ release and degradation in acidic medium was similar in all the BCPCs within the timeframe studied, although differences might be expected in longer term studies once ß-TCP, the more soluble phase was exposed to the surrounding media

    Biphasic calcium phosphate bioceramics composed of hydroxyapatite (HA) and ß-tricalcium phosphate (ß-TCP) have relevant properties as synthetic bone grafts, such as tunable resorption, bioactivity, and intrinsic osteoinduction. However, they have some limitations associated to their condition of high-temperature ceramics. In this work self-setting Biphasic Calcium Phosphate Cements (BCPCs) with different HA/ß-TCP ratios were obtained from self-setting a-TCP/ß-TCP pastes. The strategy used allowed synthesizing BCPCs with modulated composition, compressive strength, and specific surface area. Due to its higher solubility, a-TCP was fully hydrolyzed to a calcium-deficient HA (CDHA), whereas ß-TCP remained unreacted and completely embedded in the CDHA matrix. Increasing amounts of the non-reacting ß-TCP phase resulted in a linear decrease of the compressive strength, in association to the decreasing amount of precipitated HA crystals, which are responsible for the mechanical consolidation of apatitic cements. Ca2+ release and degradation in acidic medium was similar in all the BCPCs within the timeframe studied, although differences might be expected in longer term studies once ß-TCP, the more soluble phase was exposed to the surrounding media

  • Obtencion de un recubrimiento antifouling sobre titanio para aplicaciones biomedicas

     Buxadera Palomero, Judit; Canal Barnils, Cristina; Gil Mur, Francisco Javier; Rodriguez Rius, Daniel
    Congreso Nacional de Materiales
    Presentation's date: 2014-06-20
    Presentation of work at congresses

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  • Treatment of Textile Surfaces by Plasma Technology for Biomedical Applications

     Labay, Cedric Pierre
    Defense's date: 2014-06-12
    Department of Textile and Paper Engineering, Universitat Politècnica de Catalunya
    Theses

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    Las aplicaciones médicas de los textiles técnicos son un campo de investigación en expansión. Uno de los valores añadidos de estos nuevos materiales puede ser su capacidad para contener y liberar principios activos farmacéuticos y cosméticos de una forma controlada y sostenida.La incorporación de fármacos y su liberación a partir de fibras sintéticas está relacionada con la interacción del fármaco con el polímero y puede depender en gran medida de la química de superficie de la fibra. La tecnología de plasma es una herramienta que permite modificar las propiedades físicas y químicas de los primero nanómetros de la superficie de las fibras sin afectar el interior del material. Aplicado al campo de los textiles médicos, el tratamiento con plasma de fibras poliméricas podría conducir al diseño de nuevos sistemas de liberación de fármacos basados en soportes textiles.La novedad de esta Tesis Doctoral se basa en la modificación de las interacciones fármaco / fibra por tratamiento de plasma para permitir la modulación de la incorporación y la liberación de los principios activos (farmacéuticos y cosméticos) a partir de sistemas de administración de fármacos basados en material textil, sin requerir el uso de productos químicos adicionales.Esta Tesis tiene como objetivo el desarrollo de dos familias de sistemas de liberación de fármacos basados en soportes textiles, por funcionalización de la superficie mediante tratamiento de plasma, con características adecuadas bien para uso tópico como dispositivos médicos, bien para aplicación clínica en la reparación de tejidos blandos. Por tanto, esta Tesis se organiza en dos partes bien diferenciadas.En ambas partes de esta Tesis se ha seguido el siguiente esquema general: en primer lugar se ha investigado primero la modificación superficial de los materiales textiles con diferentes tipos de plasmas (plasma corona y plasma de presión atmosférica), caracterizando las modificaciones de la superficie obtenidas mediante diferentes técnicas instrumentales. Los efectos del tratamiento con plasma se han evaluado entonces sobre la incorporación de principios activos farmacéuticos o cosméticos. En el último paso, se ha estudiado la liberación del fármaco mediante ensayos de disolución "in vitro".La primera parte de la Tesis Doctoral se centra en los textiles médicos para aplicación tópica. Para ello, se ha estudiado la modificación de la superficie de tejidos de punto elástico-compresivos de poliamida 66 con plasma corona y plasma de baja presión. En este trabajo experimental se han estudiado en paralelo tejidos preparados en laboratorio y tejidos industrialmente acabados, con vistas a la posible implementación del proceso propuesto en la cadena de producción industrial textil. Se ha observado que el tratamiento con plasma mejora la cinética de liberación de un fármaco anti-inflamatorio (ketoprofeno) y de un principio activo cosmético lipolítico (cafeína), incorporados en los tejidos de poliamida 66 tratados con plasma. Se ha desarrollado un estudio fundamental comparando tres moléculas diferentes de la misma familia química (cafeína, teobromina y pentoxifilina) con respecto a la incorporación al material textil y a la liberación del principio activo.La segunda parte se centra en los textiles utilizados como implantes para la reparación de tejidos blandos (por ejemplo, hernias abdominales). La superficie de la fibra de una malla de polipropileno approvada para su uso clínico ha sido modificada por el plasma corona y plasma de baja presión. Los tratamientos estudiados tuvieron un efecto importante sobre la carga de un antibiótico (ampicilina) mostrando un importante incremento del porcentaje de impregnación. La cinética de liberación in vitro del antibiótico de la malla de polipropileno a un medio líquido isotonico fue rápida. También se investigó la posibilidad de realizar un recubrimiento de la malla de polipropileno cargada con ampicilina mediante polimerización por plasma.

  • Plasma surface functionalization and dyeing kinetics of Pan-Pmma copolymers

     Labay, Cedric; Canal Barnils, Cristina; Rodriguez Sorigue, Maria Cristina; Caballero Manresa, Gabriel; Canal Arias, Jose Maria
    Applied surface science
    Date of publication: 2013
    Journal article

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    Fiber surface modification with air corona plasma has been studied through dyeing kinetics under isothermal conditions at 30 °C on an acrylic-fiber fabric with a cationic dye (CI Basic Blue 3) analyzing the absorption, desorption and fixing on the surface of molecules having defined cationic character. The initial dyeing rate in the first 60 s indicates an increase of 58.3% in the dyeing rate due to the effect of corona plasma on the acrylic fiber surface. At the end of the dyeing process, the plasma-treated fabrics absorb 24.7% more dye, and the K/S value of the acrylic fabric increases by 8.8%. With selected dyestuff molecules, new techniques can be designed to amplify the knowledge about plasma-treated surface modifications of macromolecules.

    Fiber surface modification with air corona plasma has been studied through dyeing kinetics under isothermal conditions at 30 °C on an acrylic-fiber fabric with a cationic dye (CI Basic Blue 3) analyzing the absorption, desorption and fixing on the surface of molecules having defined cationic character. The initial dyeing rate in the first 60 s indicates an increase of 58.3% in the dyeing rate due to the effect of corona plasma on the acrylic fiber surface. At the end of the dyeing process, the plasma-treated fabrics absorb 24.7% more dye, and the K/S value of the acrylic fabric increases by 8.8%. With selected dyestuff molecules, new techniques can be designed to amplify the knowledge about plasma-treated surface modifications of macromolecules.

  • Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres

     Rodriguez Contreras, Alejandra Maria; Canal Barnils, Cristina; Calafell Monfort, Margarita; Ginebra Molins, Maria Pau; Julio Moran, Gemma; Marques Calvo, Maria Soledad
    European polymer journal
    Date of publication: 2013-11
    Journal article

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    Natural and synthetic biodegradable polymers have been investigated for controlled drug release. Poly(3-hydroxybutyrate) can be produced by bacteria and is remarkable for this application due to its excellent biocompatibility and biodegradability. The objective of this work was to study different drug-entrapment and emulsification methods for the obtaining of doxycycline-loaded PHB micro- and nano-spheres. The micro-/nano-particles were prepared by polymer precipitation via dialysis, simple emulsion (O/W) or multiple emulsion (W1/O/W2) applying solvent evaporation in the last two cases. This was carried out either by ultrasonication, dripping and/or high speed stirring. Different processing conditions were varied in order to evaluate their influence on morphology, size, and drug entrapment capabilities. The highest drug loading was obtained by single emulsion with high speed stirring. In the case of multiple emulsion, the combination of ultrasound with high speed stirring resulted in the most elevate process yield and drug loading capability. © 2013 Elsevier Ltd. All rights reserved.

    Natural and synthetic biodegradable polymers have been investigated for controlled drug release. Poly(3-hydroxybutyrate) can be produced by bacteria and is remarkable for this application due to its excellent biocompatibility and biodegradability. The objective of this work was to study different drug-entrapment and emulsification methods for the obtaining of doxycycline-loaded PHB micro- and nano-spheres. The micro-/nano-particles were prepared by polymer precipitation via dialysis, simple emulsion (O/W) or multiple emulsion (W1/O/W2) applying solvent evaporation in the last two cases. This was carried out either by ultrasonication, dripping and/or high speed stirring. Different processing conditions were varied in order to evaluate their influence on morphology, size, and drug entrapment capabilities. The highest drug loading was obtained by single emulsion with high speed stirring. In the case of multiple emulsion, the combination of ultrasound with high speed stirring resulted in the most elevate process yield and drug loading capability.

  • Relevance of microstructure for the early antibiotic release of fresh and pre-set calcium phosphate cements

     Canal Barnils, Cristina; Pastorino Carraz, David; Mestres Bea, Gemma; Schuler, Philipp; Ginebra Molins, Maria Pau
    Acta biomaterialia
    Date of publication: 2013
    Journal article

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    Calcium phosphate cements (CPCs) have great potential as carriers for controlled release and vectoring of drugs in the skeletal system. However, a lot of work still has to be done in order to obtain reproducible and predictable release kinetics. A particular aspect that adds complexity to these materials is that they cannot be considered as stable matrices, since their microstructure evolves during the setting reaction. The aims of the present work were to analyze the effect of the microstructural evolution of the CPC during the setting reaction on the release kinetics of the antibiotic doxycycline hyclate and to assess the effect of the antibiotic on the microstructural development of the CPC. The incorporation of the drug in the CPC modified the textural and microstructural properties of the cements by acting as a nucleating agent for the heterogeneous precipitation of hydroxyapatite crystals, but did not affect its antibacterial activity. In vitro release experiments were carried out on readily prepared cements (fresh CPCs), and compared to those of pre-set CPCs. No burst release was found in any formulation. A marked difference in release kinetics was found at the initial stages; the evolving microstructure of fresh CPCs led to a two-step release. Initially, when the carrier was merely a suspension of a-TCP particles in water, a faster release was recorded, which rapidly evolved to a zero-order release. In contrast, pre-set CPCs released doxycycline following non-Fickian diffusion. The final release percentage was related to the total porosity and entrance pore size of each biomaterial.

    Calcium phosphate cements (CPCs) have great potential as carriers for controlled release and vectoring of drugs in the skeletal system. However, a lot of work still has to be done in order to obtain reproducible and predictable release kinetics. A particular aspect that adds complexity to these materials is that they cannot be considered as stable matrices, since their microstructure evolves during the setting reaction. The aims of the present work were to analyze the effect of the microstructural evolution of the CPC during the setting reaction on the release kinetics of the antibiotic doxycycline hyclate and to assess the effect of the antibiotic on the microstructural development of the CPC. The incorporation of the drug in the CPC modified the textural and microstructural properties of the cements by acting as a nucleating agent for the heterogeneous precipitation of hydroxyapatite crystals, but did not affect its antibacterial activity. In vitro release experiments were carried out on readily prepared cements (fresh CPCs), and compared to those of pre-set CPCs. No burst release was found in any formulation. A marked difference in release kinetics was found at the initial stages; the evolving microstructure of fresh CPCs led to a two-step release. Initially, when the carrier was merely a suspension of α-TCP particles in water, a faster release was recorded, which rapidly evolved to a zero-order release. In contrast, pre-set CPCs released doxycycline following non-Fickian diffusion. The final release percentage was related to the total porosity and entrance pore size of each biomaterial.

  • Obtención y caracterización de un recubrimiento de poli(etilenglicol) sobre titanio por polimerización por plasma

     Buxadera Palomero, Judit; Gil Mur, Francisco Javier; Canal Barnils, Cristina; Rodriguez Rius, Daniel
    Congreso de la Sociedad Ibérica de Biomecánica y Biomateriales
    Presentation's date: 2013-10-26
    Presentation of work at congresses

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    En este trabajo se ha estudiado la formación de un recubrimiento de poli(etilenglicol) (PEG) sobre la superficie de titanio comercialmente puro de grado 2 para conferir a la superficie carácter antifouling con respecto a la adsorción de proteínas y a la adhesión bacteriana. Se ha escogido como método de inmovilización la polimerización por plasma, que es un método rápido que permite enlazar el polímero con la superficie. Este proceso consta de dos etapas: la activación superficial y la polimerización. Dichas etapas han sido estudiadas con tal de conseguir la mayor activación y el recubrimiento con mejores propiedades antifouling respecto a las proteínas y a las bacterias.

  • Atmospheric Plasma Jet for the Regulation of Drug Release on Bone Biomaterials

     Canal Barnils, Cristina; Modic, Martina; Cvelbar, Uros; Ginebra Molins, Maria Pau
    International Vacuum Congress
    Presentation's date: 2013-09-09
    Presentation of work at congresses

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  • Simvastatin acid release from low-temperature calcium phosphate scaffolds

     Gallinetti, Sara; Pastorino Carraz, David; Canal Barnils, Cristina; Ginebra Molins, Maria Pau
    European Conference on Biomaterials
    Presentation's date: 2013-09-08
    Presentation of work at congresses

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  • Enhanced adhesion at the interface between PLA fibres and calcium phosphate cements by low temperature plasma improves their mechanical properties

     Canal Barnils, Cristina; Gallinetti, Sara; Ginebra Molins, Maria Pau
    International Symposium on Ceramics in Medicine
    Presentation's date: 2013-11-07
    Presentation of work at congresses

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  • Research activities of the biomaterials, biomechanics and tissue engineering group

     Gil Mur, Francisco Javier; Ginebra Molins, Maria Pau; Canal Barnils, Cristina
    Electrical Discharges with liquids for future Applications
    Presentation's date: 2013-10-29
    Presentation of work at congresses

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  • Applications of plasmas on biomaterials for hard and soft tissue repair

     Canal Barnils, Cristina
    Biomedical Applications of Atmospheric Pressure Plasma Technology
    Presentation of work at congresses

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  • Polyester fabrics wetting

     Romero, Jenny; Canal Barnils, Cristina; Bautista, Lorenzo; Canal Arias, Jose Maria; Navarro Santañes, Antonio
    IFATCC International Congress
    Presentation's date: 2013-10-08
    Presentation of work at congresses

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  • Corona plasma surface effects on dyeing kinetics of acrilic fibre under glass transition temperature

     Labay, Cedric Pierre; Mojica Guerrero, Isabel Xarani; Canal Barnils, Cristina; Rodriguez Sorigue, Maria Cristina; Caballero Manresa, Gabriel; Canal Arias, Jose Maria
    IFATCC International Congress
    Presentation's date: 2013-05-08
    Presentation of work at congresses

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    DVD código de barras, numero 14 00569000 Y el libro de actas, que también esta registrado con el 1400808120

  • Desenvolupament de biomaterials basats em biopolimers d'origen porcí

     Ginebra Molins, Maria Pau; Canal Barnils, Cristina; Español Pons, Montserrat
    Date: 2013-05-15
    Report

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  • Electrical discharges with liquids for future applications (Cost Action TD1208)

     Canal Barnils, Cristina
    Participation in a competitive project

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  • Plasma functionalization of titanium surface for repulsion of blood platelets

     Cvelbar, Uros; Modic, Martina; Kovac, J; Lazovic, S; Filipic, G; Vujosevic, D; Junkar, Ita; Elersic, Kristina; Brühl, S.P.; Canal Barnils, Cristina; Belmonte, Thierry; Mozetic, Miran
    Surface and coatings technology
    Date of publication: 2012
    Journal article

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    Thrombosis and restenosis are the most common problems during insertion of biocompatible implants like titanium stents into human blood, due to aggregation of platelets on their surfaces. Because of this reason, we studied the response of blood platelets to a plasma treated titanium surface. The aim was to design a functionalized surface which would repel blood platelets or prevent their adhesion. Therefore, we functionalized surfaces with low-temperature inductively coupled oxygen plasma treatment, which in the first stage cleaned the surface of titanium, and in the second promoted incorporation of oxygen functional groups as well as the growth of a titanium dioxide film. In this paper we show that oxygen atoms or oxygen containing groups play an important role in the repulsion of platelets and their deactivation. At the same time, increased surface temperature of samples either through sequential thermal deactivation in oven at 150 °C or heating the surface with ion bombardment during the treatment, lowers the oxygen content and the surface repulsion for platelets.

  • Calcium phosphate cements as drug delivery materials

     Ginebra Molins, Maria Pau; Canal Barnils, Cristina; Español Pons, Montserrat; Pastorino, David; Montufar Jimenez, Edgar Benjamin
    Advanced drug delivery reviews
    Date of publication: 2012-01-25
    Journal article

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    Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions.

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    Drug delivery properties of macroporous polystyrene solid foams  Open access

     Canal Barnils, Cristina; Aparicio, Rosa María; Vílchez, Alejandro; Esquena, Jordi; García-Celma, María José
    Journal of pharmacy and pharmaceutical sciences
    Date of publication: 2012
    Journal article

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    Purpose. Polymeric porous foams have been evaluated as possible new pharmaceutical dosage forms. Methods. These materials were obtained by polymerization in the continuous phase of highly concentrated emulsions prepared by the phase inversion temperature method. Their porosity, specific surface and surface topography were characterized, and the incorporation and release of active principles was studied using ketoprofen as model lipophilic molecule. Results. Solid foams with very high pore volume, mainly inside macropores, were obtained by this method. The pore morphology of the materials was characterized, and very rough topography was observed, which contributed to their nearly superhydrophobic properties. These solid foams could be used as delivery systems for active principles with pharmaceutical interest, and in the present work ketoprofen was used as a model lipophilic molecule. Conclusions. Drug incorporation and release was studied from solid foam disks, using different concentrations of the loading solutions, achieving a delayed release with short lag-time

  • Biological decontamination using high and reduced pressure nitrogen afterglows

     Sarrette, Jean-Philippe; Cousty, Sarah; Clement, Frank; Canal Barnils, Cristina; Ricard, André
    Plasma processes and polymers
    Date of publication: 2012-06
    Journal article

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    Typical results quantifying the antibacterial efficiencies of high and reduced pressure nitrogen afterglows are presented, using the same microbiological protocol. In parallel, the diffusion of the nitrogen atoms through different polymer membranes is studied.

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    Biomateriales textiles: plasma para regular la liberación de fármacos  Open access

     Canal Barnils, Cristina
    Sociedad Española de Bioquímica y Biología Molecular - Ciencia para todos
    Date of publication: 2012
    Journal article

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    Materiales textiles encuentran aplicaciones como biomateriales para la reparación y regeneración de distintas patologías tanto en tejidos blandos como en tejidos duros y su uso como sistemas de liberación controlada de fármacos reportaría numerosas ventajas. La modificación superficial de las fibras a nivel nanométrico mediante plasma de baja temperatura puede ser utilizada como herramienta para modular las interacciones biomaterial-fármaco y por tanto, conseguir una liberación controlada de los principios activos.

  • Relevance of surface modification of polyamide 6.6 fibers by air plasma treatment on the release of caffeine

     Labay, Cédric; Canal Arias, Jose Maria; Canal Barnils, Cristina
    Plasma processes and polymers
    Date of publication: 2012-02
    Journal article

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  • Plasmas in organic biomaterials: a case study of polypropylene meshes for soft tissue repair

     Canal Barnils, Cristina; Labay, Cedric; Navarro Santañes, Antonio; Modic, Martina; Cvelbar, Uros; Ginebra Molins, Maria Pau; Canal Arias, Jose Maria
    International Union for Vacuum Science Technique and Applications
    Presentation's date: 2012-12-09
    Presentation of work at congresses

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  • Biomimetic processing of calcium phosphates: tailoring porosity from the nano- to the macroscale for bone regeneration and drug delivery applications

     Ginebra Molins, Maria Pau; Canal Barnils, Cristina; Montufar Jimenez, Edgar Benjamin; Español Pons, Montserrat
    Conference of the Scandinavian Society for Biomaterials
    Presentation's date: 2012-05-08
    Presentation of work at congresses

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    Comparison of the effects of corona and low pressure plasma on the release of caffeine from PA66 filaments  Open access

     Labay, Cedric Pierre; Canal Arias, Jose Maria; Navarro Santañes, Antonio; Canal Barnils, Cristina
    Man-Made Fibers Congress
    Presentation's date: 2012-09-19
    Presentation of work at congresses

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    Technical textiles for medical applications are a research expanding field. One of the added values of these materials can be suitable to contain and release active ingredients in a controlled manner. A possible alternative to obtain fabrics with controlled drug release properties could lie in the modification of fiber-active principle bonds, so that you get a proper release for each particular application. R & D currently developing drug delivery systems aims to achieve a controlled release of an active principle during a predetermined time. This is done in order to avoid the administration of several doses of drugs or cosmetic products and thus make the patient follow the therapy more easily. The influence of surface modification of fibers by low temperature plasma has been studied regarding the modification of the physical, chemical and topographical properties of the textile fibers. First studies evaluated the incorporation and release of anti-inflammatory and cosmetic drugs from different textile materials to evaluate the modulation of the drug release as the result of the surface modifications achieved by plasma treatment. The use of plasma technology to modulate the release of drugs is an original and innovative contribution. By altering the chemical bonds on the surface of textile fibers with plasma, the drug release kinetic profiles may be modified.

  • Antibiotic-eluting calcium phosphate foams for bone regeneration

     Pastorino Carraz, David; Canal Barnils, Cristina; Ginebra Molins, Maria Pau
    TERMIS World Congress
    Presentation's date: 2012
    Presentation of work at congresses

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  • Estudio de técnicas de liberación de aromas en materiales textiles

     Canal Barnils, Cristina; Gil Mur, Francisco Javier
    Date: 2012-12-21
    Report

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    Lana y Poliamida 6 tratadas con plasma  Open access

     Canal Barnils, Cristina
    Date of publication: 2012
    Book

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    La lana es una fibra natural que aunque posee propiedades de confort apreciadas por el consumidor, presenta el inconveniente de encoger durante el lavado en medio acuoso. En una época en que la tendencia en el cuidado de las prendas es el "easy-care" (cuidado fácil), es imperativo que cualquier producto textil sea lavable a máquina. Por ello se han desarrollado numerosos tratamientos para prevenir el encogimiento de las prendas de lana. Sin embargo, la estricta legislación ambiental de los países occidentales hace necesaria la utilización de tecnologías más limpias como, por ejemplo, el plasma de baja temperatura. Diversos factores han limitado la implementación a nivel industrial del plasma para tratamientos textiles, y en concreto en tratamientos de lana, entre ellos el elevado coste inicial de la maquinaria de plasma para aplicaciones textiles. Por otra parte se ha constatado que el plasma empeora el tacto de los tejidos de lana, aumentando su aspereza, lo que ha sido también un inconveniente de este proceso. Estudios preliminares mostraron que, a pesar de que un suavizado convencional conseguía mejorar el tacto de los tejidos de lana tratados con plasma, ello revertía en elevados valores de encogimiento. Es por tanto el mecanismo implicado en tal fenómeno, un punto clave a resolver para llegar a diseñar tejidos de lana inencogibles y suaves dentro de parámetros respetuosos con el medio ambiente. Por otra parte, estudios previos revelaron que, aunque en los tratamientos de plasma de radiofrecuencia (en el reactor empleado en este estudio) se trabaja a bajas presiones, los gases utilizados en la generación del plasma se encuentran contaminados con vapor de agua procedente de la degasificación de los tejidos de lana. Para evitar tal contaminación es de interés profundizar en los efectos de los tratamientos con plasma de vapor de agua. Hasta el momento, se han atribuido los efectos beneficiosos del plasma en fibras textiles a las numerosas especies en él presentes, como iones, electrones, átomos, radicales neutros, moléculas excitadas y radiación ultravioleta. Sin embargo, un mejor conocimiento de las especies realmente implicadas en los cambios de superficie producidos por el plasma podría ser clave para el diseño de nuevos procesos optimizados (que pudieran, potencialmente reducir los elevados costes de la maquinaria de plasma para aplicaciones textiles).La importancia de la poliamida 6 dentro de las fibras sintéticas, el hecho de que se utilice en combinación con la lana en gran número de productos textiles, así como el hecho de que compartan, en su estructura química los enlaces peptídicos (amida), aviva el interés de conocer los efectos del plasma en esta fibra química. Por todo ello, la presente Tesis Doctoral profundiza en el estudio de los tratamientos de lana con plasma como alternativa ecológica a los tratamientos de resistencia al encogimiento industriales. Se estudian principalmente las modificaciones superficiales producidas por el plasma en las fibras de lana y las variaciones en el encogimiento de los tejidos. Asimismo se analizan los efectos del plasma en poliamida 6, en concreto en sus propiedades superficiales, microestructura y propiedades tintóreas. Se han identificado las principales especies responsables de los efectos del plasma fibras y tejidos de lana y poliamida 6. Por primera vez se han realizado tratamientos de tejidos de lana y poliamida 6 en la post-descarga del plasma, mostrando la eficiencia de este tratamiento en la modificación superficial de las fibras y en la mejora de la resistencia al encogimiento de tejidos de lana. El estudio detallado del tratamiento con plasma de tejidos de lana y lambswool previamente teñidos revela la compatibilidad de estos procesos. Estudios previos mostraron que el plasma empeoraba el tacto de los tejidos, y por ello se ha estudiado la modificación del tacto de los tejidos tratados con plasma. La aplicación de suavizantes convencionales tipo amina cuaternaria en tejidos tratados con plasma produce tejidos con elevados valores de encogimiento, por lo que se estudia la aplicación de suavizantes de polisiloxanos funcionales. Los resultados obtenidos apuntan a una posible relación entre la resistencia al encogimiento y la hidrofilia de los tejidos de lana tratados con plasma y post-suavizados. Ello se confirma mediante la incorporación de cadenas hidrocarbonadas de distinta longitud a tejidos de lana tratados con plasma.

  • Surface and bulk cotton fibre modifications: plasma and cationization: Influence on dyeing with reactive dye

     Patiño Maya, Alejandro; Canal Barnils, Cristina; Rodriguez Sorigue, Maria Cristina; Caballero Manresa, Gabriel; Navarro Santañes, Antonio; Canal Arias, Jose Maria
    Cellulose
    Date of publication: 2011-05-12
    Journal article

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  • Efecto del plasma de aire en la liberación de cafeína a partir de tejidos de punto de poliamida 66  awarded activity

     Labay, Cédric; Canal Arias, Jose Maria; Canal Barnils, Cristina
    Revista de química e industria textil
    Date of publication: 2011-03-01
    Journal article

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    24º Premio de la Asociación Española de Químicos y Coloristas Textiles 2011 al "Mejor estudio textil o químico textil de aplicación a la industria"

  • Fibre-reinforced calcium phosphate cements: a review

     Canal Barnils, Cristina; Ginebra Molins, Maria Pau
    Journal of the mechanical behavior of biomedical materials
    Date of publication: 2011
    Journal article

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    Calcium phosphate cements (CPC) consist of one or more calcium orthophosphate powders, which upon mixing with water or an aqueous solution, form a paste that is able to set and harden after being implanted within the body. Different issues remain still to be improved in CPC, such as their mechanical properties to more closely mimic those of natural bone, or their macroporosity to favour osteointegration of the artificial grafts. To this end, blends of CPC with polymer and ceramic fibres in different forms have been investigated. The present work aims at providing an overview of the different approaches taken and identifying the most significant achievements in the field of fibre-reinforced calcium phosphate cements for clinical applications, with special focus on their mechanical properties.

  • Evaluation of N atom transmission of N(2) flowing post-discharges for sterilization processes through modification of wettability of textiles

     Canal Barnils, Cristina; Villeger, Sandrine; Ricard, André
    Plasma processes and polymers
    Date of publication: 2011-06-22
    Journal article

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    Plasma sterilization has been extensively studied in recent years, and at present conditioning materials such as sterilization pouches or process indicators devoted to such processes should be optimized to allow transfer of the technology to the market. The present work evaluates the possibility of using wettability modification of hydrophobic textiles to detect whether Natoms of a flowing post-discharge in sterilization conditions (1 L/min, 100W) are able to freely cross a cellulose membrane (found on the permeable side of a conventional sterilization pouch) and exert their action. Results showed that N2 postdischarge treatment did not alter pore size of the membrane, and the use of tailored hydrophobic textiles was shown to be an appropriate indicator of N atom penetration inside the pouches. Depending on the initial hydrophobic treatment of the textiles, it is possible to detect differences in the density of atoms which crossed the membrane, being capable of distinguishing between parameters such as treatment time, or altered hydrodynamics of the chamber.

  • Relevance of calcium phosphate cement microstructure for controlled antibiotic delivery

     Canal Barnils, Cristina; Schuler, Philipp; Pastorino, David; Ginebra Molins, Maria Pau
    European Conference on Biomaterials
    Presentation's date: 2011-09-05
    Presentation of work at congresses

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  • Preparación de una propuesta para la convocatoria NMP-2010-LARGE-4 del FP7

     Rodriguez Rius, Daniel; Canal Barnils, Cristina; Español Pons, Montserrat; Manero Planella, Jose M.; Gil Mur, Francisco Javier; Pegueroles Neyra, Marta; Ginebra Molins, Maria Pau
    Participation in a competitive project

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  • NOVEL BIOMIMETIC STRATEGY FOR BONE REGENERATION

     Canal Barnils, Cristina; Gil Mur, Francisco Javier; Manero Planella, Jose M.; Español Pons, Montserrat; Ginebra Molins, Maria Pau
    Participation in a competitive project

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  • 24è Premi al "Millor estudi tèxtil o químic-tèxtil d'aplicació a la industria" 2011

     Labay, Cédric; Canal Arias, Jose Maria; Canal Barnils, Cristina
    Award or recognition

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  • Biomedical Applications of Atmospheric Pressure Plasma Technology

     Canal Barnils, Cristina
    Participation in a competitive project

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  • Influence of Corona Plasma Treatment on Polypropylene and Polyamide 6.6 on the Release of a Model Drug

     Labay, Cedric Pierre; Canal Barnils, Cristina; García Celma, Mª José
    Plasma chemistry and plasma processing
    Date of publication: 2010-12
    Journal article

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  • Influence of corona discharge and chitosan surface treatment on dyeing properties of wool

     Ristic, Nebosja; Jovancic, Petar; Canal Barnils, Cristina; Jocic, Dragan
    Journal of applied polymer science
    Date of publication: 2010
    Journal article

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  • Tratamientos de cationizado y de plasma atmosférico sobre algodón, previos a la tintura con colorante reactivo

     Patiño Maya, Alejandro; Canal Barnils, Cristina; Rodriguez Sorigue, Maria Cristina; Caballero Manresa, Gabriel; Navarro Santañes, Antonio; Canal Arias, Jose Maria
    Revista de química textil
    Date of publication: 2010-03
    Journal article

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    En el presente trabajo se han evaluado los efectos de tratamiento con plasma de aire, y/o un cationizado con una epihalohidrina a distintas concentraciones, sobre el agotamiento de la tintura de algodón con colorante reactivo. Se demuestra que algunos de estos tratamientos permiten obtener tinturas con muy alto agotamiento de colorante en tejidos de algodón, con las ventajas medioambientales que ello supone. Se reflexiona sobre los posibles grupos funcionales originados por los tratamientos realizados en la superficie de la fibra de algodón, y su influencia en el agotamiento.

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    Active species in N2 and N2-O2 afterglows for surface treatments  Open access

     Ricard, André; Pointu, Anne Marie; Villeger, Sandrine; Canal Barnils, Cristina
    Journal of physics: conference series
    Date of publication: 2010
    Journal article

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    Production of active species is studied in N2 and in N2-O2 afterglows of electrical discharges at low and atmospheric gas pressures. They are produced in microwave discharges in a large range of gas pressures from a few Torr to 100 Torr and in corona discharges at atmospheric gas pressure. The active species in N2 afterglows are the N-atoms which are in the range of a few percents in the afterglows. The effect of O2 molecules in low percentages in low pressure N2 microwave plasmas and as impurity in corona N2 discharges is specially analysed. The interaction of N and O-atoms with surfaces is studied for bacteria decontamination and for transmission of N-atoms though porous membranes. The processes of bacteria decontamination in N2-O2 afterglows are described for low pressure microwave and atmospheric pressure corona discharges. Transmission of N-atoms through porous membranes is studied at medium pressure (10100 Torr) microwave afterglows.

  • Transmission of N atoms through PP membranes for nitrogen flowing post-discharge sterilisation processes

     Ricard, André; Canal Barnils, Cristina
    Plasma chemistry and plasma processing
    Date of publication: 2010
    Journal article

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    This work reports on the results of investigations conducted with three layered polypropylene (PP) membranes which were exposed to a N2 flowing microwave (100 W) post discharge, at several flow rates (0.03–1 Slm) and at gas pressure from 0.3 to 40 Torr. The N atoms transmission through the membrane was measured from the intensity variation of the N2, 580 nm afterglow which is related to N atom density, before and after the membranes. The results obtained showed that N-atoms penetrate and cross the membranes with a transmission factor (TN) varying from 20 to 70% during the exposure time (15 min), depending on flow rate and gas pressure. A maximum value TN = 0.7 (±0.05) is found for sufficient low flow rate (less than 0.1 Slm), that is for low flow gas velocity (about 2 9 102 cm s-1).

  • Microscopy techniques to evaluate plasma modifiaction on membranes for sterilization applications

     Canal Barnils, Cristina; Villeger, Sandrine; Ricard, André; Navarro Santañes, Antonio; Canal Arias, Jose Maria
    Date of publication: 2010-12
    Book chapter

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  • Modficación de la funcionalidad química del algodón mediante tratamientos con enzimas, de cationizado, y con plasmas: Evaluación del comportamiento tintóreo

     Patiño Maya, Alejandro
    Defense's date: 2010-11-05
    Department of Textile and Paper Engineering, Universitat Politècnica de Catalunya
    Theses

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