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A new gene-based association test for genome-wide association studies

Autor
Buil, A.; Martínez-Pérez, A.; Perera, A.; Rib, L.; Soria, J.; Caminal, P.
Tipus d'activitat
Article en revista
Revista
BMC proceedings (Online)
Data de publicació
2009-12-15
Volum
15
Número
3
Pàgina inicial
1
Pàgina final
5
DOI
https://doi.org/10.1186/1753-6561-3-S7-S130 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/9715 Obrir en finestra nova
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795904/?tool=pubmed Obrir en finestra nova
Resum
Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis. We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-ba...
Citació
Buil, A. [et al.]. A new gene-based association test for genome-wide association studies. "BMC proceedings (Online)", 15 Desembre 2009, vol. 15, núm. 3, p. 1-5.
Grup de recerca
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Centre de Recerca en Enginyeria Biomedica

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